| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donald H Penning, Brian Jones, Mohamed Fayed, Xiaoxia Han, Chaya Brodi. Effect of Cocaine on Potassium-Evoked Release of Glutamate From Fetal Rat Brain Synaptosomes. Cureus. vol 14. issue 10. 2022-11-16. PMID:36381732. |
in an immature rat brain synaptosome model, we explored the additive effect of cocaine alone on glutamate release and the effect of cocaine combined with simulated hypoxic depolarization using potassium as a surrogate. |
2022-11-16 |
2023-08-14 |
rat |
| María P Avalos, Andrea S Guzman, Constanza Garcia-Keller, Bethania Mongi-Bragato, María A Esparza, Daiana Rigoni, Marianela A Sanchez, Gastón D Calfa, Flavia A Bollati, Liliana M Cancel. Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091376. |
impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress. |
2022-09-12 |
2023-08-14 |
rat |
| María P Avalos, Andrea S Guzman, Constanza Garcia-Keller, Bethania Mongi-Bragato, María A Esparza, Daiana Rigoni, Marianela A Sanchez, Gastón D Calfa, Flavia A Bollati, Liliana M Cancel. Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091376. |
its hallmarks were increased basal extracellular glutamate concentrations driven by a crs-induced downregulation of glt-1, blunted glutamate levels in response to cocaine and postsynaptic structural remodeling in pre-stressed animals. |
2022-09-12 |
2023-08-14 |
rat |
| María P Avalos, Andrea S Guzman, Constanza Garcia-Keller, Bethania Mongi-Bragato, María A Esparza, Daiana Rigoni, Marianela A Sanchez, Gastón D Calfa, Flavia A Bollati, Liliana M Cancel. Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091376. |
in addition, ceftriaxone, a known glt-1 enhancer, prevented the crs-induced glt-1 downregulation, increased basal extracellular glutamate concentrations and changes in structural plasticity in the nacore as well as behavioral cross-sensitization to cocaine, emphasizing the biological importance of glt-1 in the comorbidity between chronic stress exposure and drug abuse. |
2022-09-12 |
2023-08-14 |
rat |
| I Pamela Alonso, Bethan M O'Connor, Kathleen G Bryant, Rushi K Mandalaywala, Rodrigo A Españ. Incubation of cocaine craving coincides with changes in dopamine terminal neurotransmission. Addiction neuroscience. vol 3. 2022-09-09. PMID:36081573. |
although the neurobiology underlying incubation of cocaine craving has been examined - particularly within the context of glutamate plasticity- the extent to which increased cocaine craving engenders mesolimbic dopamine (da) changes has received relatively little attention. |
2022-09-09 |
2023-08-14 |
rat |
| Yi He, Graziella Madeo, Ying Liang, Cindy Zhang, Briana Hempel, Xiaojie Liu, Lianwei Mu, Shui Liu, Guo-Hua Bi, Ewa Galaj, Hai-Ying Zhang, Hui Shen, Ross A McDevitt, Eliot L Gardner, Qing-Song Liu, Zheng-Xiong X. A red nucleus-VTA glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use. Science advances. vol 8. issue 35. 2022-09-02. PMID:36054363. |
a red nucleus-vta glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use. |
2022-09-02 |
2023-08-14 |
Not clear |
| Yi He, Graziella Madeo, Ying Liang, Cindy Zhang, Briana Hempel, Xiaojie Liu, Lianwei Mu, Shui Liu, Guo-Hua Bi, Ewa Galaj, Hai-Ying Zhang, Hui Shen, Ross A McDevitt, Eliot L Gardner, Qing-Song Liu, Zheng-Xiong X. A red nucleus-VTA glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use. Science advances. vol 8. issue 35. 2022-09-02. PMID:36054363. |
last, optogenetic stimulation of the rnm-to-vta glutamate pathway inhibited responding to cocaine. |
2022-09-02 |
2023-08-14 |
Not clear |
| Amit Puranik, Nicole Buie, Dena Arizanovska, Paul Vezina, Stephan Steid. Glutamate inputs from the laterodorsal tegmental nucleus to the ventral tegmental area are essential for the induction of cocaine sensitization in male mice. Psychopharmacology. 2022-08-25. PMID:36006414. |
glutamate inputs from the laterodorsal tegmental nucleus to the ventral tegmental area are essential for the induction of cocaine sensitization in male mice. |
2022-08-25 |
2023-08-14 |
mouse |
| Troy D Fort, Mary E Cai. The Role of Astroglial xCT in Mitigating Cue-Induced Amphetamine-Seeking. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555299. |
such a finding would suggest that amp disrupts glutamate via a different mechanism than cocaine. |
2022-05-13 |
2023-08-13 |
rat |
| Rusty W Nall, Lauren N Beloate, Michael E Meyerink, Tiffany Penaloza, Jade Doolittle, Brett Froeliger, Peter W Kalivas, Constanza Garcia-Kelle. Assessing combined effects of varenicline and N-acetylcysteine on reducing nicotine seeking in rats. Addiction biology. vol 27. issue 2. 2022-03-01. PMID:35229943. |
n-acetylcysteine (nac) normalizes glutamate transmission and prolongs cocaine abstinence. |
2022-03-01 |
2023-08-13 |
rat |
| Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M M Verheij, Fabio Fumagalli, Judith R Homber. Responsivity of serotonin transporter knockout rats to short and long access to cocaine: modulation of the glutamate signaling in the nucleus accumbens shell. British journal of pharmacology. 2022-02-17. PMID:35174489. |
responsivity of serotonin transporter knockout rats to short and long access to cocaine: modulation of the glutamate signaling in the nucleus accumbens shell. |
2022-02-17 |
2023-08-13 |
rat |
| Matthew J Horchar, Joy L Kappesser, Maria R Broderick, Makayla R Wright, Justin R Yate. Effects of NMDA receptor antagonists on behavioral economic indices of cocaine self-administration. Drug and alcohol dependence. vol 233. 2022-02-17. PMID:35176632. |
because the glun2b subunit of the glutamate n-methyl-d-aspartate (nmda) receptor is an important mediator of addiction-like behaviors, the goal of the current study was to determine if the glun2b-selective antagonist ro 63-1908 is efficacious in attenuating cocaine self-administration. |
2022-02-17 |
2023-08-13 |
Not clear |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a nmda-glun2b receptor mechanism. |
2022-01-29 |
2023-08-13 |
rat |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
in this study, we systemically evaluated the effects of multiple glutamate transporter (glt) inhibitors on extracellular glutamate and dopamine (da) in the nucleus accumbens (nac), intravenous cocaine self-administration, intracranial brain-stimulation reward, and reinstatement of cocaine seeking in male and female rats. |
2022-01-29 |
2023-08-13 |
rat |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
these findings, for the first time, indicate that glutamate in the nac negatively regulates cocaine's rewarding effects, while an excess of glutamate in multiple brain regions can trigger reinstatement of drug-seeking behavior. |
2022-01-29 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
the hallmarks of disrupted glutamate homeostasis following restraint stress are the enduring imbalance of glutamate efflux after a cocaine stimulus and increased basal concentrations of extracellular glutamate attributed to glt-1 downregulation in the nacore. |
2022-01-22 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
by using minocycline, a potent inhibitor of microglia activation with anti-inflammatory properties, we determined whether microglia could aid chronic restraint stress (crs)-induced glutamate homeostasis disruption in the nacore, underpinning stress-induced cocaine self-administration. |
2022-01-22 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
we confirm that the crs-induced facilitation of cocaine self-administration is associated with enduring glt-1 downregulation, an increase of basal extracellular glutamate and postsynaptic structural plasticity in the nacore. |
2022-01-22 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
these alterations were strongly related to the crs-induced reactive microglia and increased tnf-α mrna and protein expression, since by administering minocycline, the impaired glutamate homeostasis and the facilitation of cocaine self-administration were prevented. |
2022-01-22 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
our findings are the first to demonstrate that minocycline suppresses the crs-induced facilitation of cocaine self-administration and glutamate homeostasis disruption in the nacore. |
2022-01-22 |
2023-08-13 |
rat |