| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helene L Philogene-Khalid, Mary F Morrison, Nune Darbinian, Michael E Selzer, Joseph Schroeder, Scott M Rawl. The GLT-1 enhancer clavulanic acid suppresses cocaine place preference behavior and reduces GCPII activity and protein levels in the rat nucleus accumbens. Drug and alcohol dependence. vol 232. 2022-01-20. PMID:35051699. |
the β-lactam antibiotic ceftriaxone (ctx) is a glutamate transporter subtype 1 (glt-1) enhancer that reduces cocaine reinforcing efficacy and relapse in rats, but pharmacokinetic liabilities limit translational utility. |
2022-01-20 |
2023-08-13 |
rat |
| Helene L Philogene-Khalid, Mary F Morrison, Nune Darbinian, Michael E Selzer, Joseph Schroeder, Scott M Rawl. The GLT-1 enhancer clavulanic acid suppresses cocaine place preference behavior and reduces GCPII activity and protein levels in the rat nucleus accumbens. Drug and alcohol dependence. vol 232. 2022-01-20. PMID:35051699. |
here, we investigated effects of clav (10 mg/kg, ip) on the acquisition, expression, and maintenance of cocaine cpp in rats, and on two glutamate biomarkers associated with cocaine dependence, glt-1 and glutamate carboxypeptidase ii (gcpii). |
2022-01-20 |
2023-08-13 |
rat |
| Shunsuke Takagi, Darrick T Balu, Joseph T Coyl. Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum. Brain research. vol 1751. 2021-11-30. PMID:33171153. |
we found that the nmdar antagonist, mk801, and cocaine, psychotropic drugs that both augment glutamate release, reduce the expression of sr and daao. |
2021-11-30 |
2023-08-13 |
mouse |
| Lindsey N Friend, Bridget Wu, Jeffrey G Edward. Acute cocaine exposure occludes long-term depression in ventral tegmental area GABA neurons. Neurochemistry international. vol 145. 2021-11-18. PMID:33617930. |
our current aim was to determine cocaine's influence on vta gaba cell glutamate plasticity and circuity. |
2021-11-18 |
2023-08-13 |
mouse |
| Lindsey N Friend, Bridget Wu, Jeffrey G Edward. Acute cocaine exposure occludes long-term depression in ventral tegmental area GABA neurons. Neurochemistry international. vol 145. 2021-11-18. PMID:33617930. |
furthermore, chronic cocaine decreased ampa/nmda ratios at glutamate synapses onto vta gaba cells, compared to vehicle injection controls, the opposite change noted in dopamine cells. |
2021-11-18 |
2023-08-13 |
mouse |
| Etna J E Engeli, Niklaus Zoelch, Andreas Hock, Carlos Nordt, Lea M Hulka, Matthias Kirschner, Milan Scheidegger, Fabrizio Esposito, Markus R Baumgartner, Anke Henning, Erich Seifritz, Boris B Quednow, Marcus Herdene. Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32601455. |
impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. |
2021-11-15 |
2023-08-13 |
human |
| Etna J E Engeli, Niklaus Zoelch, Andreas Hock, Carlos Nordt, Lea M Hulka, Matthias Kirschner, Milan Scheidegger, Fabrizio Esposito, Markus R Baumgartner, Anke Henning, Erich Seifritz, Boris B Quednow, Marcus Herdene. Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32601455. |
after chronic administration of cocaine, rodents show decreased levels of accumbal glutamate, whereas drug-seeking reinstatement is associated with enhanced glutamatergic transmission. |
2021-11-15 |
2023-08-13 |
human |
| Etna J E Engeli, Niklaus Zoelch, Andreas Hock, Carlos Nordt, Lea M Hulka, Matthias Kirschner, Milan Scheidegger, Fabrizio Esposito, Markus R Baumgartner, Anke Henning, Erich Seifritz, Boris B Quednow, Marcus Herdene. Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32601455. |
however, due to technical obstacles, the role of disturbed glutamate homeostasis for cocaine addiction in humans remains only partially understood, and accordingly, no approved pharmacotherapy exists. |
2021-11-15 |
2023-08-13 |
human |
| Etna J E Engeli, Niklaus Zoelch, Andreas Hock, Carlos Nordt, Lea M Hulka, Matthias Kirschner, Milan Scheidegger, Fabrizio Esposito, Markus R Baumgartner, Anke Henning, Erich Seifritz, Boris B Quednow, Marcus Herdene. Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32601455. |
taken together, our findings reveal a disturbed accumbal glutamate homeostasis as a key neurometabolic feature of cocaine addiction also in humans. |
2021-11-15 |
2023-08-13 |
human |
| Bernadette O'Donovan, Austin Neugornet, Richik Neogi, Mengfan Xia, Pavel Ortinsk. Cocaine experience induces functional adaptations in astrocytes: Implications for synaptic plasticity in the nucleus accumbens shell. Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33864336. |
here, we provide evidence that cocaine impacts astrocytes at the functional level and alters neuronal sensitivity to astrocyte-derived glutamate. |
2021-11-10 |
2023-08-13 |
Not clear |
| C N Logan, G Rojas, C S Wilkinson, A K Polo Escorcia, C M Reichel, J Peris, L A Knacksted. Systemic oxytocin increases glutamate efflux in the nucleus accumbens core of cocaine-experienced male and female rats but only increases dopamine efflux in males. Behavioural brain research. vol 417. 2021-11-08. PMID:34551348. |
this effect is blocked by intra-accumbens antagonism of mglu2/3 and, together with our finding that intra-accumbens oxytocin increases glutamate concentrations in this brain region, indicates that pre-synaptic regulation of glutamate release by oxytocin influences cocaine relapse. |
2021-11-08 |
2023-08-13 |
rat |
| C N Logan, G Rojas, C S Wilkinson, A K Polo Escorcia, C M Reichel, J Peris, L A Knacksted. Systemic oxytocin increases glutamate efflux in the nucleus accumbens core of cocaine-experienced male and female rats but only increases dopamine efflux in males. Behavioural brain research. vol 417. 2021-11-08. PMID:34551348. |
these data are the first to find that systemic oxytocin increases nucleus accumbens glutamate after cocaine experience, providing a mechanism of action by which oxytocin attenuates the reinstatement of cocaine seeking in both male and female rats. |
2021-11-08 |
2023-08-13 |
rat |
| Conor H Murray, Daniel T Christian, Mike Milovanovic, Jessica A Loweth, Eun-Kyung Hwang, Aaron J Caccamise, Jonathan R Funke, Marina E Wol. mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving. Neuropharmacology. vol 186. 2021-11-05. PMID:33444640. |
many studies have demonstrated that negative allosteric modulators (nam) of metabotropic glutamate receptor 5 (mglu5) reduce cocaine and methamphetamine seeking in extinction-reinstatement animal models of addiction. |
2021-11-05 |
2023-08-13 |
rat |
| Andrea S Guzman, Maria P Avalos, Laura N De Giovanni, Pia V Euliarte, Marianela A Sanchez, Bethania Mongi-Bragato, Daiana Rigoni, Flavia A Bollati, Miriam B Virgolini, Liliana M Cancel. CB1R activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired context. Scientific reports. vol 11. issue 1. 2021-11-02. PMID:34155271. |
cb1r activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired context. |
2021-11-02 |
2023-08-13 |
rat |
| Luana Freese, Marilise Fraga de Souza, Maurício Schüler Nin, Greice Calleti, Valéria Flores Peres, Rosane Gomez, Helena Maria Tannhauser Barro. Elevated GABA levels in the medial prefrontal cortex and lower estrogen levels abolish cocaine sensitization behavior in ovariectomized female rats. Brain research. vol 1749. 2021-10-27. PMID:33038296. |
here we investigated the in vivo changes on gaba, glutamate, and taurine levels in the medial prefrontal cortex (mpfc) of gonadal intact or ovariectomized female rats after a cocaine challenge administration. |
2021-10-27 |
2023-08-13 |
rat |
| Luana Freese, Marilise Fraga de Souza, Maurício Schüler Nin, Greice Calleti, Valéria Flores Peres, Rosane Gomez, Helena Maria Tannhauser Barro. Elevated GABA levels in the medial prefrontal cortex and lower estrogen levels abolish cocaine sensitization behavior in ovariectomized female rats. Brain research. vol 1749. 2021-10-27. PMID:33038296. |
non-sensitized ovx-rpt rats showed a peak of gaba at 30 min after cocaine administration, with no change on glutamate and taurine levels. |
2021-10-27 |
2023-08-13 |
rat |
| Eun Sang Choe, Sung Min Ahn, Ju Hwan Yang, Bok Soon Go, John Q Wan. Linking cocaine to endoplasmic reticulum in striatal neurons: role of glutamate receptors. Basal ganglia. vol 1. issue 2. 2021-10-20. PMID:21808746. |
linking cocaine to endoplasmic reticulum in striatal neurons: role of glutamate receptors. |
2021-10-20 |
2023-08-12 |
human |
| Brooke N Bender, Mary M Torregross. Dorsolateral striatum dopamine-dependent cocaine seeking is resistant to pavlovian cue extinction in male and female rats. Neuropharmacology. vol 182. 2021-09-24. PMID:33197468. |
so-trained rats also showed increased indices of glutamate signaling in the dls relative to fr-trained rats, despite comparable levels of cocaine intake. |
2021-09-24 |
2023-08-13 |
rat |
| Lori A Knackstedt, Lizhen Wu, Jeffrey Rothstein, Svetlana Vidensky, John Gordon, Mercy Ramanjulu, Paul Dunman, Benjamin Blass, Wayne Childers, Magid Abou-Gharbi. MC-100093, a Novel The Journal of pharmacology and experimental therapeutics. vol 378. issue 2. 2021-09-23. PMID:33986035. |
in rodents, the glutamate transporter-1 (glt-1) is downregulated in the nucleus accumbens after cocaine self-administration, and increasing the expression and function of glt-1 reduces the reinstatement of cocaine seeking. |
2021-09-23 |
2023-08-13 |
Not clear |
| Mieke H J Schulte, Anna E Goudriaan, Wouter J Boendermaker, Wim van den Brink, Reinout W Wier. The effect of N-acetylcysteine and working memory training on glutamate concentrations in the dACC and rACC in regular cocaine users - A randomized proof of concept study. Neuroscience letters. vol 762. 2021-09-14. PMID:34332028. |
the effect of n-acetylcysteine and working memory training on glutamate concentrations in the dacc and racc in regular cocaine users - a randomized proof of concept study. |
2021-09-14 |
2023-08-13 |
Not clear |