| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gisela Andrea Camacho-Hernandez, Adithya Gopinath, Amarachi V Okorom, Habibeh Khoshbouei, Amy Hauck Newma. Development of a Fluorescently Labeled Ligand for Rapid Detection of DAT in Human and Mouse Peripheral Blood Monocytes. JACS Au. vol 4. issue 2. 2024-03-01. PMID:38425927. |
recent reports in a model of parkinson's disease (pd) have shown that dopamine neuronal loss in the cns impacts the expression of dat in peripheral immune cells. |
2024-03-01 |
2024-03-03 |
mouse |
| Alev Ecevitoglu, Nicolette Meka, Renee A Rotolo, Gayle A Edelstein, Sonya Srinath, Kathryn R Beard, Carla Carratala-Ros, Rose E Presby, Jianjing Cao, Amarachi Okorom, Amy H Newman, Mercè Correa, John D Salamon. Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-01. PMID:38429498. |
preclinical data indicate that dopamine transport (dat) inhibitors can reverse pharmacologically-induced low-effort biases and increase selection of high-effort options in effort-based choice tasks. |
2024-03-01 |
2024-03-04 |
rat |
| Fabio Bellia, Antonio Girella, Eugenia Annunzi, Beatrice Benatti, Matteo Vismara, Alberto Priori, Fabiana Festucci, Federico Fanti, Dario Compagnone, Walter Adriani, Bernardo Dell'Osso, Claudio D'Addari. Selective alterations of endocannabinoid system genes expression in obsessive compulsive disorder. Translational psychiatry. vol 14. issue 1. 2024-02-28. PMID:38409080. |
we found reduced daglα and nape-pld in blood samples of individuals with ocd (when compared to healthy controls) as well as in the amygdala complex and prefrontal cortex of dopamine transporter (dat) heterozygous rats, manifesting compulsive behaviours. |
2024-02-28 |
2024-03-01 |
human |
| Jie Liu, Jing Kang, Meihui Qi, Jie Tang, Yi Fang, Chunyi Liu, Jingjing Hong, Jiaojiao Zuo, Zhengping Che. Synthesis and initial evaluation of radioiodine-labelled deuterated tropane derivatives targeting dopamine transporter. Bioorganic & medicinal chemistry letters. 2024-02-26. PMID:38408514. |
the dopamine transporter (dat) is closely related to a variety of neurological disorders including parkinson's disease (pd) and other neurodegenerative diseases. |
2024-02-26 |
2024-03-02 |
Not clear |
| Concetto Puzzo, Fabiana Festucci, Giuseppe Curcio, Antonella Gigantesco, Walter Adrian. Exploring transgenerational inheritance in epigenotypes of DAT heterozygous rats: circadian anomalies and attentional vulnerability. Behavioural brain research. 2024-02-26. PMID:38408522. |
rats with ko gene for dopamine transporter (dat) coding for a truncated dat protein are in hyperdopaminergic conditions and develop stereotyped behaviors and hyperactivity. |
2024-02-26 |
2024-03-02 |
rat |
| Samantha Alvarez-Herrera, Mauricio Rosel Vales, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Yvonne Flores-Medina, José Luis Maldonado-García, Ricardo Saracco-Alvarez, Raúl Escamilla, Lenin Pavó. Risperidone Decreases Expression of Serotonin Receptor-2A (5-HT2A) and Serotonin Transporter (SERT) but Not Dopamine Receptors and Dopamine Transporter (DAT) in PBMCs from Patients with Schizophrenia. Pharmaceuticals (Basel, Switzerland). vol 17. issue 2. 2024-02-24. PMID:38399382. |
risperidone decreases expression of serotonin receptor-2a (5-ht2a) and serotonin transporter (sert) but not dopamine receptors and dopamine transporter (dat) in pbmcs from patients with schizophrenia. |
2024-02-24 |
2024-02-26 |
Not clear |
| Carlo Rossi, Alessandra Amato, Marianna Alesi, Anna Alioto, Gabriella Schiera, Patrik Drid, Giulia Messina, Andrea Pagliaro, Italia Di Liegro, Patrizia Proi. Hormonal and psychological influences on performance anxiety in adolescent female volleyball players: a multi-approach study. PeerJ. vol 12. 2024-02-23. PMID:38390388. |
genetics also seem to influence anxiety and stress management as in the case of brain-derived neurotrophic factor (bdnf) and striatal dopamine transporter (dat). |
2024-02-23 |
2024-02-25 |
Not clear |
| Tremearne Hotz, Manu Sharma, Bharat Naraparedd. A Case of Posterior Cortical Atrophy Presenting with Mood and Psychotic Symptoms. Case reports in psychiatry. vol 2024. 2024-02-16. PMID:38362124. |
the diagnosis was eventually reached utilizing a thorough clinical exam, neuropsychological testing, mri, positron emission tomography (pet), and dopamine transporter (dat) scans. |
2024-02-16 |
2024-02-18 |
Not clear |
| Therese C Ku, Jianjing Cao, Sung Joon Won, Jiqing Guo, Gisela A Camacho-Hernandez, Amarachi V Okorom, Kristine Walloe Salomon, Kuo Hao Lee, Claus J Loland, Henry J Duff, Lei Shi, Amy Hauck Newma. Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity. ACS pharmacology & translational science. vol 7. issue 2. 2024-02-15. PMID:38357284. |
we have previously discovered "atypical" dopamine transporter (dat) inhibitors that do not display psychostimulant-like behaviors and may be useful as medications to treat psud. |
2024-02-15 |
2024-02-17 |
Not clear |
| Ashley Centner, Isabella Del Priore, Nicole Chambers, Sophie R Cohen, Michelle L Terry, Michael Coyle, John Glinski, Anna C Stoll, Joseph R Patterson, Christopher J Kemp, Kathryn M Miller, Michael Kubik, Nathan Kuhn, Kelvin C Luk, Caryl E Sortwell, Christopher Bisho. Deficits in basal and evoked striatal dopamine release following alpha-synuclein preformed fibril injection: An in vivo microdialysis study. The European journal of neuroscience. 2024-02-15. PMID:38356120. |
compared with reduction in striatal th, reduction in striatal dopamine transporter (dat) was more pronounced and progressed between the 4- and 8-month p.i. |
2024-02-15 |
2024-02-17 |
rat |
| Christopher J Bergin, Aïcha Zouggar, Amanda Mendes da Silva, Tanguy Fenouil, Joshua R Haebe, Angelique N Masibag, Gautam Agrawal, Muhammad S Shah, Tamara Sandouka, Mario Tiberi, Rebecca C Auer, Michele Ardolino, Yannick D Benoi. The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors. Nature cancer. 2024-02-13. PMID:38351181. |
using a stem cell-based phenotypic drug-screening pipeline, we identified the dopamine transporter (dat) antagonist vanoxerine, a compound with previously demonstrated clinical safety, as a cancer-specific downregulator of g9a expression. |
2024-02-13 |
2024-02-16 |
Not clear |
| Julia Canzian, João V Borba, Jaíne Ames, Rossano M Silva, Cássio M Resmim, Camilla W Pretzel, Maria Cecília F Duarte, Tamiris R Storck, Khadija A Mohammed, Isaac A Adedara, Vania L Loro, Robert Gerlai, Denis B Rosember. The influence of acute dopamine transporter inhibition on manic-, depressive-like phenotypes and brain oxidative status in adult zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 2024-02-07. PMID:38325745. |
functional changes in dopamine transporter (dat) are related to various psychiatric conditions, including bipolar disorder (bd) symptoms. |
2024-02-07 |
2024-02-10 |
zebrafish |
| Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-Ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, Yuji Ikegay. Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-07. PMID:38325828. |
generation of dopamine transporter (dat)-mcherry knock-in rats by crispr-cas9 genome editing. |
2024-02-07 |
2024-02-10 |
rat |
| Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-Ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, Yuji Ikegay. Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-07. PMID:38325828. |
since dopamine transporter (dat) gene is known as a marker for dopaminergic neurons, we inserted chr2-mcherry into the downstream of the dat gene locus of the rat genome by clustered regularly interspaced short palindromic repeats (crispr)-associated protein 9 (crispr-cas9) genome editing and created dat-chr2-mcherry knock-in rats. |
2024-02-07 |
2024-02-10 |
rat |
| David L Bernstein, Stacia I Lewandowski, Christina Besada, Delaney Place, Rodrigo A España, Ole V Mortense. Inactivation of ERK1/2 Signaling in Dopaminergic Neurons by Map Kinase Phosphatase MKP3 Regulates Dopamine Signaling and Motivation for Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 5. 2024-01-31. PMID:38296649. |
following viral transfection, we found an increase in the surface expression of the dopamine transporter (dat), a protein associated with the regulation of dopamine signaling, dopamine transmission, and cocaine-associated behavior. |
2024-01-31 |
2024-02-03 |
rat |
| Margherita Tassan Mazzocco, Marcello Serra, Marco Maspero, Angela Coliva, Luca Presotto, Maria Antonietta Casu, Micaela Morelli, Rosa Maria Moresco, Sara Belloli, Annalisa Pinn. Positive relation between dopamine neuron degeneration and metabolic connectivity disruption in the MPTP plus probenecid mouse model of Parkinson's disease. Experimental neurology. 2024-01-28. PMID:38281587. |
longitudinal pet imaging of the dopamine transporter (dat) by [ |
2024-01-28 |
2024-01-31 |
mouse |
| Yatao Du, Qin Li, Guangdi Zhou, Zhenzhen Cai, Qiuhong Man, Weiye Charles Wan. Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish. The Science of the total environment. 2024-01-28. PMID:38281643. |
we studied the dopamine transporter (dat) protein, which is responsible for regulating dopamine levels through the reuptake of dopamine in neuronal cells. |
2024-01-28 |
2024-01-31 |
human |
| Yatao Du, Qin Li, Guangdi Zhou, Zhenzhen Cai, Qiuhong Man, Weiye Charles Wan. Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish. The Science of the total environment. 2024-01-28. PMID:38281643. |
taken together, we can deduce that glycosylation changes in dat lead to dysfunction of dat to regulate dopamine levels, which in turn alters behavior in larval zebrafish. |
2024-01-28 |
2024-01-31 |
human |
| Efthalia Angelopoulou, Anastasia Bougea, Alexandros Hatzimanolis, Leonidas Stefanis, Nikolaos Scarmeas, Sokratis Papageorgio. Mild Behavioral Impairment in Parkinson's Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects. Medicina (Kaunas, Lithuania). vol 60. issue 1. 2024-01-23. PMID:38256375. |
neuroimaging studies have revealed that mbi in patients with pd may be related todistinct patterns of brain atrophy, altered neuronal connectivity, and distribution of dopamine transporter (dat) depletion, shedding more light on its pathophysiological background. |
2024-01-23 |
2024-01-25 |
Not clear |
| Ralph Buchert, Balazs Szabo, Akos Kovacs, Thomas Buddenkotte, Franziska Mathies, Amir Karimzadeh, Wencke Lehnert, Susanne Klutmann, Attila Forgacs, Ivayla Apostolov. Dopamine Transporter SPECT with 12-Minute Scan Duration Using Multiple-Pinhole Collimators. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024-01-18. PMID:38238040. |
this study evaluated the potential to reduce the scan duration in dopamine transporter (dat) spect when using a second-generation multiple-pinhole (mph) collimator designed for brain spect with improved count sensitivity and improved spatial resolution compared with parallel-hole and fanbeam collimators. |
2024-01-18 |
2024-01-21 |
Not clear |