| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Castañé, Maurizio S Riga, Montserrat Cano, Luis Ruiz-Avila, Lluís Miquel-Rio, Pau Celada, Francesc Artiga. The dual 5-HT3 and 5-HT6 receptor antagonist FPPQ normalizes phencyclidine-induced disruption of brain oscillatory activity in rats. The international journal of neuropsychopharmacology. 2022-01-13. PMID:35022720. |
current antipsychotic drugs preferentially target dopamine d2-r and/or serotonergic 5-ht2a/1a-r. |
2022-01-13 |
2023-08-13 |
rat |
| Saurabh Bhatia, Ahmed Al-Harrasi, Arun Kumar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Md Khalid Anwer, Deepak Kaushik, Vineet Mittal, Sridevi Chigurupati, Pritam Babu Sharma, Lotfi Aleya, Celia Vargas-de-la-Cruz, Md Tanvir Kabi. Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn. Environmental science and pollution research international. 2022-01-04. PMID:34981370. |
anti-migraine effect of calotropis gigantea freeze-dried latex by inhibition of dopamine and serotonin receptors (d1 and d2: dopamine receptors; 5-ht: serotonin receptors); yellow color represents serotonergic, and blue color indicates dopaminergic neurons. |
2022-01-04 |
2023-08-13 |
Not clear |
| Roshan Cools, Amy F T Arnste. Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 47. issue 1. 2021-12-12. PMID:34312496. |
depletion of noradrenaline and dopamine, or of acetylcholine from the dorsolateral pfc (dlpfc), is as devastating as removing the cortex itself, and serotonergic influences are also critical to proper functioning of the orbital and medial pfc. |
2021-12-12 |
2023-08-13 |
monkey |
| Charlotte P Magee, BaoMinh D Le, Yasmeen H Siripathane, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Methcathinone decreases dopamine transporter function: Role of protein kinase C. Journal of neurochemistry. vol 159. issue 1. 2021-11-17. PMID:34320222. |
methcathinone decreases dopamine transporter function: role of protein kinase c. methcathinone (mcat) is a psychostimulant of abuse that can cause both persistent striatal dopaminergic and serotonergic, as well as hippocampal serotonergic, deficits. |
2021-11-17 |
2023-08-13 |
rat |
| Feras Altwal, Fernando E Padovan-Neto, Alexandra Ritger, Heinz Steiner, Anthony R Wes. Role of 5-HT1A Receptor in Vilazodone-Mediated Suppression of L-DOPA-Induced Dyskinesia and Increased Responsiveness to Cortical Input in Striatal Medium Spiny Neurons in an Animal Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 26. issue 19. 2021-11-16. PMID:34641332. |
research has identified abnormal dopamine release from serotonergic (5-ht) terminals contributing to this dyskinesia. |
2021-11-16 |
2023-08-13 |
Not clear |
| Kristin Water. Pharmacologic Similarities and Differences Among Hallucinogens. Journal of clinical pharmacology. vol 61 Suppl 2. 2021-11-01. PMID:34396556. |
although the serotonergic hallucinogens such as lysergic acid diethylamide, psilocybin, and n,n-dimethyltryptamine have been termed the classical hallucinogens, many hallucinogens elicit their actions through other mechanisms such as n-methyl-d-aspartate receptor antagonism, opioid receptor agonism, or inhibition of the reuptake of monoamines including serotonin, norepinephrine, and dopamine. |
2021-11-01 |
2023-08-13 |
Not clear |
| James R Docherty, Hadeel A Alsufyan. Pharmacology of Drugs Used as Stimulants. Journal of clinical pharmacology. vol 61 Suppl 2. 2021-11-01. PMID:34396557. |
psychostimulant, cardiovascular, and temperature actions of stimulants involve adrenergic (norepinephrine), dopaminergic (dopamine), and serotonergic (serotonin) pathways. |
2021-11-01 |
2023-08-13 |
Not clear |
| Tudor M Ionescu, Mario Amend, Rakibul Hafiz, Bharat B Biswal, Andreas Maurer, Bernd J Pichler, Hans F Wehrl, Kristina Herfer. Striatal and prefrontal D2R and SERT distributions contrastingly correlate with default-mode connectivity. NeuroImage. vol 243. 2021-10-29. PMID:34428573. |
the aim of this study was elucidating interactions between dopamine d2 receptors (d2r) and serotonin transporter (sert) availabilities in the striatum (cpu) and medial prefrontal cortex (mpfc), two of the main dopaminergic and serotonergic projection areas, and the default-mode network. |
2021-10-29 |
2023-08-13 |
rat |
| Michele Protti, Roberto Mandrioli, Camilla Marasca, Andrea Cavalli, Alessandro Serretti, Laura Mercolin. New-generation, non-SSRI antidepressants: Drug-drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others. Medicinal research reviews. vol 40. issue 5. 2021-10-28. PMID:32285503. |
in this second part of the review, focused on new-generation antidepressants not included among selective serotonin reuptake inhibitors, the following classes are considered: noradrenergic and selective serotonergic antidepressants; norepinephrine reuptake inhibitors; serotonin, norepinephrine and dopamine reuptake inhibitors; melatonergic agonists and selective serotonergic antagonists; norepinephrine and dopamine reuptake inhibitors; and so forth. |
2021-10-28 |
2023-08-13 |
Not clear |
| Judith Stemick, Carina Gauer, Jeanette Wihan, Sandra Moceri, Wei Xiang, Stephan von Hörsten, Zacharias Kohl, Jürgen Winkle. Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease. Brain research. vol 1748. 2021-10-25. PMID:32919983. |
particularly, serotonergic neurons have the potential to synthesize dopamine, likely associated with a disproportional dopamine release within the striatum. |
2021-10-25 |
2023-08-13 |
human |
| Judith Stemick, Carina Gauer, Jeanette Wihan, Sandra Moceri, Wei Xiang, Stephan von Hörsten, Zacharias Kohl, Jürgen Winkle. Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease. Brain research. vol 1748. 2021-10-25. PMID:32919983. |
interestingly, essential enzymes required for l-dopa turnover and dopamine release were expressed in serotonergic neurons of the rn. |
2021-10-25 |
2023-08-13 |
human |
| Judith Stemick, Carina Gauer, Jeanette Wihan, Sandra Moceri, Wei Xiang, Stephan von Hörsten, Zacharias Kohl, Jürgen Winkle. Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease. Brain research. vol 1748. 2021-10-25. PMID:32919983. |
overall, the increased serotonergic fiber density with its capacity for dopamine release within the striatum suggests a compensatory, site-specific serotonergic neuritogenesis. |
2021-10-25 |
2023-08-13 |
human |
| Dongju Seo, Christopher J Patrick, Patrick J Kenneal. Role of Serotonin and Dopamine System Interactions in the Neurobiology of Impulsive Aggression and its Comorbidity with other Clinical Disorders. Aggression and violent behavior. vol 13. issue 5. 2021-10-20. PMID:19802333. |
specifically, serotonin hypofunction may represent a biochemical trait that predisposes individuals to impulsive aggression, with dopamine hyperfunction contributing in an additive fashion to the serotonergic deficit. |
2021-10-20 |
2023-08-12 |
Not clear |
| Dongju Seo, Christopher J Patrick, Patrick J Kenneal. Role of Serotonin and Dopamine System Interactions in the Neurobiology of Impulsive Aggression and its Comorbidity with other Clinical Disorders. Aggression and violent behavior. vol 13. issue 5. 2021-10-20. PMID:19802333. |
substance abuse associated with impulsive aggression is understood in the context of dopamine dysregulation resulting from serotonergic deficiency. |
2021-10-20 |
2023-08-12 |
Not clear |
| Osama Y Alshogran, Laith N Al-Eitan, Shoroq M Altawalbeh, Hatem A Ama. Association of DRD4 exon III and 5-HTTLPR VNTR genetic polymorphisms with psychiatric symptoms in hemodialysis patients. PloS one. vol 16. issue 3. 2021-10-13. PMID:33784353. |
given that the dopaminergic and serotonergic pathways are involved in the etiology of psychiatric disease, this study evaluated the genetic association of dopamine d4 receptor (drd4) and serotonin transporter (slc6a4) genes with psychiatric symptom susceptibility among hd patients. |
2021-10-13 |
2023-08-13 |
Not clear |
| Benjamin Vidal, Elise Levigoureux, Sarah Chaib, Caroline Bouillot, Thierry Billard, Adrian Newman-Tancredi, Luc Zimme. Different Alterations of Agonist and Antagonist Binding to 5-HT1A Receptor in a Rat Model of Parkinson's Disease and Levodopa-Induced Dyskinesia: A MicroPET Study. Journal of Parkinson's disease. vol 11. issue 3. 2021-09-23. PMID:33998548. |
serotonergic neurons are partially responsible for this, by converting l-dopa into dopamine leading to its uncontrolled release as a "false neurotransmitter". |
2021-09-23 |
2023-08-13 |
rat |
| Robert W Seaman, Michelle R Doyle, Agnieszka Sulima, Kenner C Rice, Gregory T Collin. Discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) and structurally related synthetic cathinones. Behavioural pharmacology. vol 32. issue 5. 2021-09-06. PMID:33587482. |
although these studies do not support a role for serotonergic or adrenergic systems in mediating/modulating the discriminative stimulus effects of mdpv, convergent evidence is provided to suggest that the discriminative stimulus effects of mdpv are primarily mediated by its capacity to inhibit dopamine uptake, and the subsequent activation of dopamine d2 or d3 receptors. |
2021-09-06 |
2023-08-13 |
rat |
| Susanne Nikolaus, Hans-Jörg Wittsack, Christina Antke, Markus Beu, Hubertus Hautzel, Cvetana Decheva, Eduards Mamlins, Yuriko Mori, Joseph P Huston, Gerald Antoch, Hans-Wilhelm Mülle. Serotonergic Modulation of Nigrostriatal and Mesolimbic Dopamine and Motor/Exploratory Behaviors in the Rat. Frontiers in neuroscience. vol 15. 2021-08-31. PMID:34456668. |
serotonergic modulation of nigrostriatal and mesolimbic dopamine and motor/exploratory behaviors in the rat. |
2021-08-31 |
2023-08-13 |
rat |
| I M Vialichko, S V Lelevich, V V Lelevich, E M Doroshenko, V Yu Smirno. [Neurotransmitter changes in the rat brain under combined intoxication induced by alcohol and morphine]. Biomeditsinskaia khimiia. vol 67. issue 4. 2021-08-23. PMID:34414890. |
there are features of changes in the indices of the dopaminergic and serotonergic systems in these experimental conditions, confirmed by the processes of dopamine catabolism and a decrease in the norepinephrine and serotonin concentration in the hypothalamus, which are not observed under individual action of ethanol and morphine. |
2021-08-23 |
2023-08-13 |
rat |
| Katharina Ledermann, Gregor Hasler, Josef Jenewein, Haiko Sprott, Ulrich Schnyder, Chantal Martin-Soelc. 5'UTR polymorphism in the serotonergic receptor HTR3A gene is differently associated with striatal Dopamine D2/D3 receptor availability in the right putamen in Fibromyalgia patients and healthy controls-Preliminary evidence. Synapse (New York, N.Y.). vol 74. issue 5. 2021-08-09. PMID:31868947. |
5'utr polymorphism in the serotonergic receptor htr3a gene is differently associated with striatal dopamine d2/d3 receptor availability in the right putamen in fibromyalgia patients and healthy controls-preliminary evidence. |
2021-08-09 |
2023-08-13 |
Not clear |