| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katharina Ledermann, Gregor Hasler, Josef Jenewein, Haiko Sprott, Ulrich Schnyder, Chantal Martin-Soelc. 5'UTR polymorphism in the serotonergic receptor HTR3A gene is differently associated with striatal Dopamine D2/D3 receptor availability in the right putamen in Fibromyalgia patients and healthy controls-Preliminary evidence. Synapse (New York, N.Y.). vol 74. issue 5. 2021-08-09. PMID:31868947. |
here, we investigated the effect of a 5'utr snp in the serotonergic receptor htr3a gene (rs1062613) on striatal dopamine d2/d3 receptor (drd2) availability and reward-associated da release in response to unpredictable monetary rewards in 23 women with fms and 17 age-matched healthy female controls. |
2021-08-09 |
2023-08-13 |
Not clear |
| Vinod Metta, Lucia Batzu, Valentina Leta, Dhaval Trivedi, Aleksandra Powdleska, Kandadai Rukmini Mridula, Prashanth Kukle, Vinay Goyal, Rupam Borgohain, Guy Chung-Faye, K Ray Chaudhur. Parkinson's Disease: Personalized Pathway of Care for Device-Aided Therapies (DAT) and the Role of Continuous Objective Monitoring (COM) Using Wearable Sensors. Journal of personalized medicine. vol 11. issue 7. 2021-08-09. PMID:34357147. |
the management of pd should focus on personalized care addressing both motor and non-motor symptoms, ideally including not only dopamine replacement but also associated non-dopaminergic circuits, particularly focusing on noradrenergic, serotonergic, and cholinergic therapies bypassing the gastrointestinal tract (git) by infusion or device-aided therapies (dat), including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, which are available in many countries for the management of the advanced stage of parkinson's disease (apd). |
2021-08-09 |
2023-08-13 |
Not clear |
| Della Grace Thomas Parambi, Uzma Saleem, Muhammad Ajmal Shah, Fareeha Anwar, Bashir Ahmad, Amna Manzar, Aqsa Itzaz, Seetha Harilal, Md Sahab Uddin, Hoon Kim, Bijo Mathe. Exploring the Therapeutic Potentials of Highly Selective Oxygenated Chalcone Based MAO-B Inhibitors in a Haloperidol-Induced Murine Model of Parkinson's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32939670. |
parkinson's disease (pd) is a neurodegenerative disorder of dopaminergic, noradrenergic, and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are depleted and lead to the development of motor and non-motor symptoms such as tremor, bradykinesia, weight changes, fatigue, depression, and visual hallucinations. |
2021-06-02 |
2023-08-13 |
Not clear |
| Jessie F Fu, Michele Matarazzo, Jessamyn McKenzie, Nicole Neilson, Nasim Vafai, Katie Dinelle, Andre C Felicio, Martin J McKeown, A Jon Stoessl, Vesna Soss. Serotonergic System Impacts Levodopa Response in Early Parkinson's and Future Risk of Dyskinesia. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 2. 2021-04-27. PMID:33090574. |
the serotonergic system is known to contribute to levodopa-derived dopamine release in advanced parkinson's disease. |
2021-04-27 |
2023-08-13 |
Not clear |
| Ria Fisher, Atsuko Hikima, Rebecca Morris, Michael J Jackson, Sarah Rose, Mark A Varney, Ronan Depoortere, Adrian Newman-Tancred. The selective 5-HT Neuropharmacology. vol 167. 2021-04-23. PMID:32057799. |
the selective 5-ht l-dopa is the gold-standard pharmacotherapy for treatment of parkinson's disease (pd) but can lead to the appearance of troubling dyskinesia which are attributable to 'false neurotransmitter' release of dopamine by serotonergic neurons. |
2021-04-23 |
2023-08-13 |
Not clear |
| Dagmar N van Deursen, Odile A van den Heuvel, Jan Booij, Henk W Berendse, Chris Vrien. Autonomic failure in Parkinson's disease is associated with striatal dopamine deficiencies. Journal of neurology. vol 267. issue 7. 2021-04-12. PMID:32162062. |
dopamine and serotonin are known to play a role in autonomic regulation, and, therefore, pd-related degeneration of serotonergic and dopaminergic neurons in these regions may be associated with autonomic dysfunction. |
2021-04-12 |
2023-08-13 |
Not clear |
| Joseph Jankovic, Eng King Ta. Parkinson's disease: etiopathogenesis and treatment. Journal of neurology, neurosurgery, and psychiatry. vol 91. issue 8. 2021-01-19. PMID:32576618. |
the involvement of dopaminergic as well as noradrenergic, glutamatergic, serotonergic and adenosine pathways provide insights into the rich and variable clinical phenomenology associated with pd and the possibility of alternative therapeutic approaches beyond traditional dopamine replacement therapies.one of the biggest challenges in the development of potential neuroprotective therapies has been the lack of reliable and sensitive biomarkers of progression. |
2021-01-19 |
2023-08-13 |
Not clear |
| J J van der Zande, M Joling, I G Happach, C Vriend, Ph Scheltens, J Booij, A W Lemstr. Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An NeuroImage. Clinical. vol 25. 2021-01-11. PMID:31790878. |
serotonergic deficits in dementia with lewy bodies with concomitant alzheimer's disease pathology: an to study the influence of concomitant alzheimer's disease (ad) pathology in dementia with lewy bodies (dlb) on dopamine transporter (dat) and serotonin transporter (sert) availability, using |
2021-01-11 |
2023-08-13 |
Not clear |
| Xiuwen Xu, Zonghang Zhang, Haoyu Guo, Jianguang Qin, Xiumei Zhan. Changes in Aggressive Behavior, Cortisol and Brain Monoamines during the Formation of Social Hierarchy in Black Rockfish ( Animals : an open access journal from MDPI. vol 10. issue 12. 2020-12-29. PMID:33321717. |
to explore the responses of fish behavior and physiology to social hierarchy, we examined the differences in the growth performance, aggression, cortisol level, brain serotonergic activity, and brain dopamine activity between the dominant individuals and the subordinate individuals of black rockfish ( |
2020-12-29 |
2023-08-13 |
Not clear |
| Emily J Jaehne, Dzeneta Ameti, Tehani Paiva, Maarten van den Buus. Investigating the Role of Serotonin in Methamphetamine Psychosis: Unaltered Behavioral Effects of Chronic Methamphetamine in 5-HT Frontiers in psychiatry. vol 8. 2020-10-01. PMID:28473777. |
in addition to its well-known action on brain dopamine, meth also affects serotonergic (5-ht) neurons. |
2020-10-01 |
2023-08-13 |
mouse |
| Yannick Vermeiren, Jana Janssens, Debby Van Dam, Peter P De Dey. Serotonergic Dysfunction in Amyotrophic Lateral Sclerosis and Parkinson's Disease: Similar Mechanisms, Dissimilar Outcomes. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29615862. |
levodopa (l-dopa) therapy in pd largely seems to confirm the influential role of 5-ht, since serotonergic rather than dopaminergic projections release l-dopa-derived dopamine, particularly in extrastriatal regions, emphasizing the strongly interwoven interactions between both monoamine systems. |
2020-10-01 |
2023-08-13 |
Not clear |
| Stephen M. Stahl, James F. Pradko, Barbara R. Haight, Jack G. Modell, Carol B. Rockett, Susan Learned-Coughli. A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Primary care companion to the Journal of clinical psychiatry. vol 6. issue 4. 2020-09-29. PMID:15361919. |
conclusions: the preclinical and clinical data show that bupropion acts via dual inhibition of norepinephrine and dopamine reuptake and is devoid of clinically significant serotonergic effects or direct effects on postsynaptic receptors. |
2020-09-29 |
2023-08-12 |
Not clear |
| Stephen M. Stahl, James F. Pradko, Barbara R. Haight, Jack G. Modell, Carol B. Rockett, Susan Learned-Coughli. A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Primary care companion to the Journal of clinical psychiatry. vol 6. issue 4. 2020-09-29. PMID:15361919. |
however, because bupropion is a selective norepinephrine and dopamine reuptake inhibitor with no serotonergic activity, common antidepressant-associated side effects, such as sexual dysfunction, weight gain, and sedation, are not associated with bupropion therapy. |
2020-09-29 |
2023-08-12 |
Not clear |
| Ana Muñoz, Andrea Lopez-Lopez, Carmen M Labandeira, Jose L Labandeira-Garci. Interactions Between the Serotonergic and Other Neurotransmitter Systems in the Basal Ganglia: Role in Parkinson's Disease and Adverse Effects of L-DOPA. Frontiers in neuroanatomy. vol 14. 2020-09-28. PMID:32581728. |
interaction between the serotonergic and other neurotransmitters systems such as dopamine, noradrenaline, glutamate, and gaba controls the activity of striatal neurons and are particularly interesting for understanding the pathophysiology of pd. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ana Muñoz, Andrea Lopez-Lopez, Carmen M Labandeira, Jose L Labandeira-Garci. Interactions Between the Serotonergic and Other Neurotransmitter Systems in the Basal Ganglia: Role in Parkinson's Disease and Adverse Effects of L-DOPA. Frontiers in neuroanatomy. vol 14. 2020-09-28. PMID:32581728. |
serotonergic terminals can convert l-dopa to dopamine, which mediates dopamine release as a "false" transmitter. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ana Muñoz, Andrea Lopez-Lopez, Carmen M Labandeira, Jose L Labandeira-Garci. Interactions Between the Serotonergic and Other Neurotransmitter Systems in the Basal Ganglia: Role in Parkinson's Disease and Adverse Effects of L-DOPA. Frontiers in neuroanatomy. vol 14. 2020-09-28. PMID:32581728. |
the lack of any autoregulatory feedback control in serotonergic neurons to regulate l-dopa-derived dopamine release contributes to the appearance of l-dopa-induced dyskinesia (lid). |
2020-09-28 |
2023-08-13 |
Not clear |
| Jin Zhang, Yong Wang, Yi Na Sun, Li Bo Li, Li Zhang, Yuan Guo, Tao Wang, Lu Yao, Li Chen, Jian Li. Blockade of calcium-permeable AMPA receptors in the lateral habenula produces increased antidepressant-like effects in unilateral 6-hydroxydopamine-lesioned rats compared to sham-lesioned rats. Neuropharmacology. vol 157. 2020-07-21. PMID:31251995. |
our findings indicate that blockade of lhb cp-ampars produces antidepressant-like effects, which attribute to decreased firing activity of lhb neurons and increased levels of dopamine and serotonin in the mpfc, and provide further evidence that lhb cp-ampars regulate the firing activity of pvta dopaminergic neurons and mrn serotonergic neurons indirectly via the rmtg. |
2020-07-21 |
2023-08-13 |
rat |
| Jacqueline H Fortier, Beatrice Pizzarotti, Richard E Shaw, Robert J Levy, Giovanni Ferrari, Juan Gra. Drug-associated valvular heart diseases and serotonin-related pathways: a meta-analysis. Heart (British Cardiac Society). vol 105. issue 15. 2020-06-05. PMID:31129607. |
serotonergic appetite suppressants and ergot-derived dopamine agonists have been associated with drug-induced valvular heart disease. |
2020-06-05 |
2023-08-13 |
Not clear |
| Rhyomi C Sellnow, Jordan H Newman, Nicole Chambers, Anthony R West, Kathy Steece-Collier, Ivette M Sandoval, Matthew J Benskey, Christopher Bishop, Fredric P Manfredsso. Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia. Acta neuropathologica communications. vol 7. issue 1. 2020-04-02. PMID:30646956. |
regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine d2 autoreceptor blocks levodopa-induced dyskinesia. |
2020-04-02 |
2023-08-13 |
Not clear |
| Rhyomi C Sellnow, Jordan H Newman, Nicole Chambers, Anthony R West, Kathy Steece-Collier, Ivette M Sandoval, Matthew J Benskey, Christopher Bishop, Fredric P Manfredsso. Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia. Acta neuropathologica communications. vol 7. issue 1. 2020-04-02. PMID:30646956. |
it has long been hypothesized that serotonergic neurons of the dorsal raphe nucleus (drn) are capable of l-dopa uptake and dysregulated release of dopamine (da), and that this "false neurotransmission" phenomenon is a main contributor to lid development. |
2020-04-02 |
2023-08-13 |
Not clear |