| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Apparsundaram, K R Moore, M D Malone, H C Hartzell, R D Blakel. Molecular cloning and characterization of an L-epinephrine transporter from sympathetic ganglia of the bullfrog, Rana catesbiana. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 8. 1997-04-28. PMID:9092590. |
chemical signaling by dopamine (da) and l-norepinephrine (l-ne) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the da transporter (dat) and l-ne transporter (net) genes, respectively. |
1997-04-28 |
2023-08-12 |
human |
| G W Miller, J K Staley, C J Heilman, J T Perez, D C Mash, D B Rye, A I Leve. Immunochemical analysis of dopamine transporter protein in Parkinson's disease. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124811. |
the plasma membrane dopamine transporter (dat) is considered to be a reliable marker of presynaptic dopaminergic terminal loss. |
1997-04-24 |
2023-08-12 |
human |
| K Y Little, J Gorebig, F I Carroll, J Mapili, J H Meador-Woodruf. Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites. Brain research. vol 742. issue 1-2. 1997-04-22. PMID:9117410. |
depending on experimental conditions, chronic cocaine exposure can induce an increase in binding to the dopamine transporter (dat). |
1997-04-22 |
2023-08-12 |
rat |
| K Y Little, J Gorebig, F I Carroll, J Mapili, J H Meador-Woodruf. Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites. Brain research. vol 742. issue 1-2. 1997-04-22. PMID:9117410. |
one possible mechanism for the cocaine-induced-upregulation in dat binding sites is through stimulation of presynaptic d2 receptors by excess synaptic dopamine. |
1997-04-22 |
2023-08-12 |
rat |
| D Matecka, D Lewis, R B Rothman, C M Dersch, F H Wojnicki, J R Glowa, A C DeVries, A Pert, K C Ric. Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors. Journal of medicinal chemistry. vol 40. issue 5. 1997-04-17. PMID:9057857. |
a new series of heteroaromatic gbr 12935 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine] (i) and gbr 12909 [1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine] (2) analogs was synthesized and evaluated as dopamine transporter (dat) ligands. |
1997-04-17 |
2023-08-12 |
rat |
| E M Apostolakis, J Garai, J H Clark, B W O'Malle. In vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of D5 receptors in rats. Molecular endocrinology (Baltimore, Md.). vol 10. issue 12. 1997-03-20. PMID:8961269. |
to characterize the membrane pathway by which the cocaine-sensitive dopamine transporter (dat) modulates progesterone receptor activation, steroid-dependent behavior lordosis was used in estrogen-primed ovariectomized sprague-dawley rats with stereotaxic implanted third ventricle cannulas. |
1997-03-20 |
2023-08-12 |
rat |
| W S Choi, O K Rønneklei. Effects of in utero cocaine exposure on the expression of mRNAS encoding the dopamine transporter and the D1, D2 and D5 dopamine receptor subtypes in fetal rhesus monkey. Brain research. Developmental brain research. vol 96. issue 1-2. 1997-03-11. PMID:8922687. |
the effects of in utero cocaine exposure on the development of the mrnas encoding the dopamine transporter (dat) and the d1, d2 and d5 dopamine receptor subtypes were determined in fetal monkey brains at day 45 and day 60 of gestation. |
1997-03-11 |
2023-08-12 |
human |
| W S Choi, O K Rønneklei. Effects of in utero cocaine exposure on the expression of mRNAS encoding the dopamine transporter and the D1, D2 and D5 dopamine receptor subtypes in fetal rhesus monkey. Brain research. Developmental brain research. vol 96. issue 1-2. 1997-03-11. PMID:8922687. |
in day 45 fetal monkeys, dopamine d1 and d2 receptor subtype mrnas and dat mrna were found in low quantities both in control and cocaine-treated subjects. |
1997-03-11 |
2023-08-12 |
human |
| W S Choi, O K Rønneklei. Effects of in utero cocaine exposure on the expression of mRNAS encoding the dopamine transporter and the D1, D2 and D5 dopamine receptor subtypes in fetal rhesus monkey. Brain research. Developmental brain research. vol 96. issue 1-2. 1997-03-11. PMID:8922687. |
dopamine d5 receptor mrna was expressed in low quantities throughout the day 60 fetal monkey brain, whereas dat mrna was found in the midbrain only. |
1997-03-11 |
2023-08-12 |
human |
| J R Kelsoe, A D Sadovnick, H Kristbjarnarson, P Bergesch, Z Mroczkowski-Parker, M Drennan, M H Rapaport, P Flodman, M A Spence, R A Remic. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. American journal of medical genetics. vol 67. issue 6. 1997-03-11. PMID:8950410. |
the dopamine transporter (dat) plays a key role in the regulation of dopaminergic neurotransmission by mediating the active reuptake of synaptic dopamine. |
1997-03-11 |
2023-08-12 |
Not clear |
| A K Dutta, L L Coffey, M E Reit. Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity. Journal of medicinal chemistry. vol 40. issue 1. 1997-03-04. PMID:9016326. |
several analogs of the potent and selective dopamine transporter (dat) ligand 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine, 1a, were prepared and biologically evaluated at the dopamine and serotonin transporter (sert) sites. |
1997-03-04 |
2023-08-12 |
Not clear |
| D P Figlewicz, M D Brot, A L McCall, P Szo. Diabetes causes differential changes in CNS noradrenergic and dopaminergic neurons in the rat: a molecular study. Brain research. vol 736. issue 1-2. 1997-02-26. PMID:8930308. |
we have previously reported that chronic elevation of insulin in the cns of rats results in opposing changes of the mrna expression for the norepinephrine transporter (net; decreased) and the dopamine transporter (dat; increased). |
1997-02-26 |
2023-08-12 |
rat |
| M E Reith, C Xu, L Zhang, L L Coffe. Translocation of dopamine and binding of WIN 35,428 measured under identical conditions in cells expressing the cloned human dopamine transporter. Naunyn-Schmiedeberg's archives of pharmacology. vol 354. issue 3. 1997-02-18. PMID:8878059. |
the potency of dopamine in inhibiting its own translocation was close to that in inhibiting [3h]win 35,428 binding consonant with a more rapid reorientation step of the dat in the c6-hdat system than in rat striatal synaptosomes. |
1997-02-18 |
2023-08-12 |
human |
| A J Fischman, J W Babich, D R Elmaleh, S A Barrow, P Meltzer, R N Hanson, B K Madra. SPECT imaging of dopamine transporter sites in normal and MPTP-Treated rhesus monkeys. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 38. issue 1. 1997-02-11. PMID:8998169. |
since these neurons contain dopamine transporters (dat), radioligands that bind to these sites are promising radiopharmaceuticals for diagnosis and therapeutic monitoring of disease progression. |
1997-02-11 |
2023-08-12 |
monkey |
| N S Vrindavanam, P Arnaud, J X Ma, S Altman-Hamamdzic, N P Parratto, F R Salle. The effects of phosphorylation on the functional regulation of an expressed recombinant human dopamine transporter. Neuroscience letters. vol 216. issue 2. 1997-02-07. PMID:8904801. |
dopamine transporter (dat) was phosphorylated in the absence of da and dephosphorylated in the presence of the substrate. |
1997-02-07 |
2023-08-12 |
human |
| K A Harrington, S J Augood, A E Kingsbury, O J Foster, P C Emso. Dopamine transporter (Dat) and synaptic vesicle amine transporter (VMAT2) gene expression in the substantia nigra of control and Parkinson's disease. Brain research. Molecular brain research. vol 36. issue 1. 1997-02-06. PMID:9011752. |
dopamine transporter (dat) and synaptic vesicle amine transporter (vmat2) gene expression in the substantia nigra of control and parkinson's disease. |
1997-02-06 |
2023-08-12 |
human |
| S H Lee, J Rhee, J K Koh, Y S Le. Species differences in functions of dopamine transporter: paucity of MPP+ uptake and cocaine binding in bovine dopamine transporter. Neuroscience letters. vol 214. issue 2-3. 1997-01-31. PMID:8878118. |
expression of cloned cdna for human, rat and bovine dopamine transporter (dat) in cos cells allows the comparison of the functional differences among the respective dopamine transporters. |
1997-01-31 |
2023-08-12 |
human |
| S H Lee, J Rhee, J K Koh, Y S Le. Species differences in functions of dopamine transporter: paucity of MPP+ uptake and cocaine binding in bovine dopamine transporter. Neuroscience letters. vol 214. issue 2-3. 1997-01-31. PMID:8878118. |
human dat showed the highest activities for dopamine uptake, mpp+ uptake and cocaine binding, indicating that humans are more vulnerable to 1-methyl-4-phenylpyridinium (mpp+) toxicity and cocaine addiction. |
1997-01-31 |
2023-08-12 |
human |
| S H Lee, J Rhee, J K Koh, Y S Le. Species differences in functions of dopamine transporter: paucity of MPP+ uptake and cocaine binding in bovine dopamine transporter. Neuroscience letters. vol 214. issue 2-3. 1997-01-31. PMID:8878118. |
however, bovine dat showed poor mpp+ uptake and cocaine binding, even though its dopamine uptake ability was quite avid. |
1997-01-31 |
2023-08-12 |
human |
| S Kitayama, K Morita, T Doh. Uptake and release of dopamine through the rat dopamine transporter expressed in Xenopus laevis oocyte: evaluation by voltammetric measurement of intracellular dopamine concentration. Neuroscience letters. vol 211. issue 2. 1997-01-23. PMID:8830862. |
an attempt was made to evaluate the uptake and release of dopamine (da) through the rat dopamine transporter (dat) expressed in xenopus laevis oocytes. |
1997-01-23 |
2023-08-12 |
rat |