| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irena Smaga, Kinga Gawlińska, Małgorzata Frankowska, Karolina Wydra, Anna Sadakierska-Chudy, Agata Suder, Marcin Piechota, Małgorzata Fili. Extinction Training after Cocaine Self-Administration Influences the Epigenetic and Genetic Machinery Responsible for Glutamatergic Transporter Gene Expression in Male Rat Brain. Neuroscience. vol 451. 2021-05-14. PMID:33065231. |
the balance of glutamatergic transporter proteins allows long-term maintenance of glutamate homeostasis in the brain, which is impaired during cocaine use disorder. |
2021-05-14 |
2023-08-13 |
rat |
| Joseph Clerke, Patricia Preston-Ferrer, Ioannis S Zouridis, Audrey Tissot, Laura Batti, Fabian F Voigt, Stephane Pagès, Andrea Burgalossi, Manuel Mamel. Output-Specific Adaptation of Habenula-Midbrain Excitatory Synapses During Cocaine Withdrawal. Frontiers in synaptic neuroscience. vol 13. 2021-04-21. PMID:33867967. |
while cocaine withdrawal increases glutamate release from lhb onto vta-mpfc projectors, it reduces presynaptic release onto vta-nac projectors, leaving lhb synapses onto vta-to-lh unaffected. |
2021-04-21 |
2023-08-13 |
mouse |
| Anne S Gibson, Kristen A Keefe, Teri M Furlon. Accelerated habitual learning resulting from L-dopa exposure in rats is prevented by N-acetylcysteine. Pharmacology, biochemistry, and behavior. vol 198. 2021-04-13. PMID:32888972. |
we also showed that when n-acetylcysteine (nac), an antioxidant and regulator of glutamate activity, was co-administered with l-dopa, it prevented the transition to habitual behavior; an effect demonstrated previously for cocaine. |
2021-04-13 |
2023-08-13 |
rat |
| Adriana Castro-Zavala, Ana Martín-Sánchez, Miguel Ángel Luján, Olga Valverd. Maternal separation increases cocaine intake through a mechanism involving plasticity in glutamate signalling. Addiction biology. vol 26. issue 2. 2021-03-25. PMID:32329565. |
maternal separation increases cocaine intake through a mechanism involving plasticity in glutamate signalling. |
2021-03-25 |
2023-08-13 |
mouse |
| Allison R Bechard, Carly N Logan, Javier Mesa, Yasmin Padovan-Hernandez, Harrison Blount, Virginia L Hodges, Lori A Knacksted. Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cue-induced cocaine seeking. Addiction biology. vol 26. issue 2. 2021-03-25. PMID:32558119. |
ceftriaxone is an antibiotic that reliably attenuates the reinstatement of cocaine seeking after extinction while preventing the nucleus accumbens (na) core glutamate efflux that drives reinstatement. |
2021-03-25 |
2023-08-13 |
rat |
| Allison R Bechard, Carly N Logan, Javier Mesa, Yasmin Padovan-Hernandez, Harrison Blount, Virginia L Hodges, Lori A Knacksted. Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cue-induced cocaine seeking. Addiction biology. vol 26. issue 2. 2021-03-25. PMID:32558119. |
however, when rats undergo abstinence without extinction, ceftriaxone attenuates context-primed cocaine seeking but na core glutamate efflux still increases. |
2021-03-25 |
2023-08-13 |
rat |
| Allison R Bechard, Carly N Logan, Javier Mesa, Yasmin Padovan-Hernandez, Harrison Blount, Virginia L Hodges, Lori A Knacksted. Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cue-induced cocaine seeking. Addiction biology. vol 26. issue 2. 2021-03-25. PMID:32558119. |
ceftriaxone increased baseline glutamate and attenuated both cue-induced cocaine seeking and na core glutamate efflux during this test. |
2021-03-25 |
2023-08-13 |
rat |
| Allison R Bechard, Carly N Logan, Javier Mesa, Yasmin Padovan-Hernandez, Harrison Blount, Virginia L Hodges, Lori A Knacksted. Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cue-induced cocaine seeking. Addiction biology. vol 26. issue 2. 2021-03-25. PMID:32558119. |
thus, when cocaine seeking is induced by drug-associated cues, ceftriaxone is able to attenuate relapse by preventing na core glutamate efflux, likely through reducing activity in prelimbic na core-projecting neurons. |
2021-03-25 |
2023-08-13 |
rat |
| Jasper A Heinsbroek, Ana-Clara Bobadilla, Eric Dereschewitz, Ahlem Assali, Reda M Chalhoub, Christopher W Cowan, Peter W Kaliva. Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum. Cell reports. vol 30. issue 6. 2021-03-08. PMID:32049028. |
opposing regulation of cocaine seeking by glutamate and gaba neurons in the ventral pallidum. |
2021-03-08 |
2023-08-13 |
Not clear |
| Alaa M Hammad, Youssef Sar. Effects of Cocaine Exposure on Astrocytic Glutamate Transporters and Relapse-Like Ethanol-Drinking Behavior in Male Alcohol-Preferring Rats. Alcohol and alcoholism (Oxford, Oxfordshire). vol 55. issue 3. 2021-01-15. PMID:32099993. |
effects of cocaine exposure on astrocytic glutamate transporters and relapse-like ethanol-drinking behavior in male alcohol-preferring rats. |
2021-01-15 |
2023-08-13 |
rat |
| Alaa M Hammad, Youssef Sar. Effects of Cocaine Exposure on Astrocytic Glutamate Transporters and Relapse-Like Ethanol-Drinking Behavior in Male Alcohol-Preferring Rats. Alcohol and alcoholism (Oxford, Oxfordshire). vol 55. issue 3. 2021-01-15. PMID:32099993. |
glutamate has been considered as neurotransmitter that is critical in triggering relapse to drugs of abuse, including ethanol and cocaine. |
2021-01-15 |
2023-08-13 |
rat |
| Alaa M Hammad, Youssef Sar. Effects of Cocaine Exposure on Astrocytic Glutamate Transporters and Relapse-Like Ethanol-Drinking Behavior in Male Alcohol-Preferring Rats. Alcohol and alcoholism (Oxford, Oxfordshire). vol 55. issue 3. 2021-01-15. PMID:32099993. |
in this study, we investigated the effects of cocaine exposure and ampicillin/sulbactam (amp/sul), a β-lactam antibiotic known to upregulate glt-1 and xct, on relapse-like ethanol intake and the expression of astrocytic glutamate transporters in mesocorticolimbic brain regions. |
2021-01-15 |
2023-08-13 |
rat |
| Bethany A Stennett, Yasmin Padovan-Hernandez, Lori A Knacksted. Sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 3. 2020-12-28. PMID:31266052. |
sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone. |
2020-12-28 |
2023-08-13 |
rat |
| Bethany A Stennett, Yasmin Padovan-Hernandez, Lori A Knacksted. Sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 3. 2020-12-28. PMID:31266052. |
however, we noted significant changes in glutamate homeostasis in the na core of cocaine + alcohol rats relative to rats consuming cocaine alone, such as increased surface glt-1 expression and a lack of increase in glutamate efflux during reinstatement of cocaine-seeking. |
2020-12-28 |
2023-08-13 |
rat |
| Bethany A Stennett, Yasmin Padovan-Hernandez, Lori A Knacksted. Sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 3. 2020-12-28. PMID:31266052. |
as such glutamate neuroadaptations are targeted by medications to reduce cocaine relapse, preclinical models should consider polysubstance use. |
2020-12-28 |
2023-08-13 |
rat |
| Jonna M Leyrer-Jackson, M Foster Oliv. A line before liquor: a novel model of cocaine and alcohol co-abuse reveals changes in glutamate homeostasis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 3. 2020-12-28. PMID:31383937. |
a line before liquor: a novel model of cocaine and alcohol co-abuse reveals changes in glutamate homeostasis. |
2020-12-28 |
2023-08-13 |
Not clear |
| Maria Carolina Velasquez-Martinez, Bermary Santos-Vera, Maria E Velez-Hernandez, Rafael Vazquez-Torres, Carlos A Jimenez-River. Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization. International journal of molecular sciences. vol 21. issue 3. 2020-11-05. PMID:31991781. |
alpha-1 adrenergic receptors modulate glutamate and gaba neurotransmission onto ventral tegmental dopamine neurons during cocaine sensitization. |
2020-11-05 |
2023-08-13 |
Not clear |
| Maria Carolina Velasquez-Martinez, Bermary Santos-Vera, Maria E Velez-Hernandez, Rafael Vazquez-Torres, Carlos A Jimenez-River. Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization. International journal of molecular sciences. vol 21. issue 3. 2020-11-05. PMID:31991781. |
taken together, these data suggest that α1-ars may enhance da neuronal excitability after repeated cocaine administration through the reduction of gaba inhibition onto vta dopamine (da) neurons even in the absence of α1-ars' function on glutamate release and protein kinase c (pkc) activation. |
2020-11-05 |
2023-08-13 |
Not clear |
| Benjamin M Siemsen, John A McFaddin, Keiana Haigh, Ashley G Brock, Mary Nan Leath, Kaylee N Hooker, Lilly K McGonegal, Michael D Scofiel. Amperometric measurements of cocaine cue and novel context-evoked glutamate and nitric oxide release in the nucleus accumbens core. Journal of neurochemistry. vol 153. issue 5. 2020-11-04. PMID:31901130. |
amperometric measurements of cocaine cue and novel context-evoked glutamate and nitric oxide release in the nucleus accumbens core. |
2020-11-04 |
2023-08-13 |
rat |
| Benjamin M Siemsen, John A McFaddin, Keiana Haigh, Ashley G Brock, Mary Nan Leath, Kaylee N Hooker, Lilly K McGonegal, Michael D Scofiel. Amperometric measurements of cocaine cue and novel context-evoked glutamate and nitric oxide release in the nucleus accumbens core. Journal of neurochemistry. vol 153. issue 5. 2020-11-04. PMID:31901130. |
cue-induced reinstatement of cocaine seeking after self-administration (sa) and extinction relies on glutamate release in the nucleus accumbens core (nacore), which activates neuronal nitric oxide synthase interneurons. |
2020-11-04 |
2023-08-13 |
rat |