| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Alhowail, M Aldubaya. Mechanisms underlying cognitive impairment induced by prenatal cannabinoid exposure: a literature review. European review for medical and pharmacological sciences. vol 27. issue 11. 2023-06-15. PMID:37318470. |
the findings from the studies reviewed revealed that the cognitive impairment associated with prenatal cannabinoid exposure is caused by alterations in the expression and function of endocannabinoid receptor 1 (cb1r), decreased glutamate transmission, reduced neurogenesis, alterations in protein kinase b (pkb/akt) and extracellular signal‑regulated kinase 1 and 2 (erk1/2) activity, and increased mitochondrial function in the hippocampus, cortex, and cerebellum. |
2023-06-15 |
2023-08-14 |
human |
| Li-Zhe Liu, Shu-Juan Fan, Jun-Xia Gao, Wen-Bin Li, Xiao-Hui Xia. Ceftriaxone ameliorates hippocampal synapse loss by inhibiting microglial/macrophages activation in glial glutamate transporter-1 dependent manner in the APP/PS1 mouse model of Alzheimer's disease. Brain research bulletin. 2023-06-10. PMID:37301482. |
ceftriaxone ameliorates hippocampal synapse loss by inhibiting microglial/macrophages activation in glial glutamate transporter-1 dependent manner in the app/ps1 mouse model of alzheimer's disease. |
2023-06-10 |
2023-08-14 |
mouse |
| Erika Vazquez-Juarez, Ipsit Srivastava, Maria Lindsko. The effect of ketamine on synaptic mistuning induced by impaired glutamate reuptake. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-06-10. PMID:37301901. |
by recording evoked field postsynaptic potentials in the ca1 area in hippocampal slices, we found that inhibiting glutamate transporters using dl-tboa causes retuning of synaptic transmission, resulting in a new steady state with reduced synaptic strength and a lower threshold for inducing long-term synaptic potentiation (ltp). |
2023-06-10 |
2023-08-14 |
rat |
| Sebastiano A Torrisi, Silvia Rizzo, Samuele Laudani, Alessandro Ieraci, Filippo Drago, Gian Marco Leggi. Acute stress alters recognition memory and AMPA/NMDA receptor subunits in a sex-dependent manner. Neurobiology of stress. vol 25. 2023-06-09. PMID:37293561. |
because ionotropic glutamate receptors-mediated neurotransmission is essential for shaping recognition memory, we further tested the hypothesis that post training acute stress could induce sex-dependent transcriptional changes of ionotropic glutamate receptor subunits in the dorsal hippocampus. |
2023-06-09 |
2023-08-14 |
mouse |
| Elham Sajadi, Javad Sajedianfard, Saeid Hosseinzadeh, Mahnaz Taherianfar. Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats. Iranian journal of basic medical sciences. vol 26. issue 6. 2023-06-06. PMID:37275760. |
the effect of intracerebroventricular injection of insulin (ins) and oral cinnamon extract (cinn) on glucose transporter (glut) 1, 3, and 4 gene expressions in the hippocampus and spatial memory in a streptozotocin (stz)-induced ad rat model was investigated in the present study. |
2023-06-06 |
2023-08-14 |
rat |
| Jiaxin Zheng, Sisi Peng, Lingling Cui, Xi Liu, Tian Li, Zhenyu Zhao, Yaqing Li, Yuan Hu, Miao Zhang, Linling Xu, JunJian Zhan. Enriched environment attenuates hippocampal theta and gamma rhythms dysfunction in chronic cerebral hypoperfusion via improving imbalanced neural afferent levels. Frontiers in cellular neuroscience. vol 17. 2023-06-02. PMID:37265581. |
the results showed that ee significantly improved the balance of three classical neurotransmitters (acetylcholine, glutamate, and gaba) in the hippocampus, enhanced the strength of theta and slow-gamma (sg) rhythms, and dramatically improved neural coupling across frequency bands in cch rats. |
2023-06-02 |
2023-08-14 |
rat |
| Pablo Martínez San Segundo, Beatrice Terni, Artur Llobe. Multivesicular release favors short term synaptic depression in hippocampal autapses. Frontiers in cellular neuroscience. vol 17. 2023-06-02. PMID:37265578. |
here, we took advantage of the expression of sf-iglusnfr.s72a in the astrocytic feeder layer of autaptic hippocampal neuronal cultures to associate the liberation of glutamate to excitatory postsynaptic currents. |
2023-06-02 |
2023-08-14 |
Not clear |
| Siddhartha Datta, Zubin Rashid, Saptarnab Naskar, Sumantra Chattarj. Administration of the glutamate-modulating drug, riluzole, after stress prevents its delayed effects on the amygdala in male rats. PNAS nexus. vol 2. issue 6. 2023-06-02. PMID:37266396. |
riluzole, an fda-approved drug known to modulate glutamate release and facilitate glutamate clearance, prevents stress-induced deficits in the hippocampus. |
2023-06-02 |
2023-08-14 |
rat |
| Mario Díaz, Daniel Pereda de Pablo, Catalina Valdés-Baizabal, Guido Santos, Raquel Mari. Molecular and biophysical features of hippocampal "lipid rafts aging" are modified by dietary n-3 long-chain polyunsaturated fatty acids. Aging cell. 2023-05-31. PMID:37254617. |
in the present study, we have analyzed, in vivo, the effects of dietary supplementation of n-3 lcpufa on the lipid structure, membrane microviscosity, domain organization, and partitioning of ionotropic and metabotropic glutamate receptors in hippocampal lipid raffs in female mice. |
2023-05-31 |
2023-08-14 |
mouse |
| Mario Díaz, Daniel Pereda de Pablo, Catalina Valdés-Baizabal, Guido Santos, Raquel Mari. Molecular and biophysical features of hippocampal "lipid rafts aging" are modified by dietary n-3 long-chain polyunsaturated fatty acids. Aging cell. 2023-05-31. PMID:37254617. |
unexpectedly, this diet also modified the lipidome and dimension of lipid rafts, as well as the domain redistribution of glutamate receptors and acid-sensing ion channels involved in hippocampal synaptic plasticity, likely modulating functionality of lipid rafts in memory formation and reluctance to age-associated cognitive decline. |
2023-05-31 |
2023-08-14 |
mouse |
| Balázs Simon, András Buzás, Péter Bokor, Krisztina Csabafi, Katalin Eszter Ibos, Éva Bodnár, László Török, Imre Földesi, Andrea Siska, Zsolt Bagos. The Effects of Alcohol Intoxication and Withdrawal on Hypothalamic Neurohormones and Extrahypothalamic Neurotransmitters. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238959. |
the aim of the present study was to determine the effects of alcohol intoxication and withdrawal on hypothalamic neurohormones such as corticotropin-releasing factor (crf) and arginine vasopressin (avp), and extrahypothalamic neurotransmitters such as striatal dopamine (da), amygdalar gamma aminobutyric acid (gaba), and hippocampal glutamate (glu). |
2023-05-27 |
2023-08-14 |
rat |
| Ghallab Alotaibi, Amna Khan, Patrick J Ronan, Kabirullah Lutfy, Shafiqur Rahma. Glial Glutamate Transporter Modulation Prevents Development of Complete Freund's Adjuvant-Induced Hyperalgesia and Allodynia in Mice. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239279. |
glial glutamate transporter (glt-1) modulation in the hippocampus and anterior cingulate cortex (acc) is critically involved in nociceptive pain. |
2023-05-27 |
2023-08-14 |
mouse |
| Do-Wan Lee, Jae-Im Kwon, Hwon Heo, Chul-Woong Woo, Na Hee Yu, Kyung Won Kim, Dong-Cheol Wo. Cerebral Glutamate Alterations Using Chemical Exchange Saturation Transfer Imaging in a Rat Model of Lipopolysaccharide-Induced Sepsis. Metabolites. vol 13. issue 5. 2023-05-26. PMID:37233677. |
this study aimed to visualize and quantitatively evaluate hippocampal glutamate alterations in a rat model of sepsis-induced brain injury using glucest and proton magnetic resonance spectroscopy ( |
2023-05-26 |
2023-08-14 |
rat |
| Alexander Maltsev, Sergei Funikov, Alexander Rezvykh, Ekaterina Teterina, Vladimir Nebogatikov, Alexander Burov, Natalia Bal, Aleksey Ustyugov, Vadim Karpov, Alexey Morozo. Chronic Administration of Non-Constitutive Proteasome Inhibitor Modulates Long-Term Potentiation and Glutamate Signaling-Related Gene Expression in Murine Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175876. |
chronic administration of non-constitutive proteasome inhibitor modulates long-term potentiation and glutamate signaling-related gene expression in murine hippocampus. |
2023-05-14 |
2023-08-14 |
Not clear |
| Ekaterina V Pershina, Irina Yu Chernomorets, Dmitry A Fedorov, Vladimir I Arkhipo. Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175959. |
three weeks after tmt injection, functional and morphological changes in a rat hippocampus were evaluated, including the expression level of genes characterizing glutamate transmission and neuroinflammation, animal behavior, and hippocampal cell morphology. |
2023-05-14 |
2023-08-14 |
rat |
| Rafael Short Ferreira, Paulo Roberto Ribeiro, Juliana Helena Castro E Silva, Juliana Bender Hoppe, Monique Marylin Alves de Almeida, Beatriz Correia de Lima Ferreira, Gustavo Borges Andrade, Suzana Braga de Souza, Luzimar Gonzaga Ferdandez, Maria de Fátima Dias Costa, Christianne Gazzana Salbego, Andrea Domenico Rivera, Aline Longoni, Adriano Martimbianco de Assis, Francesca Pieropan, José Cláudio Fonseca Moreira, Silvia Lima Costa, Arthur Morgan Butt, Victor Diogenes Amaral da Silv. Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia. BMC complementary medicine and therapies. vol 23. issue 1. 2023-05-11. PMID:37170258. |
amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia. |
2023-05-11 |
2023-08-14 |
Not clear |
| Alaa M Hammad, Ala A Alhusban, Lujain F Alzaghari, Fawaz Alasmari, Youssef Sar. Effect of Cigarette Smoke Exposure and Aspirin Treatment on Neurotransmitters' Tissue Content in Rats' Hippocampus and Amygdala. Metabolites. vol 13. issue 4. 2023-04-28. PMID:37110173. |
we examined the effects of cigarette smoke with and without aspirin treatment on the concentrations of neurotransmitters, including dopamine, serotonin, glutamate, glutamine, and gaba in the amygdala and hippocampus. |
2023-04-28 |
2023-08-14 |
rat |
| Alaa M Hammad, Ala A Alhusban, Lujain F Alzaghari, Fawaz Alasmari, Youssef Sar. Effect of Cigarette Smoke Exposure and Aspirin Treatment on Neurotransmitters' Tissue Content in Rats' Hippocampus and Amygdala. Metabolites. vol 13. issue 4. 2023-04-28. PMID:37110173. |
dopamine, serotonin, glutamate, glutamine, and gaba were extracted from both the amygdala and hippocampus and were separated and quantified using a developed and validated hplc-ms/ms method. |
2023-04-28 |
2023-08-14 |
rat |
| Ke Du, Chuanjia Zhai, Xuejiao Li, Hongchuan Gang, Xiaoyan Ga. Feature-Based Molecular Networking Facilitates the Comprehensive Identification of Differential Metabolites in Diabetic Cognitive Dysfunction Rats. Metabolites. vol 13. issue 4. 2023-04-28. PMID:37110195. |
the pathway enrichment results showed that glutamine and glutamate metabolism, alanine, aspartate, and glutamate metabolism, glycerol phospholipid metabolism, tca cycle, and arginine biosynthesis in the hippocampus of dcd animals were changed. |
2023-04-28 |
2023-08-14 |
rat |
| Hao Zhang, Zhan Gao, Ya Sun, Tian Lu, Zhenzhen Wang, Dongmei Gao, Jieqiong Wang, Mingqi Qiao, Mingzhou Ga. Profiling GABA(A) Receptor Subunit Expression in the Hippocampus of PMDD Rat Models Based on TCM Theories. Molecular neurobiology. 2023-04-27. PMID:37103685. |
western blot analysis was used to investigate protein levels of gabaar α1, α2, α4, α5, β2, β3, and δ subunits, whereas ultra-high performance liquid chromatography-tandem mass spectrometry (uhplc-ms/ms) analysis was performed to determine gamma-aminobutyric acid (gaba) and glutamate (glu) levels in the hippocampus across each group. |
2023-04-27 |
2023-08-14 |
rat |