| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N J Hrib, J G Jurcak, D E Bregna, K L Burgher, H B Hartman, S Kafka, L L Kerman, S Kongsamut, J E Roehr, M R Szewczak, A T Woods-Kettelberger, R Corbet. Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate. Journal of medicinal chemistry. vol 39. issue 20. 1996-11-14. PMID:8831770. |
a series of piperazinyl butyl thiazolidinones structurally related to this compound were prepared and evaluated in vitro for dopamine d2 and serotonin 5ht2 and 5ht1a receptor affinity. |
1996-11-14 |
2023-08-12 |
Not clear |
| J Ichikawa, T Kuroki, M T Kitchen, H Y Meltze. R(+)-8-OH-DPAT, a 5-HT1A receptor agonist, inhibits amphetamine-induced dopamine release in rat striatum and nucleus accumbens. European journal of pharmacology. vol 287. issue 2. 1996-10-24. PMID:8749033. |
r(+)-8-oh-dpat, a 5-ht1a receptor agonist, inhibits amphetamine-induced dopamine release in rat striatum and nucleus accumbens. |
1996-10-24 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, M T Kitchen, H Y Meltze. R(+)-8-OH-DPAT, a 5-HT1A receptor agonist, inhibits amphetamine-induced dopamine release in rat striatum and nucleus accumbens. European journal of pharmacology. vol 287. issue 2. 1996-10-24. PMID:8749033. |
the ability of r(+)-8-oh-dpat (50 mu g/kg s.c.) to inhibit d-amphetamine sulfate (1.0 mg/kg s.c.)-induced increase in extracellular dopamine levels was abolished by way 100,635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride), a selective 5-ht1a receptor antagonist (100 mu g/kg s.c.), administered 5 min prior to r(+)-8-oh-dpat in both regions. |
1996-10-24 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, M T Kitchen, H Y Meltze. R(+)-8-OH-DPAT, a 5-HT1A receptor agonist, inhibits amphetamine-induced dopamine release in rat striatum and nucleus accumbens. European journal of pharmacology. vol 287. issue 2. 1996-10-24. PMID:8749033. |
these results indicate that the 5-ht1a receptor may exert an inhibitory effect on amphetamine-induced dopamine release. |
1996-10-24 |
2023-08-12 |
rat |
| M H Hedberg, J M Jansen, G Nordvall, S Hjorth, L Unelius, A M Johansso. 10-substituted 11-oxygenated (R)-aporphines: synthesis, pharmacology, and modeling of 5-HT1A receptor interactions. Journal of medicinal chemistry. vol 39. issue 18. 1996-10-17. PMID:8784447. |
the compounds were evaluated for their affinities to 5-ht1a and dopamine (da) d1 and d2a receptors in vitro. |
1996-10-17 |
2023-08-12 |
Not clear |
| M H Hedberg, T Linnanen, J M Jansen, G Nordvall, S Hjorth, L Unelius, A M Johansso. 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. Journal of medicinal chemistry. vol 39. issue 18. 1996-10-17. PMID:8784448. |
a change of the n-methyl group of the nonselective 3 to h [23, (r)-11-hydroxynoraporphine] or propyl [2, (r)-11-hydroxy-n-propylnoraporphine] increases the selectivity for 5-ht1a receptors (100-fold) and dopamine d2a receptors (3-fold), respectively. |
1996-10-17 |
2023-08-12 |
Not clear |
| P Bauman. Pharmacology and pharmacokinetics of citalopram and other SSRIs. International clinical psychopharmacology. vol 11 Suppl 1. 1996-10-09. PMID:8732438. |
in contrast to classical tricyclic antidepressants and some antipsychotics, the ssris have little affinity for the dopamine d2 receptors, 5-ht1a and 5-ht2a receptors, alpha 1-receptors, beta-receptors, muscarinic receptors and histamine h1 receptors. |
1996-10-09 |
2023-08-12 |
rat |
| M H Norman, G C Rigdon, W R Hall, F Nava. Structure-activity relationships of a series of substituted benzamides: potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents. Journal of medicinal chemistry. vol 39. issue 5. 1996-08-15. PMID:8676355. |
the target compounds were readily prepared from their benzoyl chloride, benzoic acid, or isatoic anhydride precursors, and they were evaluated in vitro for their ability to bind to dopamine d2, serotonin 5-ht2, and serotonin 5-ht1a receptors. |
1996-08-15 |
2023-08-12 |
mouse |
| D Giardinà, M Crucianelli, C Melchiorre, C Taddei, R Test. Receptor binding profile of cyclazosin, a new alpha 1B-adrenoceptor antagonist. European journal of pharmacology. vol 287. issue 1. 1996-08-07. PMID:8666020. |
the binding profile of cyclazosin, a new prazosin-related alpha 1-adrenoceptor antagonist, at alpha 1-, alpha 2-adrenoceptors, dopamine d2 and 5-ht1a receptors was compared to that of 5-methylurapidil, spiperone, risperidone and other prazosin-related ligands. |
1996-08-07 |
2023-08-12 |
Not clear |
| E A Engleman, D W Robertson, D C Thompson, K W Perry, D T Won. Antagonism of serotonin 5-HT1A receptors potentiates the increases in extracellular monoamines induced by duloxetine in rat hypothalamus. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592129. |
in the current study we examined the effects of coadministration of a serotonin 5-ht1a antagonist, (+-)-1-(1h-indol-4-yloxy)-3-(cyclohexylamino)-2-propanol maleate (ly 206130), and a dual 5-ht and norepinephrine (ne) uptake inhibitor, duloxetine, on extracellular levels of ne, 5-ht, dopamine (da), 5-hydroxyindoleacetic acid, and 3,4-dihydroxyphenylacetic acid in rat hypothalamus microdialysates. |
1996-04-03 |
2023-08-12 |
rat |
| R M Eglen, D W Bonhaus, L G Johnson, E Leung, R D Clar. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. British journal of pharmacology. vol 115. issue 8. 1996-03-04. PMID:8564196. |
the compounds exhibited lower affinities (< 6.0) at several other receptors including 5-ht1a, 5-ht1d, 5-ht2a, 5-ht2c, dopamine d1, d2 and muscarinic m1-m3 receptors. |
1996-03-04 |
2023-08-12 |
Not clear |
| M H Norman, D J Minick, G C Rigdo. Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives. Journal of medicinal chemistry. vol 39. issue 1. 1996-03-01. PMID:8568802. |
the compounds were evaluated in vitro at dopamine d2 and serotonin 5-ht1a and 5-ht2 receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. |
1996-03-01 |
2023-08-12 |
mouse |
| J F Liao, Y M Jan, S Y Huang, H H Wang, L L Yu, C F Che. Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs. Proceedings of the National Science Council, Republic of China. Part B, Life sciences. vol 19. issue 3. 1995-12-07. PMID:7480361. |
the results indicated that these water extracts contained the principles acting on the dopamine (d1 & d2), muscarinice acetylcholine (m1), or 5-ht (5-ht1a & 5-ht2) receptors, or the benzodiazepine and the gamma-amino-n-butyric acid (gaba) binding sites of gabaa receptors as determined by receptor binding assays. |
1995-12-07 |
2023-08-12 |
Not clear |
| L A Shapiro, S J Offord, G A Ordwa. The effect of chronic treatment with a novel aryl-piperazine antipsychotic on monoamine receptors in rat brain. Brain research. vol 677. issue 2. 1995-11-14. PMID:7552250. |
binding of [3h]sch-23390 and [3h]spiperone to d1 and d2 dopamine receptors, respectively, and [3h]8-hydroxy-2-(di-n-propylamino)-tetralin ([3h]8oh-dpat) to 5-ht1a receptors were measured in various brain regions using quantitative autoradiography. |
1995-11-14 |
2023-08-12 |
rat |
| L A Shapiro, S J Offord, G A Ordwa. The effect of chronic treatment with a novel aryl-piperazine antipsychotic on monoamine receptors in rat brain. Brain research. vol 677. issue 2. 1995-11-14. PMID:7552250. |
no changes in d1 dopamine or 5-ht1a receptor binding were detected following either antipsychotic treatment in any brain regions studied. |
1995-11-14 |
2023-08-12 |
rat |
| H Ito, S Akuzawa, R Tsutsumi, T Kiso, T Kamato, A Nishida, M Yamano, K Miyat. Comparative study of the affinities of the 5-HT3 receptor antagonists, YM060, YM114 (KAE-393), granisetron and ondansetron in rat vagus nerve and cerebral cortex. Neuropharmacology. vol 34. issue 6. 1995-11-14. PMID:7566499. |
ym060, ym114, granisetron and ondansetron showed low affinities for 5-ht1a, 5-ht2 receptor, adrenergic alpha 1, alpha 2, dopamine d2, muscarinic m2, mu-opioid, benzodiazepine and histamine h1 receptors. |
1995-11-14 |
2023-08-12 |
rat |
| J L Peglion, H Canton, K Bervoets, V Audinot, M Brocco, A Gobert, S Le Marouille-Girardon, M J Milla. Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines. Journal of medicinal chemistry. vol 38. issue 20. 1995-11-08. PMID:7562940. |
from the numerous arylpiperazines described in the literature, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine (3a) was chosen as a model of an arylpiperazine in view of its selectivity for 5-ht1a receptors versus alpha 1-, alpha 2-, and beta-adrenergic receptors, as well as dopamine d1 and d2 receptors. |
1995-11-08 |
2023-08-12 |
Not clear |
| J L Peglion, H Canton, K Bervoets, V Audinot, M Brocco, A Gobert, S Le Marouille-Girardon, M J Milla. Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines. Journal of medicinal chemistry. vol 38. issue 20. 1995-11-08. PMID:7562940. |
an in vivo evaluation of dopamine d2 receptor antagonist properties revealed that the majority of compounds was devoid of activity at this site, in marked contrast to bmy 7378 which displayed virtually no selectivity for 5-ht1a versus dopamine d2 receptors. |
1995-11-08 |
2023-08-12 |
Not clear |
| G Gründer, H Wetzel, A Hillert, E Jochum, C Hiemke, O Benker. The neuroendocrinological profile of roxindole, a dopamine autoreceptor agonist, in schizophrenic patients. Psychopharmacology. vol 117. issue 4. 1995-08-07. PMID:7604150. |
roxindole is a potent autoreceptor-selective dopamine agonist with additional properties as a serotonin reuptake inhibitor and 5-ht1a agonist. |
1995-08-07 |
2023-08-12 |
Not clear |
| A Gobert, F Lejeune, J M Rivet, V Audinot, A Newman-Tancredi, M J Milla. Modulation of the activity of central serotoninergic neurons by novel serotonin1A receptor agonists and antagonists: a comparison to adrenergic and dopaminergic neurons in rats. The Journal of pharmacology and experimental therapeutics. vol 273. issue 3. 1995-07-21. PMID:7791073. |
in this study, we used a complementary in vivo electrophysiological and (in individual rats) neurochemical approach to characterize the actions of chemically diverse serotonin (5-ht)1a receptor ligands at central 5-ht1a autoreceptors as compared to dopamine (da) d2 autoreceptors and presynaptic alpha-2 adrenergic receptors (ars). |
1995-07-21 |
2023-08-12 |
rat |