| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zongyue Sun, Meiqin Wang, Lei Xu, Qiongyu Li, Zhongyi Zhao, Xuehao Liu, Fantao Meng, Jing Liu, Wentao Wang, Chen Li, Shujun Jian. PPARγ/Adiponectin axis attenuates methamphetamine-induced conditional place preference via the hippocampal AdipoR1 signaling pathway. Progress in neuro-psychopharmacology & biological psychiatry. 2023-03-27. PMID:36972780. |
the meth induced adult male c57/bl6j mice model were used for testing the therapeutic activities of intraperitoneal injection of adiporon or rosiglitazone, and adipor1 overexpression in hippocampal dentate gyrus (dg), and chemogenetic inhibiting the neural activity of dg, and the changes of neurotrophic factors, synaptic molecules, and glutamate receptors, and inflammatory cytokines were also measured. |
2023-03-27 |
2023-08-14 |
mouse |
| Zongyue Sun, Meiqin Wang, Lei Xu, Qiongyu Li, Zhongyi Zhao, Xuehao Liu, Fantao Meng, Jing Liu, Wentao Wang, Chen Li, Shujun Jian. PPARγ/Adiponectin axis attenuates methamphetamine-induced conditional place preference via the hippocampal AdipoR1 signaling pathway. Progress in neuro-psychopharmacology & biological psychiatry. 2023-03-27. PMID:36972780. |
moreover, the expression of adipor1 in the hippocampus was also reduced, and adipor1 overexpression blocked the development of meth-induced cpp behavior through regulatory effects on neurotrophic factors, synaptic molecules, and glutamate receptors. |
2023-03-27 |
2023-08-14 |
mouse |
| Richard Baskerville, Thomas McGrath, Lindy Castel. The effects of physical activity on glutamate neurotransmission in neuropsychiatric disorders. Frontiers in sports and active living. vol 5. 2023-03-23. PMID:36949894. |
the hippocampus and pre-frontal cortex (pfc) containing predominantly glutamate neurotransmission, are the centres of changes seen in depression. |
2023-03-23 |
2023-08-14 |
Not clear |
| Richard Baskerville, Thomas McGrath, Lindy Castel. The effects of physical activity on glutamate neurotransmission in neuropsychiatric disorders. Frontiers in sports and active living. vol 5. 2023-03-23. PMID:36949894. |
similar hippocampal glutamate dysfunction is observed in many other neuropsychiatric conditions. |
2023-03-23 |
2023-08-14 |
Not clear |
| Gonzalo Valdivia, Alvaro O Ardiles, Abimbola Idowu, Claudia Salazar, Hey-Kyoung Lee, Michela Gallagher, Adrian G Palacios, Alfredo Kirkwoo. mGluR-dependent plasticity in rodent models of Alzheimer's disease. Frontiers in synaptic neuroscience. vol 15. 2023-03-20. PMID:36937569. |
in the ca1 region of the hippocampus ltp and ltd can be induced by the activation of either nmda receptors or mglur5 metabotropic glutamate receptors. |
2023-03-20 |
2023-08-14 |
mouse |
| Luis A Márquez, Ernesto Griego, Carolina López Rubalcava, Emilio J Galvá. NMDA receptor activity during postnatal development determines intrinsic excitability and mossy fiber long-term potentiation of CA3 pyramidal cells. Hippocampus. 2023-03-20. PMID:36938755. |
blockade of nmdars with mk-801 during early postnatal development alters glutamate release and impairs the induction of nmdar-dependent long-term plasticity at the ca1 area of the hippocampus. |
2023-03-20 |
2023-08-14 |
Not clear |
| Judit Català-Solsona, Pablo J Lituma, Stefano Lutzu, Dolores Siedlecki-Wullich, Cristina Fábregas-Ordoñez, Alfredo J Miñano-Molina, Carlos A Saura, Pablo E Castillo, José Rodriguez-Álvare. Activity-dependent Nr4a2 induction modulates synaptic expression of AMPA receptors and plasticity via a Ca The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-03-17. PMID:36931707. |
here, we report that neuronal activity enhances nr4a2 expression and function in cultured mouse hippocampal neurons (both sexes) by an ionotropic glutamate receptor/ca |
2023-03-17 |
2023-08-14 |
mouse |
| Sohir M Zohny, Mohamed Z Habib, Magda I Mohamad, Wael M Elayat, Reham M Elhossiny, Mohamed F Abd El-Salam, Ghada A M Hassan, Sawsan Aboul-Fotou. Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-03-15. PMID:36918475. |
memantine/aripiprazole combination alleviates cognitive dysfunction in valproic acid rat model of autism: hippocampal creb/bdnf signaling and glutamate homeostasis. |
2023-03-15 |
2023-08-14 |
human |
| Sohir M Zohny, Mohamed Z Habib, Magda I Mohamad, Wael M Elayat, Reham M Elhossiny, Mohamed F Abd El-Salam, Ghada A M Hassan, Sawsan Aboul-Fotou. Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-03-15. PMID:36918475. |
prenatal vpa induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated camp response element-binding protein (p-creb), brain-derived neurotrophic factor (bdnf), and gene expression of glutamate transporter-1 (glt-1) with a decline in gaba/glutamate ratio (both measured by hplc). |
2023-03-15 |
2023-08-14 |
human |
| Mohammad Keimasi, Kowsar Salehifard, Mohammadjavad Keimasi, Mohammadreza Amirsadri, Noushin Mirshah Jafar Esfahani, Majid Moradmand, Fariba Esmaeili, Mohammad Reza Mofi. Alleviation of cognitive deficits in a rat model of glutamate-induced excitotoxicity, using an N-type voltage-gated calcium channel ligand, extracted from Frontiers in molecular neuroscience. vol 16. 2023-03-06. PMID:36873105. |
under excitotoxicity condition, glutamate has negative effects on the pyramidal cells of the hippocampus, which ends in synaptic loss and elimination of these cells. |
2023-03-06 |
2023-08-14 |
rat |
| Jiao Ma, Zhechun Hu, Huimin Yue, Yujian Luo, Chao Wang, Xuan Wu, Yan Gu, Lang Wan. GRM2 regulates functional integration of adult-born DGCs by paradoxically modulating MEK/ERK1/2 pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-03-06. PMID:36878727. |
metabotropic glutamate receptor 2 (grm2) is highly expressed in hippocampal dentate granule cells (dgcs), regulating synaptic transmission and hippocampal functions. |
2023-03-06 |
2023-08-14 |
mouse |
| Jae Soon Kang, Ji Hyeong Baek, Mi Yeong Song, Naveed Ur Rehman, Hye Jin Chung, Dong Kun Lee, Dae Young Yoo, Hyun Joon Ki. Long-term exposure changes the environmentally relevant bis(2-ethylhexyl) phthalate to be a neuro-hazardous substance disrupting neural homeostasis in emotional and cognitive functions. Environmental pollution (Barking, Essex : 1987). 2023-03-04. PMID:36870594. |
long-term dehp ingestion induced collapse of glutamate (glu) and glutamine (gln) homeostasis as a result of disruption of the glu-gln cycle in the medial prefrontal cortex and hippocampus. |
2023-03-04 |
2023-08-14 |
mouse |
| Justine Fortin-Houde, Fiona Henderson, Sylvie Dumas, Guillaume Ducharme, Bénédicte Amilho. Parallel streams of raphe VGLUT3-positive inputs target the dorsal and ventral hippocampus in each hemisphere. The Journal of comparative neurology. 2023-03-01. PMID:36855269. |
the hippocampus (hp) receives neurochemically diverse inputs from the raphe nuclei, including glutamatergic axons characterized by the expression of the vesicular glutamate transporter type 3 (vglut3). |
2023-03-01 |
2023-08-14 |
Not clear |
| Ducroq Suzanne, Eric Duplus, Valérie Grange-Messent, Francesca Trivelloni, Lucille Penalva-Mousset, Isabelle Petropoulos, Mhaouty-Kodja Sakin. Cognitive and hippocampal effects of adult male mice exposure to environmentally relevant doses of phthalates. Environmental pollution (Barking, Essex : 1987). 2023-02-24. PMID:36828353. |
these behavioral alterations were associated with a lowered dendritic spine density and protein levels of glutamate receptors and postsynaptic markers, and increased protein levels of the presynaptic synaptophysin in the hippocampus. |
2023-02-24 |
2023-08-14 |
mouse |
| Isadora Matias, Luan Pereira Diniz, Ana Paula Bergamo Araujo, Isabella Vivarini Damico, Pâmella de Moura, Felipe Cabral-Miranda, Fabiola Diniz, Belisa Parmeggiani, Valeria de Mello Coelho, Renata E P Leite, Claudia K Suemoto, Gustavo Costa Ferreira, Regina Célia Cussa Kubrusly, Flávia Carvalho Alcantara Gome. Age-Associated Upregulation of Glutamate Transporters and Glutamine Synthetase in Senescent Astrocytes In Vitro and in the Mouse and Human Hippocampus. ASN neuro. vol 15. 2023-02-23. PMID:36815213. |
age-associated upregulation of glutamate transporters and glutamine synthetase in senescent astrocytes in vitro and in the mouse and human hippocampus. |
2023-02-23 |
2023-08-14 |
mouse |
| Tomohiko Maruo, Kiyohito Mizutani, Muneaki Miyata, Toshihiko Kuriu, Shotaro Sakakibara, Hatena Takahashi, Daichi Kida, Kouki Maesaka, Tsukiko Sugaya, Ayuko Sakane, Takuya Sasaki, Yoshimi Takai, Kenji Manda. s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons. The Journal of biological chemistry. 2023-02-21. PMID:36803960. |
our electrophysiological analysis revealed that the postsynaptic response to glutamate, but not its release from the presynapse, was impaired in the maguin-deficient cultured hippocampal neurons. |
2023-02-21 |
2023-08-14 |
Not clear |
| Pelin Saglam-Metiner, Utku Devamoglu, Yagmur Filiz, Soheil Akbari, Goze Beceren, Bakiye Goker, Burcu Yaldiz, Sena Yanasik, Cigir Biray Avci, Esra Erdal, Ozlem Yesil-Celikta. Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids. Communications biology. vol 6. issue 1. 2023-02-14. PMID:36788328. |
rccs and µ-platform organoids have reached ideal sizes, approximately 95% harvestability, prolonged culture time with ki-67 + /cd31 + /β-catenin+ proliferative, adhesive and endothelial-like cells and exhibited enriched cellular diversity (abundant neural/glial/ endothelial cell population), structural brain morphogenesis, further functional neuronal identities (glutamate secreting glutamatergic, gabaergic and hippocampal neurons) and synaptogenesis (presynaptic-postsynaptic interaction) during whole human brain development. |
2023-02-14 |
2023-08-14 |
human |
| Pawel Grochecki, Irena Smaga, Karolina Wydra, Marta Marszalek-Grabska, Tymoteusz Slowik, Ewa Kedzierska, Joanna Listos, Ewa Gibula-Tarlowska, Malgorzata Filip, Jolanta H Kotlinsk. Impact of Mephedrone on Fear Memory in Adolescent Rats: Involvement of Matrix Metalloproteinase-9 (MMP-9) and N-Methyl-D-aspartate (NMDA) Receptor. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768263. |
we also analyzed whether these trauma-induced changes were associated with exacerbation in metalloproteinase-9 (mmp-9) and the glun2a and glun2b subunits of n-methyl-d-aspartate (nmda) glutamate receptor expression in such brain structures as the hippocampus and basolateral amygdala. |
2023-02-11 |
2023-08-14 |
rat |
| Yanhui Hao, Weiqi Liu, Yujie Liu, Ying Liu, Zhengtao Xu, Yumeng Ye, Hongmei Zhou, Hua Deng, Hongyan Zuo, Hong Yang, Yang L. Effects of Nonthermal Radiofrequency Stimulation on Neuronal Activity and Neural Circuit in Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-02-09. PMID:36755196. |
glutamate release in the dorsal hippocampus (dhpc) ca1 region is not significantly changed after radiofrequency exposure, whereas dopamine release is reduced. |
2023-02-09 |
2023-08-14 |
mouse |
| Wenjuan Zhou, Chen Zhang, Peipei Wang, Yuanying Deng, Hongmei Dai, Jing Tian, Guojiao Wu, Lingling Zha. Chlorpyrifos-induced dysregulation of synaptic plasticity in rat hippocampal neurons. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2023-02-01. PMID:36722685. |
using cpf-exposed rat and primary hippocampal neurons model, we analyzed the impact of cpf on the synaptic morphology, the expression level of a presynaptic protein, a postsynaptic protein and ionotropic glutamate receptors (iglurs), as well as the effects on the wnt/β-catenin pathway. |
2023-02-01 |
2023-08-14 |
rat |