| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mieke H J Schulte, Anna E Goudriaan, Wouter J Boendermaker, Wim van den Brink, Reinout W Wier. The effect of N-acetylcysteine and working memory training on glutamate concentrations in the dACC and rACC in regular cocaine users - A randomized proof of concept study. Neuroscience letters. vol 762. 2021-09-14. PMID:34332028. |
this study investigates the effectiveness of a combined intervention that targets the assumed underlying glutamate pathology in cocaine users. |
2021-09-14 |
2023-08-13 |
Not clear |
| Adamantios Krokos, Olga Deda, Christina Virgiliou, Helen Gika, Nikolaos Raikos, Eleni Aggelidou, Aristeidis Kritis, Georgios Theodoridi. Evaluation of Cocaine Effect on Endogenous Metabolites of HepG2 Cells Using Targeted Metabolomics. Molecules (Basel, Switzerland). vol 26. issue 15. 2021-09-14. PMID:34361761. |
a predominant effect of cocaine administration on alanine, aspartate, and glutamate metabolic pathway was observed. |
2021-09-14 |
2023-08-13 |
human |
| Megan M Wickens, Julia M Kirkland, Melissa C Knouse, Anna G McGrath, Lisa A Brian. Sex-specific role for prefrontal cortical protein interacting with C kinase 1 in cue-induced cocaine seeking. Addiction biology. vol 26. issue 5. 2021-09-10. PMID:34110073. |
disruption of prefrontal glutamate receptor interacting protein (grip), which anchors glua2-containing ampa receptors (ampars) into the synaptic membrane, potentiates cue-induced cocaine seeking in both males and females. |
2021-09-10 |
2023-08-13 |
mouse |
| Peter U Hámor, Christina M Gobin, Marek Schwend. The role of glutamate mGlu5 and adenosine A2a receptor interactions in regulating working memory performance and persistent cocaine seeking in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 103. 2021-08-27. PMID:32470496. |
the role of glutamate mglu5 and adenosine a2a receptor interactions in regulating working memory performance and persistent cocaine seeking in rats. |
2021-08-27 |
2023-08-13 |
rat |
| Ewa Niedzielska-Andres, Lucyna Pomierny-Chamioło, Michał Andres, Maria Walczak, Lori A Knackstedt, Małgorzata Filip, Edmund Przegalińsk. Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacology & therapeutics. vol 221. 2021-08-26. PMID:33359590. |
cocaine use disorder: a look at metabotropic glutamate receptors and glutamate transporters. |
2021-08-26 |
2023-08-13 |
Not clear |
| Ewa Niedzielska-Andres, Lucyna Pomierny-Chamioło, Michał Andres, Maria Walczak, Lori A Knackstedt, Małgorzata Filip, Edmund Przegalińsk. Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacology & therapeutics. vol 221. 2021-08-26. PMID:33359590. |
the present review summarizes the changes in glutamate levels in the reward system (the prefrontal cortex, nucleus accumbens, dorsal striatum, hippocampus, and ventral tegmental area) observed in preclinical studies at different stages of cocaine exposure and withdrawal as well as after reinstatement of cocaine-seeking behavior. |
2021-08-26 |
2023-08-13 |
Not clear |
| Sumin Sohn, Sunghyun Kim, Ju Hwan Yang, Eun Sang Cho. Linking of NMDA receptors and mGluR5 in the nucleus accumbens core to repeated cocaine-induced 50-kHz ultrasonic vocalization in rats. Addiction biology. 2021-08-25. PMID:34378829. |
this study demonstrated the linking of glutamate receptors in the nucleus accumbens (nac) to vocal expression of 50-khz usv calls after repeated cocaine administration in freely moving rats. |
2021-08-25 |
2023-08-13 |
rat |
| Bethania Mongi-Bragato, María Paula Avalos, Andrea S Guzmán, Constanza García-Keller, Flavia A Bollati, Liliana M Cancel. Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience. vol 53. issue 5. 2021-06-28. PMID:33159343. |
altered glutamate transmission within the nucleus accumbens (nac) has been proposed as a central mechanism underlying behavioural sensitisation associated with repeated cocaine exposure. |
2021-06-28 |
2023-08-13 |
mouse |
| Bethania Mongi-Bragato, María Paula Avalos, Andrea S Guzmán, Constanza García-Keller, Flavia A Bollati, Liliana M Cancel. Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience. vol 53. issue 5. 2021-06-28. PMID:33159343. |
in addition to glutamate, enkephalin, an endogenous opioid peptide derived from proenkephalin, is necessary for the neuroadaptations associated with chronic cocaine. |
2021-06-28 |
2023-08-13 |
mouse |
| Bethania Mongi-Bragato, María Paula Avalos, Andrea S Guzmán, Constanza García-Keller, Flavia A Bollati, Liliana M Cancel. Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience. vol 53. issue 5. 2021-06-28. PMID:33159343. |
this study used knockout proenkephalin mice (ko) to study the influence of endogenous enkephalin on the adaptations in glutamate neurotransmission associated with repeated cocaine treatment. |
2021-06-28 |
2023-08-13 |
mouse |
| Bethania Mongi-Bragato, María Paula Avalos, Andrea S Guzmán, Constanza García-Keller, Flavia A Bollati, Liliana M Cancel. Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience. vol 53. issue 5. 2021-06-28. PMID:33159343. |
on days 15 and 21, the animals received a cocaine challenge and locomotor sensitisation was evaluated, and microdialysis was performed to determine accumbens glutamate content on day 21. |
2021-06-28 |
2023-08-13 |
mouse |
| Bethania Mongi-Bragato, María Paula Avalos, Andrea S Guzmán, Constanza García-Keller, Flavia A Bollati, Liliana M Cancel. Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience. vol 53. issue 5. 2021-06-28. PMID:33159343. |
consistently, these showed no changes in glutamate transmission in the nac associated with repeated cocaine. |
2021-06-28 |
2023-08-13 |
mouse |
| Bethania Mongi-Bragato, María Paula Avalos, Andrea S Guzmán, Constanza García-Keller, Flavia A Bollati, Liliana M Cancel. Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience. vol 53. issue 5. 2021-06-28. PMID:33159343. |
this study reveals the central role of enkephalin in regulating the glutamate mechanisms associated with cocaine sensitisation. |
2021-06-28 |
2023-08-13 |
mouse |
| Jerome A J Becker, Lucie P Pellissier, Yannick Corde, Thibaut Laboute, Audrey Léauté, Jorge Gandía, Julie Le Merre. Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 7. 2021-06-23. PMID:33349673. |
by comparing the long-term transcriptional consequences of morphine and cocaine exposure, we identified the metabotropic glutamate receptor subtype 4 (mglur4) as a promising pharmacological target in morphine abstinence. |
2021-06-23 |
2023-08-13 |
mouse |
| Lan-Yuan Zhang, Yue-Qing Zhou, Zhi-Peng Yu, Xiao-Qin Zhang, Jie Shi, Hao-Wei She. Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33514875. |
restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. |
2021-06-23 |
2023-08-13 |
rat |
| Lan-Yuan Zhang, Yue-Qing Zhou, Zhi-Peng Yu, Xiao-Qin Zhang, Jie Shi, Hao-Wei She. Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33514875. |
here, using cocaine self-administration in rats, we investigated the role of endocannabinoids in impaired glutamate homeostasis in the core of nucleus accumbens (nacore), which was indicated by augmentation of spontaneous synaptic glutamate release, downregulation of metabotropic glutamate receptor 2/3 (mglur2/3), and mglur5-mediated astrocytic glutamate release. |
2021-06-23 |
2023-08-13 |
rat |
| Lan-Yuan Zhang, Yue-Qing Zhou, Zhi-Peng Yu, Xiao-Qin Zhang, Jie Shi, Hao-Wei She. Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33514875. |
in rats with a history of cocaine self-administration and extinction training, aea failed to alter synaptic glutamate release in the nacore, whereas cb1r-mediated astrocytic glutamate release by aea remained functional. |
2021-06-23 |
2023-08-13 |
rat |
| Lan-Yuan Zhang, Yue-Qing Zhou, Zhi-Peng Yu, Xiao-Qin Zhang, Jie Shi, Hao-Wei She. Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33514875. |
these results demonstrate that enhancing endocannabinoid signaling is a potential pathway to restore glutamate homeostasis and may represent a promising therapeutic strategy for preventing cocaine relapse. |
2021-06-23 |
2023-08-13 |
rat |
| Karen D Ersche, Tsen Vei Lim, Alexander G Murley, Catarina Rua, Matilde M Vaghi, Tara L White, Guy B Williams, Trevor W Robbin. Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction. Biological psychiatry. vol 89. issue 10. 2021-06-02. PMID:33581835. |
reduced glutamate turnover in the putamen is linked with automatic habits in human cocaine addiction. |
2021-06-02 |
2023-08-13 |
human |
| Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M M Verheij, Judith Homberg, Fabio Fumagall. Long access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats. British journal of pharmacology. 2021-05-21. PMID:33880773. |
long access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats. |
2021-05-21 |
2023-08-13 |
rat |