| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G J Wang, N D Volkow, J S Fowler, Y S Ding, J Logan, S J Gatley, R R MacGregor, A P Wol. Comparison of two pet radioligands for imaging extrastriatal dopamine transporters in human brain. Life sciences. vol 57. issue 14. 1995-10-23. PMID:7564877. |
we compared the sensitivity of two dopamine transporter (dat) ligands ([c-11]cocaine and [c-11]d-threo-methylphenidate) for measurement of extrastriatal dat availability using positron emission tomography (pet) on separated groups of 10 age matched male volunteers (age range, 21-49 years). |
1995-10-23 |
2023-08-12 |
human |
| D M Donovan, D J Vandenbergh, M P Perry, G S Bird, R Ingersoll, E Nanthakumar, G R Uh. Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures. Brain research. Molecular brain research. vol 30. issue 2. 1995-09-13. PMID:7637582. |
synaptic reaccumulation of the neurotransmitter dopamine is mediated by the dopamine transporter (dat), a member of the family of twelve transmembrane domain, sodium- and chloride-dependent neurotransmitter transporters. |
1995-09-13 |
2023-08-12 |
mouse |
| T Himi, M Cao, N Mor. Reduced expression of the molecular markers of dopaminergic neuronal atrophy in the aging rat brain. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 50. issue 4. 1995-08-18. PMID:7614230. |
expression of mrnas encoding the dopamine transporter (dat) and tyrosine hydroxylase (th) in dopaminergic neurons of the substantia nigra (sn) was examined in young and aged fischer 344 rats by in situ hybridization. |
1995-08-18 |
2023-08-12 |
rat |
| T Himi, M Cao, N Mor. Reduced expression of the molecular markers of dopaminergic neuronal atrophy in the aging rat brain. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 50. issue 4. 1995-08-18. PMID:7614230. |
our findings indicate that dat may be a marker of atrophy in dopamine neurons during normal aging. |
1995-08-18 |
2023-08-12 |
rat |
| J T Kuikka, K A Bergström, A Ahonen, J Hiltunen, J Haukka, E Länsimies, S Wang, J L Neumeye. Comparison of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and 2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain. European journal of nuclear medicine. vol 22. issue 4. 1995-08-16. PMID:7607268. |
several cocaine congeners are of potential for imaging the dopamine transporter (dat). |
1995-08-16 |
2023-08-12 |
human |
| N D Volkow, S J Gatley, J S Fowler, R Chen, J Logan, S L Dewey, Y S Ding, N Pappas, P King, R R MacGrego. Long-lasting inhibition of in vivo cocaine binding to dopamine transporters by 3 beta-(4-iodophenyl)tropane-2-carboxylic acid methyl ester: RTI-55 or beta CIT. Synapse (New York, N.Y.). vol 19. issue 3. 1995-07-18. PMID:7784960. |
cocaine analogs such as 3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid methyl ester (rti-55 or beta cit) with a higher affinity for the dopamine transporter (dat) may be potentially useful in interfering with cocaine's actions in brain. |
1995-07-18 |
2023-08-12 |
mouse |
| A P Patel, C Cerruti, R A Vaughan, M J Kuha. Developmentally regulated glycosylation of dopamine transporter. Brain research. Developmental brain research. vol 83. issue 1. 1995-05-02. PMID:7697870. |
the dopamine transporter (dat) in rat striatum was examined during postnatal development and aging after photolabeling with [125i]deep. |
1995-05-02 |
2023-08-12 |
rat |
| S C Wall, H Gu, G Rudnic. Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: amphetamine specificity for inhibition and efflux. Molecular pharmacology. vol 47. issue 3. 1995-04-28. PMID:7700252. |
llc-pk1 cells have been stably transfected with cdnas encoding the human norepinephrine transporter (net), rat dopamine transporter (dat), and rat serotonin transporter. |
1995-04-28 |
2023-08-12 |
human |
| B J Ciliax, C Heilman, L L Demchyshyn, Z B Pristupa, E Ince, S M Hersch, H B Niznik, A I Leve. The dopamine transporter: immunochemical characterization and localization in brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 1. 1995-04-20. PMID:7534339. |
antibodies specific for the dopamine transporter (dat) was developed and characterized by immunoblot analysis, immunoprecipitation, and immunocytochemistry, and used for immunolocalization of transporter protein in rat brain at the light microscopic level. |
1995-04-20 |
2023-08-12 |
human |
| B J Ciliax, C Heilman, L L Demchyshyn, Z B Pristupa, E Ince, S M Hersch, H B Niznik, A I Leve. The dopamine transporter: immunochemical characterization and localization in brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 1. 1995-04-20. PMID:7534339. |
however, certain mismatches between immunocytochemical distributions of dat and tyrosine hydroxylase were apparent, indicating that dopaminergic systems are heterogeneous and may use independent mechanisms for the regulation of dopamine levels in brain. |
1995-04-20 |
2023-08-12 |
human |
| J Gelernter, H R Kranzler, S L Satel, P A Ra. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 11. issue 3. 1995-03-29. PMID:7865100. |
several lines of evidence suggest that this phenomenon may be related to function of the dopamine transporter protein (dat). |
1995-03-29 |
2023-08-12 |
Not clear |
| J Gelernter, H R Kranzler, S L Satel, P A Ra. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 11. issue 3. 1995-03-29. PMID:7865100. |
dat is the site of presynaptic reuptake of dopamine, an event that terminates its synaptic activity. |
1995-03-29 |
2023-08-12 |
Not clear |
| C Pifl, H Drobny, H Reither, O Hornykiewicz, E A Singe. Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Molecular pharmacology. vol 47. issue 2. 1995-03-29. PMID:7870046. |
the effects of amphetamine and cocaine were studied in [3h]-dopamine-loaded and superfused cos-7 cells transfected with either the cdna of the plasmalemmal dopamine transporter ("dat cells") or the cdna of the vesicular amine transporter ("vat cells"), or with both transporters ("dat/vat cells"). |
1995-03-29 |
2023-08-12 |
Not clear |
| C Pifl, H Drobny, H Reither, O Hornykiewicz, E A Singe. Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Molecular pharmacology. vol 47. issue 2. 1995-03-29. PMID:7870046. |
amphetamine (0.01-100 microm, added for 4 min of superfusion) led to a concentration-dependent increase in dopamine release in dat cells, as well as in dat/vat cells. |
1995-03-29 |
2023-08-12 |
Not clear |
| C Pifl, H Drobny, H Reither, O Hornykiewicz, E A Singe. Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Molecular pharmacology. vol 47. issue 2. 1995-03-29. PMID:7870046. |
with longer exposure to amphetamine, dopamine efflux from dat cells reached a peak and quickly returned to baseline, in spite of the continued presence of the drug, whereas in dat/vat cells and in vat cells the effect was sustained. |
1995-03-29 |
2023-08-12 |
Not clear |
| C Pifl, H Drobny, H Reither, O Hornykiewicz, E A Singe. Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Molecular pharmacology. vol 47. issue 2. 1995-03-29. PMID:7870046. |
cocaine (up to 100 microm) did not exert any effect of its own in dat cells or vat cells but inhibited the amphetamine-induced release of dopamine from dat cells in a competitive manner. |
1995-03-29 |
2023-08-12 |
Not clear |
| J B Wang, A Moriwaki, G R Uh. Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression. Journal of neurochemistry. vol 64. issue 3. 1995-03-17. PMID:7861176. |
studies with thiol-modifying reagents have suggested that cysteines might play important roles in the function of the dopamine transporter (dat). |
1995-03-17 |
2023-08-12 |
Not clear |
| J B Wang, A Moriwaki, G R Uh. Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression. Journal of neurochemistry. vol 64. issue 3. 1995-03-17. PMID:7861176. |
to identify dat cysteines with important thiol groups, we have studied six mutant dopamine transporters in which cysteines were replaced by alanines. |
1995-03-17 |
2023-08-12 |
Not clear |
| M K Sanghera, K F Manaye, C L Liang, A M Lacopino, M J Bannon, D C Germa. Low dopamine transporter mRNA levels in midbrain regions containing calbindin. Neuroreport. vol 5. issue 13. 1995-02-10. PMID:7819538. |
the dopamine transporter (dat) is the site at which the neurotoxic metabolite of mptp gains access to midbrain dopaminergic (da) neurons. |
1995-02-10 |
2023-08-12 |
mouse |
| M Fujita, S Shimada, K Fukuchi, M Tohyama, T Nishimur. Distribution of cocaine recognition sites in rat brain: in vitro and ex vivo autoradiography with [125I]RTI-55. Journal of chemical neuroanatomy. vol 7. issue 1-2. 1995-01-31. PMID:7802967. |
the distribution of binding sites of [125i]rti-55 (3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester), a phenyl tropane analog of cocaine, and the selective labeling of the dopamine transporter (dat) were studied by in vitro and ex vivo autoradiography in the rat whole brain. |
1995-01-31 |
2023-08-12 |
rat |