| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Luiza Diniz Lima, Emanuele Guimarães Silva, Pablo Leal Cardozo, Maria Carolina Machado da Silva, Suélyn Koerich, Fabíola Mara Ribeiro, Fabrício A Moreira, Luciene Bruno Vieir. Isradipine, an L-type calcium channel blocker, attenuates cocaine effects in mice by reducing central glutamate release. European journal of pharmacology. 2024-03-16. PMID:38492875. |
isradipine, an l-type calcium channel blocker, attenuates cocaine effects in mice by reducing central glutamate release. |
2024-03-16 |
2024-03-19 |
mouse |
| Yi He, Hui Shen, Guo-Hua Bi, Hai-Ying Zhang, Omar Soler-Cedeño, Hannah Alton, Yihong Yang, Zheng-Xiong X. GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice. Translational psychiatry. vol 14. issue 1. 2024-02-19. PMID:38374108. |
here we report that gpr55 is predominantly found in glutamate neurons in the brain, and its activation reduces self-administration of cocaine and nicotine in rats and mice. |
2024-02-19 |
2024-02-22 |
mouse |
| Shailesh N Khatri, Hanaa Ulangkaya, Erin E Maher, Safiyah Sadek, Mei Hong, Andrea M Woodcox, William W Stoops, Cassandra D Gipso. Oxycodone withdrawal is associated with increased cocaine self-administration and aberrant accumbens glutamate plasticity in rats. Neuropharmacology. 2023-10-21. PMID:37865136. |
oxycodone withdrawal is associated with increased cocaine self-administration and aberrant accumbens glutamate plasticity in rats. |
2023-10-21 |
2023-11-08 |
rat |
| Shailesh N Khatri, Hanaa Ulangkaya, Erin E Maher, Safiyah Sadek, Mei Hong, Andrea M Woodcox, William W Stoops, Cassandra D Gipso. Oxycodone withdrawal is associated with increased cocaine self-administration and aberrant accumbens glutamate plasticity in rats. Neuropharmacology. 2023-10-21. PMID:37865136. |
preclinically, aberrant glutamate signaling within the nucleus accumbens core (nacore) occurs following use of cocaine or opioids, whereby medium spiny neurons (msns) rest in a potentiated or depotentiated state, respectively. |
2023-10-21 |
2023-11-08 |
rat |
| Shailesh N Khatri, Hanaa Ulangkaya, Erin E Maher, Safiyah Sadek, Mei Hong, Andrea M Woodcox, William W Stoops, Cassandra D Gipso. Oxycodone withdrawal is associated with increased cocaine self-administration and aberrant accumbens glutamate plasticity in rats. Neuropharmacology. 2023-10-21. PMID:37865136. |
however, it is not clear if cocaine can exacerbate opioid-induced changes in glutamate signaling. |
2023-10-21 |
2023-11-08 |
rat |
| Shailesh N Khatri, Hanaa Ulangkaya, Erin E Maher, Safiyah Sadek, Mei Hong, Andrea M Woodcox, William W Stoops, Cassandra D Gipso. Oxycodone withdrawal is associated with increased cocaine self-administration and aberrant accumbens glutamate plasticity in rats. Neuropharmacology. 2023-10-21. PMID:37865136. |
together, behavioral signs of oxycodone withdrawal may drive cocaine use and further dysregulate nacore glutamate signaling. |
2023-10-21 |
2023-11-08 |
rat |
| Sara L Kroll, Lea M Hulka, Ann-Kathrin Kexel, Matthias Vonmoos, Katrin H Preller, Valerie Treyer, Simon M Ametamey, Markus R Baumgartner, Carola Boost, Franziska Pahlisch, Cathrin Rohleder, F Markus Leweke, Boris B Quedno. Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density. Translational psychiatry. vol 13. issue 1. 2023-10-19. PMID:37857616. |
plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density. |
2023-10-19 |
2023-11-08 |
human |
| Etna J E Engeli, Andrea G Russo, Sara Ponticorvo, Niklaus Zoelch, Andreas Hock, Lea M Hulka, Matthias Kirschner, Katrin H Preller, Erich Seifritz, Boris B Quednow, Fabrizio Esposito, Marcus Herdene. Accumbal-thalamic connectivity and associated glutamate alterations in human cocaine craving: A state-dependent rs-fMRI and NeuroImage. Clinical. vol 39. 2023-08-28. PMID:37639901. |
accumbal-thalamic connectivity and associated glutamate alterations in human cocaine craving: a state-dependent rs-fmri and craving is a core symptom of cocaine use disorder and a major factor for relapse risk. |
2023-08-28 |
2023-09-07 |
human |
| Danielle M Giangrasso, Kaliana M Veros, Maureen M Timm, Peter J West, Karen S Wilcox, Kristen A Keef. Glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior. Frontiers in molecular neuroscience. vol 16. 2023-05-30. PMID:37251646. |
together, these results suggest that glutamate clearance and release dynamics in the dls are largely unaltered by a history of cocaine self-administration on this established cocaine seeking-taking paradigm, regardless of whether the control over the cocaine seeking behavior was habitual or goal directed. |
2023-05-30 |
2023-08-14 |
rat |
| Shaun Yon-Seng Khoo, Anne-Noël Samah. Metabotropic glutamate group II receptor activation in the ventrolateral dorsal striatum suppresses incentive motivation for cocaine in rats. Psychopharmacology. 2023-04-15. PMID:37060471. |
metabotropic glutamate group ii receptor activation in the ventrolateral dorsal striatum suppresses incentive motivation for cocaine in rats. |
2023-04-15 |
2023-08-14 |
rat |
| Shaun Yon-Seng Khoo, Anne-Noël Samah. Metabotropic glutamate group II receptor activation in the ventrolateral dorsal striatum suppresses incentive motivation for cocaine in rats. Psychopharmacology. 2023-04-15. PMID:37060471. |
within the dorsal striatum, chronic cocaine use changes metabotropic glutamate type ii receptor (mglu |
2023-04-15 |
2023-08-14 |
rat |
| Javier R Mesa, Emily Carter, Yasmin Padovan-Hernandez, Lori A Knacksted. Alcohol consumption modulates prelimbic cortex response to cocaine following sequential cocaine and alcohol polysubstance use in the rat. Frontiers in pharmacology. vol 14. 2023-04-03. PMID:37007027. |
ceftriaxone, a beta-lactam antibiotic, reliably attenuates reinstatement of cocaine seeking in pre-clinical models by restoring glutamate homeostasis following cocaine self-administration but fails to do so when rats consume both cocaine and alcohol (cocaine + alcohol psu). |
2023-04-03 |
2023-08-14 |
rat |
| Claire M Corbett, Emily N D Miller, Jessica A Lowet. mGlu5 inhibition in the basolateral amygdala prevents estrous cycle-dependent changes in cue-induced cocaine seeking. Addiction neuroscience. vol 5. 2023-02-13. PMID:36778664. |
one region that contributes to both sex differences in behavioral responding and cue-induced cocaine seeking is the basolateral amygdala (bla), while one receptor known to play a critical role in mediating cocaine seeking behavior is metabotropic glutamate receptor 5 (mglu5). |
2023-02-13 |
2023-08-14 |
Not clear |
| Thi Dong Binh Tran, Hoan Nguyen, Erica Sodergren, Center For Systems Neurogenetics Of Addiction, Price E Dickson, Susan N Wright, Vivek M Philip, George M Weinstock, Elissa J Chesler, Yanjiao Zhou, Jason A Bubie. Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice. Neuropharmacology. 2023-01-02. PMID:36592885. |
microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice. |
2023-01-02 |
2023-08-14 |
mouse |
| Thi Dong Binh Tran, Hoan Nguyen, Erica Sodergren, Center For Systems Neurogenetics Of Addiction, Price E Dickson, Susan N Wright, Vivek M Philip, George M Weinstock, Elissa J Chesler, Yanjiao Zhou, Jason A Bubie. Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice. Neuropharmacology. 2023-01-02. PMID:36592885. |
functional analysis of the microbiome composition of a subset of mice suggested that gut-brain modules encoding glutamate metabolism genes are associated with the propensity to self-administer cocaine. |
2023-01-02 |
2023-08-14 |
mouse |
| Thi Dong Binh Tran, Hoan Nguyen, Erica Sodergren, Center For Systems Neurogenetics Of Addiction, Price E Dickson, Susan N Wright, Vivek M Philip, George M Weinstock, Elissa J Chesler, Yanjiao Zhou, Jason A Bubie. Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice. Neuropharmacology. 2023-01-02. PMID:36592885. |
these findings establish associations between the microbiome composition and glutamate metabolic potential and the ability to acquire cocaine ivsa thus indicating the potential translational impact of targeting the gut microbiome or microbial metabolites for treatment of sud. |
2023-01-02 |
2023-08-14 |
mouse |
| He Chen, Limei Chen, Zhirong Yuan, Jiajie Yuan, Yitong Li, Yuesi Xu, Jieyi Wu, Lu Zhang, Guohua Wang, Juan L. Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity. Frontiers in cellular neuroscience. vol 16. 2022-11-21. PMID:36406750. |
glutamate receptor-interacting protein 1 in d1- and d2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity. |
2022-11-21 |
2023-08-14 |
Not clear |
| He Chen, Limei Chen, Zhirong Yuan, Jiajie Yuan, Yitong Li, Yuesi Xu, Jieyi Wu, Lu Zhang, Guohua Wang, Juan L. Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity. Frontiers in cellular neuroscience. vol 16. 2022-11-21. PMID:36406750. |
glutamate receptor-interacting protein 1 (grip1) is known to be associated with cocaine addiction, but the role of grip1 in d1-msns and d2-msns of the nac in cocaine acquisition and reinstatement remains unknown. |
2022-11-21 |
2023-08-14 |
Not clear |
| Donald H Penning, Brian Jones, Mohamed Fayed, Xiaoxia Han, Chaya Brodi. Effect of Cocaine on Potassium-Evoked Release of Glutamate From Fetal Rat Brain Synaptosomes. Cureus. vol 14. issue 10. 2022-11-16. PMID:36381732. |
effect of cocaine on potassium-evoked release of glutamate from fetal rat brain synaptosomes. |
2022-11-16 |
2023-08-14 |
rat |
| Donald H Penning, Brian Jones, Mohamed Fayed, Xiaoxia Han, Chaya Brodi. Effect of Cocaine on Potassium-Evoked Release of Glutamate From Fetal Rat Brain Synaptosomes. Cureus. vol 14. issue 10. 2022-11-16. PMID:36381732. |
in an immature rat brain synaptosome model, we explored the additive effect of cocaine alone on glutamate release and the effect of cocaine combined with simulated hypoxic depolarization using potassium as a surrogate. |
2022-11-16 |
2023-08-14 |
rat |