| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Jones-Humble, M J Durcan, D Lyerly, R M Norton, F L Tang, A V Russell, M J Watson, P J Gengo, P F Morgan, C M Wang, B R Cooper, R F Co. Preclinical neurochemical and electrophysiological profile of 1192U90, a potential antipsychotic. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 3. 1997-01-15. PMID:8873105. |
the results suggest that 1192u90 is a preferential dopamine d2 antagonist as well as a 5-ht1a agonist that may prove to be an atypical antipsychotic. |
1997-01-15 |
2023-08-12 |
rat |
| M H Norman, F Navas, J B Thompson, G C Rigdo. Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents. Journal of medicinal chemistry. vol 39. issue 24. 1997-01-06. PMID:8941382. |
these analogues were evaluated in vitro for their binding to the dopamine d2, serotonin 5-ht2, and serotonin 5-ht1a receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. |
1997-01-06 |
2023-08-12 |
mouse |
| D Goldman, J Lappalainen, N Ozak. Direct analysis of candidate genes in impulsive behaviours. Ciba Foundation symposium. vol 194. 1997-01-02. PMID:8862874. |
direct gene analyses have revealed non-conservative amino acid substitutions and structural variants (generally rare) at drd2, drd3 and drd4 dopamine receptors and 5-ht1a, 5-ht2a, 5-ht2c and 5-ht7 serotonin receptors. |
1997-01-02 |
2023-08-12 |
Not clear |
| H Ujike, K Akiyama, S Kurod. [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma 1 and sigma 2 receptor subtypes. Neuroreport. vol 7. issue 5. 1996-12-11. PMID:8804051. |
using k+ phosphate buffer with 25 nm spiperone, [3h]ym-09151-2 binding showed a high affinity for sigma receptors but no affinity for d2 dopamine or 5-ht1a receptors in rat brain. |
1996-12-11 |
2023-08-12 |
rat |
| H Yu, Y Liu, A Malmberg, N Mohell, U Hacksell, T Lewande. Differential serotoninergic and dopaminergic activities of the (R)- and the (S)-enantiomers of 2-(di-n-propylamino)tetralin. European journal of pharmacology. vol 303. issue 3. 1996-12-11. PMID:8813561. |
thus, in functional tests of postsynaptic actions (r)-dpat behaves as a 5-ht1a receptor agonist and (s)-dpat as a dopamine d2 receptor agonist. |
1996-12-11 |
2023-08-12 |
Not clear |
| H Yu, Y Liu, A Malmberg, N Mohell, U Hacksell, T Lewande. Differential serotoninergic and dopaminergic activities of the (R)- and the (S)-enantiomers of 2-(di-n-propylamino)tetralin. European journal of pharmacology. vol 303. issue 3. 1996-12-11. PMID:8813561. |
presynaptically, (r)-dpat shows selectivity for 5-ht1a receptors and (s)-dpat for dopamine d2 receptors. |
1996-12-11 |
2023-08-12 |
Not clear |
| H Yu, Y Liu, A Malmberg, N Mohell, U Hacksell, T Lewande. Differential serotoninergic and dopaminergic activities of the (R)- and the (S)-enantiomers of 2-(di-n-propylamino)tetralin. European journal of pharmacology. vol 303. issue 3. 1996-12-11. PMID:8813561. |
receptor binding studies, utilizing [3h]8-hydroxy-2-(di-n-propylamino)tetralin and [3h]quinpirole as radioligands for 5-ht1a and dopamine d2 receptors, respectively, showed (r)-dpat to have a 3-fold higher affinity than (s)-dpat for 5-ht1a receptors, whereas (s)-dpat had a 6-fold higher affinity than (r)-dpat for dopamine d2 receptors. |
1996-12-11 |
2023-08-12 |
Not clear |
| H Yu, Y Liu, A Malmberg, N Mohell, U Hacksell, T Lewande. Differential serotoninergic and dopaminergic activities of the (R)- and the (S)-enantiomers of 2-(di-n-propylamino)tetralin. European journal of pharmacology. vol 303. issue 3. 1996-12-11. PMID:8813561. |
thus, the results from receptor binding studies support the conclusion that (r)- and (s)-dpat are agonists showing selectivity for 5-ht1a and dopamine d2 receptors, respectively. |
1996-12-11 |
2023-08-12 |
Not clear |
| T Ishibashi, K Ikeda, K Ishida, J Yasui, R Tojima, M Nakamura, Y Ohn. Contrasting effects of SM-9018, a potential atypical antipsychotic, and haloperidol on c-fos mRNA expression in the rat striatum. European journal of pharmacology. vol 303. issue 3. 1996-12-11. PMID:8813576. |
sm-9018 (cis-2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl) hexahydro-1 h-isoindole-1,3(2h)-dione hcl) is a potential atypical antipsychotic with high affinity for 5-ht2, dopamine d2 and 5-ht1a receptors. |
1996-12-11 |
2023-08-12 |
rat |
| P Soares-da-Silva, M A Vieira-Coelho, M Pestan. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: endogenous 5-hydroxytryptamine, 5-HT1A receptors and antinatriuresis during high sodium intake. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882615. |
antagonistic actions of renal dopamine and 5-hydroxytryptamine: endogenous 5-hydroxytryptamine, 5-ht1a receptors and antinatriuresis during high sodium intake. |
1996-12-11 |
2023-08-12 |
rat |
| P Soares-da-Silva, M A Vieira-Coelho, M Pestan. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: endogenous 5-hydroxytryptamine, 5-HT1A receptors and antinatriuresis during high sodium intake. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882615. |
the present study has examined the effect of (+)-way 100135, a selective antagonist of 5-ht1a receptors, and ketanserin, an antagonist of 5-ht2 receptors, on the urinary excretion of na+, k+, dopamine, 5-hydroxytryptamine (5-ht) and their metabolites in rats treated with the selective type a monoamine oxidase (mao-a) inhibitor, ro 41-1049 (15 mg kg-1 day-1) in conditions of normal sodium (ns) and high sodium (hs; 1.0% nacl in drinking water) intake. |
1996-12-11 |
2023-08-12 |
rat |
| P Soares-da-Silva, P C Pinto-do-O, A M Bertorell. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: increase in Na+, K(+)-ATPase activity in renal proximal tubules via activation of 5-HT1A receptors. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882616. |
antagonistic actions of renal dopamine and 5-hydroxytryptamine: increase in na+, k(+)-atpase activity in renal proximal tubules via activation of 5-ht1a receptors. |
1996-12-11 |
2023-08-12 |
Not clear |
| G G Nomikos, L Arborelius, B B Höök, U Hacksell, T H Svensso. The 5-HT1A receptor antagonist (S)-UH-301 decreases dopamine release in the rat nucleus accumbens and striatum. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 5. 1996-12-10. PMID:8811500. |
the 5-ht1a receptor antagonist (s)-uh-301 decreases dopamine release in the rat nucleus accumbens and striatum. |
1996-12-10 |
2023-08-12 |
rat |
| G G Nomikos, L Arborelius, B B Höök, U Hacksell, T H Svensso. The 5-HT1A receptor antagonist (S)-UH-301 decreases dopamine release in the rat nucleus accumbens and striatum. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 5. 1996-12-10. PMID:8811500. |
in this study we employed in vivo microdialysis to examine the effects of the selective 5-ht1a receptor antagonist (s)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin [(s)-uh-301] on extracellular concentrations of dopamine (da) and its metabolites dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the nucleus accumbens (nac) and dorsal striatum of awake freely moving rats. |
1996-12-10 |
2023-08-12 |
rat |
| A Malmberg, B B Höök, A M Johansson, U Hacksel. Novel (R)-2-amino-5-fluorotetralins: dopaminergic antagonists and inverse agonists. Journal of medicinal chemistry. vol 39. issue 22. 1996-12-10. PMID:8893836. |
the affinities of the compounds for [3h]raclopride-labeled cloned human dopamine (da) d2 and d3 receptors as well as [3h]-8-oh-dpat-labeled rat hippocampal 5-ht1a receptors were determined. |
1996-12-10 |
2023-08-12 |
human |
| M L Wadenber. Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat. Neuroscience and biobehavioral reviews. vol 20. issue 2. 1996-12-06. PMID:8811720. |
there is strong evidence to suggest that (1) the catalepsy produced by dopamine d1 or d2 receptor antagonists can be completely antagonized by the administration of 5-ht1a receptor agonists acting at 5-ht autoreceptors in the median raphe nucleus; (2) the catalepsy produced by a dopamine d2 receptor antagonist can be completely antagonized by treatment with a 5-ht2a/c receptor agonist; and (3) the catalepsy produced by blockade of either dopamine d1 or d2 receptors is not affected by the administration of a 5-ht2a/c receptor antagonist. |
1996-12-06 |
2023-08-12 |
rat |
| E A Johnson, J L Fox, A J Azzar. The anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788529. |
the inhibitory effects of each agent were attenuated by prior exposure to the 5-ht1a antagonist nan-190, (10 microm) (p < 0.05), but not by the dopamine d2 antagonist (-)-sulpiride (10 microm). |
1996-12-04 |
2023-08-12 |
rat |
| E A Johnson, J L Fox, A J Azzar. The anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788529. |
the potencies of 8-oh-dpat, bus, ipsap and gep were correlated with their reported affinities for the 5-ht1a receptor (p < 0.01) but not the dopamine d2 receptor. |
1996-12-04 |
2023-08-12 |
rat |
| E A Johnson, J L Fox, A J Azzar. The anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788529. |
these results support the hypothesis that bus, ipsap and gep inhibit th through activation of a striatal 5-ht1a heteroreceptor on dopamine nerve terminals. |
1996-12-04 |
2023-08-12 |
rat |
| C Comoy, C Marot, T Podona, M L Baudin, L Morin-Allory, G Guillaumet, B Pfeiffer, D H Caignard, P Renard, M C Rettori, G Adam, B Guardiola-Lemaitr. 3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]. Journal of medicinal chemistry. vol 39. issue 21. 1996-11-25. PMID:8863806. |
affinities for the 5-ht1a receptors were in the nanomolar range for the best compounds ((+)-11a,23) with a high selectivity versus other 5-ht (5-ht1b, 5-ht2, 5-ht3) or dopamine (d1, d2) receptor subtypes. |
1996-11-25 |
2023-08-12 |
Not clear |