| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lun-Ching Chang, Stephane Jamain, Chien-Wei Lin, Dan Rujescu, George C Tseng, Etienne Sibill. A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies. PloS one. vol 9. issue 3. 2015-02-12. PMID:24608543. |
genes in the identified module encode proteins implicated in neuronal signaling and structure, including glutamate metabotropic receptors (grm1, grm7), gaba receptors (gabra2, gabra4), and neurotrophic and development-related proteins [bdnf, reelin (reln), ephrin receptors (epha3, epha5)]. |
2015-02-12 |
2023-08-12 |
human |
| Aki Takahashi, Isabel M Quadros, Rosa M M de Almeida, Klaus A Micze. Behavioral and pharmacogenetics of aggressive behavior. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22297576. |
studies of aggression in genetically modified mice identified several molecules that affect the 5-ht system directly (e.g., tph2, 5-ht1b, 5-ht transporter, pet1, maoa) or indirectly[e.g., bdnf, neuronal nitric oxide (nnos), acamkii, neuropeptide y].the future agenda delineates specific receptor subpopulations for gaba, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior. |
2015-01-20 |
2023-08-12 |
mouse |
| Liangfang Zhao, Eric S Levin. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. Journal of neurophysiology. vol 111. issue 5. 2014-10-30. PMID:24335212. |
previously we have found that bdnf suppresses presynaptic gaba release in layer 2/3 of the neocortex via postsynaptic tropomyosin-related kinase receptor b (trkb) receptor-induced release of endocannabinoids. |
2014-10-30 |
2023-08-12 |
mouse |
| Ewelina Ziemlińska, Sebastian Kügler, Melitta Schachner, Iwona Wewiór, Julita Czarkowska-Bauch, Małgorzata Sku. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551172. |
bdnf overexpression resulted in clear increases in expression levels of molecules involved in glutamatergic (vglut2) and gabaergic (gaba, gad65, gad67) neurotransmission in parallel with a reduction of the potassium-chloride co-transporter (kcc2) which contributes to an inhibitory neurotransmission. |
2014-10-21 |
2023-08-12 |
rat |
| Jiawei Xin, Junjian Zhang, Ying Yang, Min Deng, Xiaofeng Xi. Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment. Current neurovascular research. vol 10. issue 4. 2014-04-16. PMID:23937197. |
the present study supports the hypothesis that adult neurogenesis is required for ras to facilitate recovery from the cognitive impairment induced by chronic cerebral hypoperfusion, while neurogenic enhancement secondary to ras treatment may be due to increased bdnf and phosphorylated camp-responsive element binding protein (p-creb) levels and increased γ-aminobutyric acid (gaba) expression. |
2014-04-16 |
2023-08-12 |
rat |
| V De Chiara, C Motta, S Rossi, V Studer, F Barbieri, D Lauro, G Bernardi, D Centonz. Interleukin-1β alters the sensitivity of cannabinoid CB1 receptors controlling glutamate transmission in the striatum. Neuroscience. vol 250. 2014-04-04. PMID:23856068. |
we also provided evidence that il1β-cb1rs(gaba) but not il1β-cb1rs(glu) interaction is under the control of the brain-derived neurotrophic factor (bdnf)/trkb signaling and of lipid raft composition, because bdnf gene partial deletion, pharmacological blockade of trkb and membrane cholesterol removal with methyl-β-cyclodextrin all blocked il1β-mediated inhibition of cb1rs(gaba) but left unaltered the sensitivity of cb1rs(glu) to this cytokine. |
2014-04-04 |
2023-08-12 |
Not clear |
| S Valdeolivas, M R Pazos, T Bisogno, F Piscitelli, F A Iannotti, M Allarà, O Sagredo, V Di Marzo, J Fernández-Rui. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. Cell death & disease. vol 4. 2014-03-12. PMID:24136226. |
however, surprisingly, the inhibitor attenuated malonate-induced gaba and bdnf deficiencies and the reduction in nissl staining, as well as the increase in gfap immunostaining. |
2014-03-12 |
2023-08-12 |
rat |
| b' Przemys\\xc5\\x82aw Kowia\\xc5\\x84ski, Gra\\xc5\\xbcyna Lietzau, Aleksandra Steliga, Monika Wa\\xc5\\x9bkow, Janusz Mory\\xc5\\x9. The astrocytic contribution to neurovascular coupling--still more questions than answers? Neuroscience research. vol 75. issue 3. 2014-01-20. PMID:23419863.' |
the critical factors that determine the polarity of astrocytic response include: metabolites (e.g., arachidonic acid and its derivatives, lactate and oxygen concentrations), ions (h(+), ca(2+) and k(+)), gliotransmitters (glutamate, glu; gamma-aminobutyric acid, gaba; d-serine; adenosine 5'-triphosphate, atp and brain derived neurotrophic factor, bdnf), neuronal activity and vascular tone. |
2014-01-20 |
2023-08-12 |
Not clear |
| T L Huan. Effects of antipsychotics on the BDNF in schizophrenia. Current medicinal chemistry. vol 20. issue 3. 2014-01-17. PMID:23157625. |
bdnf is also believed to interact with other neurotransmitter systems implicated in schizophrenia, such as dopamine, glutamate, serotonin and gaba. |
2014-01-17 |
2023-08-12 |
Not clear |
| Francesco Ferrini, Yves De Koninc. Microglia control neuronal network excitability via BDNF signalling. Neural plasticity. vol 2013. 2013-12-30. PMID:24089642. |
the efforts made by different laboratories during the last decade have collectively provided a robust mechanistic paradigm which elucidates the mechanisms involved in the synthesis and release of bdnf from microglia, the downstream trkb-mediated signals in neurons, and the biophysical mechanism by which disinhibition occurs, via the downregulation of the k⁺-cl⁻ cotransporter kcc2, dysrupting cl⁻ homeostasis, and hence the strength of gaba(a)- and glycine receptor-mediated inhibition. |
2013-12-30 |
2023-08-12 |
Not clear |
| Mansi Vithlani, Rochelle M Hines, Ping Zhong, Miho Terunuma, Dustin J Hines, Raquel Revilla-Sanchez, Rachel Jurd, Phillip Haydon, Maribel Rios, Nicholas Brandon, Zhen Yan, Stephen J Mos. The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 39. 2013-11-25. PMID:24068823. |
the ability of bdnf to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the gaba(a)-receptor γ2 subunit. |
2013-11-25 |
2023-08-12 |
mouse |
| Mansi Vithlani, Rochelle M Hines, Ping Zhong, Miho Terunuma, Dustin J Hines, Raquel Revilla-Sanchez, Rachel Jurd, Phillip Haydon, Maribel Rios, Nicholas Brandon, Zhen Yan, Stephen J Mos. The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 39. 2013-11-25. PMID:24068823. |
here we reveal that bdnf induces long-lasting enhancements in the efficacy of synaptic inhibition by stabilizing γ2 subunit-containing gaba(a) receptors (gaba(a)rs) at the cell surface, leading to persistent reductions in neuronal excitability. |
2013-11-25 |
2023-08-12 |
mouse |
| Mansi Vithlani, Rochelle M Hines, Ping Zhong, Miho Terunuma, Dustin J Hines, Raquel Revilla-Sanchez, Rachel Jurd, Phillip Haydon, Maribel Rios, Nicholas Brandon, Zhen Yan, Stephen J Mos. The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 39. 2013-11-25. PMID:24068823. |
collectively, our results suggest a critical role for gaba(a)r γ2 subunit y365/7 phosphorylation and function in regulating the effects of bdnf. |
2013-11-25 |
2023-08-12 |
mouse |
| A Shulga, C River. Interplay between thyroxin, BDNF and GABA in injured neurons. Neuroscience. vol 239. 2013-10-17. PMID:23246615. |
interplay between thyroxin, bdnf and gaba in injured neurons. |
2013-10-17 |
2023-08-12 |
Not clear |
| Yuan Hu, Ming Liu, Ping Liu, Juan-Juan Yan, Ming-Yue Liu, Gang-Qiang Zhang, Xiao-Jiang Zhou, Bing-Ying Y. Effect of kai xin san on learning and memory in a rat model of paradoxical sleep deprivation. Journal of medicinal food. vol 16. issue 4. 2013-09-17. PMID:23514232. |
furthermore, its effect on the glutamic acid (glu) and γ-amino-butyric acid (gaba) levels in the brain tissue, brain-derived neurotrophic factor (bdnf), cyclic amp response element binding protein (creb), and phosphorylated-creb (p-creb) expression in the hippocampus was also tested. |
2013-09-17 |
2023-08-12 |
rat |
| Yuan Hu, Ming Liu, Ping Liu, Juan-Juan Yan, Ming-Yue Liu, Gang-Qiang Zhang, Xiao-Jiang Zhou, Bing-Ying Y. Effect of kai xin san on learning and memory in a rat model of paradoxical sleep deprivation. Journal of medicinal food. vol 16. issue 4. 2013-09-17. PMID:23514232. |
kxs exerted the greatest cognition against the 48 h psd-induced cognitive deficit and these effects may be mediated by decreasing the glu and gaba levels and increasing the levels of bdnf, creb, and p-creb. |
2013-09-17 |
2023-08-12 |
rat |
| M Meyer, M C Gonzalez Deniselle, G Gargiulo-Monachelli, A Lima, P Roig, R Guennoun, M Schumacher, A F De Nicol. Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse. Journal of neuroendocrinology. vol 25. issue 3. 2013-08-12. PMID:23157231. |
we found that the hippocampal pathology of the untreated wobblers involved a decreased expression of brain-derived neurotrophic factor (bdnf) mrna, decreased astrogliosis in the stratum lucidum, stratum radiatum and stratum lacunosum-moleculare, decreased doublecortin (dcx)-positive neuroblasts in the subgranular zone of the dentate gyrus and a decreased density of gaba immunoreactive hippocampal interneurones and granule cells of the dentate gyrus. |
2013-08-12 |
2023-08-12 |
mouse |
| L C Jansson, L Louhivuori, H-K Wigren, T Nordström, V Louhivuori, M L Castrén, K E Åkerma. Brain-derived neurotrophic factor increases the motility of a particular N-methyl-D-aspartate /GABA-responsive subset of neural progenitor cells. Neuroscience. vol 224. 2013-06-17. PMID:22922352. |
the results demonstrate that bdnf does not affect cell motility per se but alters the phasic behavior of cell movement by promoting periods of high motility in a defined subpopulation of cells which give a robust ca(2+) response to nmda and gaba. |
2013-06-17 |
2023-08-12 |
Not clear |
| J-P Guilloux, G Douillard-Guilloux, R Kota, X Wang, A M Gardier, K Martinowich, G C Tseng, D A Lewis, E Sibill. Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. Molecular psychiatry. vol 17. issue 11. 2013-04-23. PMID:21912391. |
among the most robust findings were downregulated transcripts for genes coding for γ-aminobutyric acid (gaba) interneuron-related peptides, including somatostatin (sst), tachykinin, neuropeptide y (npy) and cortistatin, in a pattern reminiscent to that previously reported in mice with low brain-derived neurotrophic factor (bdnf). |
2013-04-23 |
2023-08-12 |
mouse |
| J-P Guilloux, G Douillard-Guilloux, R Kota, X Wang, A M Gardier, K Martinowich, G C Tseng, D A Lewis, E Sibill. Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. Molecular psychiatry. vol 17. issue 11. 2013-04-23. PMID:21912391. |
supporting studies in mutant mice models suggest a complex mechanism of low constitutive and activity-dependent bdnf function in mdd, particularly affecting sst/npy-related gaba neurons, thus linking the neurotrophic and gaba hypotheses of depression. |
2013-04-23 |
2023-08-12 |
mouse |