| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheolho Sim, David L Denlinge. Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 18. 2008-05-28. PMID:18448677. |
we suggest that insulin signaling and foxo (forkhead transcription factor), a downstream molecule in the insulin signaling pathway, mediate the diapause response. |
2008-05-28 |
2023-08-12 |
caenorhabditis_elegans |
| Cheolho Sim, David L Denlinge. Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 18. 2008-05-28. PMID:18448677. |
when dsrna directed against foxo was injected into mosquitoes programmed for diapause (reared under short day lengths) fat storage was dramatically reduced and the mosquito's lifespan was shortened, results suggesting that a shutdown of insulin signaling prompts activation of the downstream gene foxo, leading to the diapause phenotype. |
2008-05-28 |
2023-08-12 |
caenorhabditis_elegans |
| B M Th Burgerin. A brief introduction to FOXOlogy. Oncogene. vol 27. issue 16. 2008-04-25. PMID:18391968. |
multiple signal transduction pathways regulate foxo function, but most importantly, they are negatively regulated by protein kinase b (pkb/akt)-mediated phosphorylation and constitute, therefore, an important downstream component of insulin signalling. |
2008-04-25 |
2023-08-12 |
Not clear |
| D R Calnan, A Brune. The FoxO code. Oncogene. vol 27. issue 16. 2008-04-25. PMID:18391970. |
foxo transcription factors translate a variety of environmental stimuli, including insulin, growth factors, nutrients and oxidative stress, into specific gene-expression programs. |
2008-04-25 |
2023-08-12 |
Not clear |
| Michel L Tremblay, Vincent Giguèr. Phosphatases at the heart of FoxO metabolic control. Cell metabolism. vol 7. issue 2. 2008-04-24. PMID:18249169. |
foxo transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. |
2008-04-24 |
2023-08-12 |
Not clear |
| Kieran F Harvey, Jaakko Mattila, Avi Sofer, F Christian Bennett, Matthew R Ramsey, Leif W Ellisen, Oscar Puig, Iswar K Harihara. FOXO-regulated transcription restricts overgrowth of Tsc mutant organs. The Journal of cell biology. vol 180. issue 4. 2008-04-07. PMID:18299344. |
foxo is thought to function as a repressor of growth that is, in turn, inhibited by insulin signaling. |
2008-04-07 |
2023-08-12 |
drosophila_melanogaster |
| Yanmei Zhang, Jinling Xu, Cristina Puscau, Yongsoon Kim, Xi Wang, Hena Alam, Patrick J H. Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Developmental biology. vol 315. issue 2. 2008-03-27. PMID:18241854. |
insulin regulates development, metabolism, and lifespan via a conserved pi3k/akt pathway that promotes cytoplasmic sequestration of foxo transcription factors. |
2008-03-27 |
2023-08-12 |
caenorhabditis_elegans |
| Jun Nakae, Yongheng Cao, Miyo Oki, Yasuko Orba, Hirofumi Sawa, Hiroshi Kiyonari, Kristy Iskandar, Koji Suga, Marc Lombes, Yoshitake Hayash. Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure. Diabetes. vol 57. issue 3. 2008-03-21. PMID:18162510. |
forkhead box-containing protein o subfamily (foxo) 1 mediates insulin action at the transcriptional level. |
2008-03-21 |
2023-08-12 |
Not clear |
| Terhi Vihervaara, Oscar Pui. dFOXO regulates transcription of a Drosophila acid lipase. Journal of molecular biology. vol 376. issue 5. 2008-03-14. PMID:18234213. |
our results suggest an additional role for foxo transcription factors: the regulation of lipid homeostasis by insulin. |
2008-03-14 |
2023-08-12 |
human |
| Yan G Ni, Na Wang, Dian J Cao, Nita Sachan, David J Morris, Robert D Gerard, Makoto Kuro-O, Beverly A Rothermel, Joseph A Hil. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 51. 2008-01-28. PMID:18077353. |
foxo transcription factors activate akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. |
2008-01-28 |
2023-08-12 |
Not clear |
| Yan G Ni, Na Wang, Dian J Cao, Nita Sachan, David J Morris, Robert D Gerard, Makoto Kuro-O, Beverly A Rothermel, Joseph A Hil. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 51. 2008-01-28. PMID:18077353. |
acting through the pi3k/akt pathway, insulin and insulin-like growth factor-1 (igf-1) inactivate foxo transcription factors, a class of highly conserved proteins important in numerous physiological functions. |
2008-01-28 |
2023-08-12 |
Not clear |
| Yan G Ni, Na Wang, Dian J Cao, Nita Sachan, David J Morris, Robert D Gerard, Makoto Kuro-O, Beverly A Rothermel, Joseph A Hil. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 51. 2008-01-28. PMID:18077353. |
however, even as foxo is a downstream target of insulin, foxo factors also control upstream signaling elements governing insulin sensitivity and glucose metabolism. |
2008-01-28 |
2023-08-12 |
Not clear |
| Yan G Ni, Na Wang, Dian J Cao, Nita Sachan, David J Morris, Robert D Gerard, Makoto Kuro-O, Beverly A Rothermel, Joseph A Hil. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 51. 2008-01-28. PMID:18077353. |
taken together, this study demonstrates that changes in foxo activity have a dose-responsive repressive effect on insulin signaling in cardiomyocytes through inhibition of protein phosphatases, which leads to altered akt activation, reduced insulin sensitivity, and impaired glucose metabolism. |
2008-01-28 |
2023-08-12 |
Not clear |
| Xiangzhong Zheng, Zhaohai Yang, Zhifeng Yue, John D Alvarez, Amita Sehga. FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 40. 2007-11-27. PMID:17895391. |
foxo and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. |
2007-11-27 |
2023-08-12 |
Not clear |
| Tadahiro Kitamur. [Role of FoxO proteins in insulin signaling]. Seikagaku. The Journal of Japanese Biochemical Society. vol 79. issue 8. 2007-10-30. PMID:17877026. |
[role of foxo proteins in insulin signaling]. |
2007-10-30 |
2023-08-12 |
Not clear |
| Adnan Ero. Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 29. issue 8. 2007-10-12. PMID:17621670. |
in the presence of insulin, foxo proteins are localized from the nucleus to the cytoplasm and degraded. |
2007-10-12 |
2023-08-12 |
Not clear |
| Alistair V W Nunn, Jimmy Bell, Philip Barte. The integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balance. Nuclear receptor. vol 5. issue 1. 2007-07-31. PMID:17531095. |
ways in which ppars may reduce oxidative stress involve modulation of mitochondrial uncoupling protein (ucp) expression (thus reducing reactive oxygen species, ros), optimising forkhead box class o factor (foxo) activity (by improving whole body insulin sensitivity) and suppressing nfkb (at the transcriptional level). |
2007-07-31 |
2023-08-12 |
Not clear |
| Mourad Naïmi, Nadine Gautier, Claire Chaussade, Angela M Valverde, Domenico Accili, Emmanuel Van Obberghe. Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes. Endocrinology. vol 148. issue 5. 2007-06-04. PMID:17303659. |
insulin inhibits forkhead o class (foxo) transcription factors, which down-regulate the expression of genes involved in metabolism, cell cycle arrest, and apoptosis. |
2007-06-04 |
2023-08-12 |
Not clear |
| Michal Armoni, Chava Harel, Eddy Karniel. Transcriptional regulation of the GLUT4 gene: from PPAR-gamma and FOXO1 to FFA and inflammation. Trends in endocrinology and metabolism: TEM. vol 18. issue 3. 2007-05-23. PMID:17317207. |
in these tissues, the peroxisome proliferator-activated receptor (ppar) family of nuclear receptors and the winged-helix-forkhead box class o (foxo) family of factors are two key families of transcription factors that regulate glucose homeostasis and insulin responsiveness. |
2007-05-23 |
2023-08-12 |
Not clear |
| Wendy B Iser, Minaxi S Gami, Catherine A Wolko. Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs. Developmental biology. vol 303. issue 2. 2007-04-26. PMID:17257591. |
several studies have shown that insulin signaling affects lifespan in an endocrine-like manner from different cells, while the major downstream target of insulin, the foxo transcription factor encoded by daf-16, may act preferentially in intestinal cells to prolong lifespan. |
2007-04-26 |
2023-08-12 |
caenorhabditis_elegans |