| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Quanxiang Xian, Zhihai Qiu, Suresh Murugappan, Shashwati Kala, Kin Fung Wong, Danni Li, Guofeng Li, Yizhou Jiang, Yong Wu, Min Su, Xuandi Hou, Jiejun Zhu, Jinghui Guo, Weibao Qiu, Lei Su. Modulation of deep neural circuits with sonogenetics. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 22. 2023-05-22. PMID:37216521. |
ultrasound stimulation of mscl-expressing neurons in the ventral tegmental area could activate the mesolimbic pathway to trigger dopamine release in the nucleus accumbens and modulate appetitive conditioning. |
2023-05-22 |
2023-08-14 |
mouse |
| Sukanya G Gakare, Rajesh R Ugal. Pharmacological evaluation of lateral habenula and rostromedial tegmental nucleus in the expression of ethanol-induced place preference. Behavioural pharmacology. vol 34. issue 4. 2023-05-12. PMID:37171461. |
in immunohistochemistry, we found that pdc administration significantly decreased, whereas lamotrigine treatment significantly increased tyrosine hydroxylase immunoreactivity (th-ir) in vta and nucleus accumbens (nac). |
2023-05-12 |
2023-08-14 |
Not clear |
| Marjan Nikbakhtzadeh, Hoda Ranjbar, Khadijeh Moradbeygi, Elham Zahedi, Mahnaz Bayat, Monavareh Soti, Mohammad Shaban. Cross-talk between the HPA axis and addiction-related regions in stressful situations. Heliyon. vol 9. issue 4. 2023-05-08. PMID:37151697. |
first, we will provide an overview of changes in the hypothalamus-pituitary-adrenal (hpa) axis component following stress, which impact reward-related regions including the ventral tegmental area (vta) and nucleus accumbens (nac). |
2023-05-08 |
2023-08-14 |
Not clear |
| Ming Sun, Chao Wu, Lixin Liu, Liang Gu, Zihao Wang, Feng Xu, Donglin Zh. Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway. Biochemical pharmacology. 2023-05-03. PMID:37137415. |
moreover, dopamine accumulated in the vta and nucleus accumbens of ia2bc rats. |
2023-05-03 |
2023-08-14 |
rat |
| Ani Gasparyan, Francisco Navarrete, Daniela Navarro, Jorge Manzanare. Cannabidiol regulates behavioral and brain alterations induced by spontaneous alcohol withdrawal. Neuropharmacology. 2023-04-21. PMID:37085012. |
gene expression analyses of cannabinoid receptors 1 (cnr1) and 2 (cnr2), mu-opioid receptor (opmr1), and proopiomelanocortin (pomc) in the nucleus accumbens (nacc), and pomc and tyrosine hydroxylase (th) in the ventral tegmental area (vta), were carried out by real time-pcr. |
2023-04-21 |
2023-08-14 |
mouse |
| Javier Cuitavi, Paula Andrés-Herrera, David Meseguer, Yolanda Campos-Jurado, Jesús D Lorente, Hannah Caruana, Lucía Hipólit. Focal mu-opioid receptor activation promotes neuroinflammation and microglial activation in the mesocorticolimbic system: Alterations induced by inflammatory pain. Glia. 2023-04-05. PMID:37017183. |
furthermore, mor pharmacological activation in the ventral tegmental area (vta) modified the levels of iba1-positive cells in the vta, prefrontal cortex, the nucleus accumbens and the amygdala in a dose-dependent way, without impacting mechanical nociception. |
2023-04-05 |
2023-08-14 |
rat |
| ManHua Zhu, Neil G Rogers, Jasmine V Jahad, Melissa A Herma. Sex differences in the impact of electronic nicotine vapor on corticotropin-releasing factor receptor 1 neurons in the mouse ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-03-31. PMID:37001989. |
we found that vta crf1 neurons are mainly dopaminergic and project to the nucleus accumbens ( |
2023-03-31 |
2023-08-14 |
mouse |
| Asif Iqbal, Abdul Hamid, Syed Muzzammil Ahmad, Kabirullah Lutf. The Role of Mu Opioid Receptors in High Fat Diet-Induced Reward and Potentiation of the Rewarding Effect of Oxycodone. Life (Basel, Switzerland). vol 13. issue 3. 2023-03-29. PMID:36983775. |
excessive high fat diet (hfd) consumption can induce food addiction, which is believed to involve the communication between the hypothalamus and mesolimbic dopaminergic neurons, originating in the ventral tegmental area (vta) and projecting to the nucleus accumbens (nac). |
2023-03-29 |
2023-08-14 |
mouse |
| Teresa M Nufer, Bridget J Wu, Zachary Boyce, Scott C Steffensen, Jeffrey G Edward. Ethanol blocks a novel form of iLTD, but not iLTP of inhibitory inputs to VTA GABA neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-03-10. PMID:36899030. |
while synaptic plasticity to vta da neurons as well as prefrontal cortex to nucleus accumbens gaba neurons are well studied, vta gaba cell plasticity, specifically inhibitory inputs to vta gaba neurons, is less understood. |
2023-03-10 |
2023-08-14 |
mouse |
| Lisha Deng, Zheng Chu, Peng Liu, Baijia Li, Gang Lei, Shaofu Li, Yongkang Ma, Yonghui Dan. Effects of brain-derived neurotrophic factor and adeno-associated viral vector on morphine-induced condition through target concentration changes in the ventral tegmental area and nucleus accumbens. Behavioural brain research. 2023-03-08. PMID:36889465. |
effects of brain-derived neurotrophic factor and adeno-associated viral vector on morphine-induced condition through target concentration changes in the ventral tegmental area and nucleus accumbens. |
2023-03-08 |
2023-08-14 |
mouse |
| Lisha Deng, Zheng Chu, Peng Liu, Baijia Li, Gang Lei, Shaofu Li, Yongkang Ma, Yonghui Dan. Effects of brain-derived neurotrophic factor and adeno-associated viral vector on morphine-induced condition through target concentration changes in the ventral tegmental area and nucleus accumbens. Behavioural brain research. 2023-03-08. PMID:36889465. |
the overexpression of bdnf in the ventral tegmental area (vta) caused by bdnf-aav injection decreased the total distance of locomotion in mice who underwent morphine-induced bs and increased the concentrations of bdnf, trkb, and creb in the vta and nucleus accumbens (nac). |
2023-03-08 |
2023-08-14 |
mouse |
| Soren D Emerson, Maxime Chevée, Philipp Mews, Erin S Calipar. The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic system. Molecular and cellular neurosciences. 2023-03-03. PMID:36868542. |
in this study, we utilized rna sequencing to characterize how the transcriptome-wide effects of acute cocaine exposure were altered by a history of cocaine self-administration and long-term withdrawal (30 days) in the ventral tegmental area (vta), nucleus accumbens (nac), and prefrontal cortex (pfc) in male mice. |
2023-03-03 |
2023-08-14 |
mouse |
| Eric J Nunes, Nardos Kebede, Joshua L Haight, Daniel J Foster, Craig Lindsley, P Jeffrey Conn, Nii Add. Ventral tegmental area M5 muscarinic receptors mediate effort-choice responding and nucleus accumbens dopamine in a sex-specific manner. The Journal of pharmacology and experimental therapeutics. 2023-02-24. PMID:36828630. |
ventral tegmental area m5 muscarinic receptors mediate effort-choice responding and nucleus accumbens dopamine in a sex-specific manner. |
2023-02-24 |
2023-08-14 |
rat |
| Hillary A Wadsworth, Elizabeth Q Anderson, Benjamin M Williams, Joakim W Ronström, Janna K Moen, Anna M Lee, J Michael McIntosh, Jie Wu, Jordan T Yorgason, Scott C Steffense. Role of α6-Nicotinic Receptors in Alcohol-Induced GABAergic Synaptic Transmission and Plasticity to Cholinergic Interneurons in the Nucleus Accumbens. Molecular neurobiology. 2023-02-21. PMID:36802012. |
the prevailing view is that enhancement of dopamine (da) transmission in the mesolimbic system, consisting of da neurons in the ventral tegmental area (vta) that project to the nucleus accumbens (nac), underlies the reward properties of ethanol (etoh) and nicotine (nic). |
2023-02-21 |
2023-08-14 |
mouse |
| José Luis Marcos, Rossy Olivares-Barraza, Karina Ceballo, Melisa Wastavino, Víctor Ortiz, Julio Riquelme, Jonathan Martínez-Pinto, Pablo Muñoz, Gonzalo Cruz, Ramón Sotomayor-Zárat. Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674982. |
brain areas such as the lateral hypothalamus (lh), lateral septum (ls), ventral tegmental area (vta), and nucleus accumbens (nacc) have been implicated in the homeostatic and hedonic control of feeding in experimental models of diet-induced obesity. |
2023-01-21 |
2023-08-14 |
Not clear |
| Junhua Yang, Jianan Chen, Yongqing Liu, Kevin Hong Chen, Jay M Baraban, Zhaozhu Qi. Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. Neuron. 2023-01-21. PMID:36681074. |
repeated cocaine exposure potentiates astrocytic tonic gaba release through volume-regulated anion channels (vracs) and augments tonic inhibition of vta gaba neurons, thus downregulating their activities and disinhibiting nucleus accumbens (nac) projecting da neurons. |
2023-01-21 |
2023-08-14 |
mouse |
| Mannan Abdul, Hao-Qi Yan, Wei-Nan Zhao, Xiao-Bin Lyu, Zheng Xu, Xiao-Lu Yu, Yi-Hong Gao, Jun-Li Ca. VTA-NAc glutaminergic projection involves in the regulation of pain and pain-related anxiety. Frontiers in molecular neuroscience. vol 15. 2023-01-02. PMID:36590915. |
besides the established role of dopamine neurons and projections in nociceptive stimuli, the involvement of ventral tegmental area (vta) glutamatergic projections to nucleus accumbens (nac) in pain remains unknown. |
2023-01-02 |
2023-08-14 |
Not clear |
| Laura C Ornelas, Giorgia Boero, Kalynn Van Voorhies, Todd K O'Buckley, Joyce Besheer, A Leslie Morro. Pharmacological administration of 3α,5α-THP into nucleus accumbens core increases 3α,5α-THP expression and reduces alcohol self-administration. Alcoholism, clinical and experimental research. 2023-01-01. PMID:36587947. |
alcohol affects multiple circuits in the brain, mainly disrupting the delicate balance between inhibitory γ-aminobutyric acid (gaba) transmission and excitatory glutamate signaling in brain areas involved in reward circuits, such as amygdala, nucleus accumbens (acb) and ventral tegmental area (vta), causing loss of control in circuits that regulate behavioral control of craving, alcohol-seeking and intake. |
2023-01-01 |
2023-08-14 |
human |
| Lei Fan, Huan Chen, Yong Liu, Hongwei Hou, Qingyuan H. ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice. Pharmacology, biochemistry, and behavior. 2022-12-24. PMID:36565790. |
nicotine is an addictive compound that interacts with nicotinic acetylcholine receptors (nachrs) in the ventral tegmental area (vta), inducing a release of dopamine in the nucleus accumbens (nac). |
2022-12-24 |
2023-08-14 |
mouse |
| Maria Pina Serra, Francesco Sanna, Marianna Boi, Laura Poddighe, Lorenzo Secci, Marcello Trucas, Alberto Fernández-Teruel, Maria Giuseppa Corda, Osvaldo Giorgi, Marina Quart. Acute Stress Induces Different Changes on the Expression of BDNF and trkB in the Mesocorticolimbic System of Two Lines of Rats Differing in Their Response to Stressors. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499323. |
the present work was undertaken to investigate the effects of acute forced swimming (fs) on the levels of brain-derived neurotrophic factor (bdnf) and tyrosine kinase receptor b (trkb) proteins in: the ventral tegmental area (vta); the nucleus accumbens (acb) shell and core compartments; and the anterior cingulate (acg), prelimbic (pl) and infralimbic (il) territories of the prefrontal cortex of genetic models of vulnerability (rla, roman low-avoidance rats) and resistance (rha, roman high-avoidance rats) to stress-induced depression. |
2022-12-11 |
2023-08-14 |
rat |