| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Sato, M Sakamori, K Haga, S Takehara, M Setoguch. Antagonistic activity of Y-25130 on 5-HT3 receptors. Japanese journal of pharmacology. vol 59. issue 4. 1992-12-18. PMID:1331590. |
y-25130 showed low affinity for histamine h1 receptors (ic50 = 4.4 microm) but it could not reveal any affinities for the other receptors (5-ht1a, 5-ht2, dopamine d1, dopamine d2, alpha 1-adrenoceptor, alpha 2-adrenoceptor, muscarine and benzodiazepine) even at a 10 microm concentration. |
1992-12-18 |
2023-08-11 |
rat |
| G C Rigdon, J K Weatherspoo. 5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex. The Journal of pharmacology and experimental therapeutics. vol 263. issue 2. 1992-12-08. PMID:1432685. |
reduction of prepulse inhibition by 8-ohdpat was antagonized by (-)propranolol, a 5-ht1a receptor antagonist, and partially by haloperidol, a dopamine d2 receptor antagonist, but not by ketanserin or methysergide, 5-ht2 receptor antagonists. |
1992-12-08 |
2023-08-11 |
human |
| P Simon, B Guardiola, J Bizot-Espiard, P Schiavi, J Costenti. 5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1357709. |
5-ht1a receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists. |
1992-11-25 |
2023-08-11 |
mouse |
| P Simon, B Guardiola, J Bizot-Espiard, P Schiavi, J Costenti. 5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1357709. |
(+) s-20499 displayed a 10(-8) m affinity for d2 dopamine (da) receptors, 100 fold lower than for 5-ht1a receptors. |
1992-11-25 |
2023-08-11 |
mouse |
| E Chojnacka-Wójci. Involvement of dopamine autoreceptors in the hypoactivity induced by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice. Polish journal of pharmacology and pharmacy. vol 44. issue 2. 1992-11-17. PMID:1357637. |
the hypoactivity induced by 8-oh-dpat (1.5 mg/kg) was abolished by the dopamine (d1 and d2) receptor antagonist-haloperidol (0.00125 and 0.0025 mg/kg, but not in higher doses) and by the d2 antagonist with affinity for 5-ht1a and 5-ht2 receptors-spiperone (0.0025 and 0.005 mg/kg, but not in higher doses). |
1992-11-17 |
2023-08-11 |
mouse |
| K Yoshimoto, W J McBrid. Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat. Neurochemical research. vol 17. issue 5. 1992-10-22. PMID:1356241. |
the effects of microinfusing l-glutamate, serotonin (5-ht), (+-)-8-hydroxy-2-(di-n-propylamino) tetralin (8-oh dpat; a 5-ht1a agonist), and muscimol (a gabaa agonist) into the dorsal raphe nucleus on the extracellular levels of 5-ht, dopamine (da) and their metabolites in the nucleus accumbens were studied in unanesthetized, freely moving, adult male wistar rats, using the technique of microdialysis coupled with small-bore hplc. |
1992-10-22 |
2023-08-11 |
rat |
| K Bohmaker, F Bordi, E Melle. The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve. Neuropharmacology. vol 31. issue 5. 1992-10-20. PMID:1356248. |
the effects of pertussis toxin on dopamine d2 and serotonin 5-ht1a autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve. |
1992-10-20 |
2023-08-11 |
Not clear |
| K J Friston, P M Grasby, C J Bench, C D Frith, P J Cowen, P F Liddle, R S Frackowiak, R Dola. Measuring the neuromodulatory effects of drugs in man with positron emission tomography. Neuroscience letters. vol 141. issue 1. 1992-09-22. PMID:1354845. |
using positron emission tomography (pet), measurements of regional cerebral blood flow were made during the performance of memory tasks, before and after the administration of apomorphine (dopamine agonist), buspirone (5-ht1a partial agonist) or placebo. |
1992-09-22 |
2023-08-11 |
Not clear |
| M D Ennis, M E Baze, M W Smith, C F Lawson, R B McCall, R A Lahti, M F Pierce. Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor. Journal of medicinal chemistry. vol 35. issue 16. 1992-09-17. PMID:1323682. |
these compounds also bind to the dopamine d-2 receptor, but generally with higher inhibition constants than those for 5-ht1a. |
1992-09-17 |
2023-08-11 |
mouse |
| M Rinaldi-Carmona, C Congy, V Santucci, J Simiand, B Gautret, G Neliat, B Labeeuw, G Le Fur, P Soubrie, J C Brelier. Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. The Journal of pharmacology and experimental therapeutics. vol 262. issue 2. 1992-09-11. PMID:1501121. |
furthermore, sr 46349b displayed moderate affinity for the 5-ht1c receptor and had no affinity for the other 5-ht1 subclass (5-ht1a, 5-ht1b or 5-ht1d), dopamine (d1 or d2), "alpha" adrenergic (alpha-1 or alpha-2), sodium and calcium channel and histamine (h1) receptors. |
1992-09-11 |
2023-08-11 |
mouse |
| A D Levy, L D Van de Ka. Endocrine and receptor pharmacology of serotonergic anxiolytics, antipsychotics and antidepressants. Life sciences. vol 51. issue 2. 1992-07-28. PMID:1352027. |
5-ht1a agonists are considered potential anxiolytics, while some atypical antipsychotics are potent 5-ht2 antagonists (and also have modest dopamine d2 affinity). |
1992-07-28 |
2023-08-11 |
Not clear |
| S G Dahl, O Edvardsen, I Sylt. Molecular modeling of antipsychotic drugs and G protein coupled receptors. Therapie. vol 46. issue 6. 1992-07-20. PMID:1819151. |
three dimensional models of the 5-ht1a and 5-ht2 receptor and of the dopamine d2 receptor were constructed from the amino acid sequences. |
1992-07-20 |
2023-08-11 |
Not clear |
| M W Moon, J K Morris, R F Heier, C G Chidester, W E Hoffmann, M F Piercey, J S Althaus, P F Von Voigtlander, D L Evans, L M Figu. Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds. Journal of medicinal chemistry. vol 35. issue 6. 1992-04-28. PMID:1348089. |
the synthesis of 5-(dipropylamino)-5,6-dihydro-4h-imidazo[4,5,1-ij] quinolin-2(1h)-one (5), a potent dopamine d2 agonist showing high dopamine/serotonin (5ht1a) selectivity, is described. |
1992-04-28 |
2023-08-11 |
Not clear |
| N M Barnes, B Costall, A M Domeney, P A Gerrard, M E Kelly, H Krähling, R J Naylor, D M Tomkins, T J William. The effects of umespirone as a potential anxiolytic and antipsychotic agent. Pharmacology, biochemistry, and behavior. vol 40. issue 1. 1992-03-10. PMID:1685786. |
in radioligand binding assays umespirone demonstrated nanomolar affinity for the alpha 1-adrenoceptor and the 5-ht1a and dopamine d2 receptors. |
1992-03-10 |
2023-08-11 |
mouse |
| G Gross, X Xin, M Gastpa. Trimipramine: pharmacological reevaluation and comparison with clozapine. Neuropharmacology. vol 30. issue 11. 1992-03-05. PMID:1663593. |
in radioligand binding studies, d,l-trimipramine showed fairly high affinities (ki 10-60 nm) for some dopamine (da), noradrenaline and 5-hydroxytryptamine (5-ht) receptor subtypes (5-ht2 receptors = alpha 1a/b-adrenoceptors greater than or equal to d2 receptors), intermediate affinities (300-550 nm) for d1 receptors, alpha 2b-adrenoceptors and 5-ht1c receptors but only low affinities (greater than 1000 nm) for alpha 2a-adrenoceptors, 5-ht1a, 5-ht1d and 5-ht3 receptors. |
1992-03-05 |
2023-08-11 |
rat |
| K Svensson, A Ekman, M F Piercey, W E Hoffmann, J T Lum, A Carlsso. Effects of the partial dopamine receptor agonists SDZ 208-911, SDZ 208-912 and terguride on central monoamine receptors. A behavioral, biochemical and electrophysiological study. Naunyn-Schmiedeberg's archives of pharmacology. vol 344. issue 3. 1992-01-09. PMID:1683686. |
the three partial agonists displayed comparatively high affinities in vitro for the dopamine d2 (3h-spiperone) receptor site and somewhat lower affinity for the 5-ht1a (3h-8-oh-dpat) receptor site. |
1992-01-09 |
2023-08-11 |
rat |
| E Chojnacka-Wójcik, E Tatarczyńska, K Gołembiowska, E Przegalińsk. Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681449. |
the results obtained suggest that the anti-immobility effect of gepirone is mediated by activation of 5-ht1a receptors, most probably located postsynaptically and that dopamine may be involved in this action. |
1991-11-04 |
2023-08-11 |
rat |
| W J Florijn, T De Boer, J A Tonnaer, J W Van Nispen, D H Verstee. ACTH/MSH-like peptides inhibit the binding of dopaminergic ligands to the dopamine D2 receptor in vitro. European journal of pharmacology. vol 207. issue 1. 1991-11-01. PMID:1680721. |
acth-(1-24) also reduced the binding of the dopamine d2 receptor antagonist [3h]spiperone to striatal membranes, with a ki of 10(-6) m. much higher concentrations of acth-(1-24), up to 10(-4) m, were needed for the displacement of appropriate radiolabelled ligands from dopamine d1 receptors, serotonin 5-ht1a, serotonin 5-ht1b, muscarinic m1 acetylcholine and histamine h1 receptors. |
1991-11-01 |
2023-08-11 |
rat |
| A C Barton, H C Kang, M S Rinaudo, F J Monsma, R M Stewart-Fram, J A Macinko, R P Haugland, M A Ariano, D R Sible. Multiple fluorescent ligands for dopamine receptors. I. Pharmacological characterization and receptor selectivity. Brain research. vol 547. issue 2. 1991-10-04. PMID:1679366. |
the interaction of these fluorescent ligands with dopamine and serotonin receptors was evaluated by examining their ability to compete for radioligand binding to d1 and d2 dopamine receptors and 5-ht1a, 5-ht1c and 5-ht2 serotonin receptors. |
1991-10-04 |
2023-08-11 |
Not clear |
| B E Léonar. Antidepressants. Current concepts of mode of action. L'Encephale. vol 17 Spec No 1. 1991-09-11. PMID:1677887. |
such studies suggest that antidepressants decrease alpha 2 and beta-adrenoceptor function, increase alpha 1 receptor function, reduce 5-ht1a and dopamine autoreceptor function and increase gaba b function; changes also occur in 5-ht2 receptor function with antidepressants decreasing while ect increases the activity of these receptors. |
1991-09-11 |
2023-08-11 |
rat |