| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Ling Wang, Shiliang Zhang, Jia Qi, Huikun Wang, Roger Cachope, Carlos A Mejias-Aponte, Jorge A Gomez, Gabriel E Mateo-Semidey, Gerard M J Beaudoin, Carlos A Paladini, Joseph F Cheer, Marisela Morale. Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons. Cell reports. vol 26. issue 5. 2020-03-13. PMID:30699344. |
our findings suggest a path-specific input from dr serotonergic neurons to vta that promotes reward by the release of glutamate and activation of mesoaccumbens dopamine neurons. |
2020-03-13 |
2023-08-13 |
Not clear |
| Tatiana O Kolesnikova, Sergey L Khatsko, Konstantin A Demin, Vadim A Shevyrin, Allan V Kaluef. DARK Classics in Chemical Neuroscience: α-Pyrrolidinovalerophenone ("Flakka"). ACS chemical neuroscience. vol 10. issue 1. 2020-02-06. PMID:30384587. |
its interesting pharmacological profile (co-inhibition of dopamine and norepinephrine, but not serotonin, transporters) also calls for further studies of α-pvp in animal models, to dissect serotonergic from other monoaminergic mechanisms of action of drugs of abuse. |
2020-02-06 |
2023-08-13 |
Not clear |
| P. Vezina, G. Blanc, J. Glowinski, J.-P. Tassi. Opposed Behavioural Outputs of Increased Dopamine Transmission in Prefrontocortical and Subcortical Areas: A Role for the Cortical D-1 Dopamine Receptor. The European journal of neuroscience. vol 3. issue 10. 2019-11-20. PMID:12106258. |
further, intra-mpfc injections of the d-1 dopamine receptor antagonist sch-23390, but not other dopamine antagonists with greater affinities for noradrenergic, serotonergic and d-2 dopamine receptors, enhanced the locomotion induced by intra-n.acc. |
2019-11-20 |
2023-08-12 |
rat |
| Syed F Ali, Yossef Itzha. Effects of 7-Nitroindazole, an NOS Inhibitor on Methamphetamine-Induced Dopaminergic and Serotonergic Neurotoxicity in Mice Annals of the New York Academy of Sciences. vol 844. issue 1. 2019-11-20. PMID:29090810. |
effects of 7-nitroindazole, an nos inhibitor on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in mice methamphetamine (meth) is one of the major drugs of abuse that is postulated to cause neurotoxicity by depleting dopamine (da) and its metabolites, high-affinity da uptake sites, and the activity of tyrosine hydroxylase. |
2019-11-20 |
2023-08-13 |
mouse |
| Julieta Acosta, Marcos A Campolongo, Christian Höcht, Amaicha M Depino, Diego A Golombek, Patricia V Agostin. Deficits in temporal processing in mice prenatally exposed to Valproic Acid. The European journal of neuroscience. vol 47. issue 6. 2019-11-12. PMID:28612411. |
furthermore, catecholamine determination by hplc-ed indicated significant differences in striatal dopaminergic, but not serotonergic, content in female and male vpa mice, consistent with previously identified alterations in dopamine metabolism in asd. |
2019-11-12 |
2023-08-13 |
mouse |
| Gennaro Pagano, Flavia Niccolini, Marios Politi. The serotonergic system in Parkinson's patients with dyskinesia: evidence from imaging studies. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29264660. |
serotonergic terminals convert exogenous levodopa into dopamine in a non-physiological manner and release an abnormal amount of dopamine without an auto-regulatory feedback. |
2019-11-04 |
2023-08-13 |
Not clear |
| Véronique Sgambato, Léon Trembla. Pathophysiology of dyskinesia and behavioral disorders in non-human primates: the role of serotonergic fibers. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29502255. |
a major breakthrough has then been made regarding the hypothesis of the involvement of serotonergic fibers in the conversion of l-dopa to dopamine when dopaminergic neurons are dying and to release it, in an uncontrolled manner, as serotonergic neurons are deprived from the machinery required for buffering dopamine from the synaptic cleft. |
2019-11-04 |
2023-08-13 |
monkey |
| Augusta Pisanu, Laura Boi, Giovanna Mulas, Saturnino Spiga, Sandro Fenu, Anna R Cart. Neuroinflammation in L-DOPA-induced dyskinesia: beyond the immune function. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29541852. |
it is proposed that tnf-α may contribute to the altered neuronal responses occurring in lid by targeting receptor trafficking and function in msns, but also dopamine synthesis in preserved dopaminergic terminals and serotonin metabolism in serotonergic neurons. |
2019-11-04 |
2023-08-13 |
rat |
| R Feio-Azevedo, V M Costa, D J Barbosa, A Teixeira-Gomes, I Pita, S Gomes, F C Pereira, M Duarte-Araújo, J A Duarte, F Marques, E Fernandes, M L Bastos, F Carvalho, J P Capel. Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity. Archives of toxicology. vol 92. issue 7. 2019-10-07. PMID:29869127. |
mdma promoted serotonergic neurotoxicity only in the hippocampus of aged, but not in the adolescents' brain, and did not change the levels of dopamine or serotonin metabolite in the striatum of both groups. |
2019-10-07 |
2023-08-13 |
rat |
| Trevor C Chopko, Craig W Lindsle. Classics in Chemical Neuroscience: Risperidone. ACS chemical neuroscience. vol 9. issue 7. 2019-09-30. PMID:29695153. |
after the identification of the influence of serotonergic receptors in ameliorating the negative symptoms associated with schizophrenia, atypical antipsychotics were developed by incorporating dopamine and serotonin antagonism. |
2019-09-30 |
2023-08-13 |
Not clear |
| Alberto J Espay, Francesca Morgante, Aristide Merola, Alfonso Fasano, Luca Marsili, Susan H Fox, Erwan Bezard, Barbara Picconi, Paolo Calabresi, Anthony E Lan. Levodopa-induced dyskinesia in Parkinson disease: Current and evolving concepts. Annals of neurology. vol 84. issue 6. 2019-08-26. PMID:30357892. |
pathogenic mechanisms include phasic stimulation of dopamine receptors, nonphysiological levodopa-to-dopamine conversion in serotonergic neurons, hyperactivity of corticostriatal glutamatergic transmission, and overstimulation of nicotinic acetylcholine receptors on dopamine-releasing axons. |
2019-08-26 |
2023-08-13 |
Not clear |
| Thomas R Barber, Ludovica Griffanti, Kinan Muhammed, Daniel S Drew, Kevin M Bradley, Daniel R McGowan, Marie Crabbe, Christine Lo, Clare E Mackay, Masud Husain, Michele T Hu, Johannes C Klei. Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the dorsal raphe nucleus. Brain : a journal of neurology. vol 141. issue 10. 2019-07-05. PMID:30212839. |
the integrity of the raphe serotonergic system can be assessed alongside dopaminergic basal ganglia imaging using the radioligand 123i-ioflupane, which binds both serotonin and dopamine transporters. |
2019-07-05 |
2023-08-13 |
Not clear |
| Jacopo Pasquini, Roberto Ceravolo, Zahi Qamhawi, Jee-Young Lee, Günther Deuschl, David James Brooks, Ubaldo Bonuccelli, Nicola Paves. Progression of tremor in early stages of Parkinson's disease: a clinical and neuroimaging study. Brain : a journal of neurology. vol 141. issue 3. 2019-06-27. PMID:29365117. |
as disease progresses, both raphe serotonergic dysfunction and putamen dopamine depletion could contribute to the occurrence of rest tremor. |
2019-06-27 |
2023-08-13 |
Not clear |
| A M da Rocha, L W Kist, E A Almeida, D G H Silva, C D Bonan, S Altenhofen, C G Kaufmann, M R Bogo, D M Barros, S Oliveira, V Geraldo, R G Lacerda, A S Ferlauto, Luiz Orlando Ladeira, J M Monserra. Neurotoxicity in zebrafish exposed to carbon nanotubes: Effects on neurotransmitters levels and antioxidant system. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 218. 2019-04-01. PMID:30543862. |
cholinergic, serotonergic, and dopaminergic systems, through ache activity and serotonin and dopamine levels, respectively were affected by swcnt in the zebrafish brain. |
2019-04-01 |
2023-08-13 |
zebrafish |
| Xiaoqing Peng, Lisa A Brenner, Ashwin J Mathai, Thomas B Cook, Dietmar Fuchs, Nadine Postolache, Maureen W Groer, Janardan P Pandey, Farooq Mohyuddin, Ina Giegling, Abhishek Wadhawan, Annette M Hartmann, Bettina Konte, Lena Brundin, Marion Friedl, John W Stiller, Christopher A Lowry, Dan Rujescu, Teodor T Postolach. Moderation of the relationship between Toxoplasma gondii seropositivity and trait impulsivity in younger men by the phenylalanine-tyrosine ratio. Psychiatry research. vol 270. 2019-03-26. PMID:30057257. |
as dopaminergic and serotonergic signaling regulate impulsivity, and as t. gondii directly and indirectly affects dopaminergic signaling and induces activation of the kynurenine pathway leading to the diversion of tryptophan from serotonin production, we investigated if dopamine and serotonin precursors or the tryptophan metabolite kynurenine interact with the t. gondii-impulsivity association. |
2019-03-26 |
2023-08-13 |
human |
| Rosalyn J Moran, Kenneth T Kishida, Terry Lohrenz, Ignacio Saez, Adrian W Laxton, Mark R Witcher, Stephen B Tatter, Thomas L Ellis, Paul Em Phillips, Peter Dayan, P Read Montagu. The Protective Action Encoding of Serotonin Transients in the Human Brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 6. 2019-03-04. PMID:29297512. |
this provides initial evidence that the serotonergic system acts as an opponent to dopamine signaling, as anticipated by theoretical models. |
2019-03-04 |
2023-08-13 |
human |
| Shu-Ying Liu, Daryl J Wile, Jessie Fanglu Fu, Jason Valerio, Elham Shahinfard, Siobhan McCormick, Rostom Mabrouk, Nasim Vafai, Jess McKenzie, Nicole Neilson, Alexandra Perez-Soriano, Julieta E Arena, Mariya Cherkasova, Piu Chan, Jing Zhang, Cyrus P Zabetian, Jan O Aasly, Zbigniew K Wszolek, Martin J McKeown, Michael J Adam, Thomas J Ruth, Michael Schulzer, Vesna Sossi, A Jon Stoess. The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study. The Lancet. Neurology. vol 17. issue 4. 2019-02-27. PMID:29456161. |
previous pet studies have suggested amplified dopamine turnover and preserved serotonergic innervation in lrrk2 mutation carriers. |
2019-02-27 |
2023-08-13 |
Not clear |
| Gurjit Kaur, Deepti Gupta, Bir Singh Chavan, Vikas Sinhmar, Rajendra Prasad, Adarsh Tripathi, P D Garg, Rajiv Gupta, Hitesh Khurana, Shiv Gautam, Mushtaq Ahmed Margoob, Jitender Anej. Identification of genetic correlates of response to Risperidone: Findings of a multicentric schizophrenia study from India. Asian journal of psychiatry. vol 29. 2018-06-22. PMID:28692863. |
so, we attempted to evaluate the association between dopamine d2 (drd2) receptor, serotonergic (5ht2a) receptor and cyp2d6 gene polymorphisms and response to treatment with risperidone in persons with schizophrenia from north india. |
2018-06-22 |
2023-08-13 |
Not clear |
| B Oranje, B Aggernaes, H Rasmussen, B H Ebdrup, B Y Glenthø. Selective attention and mismatch negativity in antipsychotic-naïve, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy. Psychological medicine. vol 47. issue 12. 2018-04-26. PMID:28443529. |
in this study, the influence of 6 months treatment with quetiapine, a compound with less affinity for dopamine d2 receptors than for serotonergic 5-ht2a receptors, on electrophysiological parameters of attention was investigated in a group of antipsychotic-naïve, first-episode schizophrenia patients compared with a group of age- and gender-matched healthy controls. |
2018-04-26 |
2023-08-13 |
Not clear |
| Claire O'Callaghan, Simon J G Lewi. Cognition in Parkinson's Disease. International review of neurobiology. vol 133. 2018-04-26. PMID:28802933. |
increasingly, changes in neurotransmitter systems beyond dopamine, including the noradrenergic, serotonergic, and cholinergic systems, are being recognized for their contribution to cognitive decline. |
2018-04-26 |
2023-08-13 |
human |