| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin M Siemsen, John A McFaddin, Keiana Haigh, Ashley G Brock, Mary Nan Leath, Kaylee N Hooker, Lilly K McGonegal, Michael D Scofiel. Amperometric measurements of cocaine cue and novel context-evoked glutamate and nitric oxide release in the nucleus accumbens core. Journal of neurochemistry. vol 153. issue 5. 2020-11-04. PMID:31901130. |
these results demonstrate a dissociation between the magnitude of cocaine cue- and novel context-evoked glutamate and no release in the nacore, yet similarity in the temporal dynamics of their release. |
2020-11-04 |
2023-08-13 |
rat |
| Bethany A Stennett, Lori A Knacksted. A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens. Frontiers in neuroscience. vol 14. 2020-10-03. PMID:32982672. |
a rat model of cocaine-alcohol polysubstance use reveals altered cocaine seeking and glutamate levels in the nucleus accumbens. |
2020-10-03 |
2023-08-13 |
rat |
| Bethany A Stennett, Lori A Knacksted. A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens. Frontiers in neuroscience. vol 14. 2020-10-03. PMID:32982672. |
we previously reported that when rats consume alcohol after daily intravenous cocaine self-administration, nucleus accumbens (na) core basal glutamate levels are reduced below those of rats that consumed only cocaine, and do not increase during cue + cocaine-primed reinstatement of cocaine-seeking. |
2020-10-03 |
2023-08-13 |
rat |
| Bethany A Stennett, Lori A Knacksted. A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens. Frontiers in neuroscience. vol 14. 2020-10-03. PMID:32982672. |
here we used the same model of sequential cocaine and alcohol self-administration to test the hypothesis that a similar pattern of glutamate changes would be observed in the na core prior to and during a cocaine-primed reinstatement test. |
2020-10-03 |
2023-08-13 |
rat |
| Bethany A Stennett, Lori A Knacksted. A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens. Frontiers in neuroscience. vol 14. 2020-10-03. PMID:32982672. |
we found that as in our previous work, cocaine + alcohol-consuming rats displayed basal glutamate levels below those of rats that self-administered only cocaine. |
2020-10-03 |
2023-08-13 |
rat |
| Bethany A Stennett, Lori A Knacksted. A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens. Frontiers in neuroscience. vol 14. 2020-10-03. PMID:32982672. |
during the cocaine-primed reinstatement test, rats that consumed only cocaine displayed increased glutamate efflux in the na core while those that consumed cocaine + alcohol did not. |
2020-10-03 |
2023-08-13 |
rat |
| Rachel Jarvis, Alessandra Tamashiro-Orrego, Vanessa Promes, Leona Tu, Jinyuan Shi, Yongjie Yan. Cocaine Self-administration and Extinction Inversely Alter Neuron to Glia Exosomal Dynamics in the Nucleus Accumbens. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31998080. |
astroglial mechanisms for maintaining extracellular glutamate homeostasis through cysteine/glutamate exchanger (xct) and glutamate transporter glt1 are dysregulated following cocaine exposure and contribute to altered glutamatergic synaptic plasticity. |
2020-09-29 |
2023-08-13 |
Not clear |
| Ilse Delint-Ramirez, Amir Segev, Asha Pavuluri, David W Self, Saïd Kourric. Cocaine-Induced Synaptic Redistribution of NMDARs in Striatal Neurons Alters NMDAR-Dependent Signal Transduction. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32760242. |
the consequence of repeated cocaine exposure and prolonged abstinence on glutamate receptor expression in the nucleus accumbens has been extensively studied. |
2020-09-28 |
2023-08-13 |
Not clear |
| Erik J Garcia, David L Arndt, Mary E Cai. Dynamic interactions of ceftriaxone and environmental variables suppress amphetamine seeking. Brain research. vol 1712. 2020-09-11. PMID:30716289. |
cocaine, ethanol, and methamphetamine reduce the expression of cystine-glutamate antiporter (xct) and primary glial glutamate transporter 1 (glt1) leading to increased extrasynaptic glutamate. |
2020-09-11 |
2023-08-13 |
rat |
| Ewa Niedzielska-Andres, Józef Mizera, Anna Sadakierska-Chudy, Lucyna Pomierny-Chamioło, Małgorzata Fili. Changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone. Behavioural brain research. vol 370. 2020-07-30. PMID:31100299. |
changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone. |
2020-07-30 |
2023-08-13 |
human |
| Paul W Czoty, Bruce E Blough, Antonio Landavazo, Michael A Nade. Effects of the mGluR2/3 receptor agonist LY379268 on the reinforcing strength of cocaine in rhesus monkeys. Psychopharmacology. vol 237. issue 2. 2020-07-28. PMID:31705165. |
because chronic cocaine exposure produces profound effects on brain glutamate function, this system has been investigated as a target for novel medications for cocaine use disorder. |
2020-07-28 |
2023-08-13 |
monkey |
| Megan M Wickens, Andre U Deutschmann, Anna G McGrath, Vinay Parikh, Lisa A Brian. Glutamate receptor interacting protein acts within the prefrontal cortex to blunt cocaine seeking. Neuropharmacology. vol 157. 2020-07-21. PMID:31233823. |
glutamate receptor interacting protein acts within the prefrontal cortex to blunt cocaine seeking. |
2020-07-21 |
2023-08-13 |
mouse |
| Megan M Wickens, Andre U Deutschmann, Anna G McGrath, Vinay Parikh, Lisa A Brian. Glutamate receptor interacting protein acts within the prefrontal cortex to blunt cocaine seeking. Neuropharmacology. vol 157. 2020-07-21. PMID:31233823. |
given that cocaine administration alters glutamate receptor trafficking within the prefrontal cortex (pfc), a better understanding of the role of receptor trafficking proteins could lead to a more complete understanding of addictive phenotypes. |
2020-07-21 |
2023-08-13 |
mouse |
| Ritchy Hodebourg, Jennifer E Murray, Maxime Fouyssac, Mickaël Puaud, Barry J Everitt, David Beli. Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:29514413. |
while cocaine reinforcement depends on the mesolimbic system, well-established cocaine seeking is dependent on dorsolateral striatum (adls) dopamine-dependent mechanisms which are disrupted by n-acetylcysteine, through normalisation of corticostriatal glutamate homeostasis. |
2020-06-30 |
2023-08-13 |
rat |
| Ritchy Hodebourg, Jennifer E Murray, Maxime Fouyssac, Mickaël Puaud, Barry J Everitt, David Beli. Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:29514413. |
comparison with previous data on cocaine suggests that the development of drug seeking habits and the alteration of corticostriatal glutamate homeostasis, which is restored by n-acetylcysteine, are quantitatively similar between heroin and cocaine. |
2020-06-30 |
2023-08-13 |
rat |
| Pengbo Shi, Jiaxun Nie, Hou Liu, Yuehan Li, Xue Lu, Xu Shen, Feifei Ge, Ti-Fei Yuan, Xiaowei Gua. Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 7. 2020-05-20. PMID:31034782. |
the molecules in the gabaergic system in adult prl were also changed by adolescent cocaine use, as indicated by increased glutamate decarboxylase 67 kda, gaba |
2020-05-20 |
2023-08-13 |
mouse |
| Fumiya Shinohara, Yuta Asaoka, Hironori Kamii, Masabumi Minami, Katsuyuki Kaned. Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry. Addiction biology. vol 24. issue 3. 2020-05-18. PMID:29480583. |
additionally, intra-ventral tegmental area (vta) microinjection of antagonists for the muscarinic acetylcholine, nicotinic acetylcholine or glutamate receptors attenuated the stress-induced enhancement of cocaine cpp. |
2020-05-18 |
2023-08-13 |
rat |
| Frank J Meye, Mariano Soiza-Reilly, Tamar Smit, Marco A Diana, Martin K Schwarz, Manuel Mamel. Author Correction: Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse. Nature neuroscience. vol 23. issue 4. 2020-04-20. PMID:32139892. |
author correction: shifted pallidal co-release of gaba and glutamate in habenula drives cocaine withdrawal and relapse. |
2020-04-20 |
2023-08-13 |
Not clear |
| Christina Gobin, Marek Schwend. The cognitive cost of reducing relapse to cocaine-seeking with mGlu5 allosteric modulators. Psychopharmacology. vol 237. issue 1. 2020-04-10. PMID:31446451. |
antagonism of metabotropic glutamate receptor 5 (mglu5) has been demonstrated to decrease cocaine-seeking but may also further compromise cognitive function in long-term cocaine users. |
2020-04-10 |
2023-08-13 |
Not clear |
| Matthew D Puhl, Rajeev I Desai, Shunsuke Takagi, Kendall T Presti, Michelle R Doyle, Rachel J Donahue, Samantha M Landino, Jack Bergman, William A Carlezon, Joseph T Coyl. N-Methyl-d-aspartate receptor co-agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse. Addiction biology. vol 24. issue 1. 2020-04-02. PMID:29168271. |
together, these findings suggest that the impaired nmdar function and a consequent decrease in sensitivity to cocaine effects on behavior are mediated by blunted da and glutamate responses normally triggered by the drug. |
2020-04-02 |
2023-08-13 |
mouse |