| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Matecka, R B Rothman, L Radesca, B R de Costa, C M Dersch, J S Partilla, A Pert, J R Glowa, F H Wojnicki, K C Ric. Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909). Journal of medicinal chemistry. vol 39. issue 24. 1997-01-06. PMID:8941383. |
the design, synthesis, and biological evaluation of compounds related to the dopamine (da) uptake inhibitors: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (1) and 1-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (2) (gbr 12395 and gbr 12909, respectively), directed toward the development and identification of new ligands interacting with high potency and selectivity at the dopamine transporter (dat) is reported. |
1997-01-06 |
2023-08-12 |
Not clear |
| Z Chen, S Izenwasser, J L Katz, N Zhu, C L Klein, M L Trudel. Synthesis and dopamine transporter affinity of 2-(methoxycarbonyl)-9-methyl-3-phenyl-9-azabicyclo[3.3.1]nonane derivatives. Journal of medicinal chemistry. vol 39. issue 24. 1997-01-06. PMID:8941387. |
a series of 9-methyl-3 beta-phenyl-2-substituted-9-azabicyclo[3.3.1]nonane derivatives were synthesized and evaluated as cocaine-binding site ligands at the dopamine transporter (dat). |
1997-01-06 |
2023-08-12 |
rat |
| M Fujita, S Shimada, M Tohyama, T Nishimur. Visualization of ischemic insult in caudate putamen with beta-CIT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 7. 1996-12-26. PMID:8965201. |
the goal of this study was to examine the change in the dopamine transporter (dat) after ischemic insult in cpu. |
1996-12-26 |
2023-08-12 |
Not clear |
| T Inada, T Sugita, I Dobashi, A Inagaki, Y Kitao, G Matsuda, S Kato, T Takano, G Yagi, M Asa. Dopamine transporter gene polymorphism and psychiatric symptoms seen in schizophrenic patients at their first episode. American journal of medical genetics. vol 67. issue 4. 1996-12-13. PMID:8837710. |
to investigate the possible role of the dopamine transporter (dat) gene in determining the phenotype in human subjects, allele frequencies for the 40-bp variable number of tandem repeats (vntr) polymorphism at this site were compared between 117 japanese normal controls and 118 schizophrenic patients, including six subgroups: early-onset, those with a family history, and those suffering from one of the following psychiatric symptoms at their first episode: delusion and hallucination; disorganization; bizarre behavior; and negative symptoms. |
1996-12-13 |
2023-08-12 |
human |
| W Maier, J Minges, N Eckstein, C Brodski, M Albus, B Lerer, J Hallmayer, R Fimmers, M Ackenheil, R E Ebstein, M Borrmann, D Lichtermann, D B Wildenaue. Genetic relationship between dopamine transporter gene and schizophrenia: linkage and association. Schizophrenia research. vol 20. issue 1-2. 1996-12-05. PMID:8794507. |
this study explores the genetic relationship between schizophrenia and the dopamine transporter gene (dat) by a variety of methods. |
1996-12-05 |
2023-08-12 |
Not clear |
| M Fujita, H Nishino, M Kumazaki, S Shimada, M Tohyama, T Nishimur. Expression of dopamine transporter mRNA and its binding site in fetal nigral cells transplanted into the striatum of 6-OHDA lesioned rat. Brain research. Molecular brain research. vol 39. issue 1-2. 1996-12-03. PMID:8804721. |
however, the role of the dopamine transporter (dat) in this recovery has not been clarified. |
1996-12-03 |
2023-08-12 |
rat |
| C Perrone-Capano, A Tino, G Amadoro, R Pernas-Alonso, U di Porzi. Dopamine transporter gene expression in rat mesencephalic dopaminergic neurons is increased by direct interaction with target striatal cells in vitro. Brain research. Molecular brain research. vol 39. issue 1-2. 1996-12-03. PMID:8804724. |
by using a semi-quantitative reverse transcriptase-pcr assay (rt-pcr) we have analyzed dopamine transporter (dat), tyrosine hydroxylase (th) and synaptic vesicle monoamine transporter (vmat2) gene expression in rat mesencephalic (mes) primary cultures. |
1996-12-03 |
2023-08-12 |
rat |
| A Hitri, K Y Little, E H Ellinwoo. Effect of cocaine on dopamine transporter receptors depends on routes of chronic cocaine administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866704. |
continuous infusion of cocaine did not alter the [3h]gbr 12935 dopamine transporter (dat) binding either in the caudate nucleus or in the prefrontal cortex, but it enhanced the density of [3h]win 35,428-labeled dat receptor sites in the caudate putamen. |
1996-12-03 |
2023-08-12 |
rat |
| A E Fleckenstein, S Pögün, F I Carroll, M J Kuha. Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 [3 beta-(3p-chlorophenyl) tropan-2 beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride]. The Journal of pharmacology and experimental therapeutics. vol 279. issue 1. 1996-11-18. PMID:8858994. |
effects of in vivo, intrastriatal administration of rti-76 ¿3 beta-(3-p-chlorophenyl) tropan-2 beta-carboxylic acid p-isothiocyanato-phenylethyl ester hydrochloride¿, an irreversible inhibitor of dopamine transporter (dat) binding in vitro, on [125i]rti-55 ¿3 beta-[4-iodophenyl]tropan-2 beta-carboxylic acid methyl ester tartrate¿ binding to striatal dat in vitro were examined in male rats. |
1996-11-18 |
2023-08-12 |
rat |
| N D Volkow, G J Wang, J S Fowler, S J Gatley, Y S Ding, J Logan, S L Dewey, R Hitzemann, J Lieberma. Relationship between psychostimulant-induced "high" and dopamine transporter occupancy. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 19. 1996-11-13. PMID:8816810. |
the ability of cocaine to inhibit the dopamine transporter (dat) appears to be crucial for its reinforcing properties. |
1996-11-13 |
2023-08-12 |
human |
| T Kadota, T Yamaai, Y Saito, Y Akita, S Kawashima, K Moroi, N Inagaki, K Kadot. Expression of dopamine transporter at the tips of growing neurites of PC12 cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 44. issue 9. 1996-11-06. PMID:8773564. |
the four kinds of oligopeptides specific in amino acid sequence to a rat dopamine transporter (dat), peptide-1-peptide-4, were chemically synthethized. |
1996-11-06 |
2023-08-12 |
rat |
| F J Lee, Z B Pristupa, B J Ciliax, A I Levey, H B Nizni. The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain. The Journal of biological chemistry. vol 271. issue 34. 1996-10-11. PMID:8702845. |
in order to delineate structural motifs regulating substrate affinity and recognition for the human dopamine transporter (dat), we assessed [3h]dopamine uptake kinetics and [3h]cft binding characteristics of cos-7 cells transiently expressing mutant dats in which the cooh terminus was truncated or substituted. |
1996-10-11 |
2023-08-12 |
human |
| F J Lee, Z B Pristupa, B J Ciliax, A I Levey, H B Nizni. The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain. The Journal of biological chemistry. vol 271. issue 34. 1996-10-11. PMID:8702845. |
complete truncation of the carboxyl tail from ser582 allowed for the expression of biphasic [3h]dopamine uptake kinetics displaying both a low capacity (vmax approximately 0.4 pmol/10(5) cells/min) high affinity (km approximately 300 nm) component and one exhibiting low affinity (km approximately 15 microm] and high capacity (vmax approximately 5 pmol/10(5)cells/min) with a concomitant 40% decrease in overall apparent vmax relative to wild type (wt) dat. |
1996-10-11 |
2023-08-12 |
human |
| F J Lee, Z B Pristupa, B J Ciliax, A I Levey, H B Nizni. The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain. The Journal of biological chemistry. vol 271. issue 34. 1996-10-11. PMID:8702845. |
truncation of the last 22 amino acids or substitution of the dat-cooh tail with sequences encoding the intracellular carboxyl-terminal of either dopamine d1 or d5 receptors produced results that were identical to those with the fully truncated dat, suggesting that the induction of biphasic dopamine uptake kinetics is likely conferred by removal of dat-specific sequence motifs distal to pro597. |
1996-10-11 |
2023-08-12 |
human |
| F J Lee, Z B Pristupa, B J Ciliax, A I Levey, H B Nizni. The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain. The Journal of biological chemistry. vol 271. issue 34. 1996-10-11. PMID:8702845. |
the attenuation of wt transport activity, either by lowering levels of dat expression or by pretreatment of cells with phorbol 12-myristate 13-acetate (1 microm), did not affect the kinetics of [3h]dopamine transport. |
1996-10-11 |
2023-08-12 |
human |
| F J Lee, Z B Pristupa, B J Ciliax, A I Levey, H B Nizni. The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain. The Journal of biological chemistry. vol 271. issue 34. 1996-10-11. PMID:8702845. |
the estimated affinity of dopamine (ki approximately 180 nm) for all truncated/substituted dat mutants was 10-fold lower than that of wt dat (approximately 2000 nm) and appears selective for the endogenous substrate, since the estimated inhibitory constants for numerous putative substrates or uptake inhibitors were virtually identical to those obtained for wt dats. |
1996-10-11 |
2023-08-12 |
human |
| F J Lee, Z B Pristupa, B J Ciliax, A I Levey, H B Nizni. The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain. The Journal of biological chemistry. vol 271. issue 34. 1996-10-11. PMID:8702845. |
in marked contrast, dat truncation/substitution mutants displayed significantly reduced high affinity [3h]cft binding interactions with estimated ki values for dopamine and numerous other substrates and inhibitors tested from 10-100-fold lower than that observed for wt dat. |
1996-10-11 |
2023-08-12 |
human |
| S Bodeau-Péan, C Laurent, D Campion, M Jay, F Thibaut, S Dollfus, M Petit, D Samolyk, T d'Amato, M Martine. No evidence for linkage or association between the dopamine transporter gene and schizophrenia in a French population. Psychiatry research. vol 59. issue 1-2. 1996-09-26. PMID:8771214. |
pharmacological and clinical findings suggest that the dopamine transporter (dat) gene may be involved in the genetic predisposition to schizophrenia. |
1996-09-26 |
2023-08-12 |
human |
| R Revay, R Vaughan, S Grant, M J Kuha. Dopamine transporter immunohistochemistry in median eminence, amygdala, and other areas of the rat brain. Synapse (New York, N.Y.). vol 22. issue 2. 1996-09-26. PMID:8787132. |
in an extension of our previous work, an antibody directed against a peptide from the n-terminal region of dat was used to localize specific dopamine transporter immunoreactivity (dat-ir) in several regions of rat brain. |
1996-09-26 |
2023-08-12 |
rat |
| R Revay, R Vaughan, S Grant, M J Kuha. Dopamine transporter immunohistochemistry in median eminence, amygdala, and other areas of the rat brain. Synapse (New York, N.Y.). vol 22. issue 2. 1996-09-26. PMID:8787132. |
a possible explanation is that different dopamine containing cell groups express different levels of dat mrna and protein, as we have previously shown. |
1996-09-26 |
2023-08-12 |
rat |