| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Millan, J M Rivet, V Audinot, A Gobert, F Lejeune, M Brocco, A Newman-Tancredi, S Maurel-Remy, K Bervoet. Antagonist properties of LY 165,163 at pre- and postsynaptic dopamine D2, D3 and D1 receptors: modulation of agonist actions at 5-HT1A receptors in vivo. The Journal of pharmacology and experimental therapeutics. vol 273. issue 3. 1995-07-21. PMID:7791116. |
antagonist properties of ly 165,163 at pre- and postsynaptic dopamine d2, d3 and d1 receptors: modulation of agonist actions at 5-ht1a receptors in vivo. |
1995-07-21 |
2023-08-12 |
mouse |
| M J Millan, J M Rivet, V Audinot, A Gobert, F Lejeune, M Brocco, A Newman-Tancredi, S Maurel-Remy, K Bervoet. Antagonist properties of LY 165,163 at pre- and postsynaptic dopamine D2, D3 and D1 receptors: modulation of agonist actions at 5-HT1A receptors in vivo. The Journal of pharmacology and experimental therapeutics. vol 273. issue 3. 1995-07-21. PMID:7791116. |
in this study, we examined the influence of the actions of the halogenated phenylpiperazine ly 165,163 at dopamine d1, d2 and d3 receptors on its 5-ht1a agonist properties in vivo. |
1995-07-21 |
2023-08-12 |
mouse |
| J Perregaard, E K Moltzen, E Meier, C Sánche. Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. Journal of medicinal chemistry. vol 38. issue 11. 1995-07-18. PMID:7783131. |
additionally, these compounds had relatively high affinity for serotonin 5-ht1a and 5-ht2a, dopamine d2, and adrenergic alpha 1 receptors. |
1995-07-18 |
2023-08-12 |
rat |
| M D Ennis, P Stjernlöf, R L Hoffman, N B Ghazal, M W Smith, K Svensson, H Wikström, S R Haadsma-Svensson, C H Li. Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology. Journal of medicinal chemistry. vol 38. issue 12. 1995-07-14. PMID:7783153. |
these compounds were evaluated for both in vitro and in vivo effects, including the establishment of a receptor binding profile for these analogs at the 5-ht1a, dopamine d-2, dopamine d-3, 5-ht1d alpha, and 5-ht1d beta sites. |
1995-07-14 |
2023-08-12 |
rat |
| M D Ennis, P Stjernlöf, R L Hoffman, N B Ghazal, M W Smith, K Svensson, H Wikström, S R Haadsma-Svensson, C H Li. Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology. Journal of medicinal chemistry. vol 38. issue 12. 1995-07-14. PMID:7783153. |
nearly all of the compounds prepared for this study were exceedingly potent at the 5-ht1a receptor, although most also displayed significant affinity for the dopamine d-2 receptor. |
1995-07-14 |
2023-08-12 |
rat |
| A D Levy, Q Li, M Gustafson, L D Van de Ka. Neuroendocrine profile of the potential anxiolytic drug S-20499. European journal of pharmacology. vol 274. issue 1-3. 1995-07-05. PMID:7768266. |
the data suggest that s-20499 stimulates the hypothalamic-pituitary adrenal axis by activating 5-ht1a receptors, although activation of dopamine d2 receptors may contribute to these responses. |
1995-07-05 |
2023-08-12 |
rat |
| P de Koning, M H de Vrie. A comparison of the neuro-endocrinological and temperature effects of DU 29894, flesinoxan, sulpiride and haloperidol in normal volunteers. British journal of clinical pharmacology. vol 39. issue 1. 1995-06-23. PMID:7756102. |
with a separation of 1 week between sessions, volunteers received randomly one oral dose of each of the following compounds: 3 or 10 mg of the dopamine (da2) receptor antagonist and serotonin (5ht1a) agonist du 29894, 1 mg flesinoxan, 400 mg sulpiride, 3 mg haloperidol or placebo. |
1995-06-23 |
2023-08-12 |
human |
| C Sonesson, T Barf, J Nilsson, D Dijkstra, A Carlsson, K Svensson, M W Smith, I J Martin, J N Duncan, L J Kin. Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity. Journal of medicinal chemistry. vol 38. issue 8. 1995-05-31. PMID:7731017. |
consequently, the 8-otf-substituted compound r-(+)-6 was found to be a potent and selective 5-ht1a (5-hydroxytryptamine) receptor agonist inducing a full-blown 5-ht syndrome in normal rats, while the corresponding 5-otf-substituted compound s-(-)-12 was found to be a preferential dopamine (da) autoreceptor agonist. |
1995-05-31 |
2023-08-12 |
rat |
| M P Kung, S Chumpradit, D Frederick, S Garner, K D Burris, P B Molinoff, H F Kun. Characterization of binding sites for [125I]R(+)trans-7-OH-PIPAT in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 350. issue 6. 1995-05-11. PMID:7708118. |
in the presence of gtp (to inhibit binding to d2 and 5-ht1a receptors) and dtg (to inhibit binding to sigma sites), dopamine d3 receptors could be selectively labeled with [125i]r(+)trans-7-oh-pipat. |
1995-05-11 |
2023-08-12 |
rat |
| R Perrone, F Berardi, N A Colabufo, M Leopoldo, V Tortorella, F Fiorentini, V Olgiati, A Ghiglieri, S Govon. High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2. Journal of medicinal chemistry. vol 38. issue 6. 1995-04-28. PMID:7699710. |
final compounds were evaluated for in vitro activity on dopamine d-1 and d-2, serotonin 5-ht1a, 5-ht1b, 5-ht1c, and 5-ht2, alpha 1 adrenergic, and sigma receptors by radioreceptor binding assay. |
1995-04-28 |
2023-08-12 |
Not clear |
| E Chojnacka-Wójcik, A Kłodzińska, A Dereń-Wesołe. Involvement of 5-HT2C receptors in the m-CPP-induced antinociception in mice. Polish journal of pharmacology. vol 46. issue 5. 1995-04-24. PMID:7894529. |
on the other hand, spiperone (0.25-0.5 mg/kg), a dopamine, 5-ht1a and 5-ht2a receptor antagonist; pindolol (4-8 mg/kg), a beta-adrenoceptor, 5-ht1a and 5-ht1b receptor antagonist and zacopride (0.1-1 mg/kg) a 5-ht3 receptor antagonist, did not affect the analgesia induced by m-cpp. |
1995-04-24 |
2023-08-12 |
mouse |
| N H Chen, M E Reit. Monoamine interactions measured by microdialysis in the ventral tegmental area of rats treated systemically with (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin. Journal of neurochemistry. vol 64. issue 4. 1995-04-18. PMID:7891086. |
the effect of (+/-)-8-hydroxy-2-(di-n-propyl-amino)tetralin (8-oh-dpat), a selective serotonin 5-ht1a agonist, on levels of extracellular norepinephrine (ne), dopamine (da), and 5-ht (measured simultaneously) was investigated by microdialysis in the ventral tegmental area (vta) of freely moving rats, and their behavioral activity was monitored. |
1995-04-18 |
2023-08-12 |
rat |
| C N Ryan, J L Evenden, M Petterso. Effects of buspirone and ipsapirone on schedule induced polydipsia: comparison with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and raclopride. Psychopharmacology. vol 112. issue 1. 1995-03-29. PMID:7871008. |
because buspirone is known to block dopamine receptors and both buspirone and ipsapirone act as agonists at the 5-ht1a receptor, their effects on polydipsia were compared to raclopride, an antagonist at d2 receptors, and 8-oh-dpat, an agonist at the 5-ht1a receptor, thus providing information about the relative importance of the serotonergic and/or dopaminergic systems for the maintenance of polydipsia. |
1995-03-29 |
2023-08-12 |
Not clear |
| H C Dringenberg, R A Kornelsen, C H Vanderwol. Food carrying in rats is blocked by the putative anxiolytic agent buspirone. Pharmacology, biochemistry, and behavior. vol 49. issue 3. 1995-03-22. PMID:7862731. |
buspirone appears to exert its effects through 5-ht1a and/or dopamine receptors, whereas diazepam interacts with benzodiazepine receptors. |
1995-03-22 |
2023-08-12 |
rat |
| B Cusack, A Nelson, E Richelso. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology. vol 114. issue 4. 1995-03-16. PMID:7855217. |
using radioligand binding assays and post-mortem normal human brain tissue, we obtained equilibrium dissociation constants (kds) for 17 antidepressants and two of their metabolites at histamine h1, muscarinic, alpha 1-adrenergic, alpha 2-adrenergic, dopamine d2, serotonin 5-ht1a, and serotonin 5-ht2 receptors. |
1995-03-16 |
2023-08-12 |
human |
| A M Rasmusson, L E Goldstein, A Y Deutch, B S Bunney, R H Rot. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Synapse (New York, N.Y.). vol 18. issue 3. 1995-03-14. PMID:7855734. |
5-ht1a agonist +/-8-oh-dpat modulates basal and stress-induced changes in medial prefrontal cortical dopamine. |
1995-03-14 |
2023-08-12 |
human |
| A M Rasmusson, L E Goldstein, A Y Deutch, B S Bunney, R H Rot. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Synapse (New York, N.Y.). vol 18. issue 3. 1995-03-14. PMID:7855734. |
in this study, we investigated the effects of +/-8-hydroxy-2(di-n-propylamino)tetralin [+/-8-oh-dpat], a serotonergic 5-ht1a agonist, on basal and stress-induced changes in dopamine utilization and release in selected forebrain dopamine terminal fields in the rat. |
1995-03-14 |
2023-08-12 |
human |
| A M Rasmusson, L E Goldstein, A Y Deutch, B S Bunney, R H Rot. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Synapse (New York, N.Y.). vol 18. issue 3. 1995-03-14. PMID:7855734. |
this 5-ht1a agonist diminished the magnitude of footshock-induced increases in prefrontal cortical dopamine utilization. |
1995-03-14 |
2023-08-12 |
human |
| A M Rasmusson, L E Goldstein, A Y Deutch, B S Bunney, R H Rot. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Synapse (New York, N.Y.). vol 18. issue 3. 1995-03-14. PMID:7855734. |
these data suggest that 5-ht1a agonists may dose-dependently modulate both basal and stress-induced changes in dopamine utilization in the medial prefrontal cortex. |
1995-03-14 |
2023-08-12 |
human |
| M Ballarín, A Carceller, X Guitar. Effect of acute administration of the 5-HT1A receptor ligand, lesopitron, on rat cortical 5-HT and dopamine turnover. British journal of pharmacology. vol 113. issue 2. 1995-03-01. PMID:7530571. |
effect of acute administration of the 5-ht1a receptor ligand, lesopitron, on rat cortical 5-ht and dopamine turnover. |
1995-03-01 |
2023-08-12 |
rat |