| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N N Bogdanov, M B Bogdano. The role of 5-HT1A serotonin and D2 dopamine receptors in buspirone effects on cortical electrical activity in rats. Neuroscience letters. vol 177. issue 1-2. 1995-02-10. PMID:7824156. |
the role of 5-ht1a serotonin and d2 dopamine receptors in buspirone effects on cortical electrical activity in rats. |
1995-02-10 |
2023-08-12 |
rat |
| S Chumpradit, M P Kung, J Vessotskie, C Foulon, M Mu, H F Kun. Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors. Journal of medicinal chemistry. vol 37. issue 24. 1995-01-09. PMID:7990123. |
these compounds were evaluated for their binding profiles in several membrane preparations: spodoptera frugiperda (sf9) cells expressing dopamine d2 (non-gtp coupled, low-affinity states) and d3 receptors, hek293 cells expressing dopamine d2 receptors in high-affinity states (d2h), rat hippocampal homogenates for 5-ht1a receptors, and cerebellar homogenates for sigma receptors. |
1995-01-09 |
2023-08-12 |
rat |
| Mark J Milla. Serotonin and pain: evidence that activation of 5-HT1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice. Pain. vol 58. issue 1. 1994-12-19. PMID:7970839. |
the 5-ht1c/2 antagonist, ritanserin, the 5-ht3 antagonist, ondansetron, the dopamine d2 receptor antagonist, raclopride, and the alpha 1-adrenoceptor antagonist, prazosin, were also ineffective in modifying the antinociception evoked by 5-ht1a agonists and partial agonists in the hot-plate test. |
1994-12-19 |
2023-08-12 |
mouse |
| M Yamada, T Nishigami, K Nakasho, Y Nishimoto, H Miyaj. Relationship between sigma-like site and progesterone-binding site of adult male rat liver microsomes. Hepatology (Baltimore, Md.). vol 20. issue 5. 1994-11-23. PMID:7927262. |
as a result, we demonstrated that adult male rat liver microsomes, especially smooth endoplasmic reticulum, possessed a saturable haloperidol-binding site closely resembling the sigma site, with a high affinity (kd 1.0 +/- 0.3 nmol/l) and high capacity (bmax 9.3 +/- 1.5 pmol/mg protein) and with the rank order of affinity of the ligands: haloperidol > reduced haloperidol > clorgyline > ifenprodil > 1,3-di(2-tolyl)guanidine, (-)-butaclamol > gbr-12909 > skf-525a > progesterone > 5 alpha-dihydrotestosterone > r(+)-3- (hydroxyphenyl)-n-propylpiperidine > testosterone >> corticosteroids, estradiol-17 beta, cholesterol and neuroactive compounds displaying high affinities for other neurotransmitter receptors such as dopamine d2, serotonin (5-ht1a and 5-ht2) and alpha 1-adrenergic and gabaa receptors. |
1994-11-23 |
2023-08-12 |
rat |
| K A Wardle, E S Ellis, G S Baxter, G A Kennett, L M Gaster, G J Sange. The effects of SB 204070, a highly potent and selective 5-HT4 receptor antagonist, on guinea-pig distal colon. British journal of pharmacology. vol 112. issue 3. 1994-11-09. PMID:7921604. |
radioligand binding studies show that sb 204070 has a greater that 5000 fold selectivity for the 5-ht4 receptor over 5-ht1a, 5-ht1d, 5-ht1e, 5-ht2a, 5-ht2c, 5-ht3, gabaa, bdz, tbps, a1 adenosine receptors, alpha 1, alpha 2, beta 1, beta 2 adrenoceptors and d1, d2 and d3 dopamine receptors. |
1994-11-09 |
2023-08-12 |
Not clear |
| I Hirotsu, M Koyama, N Honbo, T Ohn. Pharmacological characteristics of hyperambulation induced by the sigma ligand (+)-3-PPP in rats. Japanese journal of pharmacology. vol 65. issue 1. 1994-10-19. PMID:7916383. |
moreover, the (+)-3-ppp effect was antagonized by the dopamine d2 antagonist sulpiride, whereas pretreatment with the 5-ht1a agonist 8-oh-dpat and the alpha-adrenoceptor antagonist phenoxybenzamine did not exert any significant effect. |
1994-10-19 |
2023-08-12 |
rat |
| M H Norman, G C Rigdon, F Navas, B R Coope. Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents. Journal of medicinal chemistry. vol 37. issue 16. 1994-09-13. PMID:7914539. |
the target compounds were examined in vitro for their binding affinities to the dopamine d2, serotonin 5-ht2, and serotonin 5-ht1a receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. |
1994-09-13 |
2023-08-12 |
mouse |
| N J Hrib, J G Jurcak, K L Burgher, P G Conway, H B Hartman, L L Kerman, J E Roehr, A T Wood. Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents. Journal of medicinal chemistry. vol 37. issue 15. 1994-09-12. PMID:7914536. |
in general, the compounds showed an affinity for dopamine d2 and serotonin 5ht2a and 5ht1a receptors. |
1994-09-12 |
2023-08-12 |
Not clear |
| C E Ybema, B Olivier, J Mos, M T Tulp, J L Slange. Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan. European journal of pharmacology. vol 256. issue 2. 1994-09-02. PMID:8050464. |
adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-ht1a receptor agonist flesinoxan. |
1994-09-02 |
2023-08-12 |
rat |
| P Salmi, T Karlsson, S Ahleniu. Antagonism by SCH 23390 of clozapine-induced hypothermia in the rat. European journal of pharmacology. vol 253. issue 1-2. 1994-07-26. PMID:7912199. |
clozapine did not antagonize hypothermia produced by selective dopamine d1 and d2 receptor agonists (a 68930 and quinpirole), the alpha 2-adrenoceptor agonist clonidine, the 5-ht1a receptor agonist 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)tetralin) or the muscarinic m1 receptor agonist oxotremorine. |
1994-07-26 |
2023-08-12 |
rat |
| L Cervo, C Bendotti, G Tarizzo, A Cagnotto, M Skorupska, T Mennini, R Samani. Potential antidepressant properties of SR 57746A, a novel compound with selectivity and high affinity for 5-HT1A receptors. European journal of pharmacology. vol 253. issue 1-2. 1994-07-26. PMID:8013540. |
the compound showed a high affinity for 5-ht1a specific binding sites in the rat hippocampus (ic50 3 nm), moderate affinity (10(-7)-10(-6) m) for dopamine d2 receptor, 5-ht uptake, 5-ht2 and alpha 1-adrenoceptor binding sites and practically no effect on binding sites of monoamine, gabaa, benzodiazepine and histamine receptors. |
1994-07-26 |
2023-08-12 |
rat |
| M L Wadenberg, L Cortizo, S Ahleniu. Evidence for specific interactions between 5-HT1A and dopamine D2 receptor mechanisms in the mediation of extrapyramidal motor functions in the rat. Pharmacology, biochemistry, and behavior. vol 47. issue 3. 1994-07-11. PMID:8208768. |
evidence for specific interactions between 5-ht1a and dopamine d2 receptor mechanisms in the mediation of extrapyramidal motor functions in the rat. |
1994-07-11 |
2023-08-12 |
rat |
| M L Wadenberg, L Cortizo, S Ahleniu. Evidence for specific interactions between 5-HT1A and dopamine D2 receptor mechanisms in the mediation of extrapyramidal motor functions in the rat. Pharmacology, biochemistry, and behavior. vol 47. issue 3. 1994-07-11. PMID:8208768. |
administration of the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat; 0.1 mg kg-1 sc) completely antagonised the catalepsy produced by the dopamine (da) d2 receptor antagonist raclopride (16 mg kg-1 sc). |
1994-07-11 |
2023-08-12 |
rat |
| M F Piercey, M W Smith, J T Lum-Raga. Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:8138943. |
the 5-ht1a receptor agonists buspirone, 8-hydroxy-n,n-dipropyl-2-aminotetralin, gepirone and ipsapirone were evaluated for their receptor binding profiles and their effects on firing rates of 5-ht, dopamine (da) and noradrenaline (na) neurons in the dorsal raphe, substantia nigra pars compacta and the locus ceruleus, respectively. |
1994-04-25 |
2023-08-12 |
Not clear |
| M F Piercey, M W Smith, J T Lum-Raga. Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:8138943. |
all agents also bound to dopamine d2 receptors but, with the exception of buspirone, affinities were usually much lower than for 5-ht1a receptors. |
1994-04-25 |
2023-08-12 |
Not clear |
| J A Lieberma. Understanding the mechanism of action of atypical antipsychotic drugs. A review of compounds in use and development. The British journal of psychiatry. Supplement. issue 22. 1994-03-31. PMID:7906527. |
the following have been pursued: (a) selective dopamine receptor antagonists; (b) serotonin receptor agonists and antagonists (5-ht1a,e'5-ht2,5-ht3) or mixed 5-ht2-d2 receptor antagonist; (c) selective dopamine agonists or partial agonists; and (d) sigma-site and excitatory amino-acid antagonists. |
1994-03-31 |
2023-08-12 |
Not clear |
| M J Millan, H Canton, A Gobert, F Lejeune, J M Rivet, K Bervoets, M Brocco, P Widdowson, T Mennini, V Audino. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. The Journal of pharmacology and experimental therapeutics. vol 268. issue 1. 1994-03-10. PMID:8301575. |
the affinity of 15535 for dopamine d1 and d2 receptors, as well as for beta-, alpha 1- and alpha 2-adrenoceptors, was > 100-fold lower than its affinity for 5-ht1a receptors. |
1994-03-10 |
2023-08-12 |
Not clear |
| R Perrone, F Berardi, N A Colabufo, V Tortorella, F Fiorentini, V Olgiati, E Vanotti, S Govon. Mixed 5-HT1A/D-2 activity of a new model of arylpiperazines: 1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines. 1. Synthesis and structure-activity relationships. Journal of medicinal chemistry. vol 37. issue 1. 1994-02-22. PMID:8289207. |
title compounds were evaluated for in vitro activity on dopamine d-2 and serotonin 5-ht1a and 5-ht2 receptors by radioreceptor binding assays. |
1994-02-22 |
2023-08-12 |
Not clear |
| P J Kontur, M al-Tikriti, R B Innis, R H Rot. Postmortem stability of monoamines, their metabolites, and receptor binding in rat brain regions. Journal of neurochemistry. vol 62. issue 1. 1994-01-24. PMID:7505313. |
binding of raclopride to dopamine d2, sch-23390 to dopamine d1, ketanserin to serotonin 5-ht2, 8-hydroxy-2-(di-n-propylamino)tetralin to serotonin 5-ht1a, and cholecystokinin (cck)-8 to cck-b sites was measured in tissue homogenates from the striatum or fronto-parietal cortex. |
1994-01-24 |
2023-08-12 |
human |
| D W Bonhaus, D N Loury, L B Jakeman, Z To, A DeSouza, R M Eglen, E H Won. [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus. The Journal of pharmacology and experimental therapeutics. vol 267. issue 2. 1994-01-06. PMID:8246171. |
the affinity of bimu-1 for sigma-2 binding sites (ki = 32 nm) was 200-fold greater than that for sigma-1 binding sites (ki = 6.3 microm), dopamine (d1 and d2), other serotonin (5-ht1a, 5-ht2a, 5-ht2c) and muscarinic (m1, m2, m3 and m4) receptors (ki > 10 microm). |
1994-01-06 |
2023-08-12 |
Not clear |