| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Becker, Gerrit Loch, Marc Beyer, Ingo Zinke, Anna C Aschenbrenner, Pilar Carrera, Therese Inhester, Joachim L Schultze, Michael Hoc. FOXO-dependent regulation of innate immune homeostasis. Nature. vol 463. issue 7279. 2010-03-03. PMID:20090753. |
in non-infected animals, amp genes are activated in response to nuclear foxo activity when induced by starvation, using insulin signalling mutants, or by applying small molecule inhibitors. |
2010-03-03 |
2023-08-12 |
human |
| Justin R DiAngelo, Morris J Birnbau. Regulation of fat cell mass by insulin in Drosophila melanogaster. Molecular and cellular biology. vol 29. issue 24. 2010-01-05. PMID:19822665. |
the ability of insulin to accomplish the former depends on its capacity to bring about phosphorylation and inhibition of the transcription factor drosophila foxo (dfoxo) and the serine/threonine protein kinase shaggy, the fly ortholog of glycogen synthase kinase 3 (gsk3). |
2010-01-05 |
2023-08-12 |
drosophila_melanogaster |
| Bashayer Al-Mubarak, Francesc X Soriano, Giles E Hardingha. Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene. Channels (Austin, Tex.). vol 3. issue 4. 2009-12-30. PMID:19690465. |
we found that foxo3, and to a lesser extent foxo1 transactivates the foxo1 promoter via a consensus foxo binding site (gta aac aa), and also an upstream sequence resembling a classical foxo-binding insulin response sequence (caa aac aa). |
2009-12-30 |
2023-08-12 |
Not clear |
| Adnan Ero. Unraveling the molecular mechanisms behind the metabolic basis of sporadic Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19221404. |
the deficient insulin signaling is ultimately linked to protein kinase b (akt) pathway and subsequently glycogen synthase kinase-3 (gsk3) and forkhead transcription factors (foxo). |
2009-12-16 |
2023-08-12 |
Not clear |
| Adnan Ero. Unraveling the molecular mechanisms behind the metabolic basis of sporadic Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19221404. |
peripheral insulin resistance related intense interactions between jnk, gsk3, foxo factors, and p53, which may lead to apoptotic neuronal death, are outlined in a postulate. |
2009-12-16 |
2023-08-12 |
Not clear |
| Jaakko Mattila, Anna Bremer, Linda Ahonen, Risto Kostiainen, Oscar Pui. Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase. Molecular and cellular biology. vol 29. issue 19. 2009-10-02. PMID:19651894. |
foxo proteins are important mediators of the insulin signaling pathway, adjusting growth and metabolism to nutrient availability. |
2009-10-02 |
2023-08-12 |
drosophila_melanogaster |
| Eric L Greer, Max R Banko, Anne Brune. AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity. Annals of the New York Academy of Sciences. vol 1170. 2009-09-25. PMID:19686213. |
the signaling pathway connecting insulin to foxo transcription factors integrates environmental stimuli to regulate lifespan. |
2009-09-25 |
2023-08-12 |
caenorhabditis_elegans |
| Danielle N Gross, Min Wan, Morris J Birnbau. The role of FOXO in the regulation of metabolism. Current diabetes reports. vol 9. issue 3. 2009-08-12. PMID:19490822. |
given the impact of insulin signaling on akt-mediated phosphorylation of foxo and the relatively high expression of foxo1 in insulin-responsive tissues, this transcription factor is highly poised to regulate energy metabolism. |
2009-08-12 |
2023-08-12 |
Not clear |
| Jane J Kim, Pingping Li, Jessica Huntley, Jeffrey P Chang, Karen C Arden, Jerrold M Olefsk. FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue. Diabetes. vol 58. issue 6. 2009-07-17. PMID:19289458. |
forkhead box o (foxo) transcription factors represent evolutionarily conserved targets of insulin signaling, regulating metabolism and cellular differentiation in response to changes in nutrient availability. |
2009-07-17 |
2023-08-12 |
Not clear |
| Toshihiko Yanase, Wuqiang Fa. Modification of androgen receptor function by IGF-1 signaling implications in the mechanism of refractory prostate carcinoma. Vitamins and hormones. vol 80. 2009-06-23. PMID:19251054. |
insulin and insulin-like growth factor-1 (igf-1) signaling negatively regulate a member of the forkhead box-containing protein o subfamily (foxo), foxo-1, and associated biological functions. |
2009-06-23 |
2023-08-12 |
Not clear |
| Joo Hyun Lim, Hyo Jung Lee, Myeong Ho Jung, Jihyun Son. Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance. Cellular signalling. vol 21. issue 1. 2009-02-06. PMID:18950706. |
in addition, abnormal activation of c-jun n-terminal kinase (jnk) influences the pepck expression by affecting insulin signaling and forkhead box o (foxo) 1 activity. |
2009-02-06 |
2023-08-12 |
human |
| Hannah Crossland, Dumitru Constantin-Teodosiu, Sheila M Gardiner, Despina Constantin, Paul L Greenhaf. A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle. The Journal of physiology. vol 586. issue 22. 2009-02-04. PMID:18818241. |
therefore, the present study examined the effects of lipopolysaccharide (lps)-induced endotoxaemia on the expression of akt, forkhead box o (foxo) and its downstream targets, to identify any associations between changes in foxo-dependent processes influencing muscle atrophy and insulin resistance during sepsis. |
2009-02-04 |
2023-08-12 |
rat |
| Ina Berniakovich, Mirella Trinei, Massimo Stendardo, Enrica Migliaccio, Saverio Minucci, Paolo Bernardi, Pier Giuseppe Pelicci, Marco Giorgi. p66Shc-generated oxidative signal promotes fat accumulation. The Journal of biological chemistry. vol 283. issue 49. 2009-02-04. PMID:18838380. |
we report that insulin activates the redox enzyme activity of p66(shc) specifically in adipocytes and that p66(shc)-generated ros regulate insulin signaling through multiple mechanisms, including akt phosphorylation, foxo localization, and regulation of selected insulin target genes. |
2009-02-04 |
2023-08-12 |
mouse |
| Tianru Jin, I George Fantus, Jane Su. Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin. Cellular signalling. vol 20. issue 10. 2008-11-14. PMID:18555664. |
insulin and growth factors, on the other hand, control the balance between tcf- and foxo-mediated gene transcription via phosphorylation and nuclear exclusion of foxo proteins. |
2008-11-14 |
2023-08-12 |
human |
| Brian H Lee, Kaveh Ashraf. A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. PLoS genetics. vol 4. issue 10. 2008-11-14. PMID:18846209. |
this extended survival was reminiscent of that seen in daf-2 insulin-signaling deficient mutants and was ultimately dependent on daf-16, which encodes a foxo transcription factor whose activity is inhibited by insulin signaling. |
2008-11-14 |
2023-08-12 |
caenorhabditis_elegans |
| Jamie M Kramer, Jennifer D Slade, Brian E Stavele. foxo is required for resistance to amino acid starvation in Drosophila. Genome. vol 51. issue 8. 2008-10-17. PMID:18650956. |
under conditions of low insulin, the foxo family of transcription factors are activated. |
2008-10-17 |
2023-08-12 |
drosophila_melanogaster |
| Dae Hyun Kim, Ji Young Kim, Byung Pal Yu, Hae Young Chun. The activation of NF-kappaB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. Biogerontology. vol 9. issue 1. 2008-08-05. PMID:17972158. |
treatment of the cell with insulin led to nf-kappab activation through the phosphorylation of foxo via the pi3k/akt pathway. |
2008-08-05 |
2023-08-12 |
rat |
| E L Greer, A Brune. FOXO transcription factors in ageing and cancer. Acta physiologica (Oxford, England). vol 192. issue 1. 2008-07-11. PMID:18171426. |
the signalling pathway connecting insulin and foxo transcription factors provides the most compelling example for a conserved genetic pathway at the interface between ageing and cancer. |
2008-07-11 |
2023-08-12 |
Not clear |
| Dervis A M Salih, Anne Brune. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Current opinion in cell biology. vol 20. issue 2. 2008-07-07. PMID:18394876. |
foxo factors are key downstream targets of insulin, growth factor, nutrient, and oxidative stress stimuli that coordinate a wide range of cellular outputs. |
2008-07-07 |
2023-08-12 |
Not clear |
| Cheolho Sim, David L Denlinge. Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 18. 2008-05-28. PMID:18448677. |
insulin signaling and foxo regulate the overwintering diapause of the mosquito culex pipiens. |
2008-05-28 |
2023-08-12 |
caenorhabditis_elegans |