| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marieke A G Essers, Lydia M M de Vries-Smits, Nick Barker, Paulien E Polderman, Boudewijn M T Burgering, Hendrik C Korswage. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science (New York, N.Y.). vol 308. issue 5725. 2005-06-01. PMID:15905404. |
here, we report an evolutionarily conserved interaction of beta-catenin with foxo transcription factors, which are regulated by insulin and oxidative stress signaling. |
2005-06-01 |
2023-08-12 |
caenorhabditis_elegans |
| Tomoshige Kino, Massimo U De Martino, Evangelia Charmandari, Takamasa Ichijo, Taoufik Outas, George P Chrouso. HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients. Diabetes. vol 54. issue 1. 2005-04-14. PMID:15616007. |
hiv-1 accessory protein vpr inhibits the effect of insulin on the foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of hiv-1-infected patients. |
2005-04-14 |
2023-08-12 |
Not clear |
| Tomoshige Kino, Massimo U De Martino, Evangelia Charmandari, Takamasa Ichijo, Taoufik Outas, George P Chrouso. HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients. Diabetes. vol 54. issue 1. 2005-04-14. PMID:15616007. |
moreover, vpr antagonized insulin-induced suppression of the mrna expression of the glucose 6-phosphatase, manganese superoxide dismutase, and sterol carrier protein 2 genes, which are known targets of insulin and foxo, in hepg2 cells. |
2005-04-14 |
2023-08-12 |
Not clear |
| Martin A Jünger, Felix Rintelen, Hugo Stocker, Jonathan D Wasserman, Mátyás Végh, Thomas Radimerski, Michael E Greenberg, Ernst Hafe. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. Journal of biology. vol 2. issue 3. 2004-12-14. PMID:12908874. |
the drosophila forkhead transcription factor foxo mediates the reduction in cell number associated with reduced insulin signaling. |
2004-12-14 |
2023-08-12 |
caenorhabditis_elegans |
| Martin A Jünger, Felix Rintelen, Hugo Stocker, Jonathan D Wasserman, Mátyás Végh, Thomas Radimerski, Michael E Greenberg, Ernst Hafe. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. Journal of biology. vol 2. issue 3. 2004-12-14. PMID:12908874. |
forkhead transcription factors belonging to the foxo subfamily are negatively regulated by protein kinase b (pkb) in response to signaling by insulin and insulin-like growth factor in caenorhabditis elegans and mammals. |
2004-12-14 |
2023-08-12 |
caenorhabditis_elegans |
| Tomoshige Kino, George P Chrouso. Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? Annals of the New York Academy of Sciences. vol 1024. 2004-08-13. PMID:15265780. |
since the foxo proteins function as negative transcription factors for insulin, vpr may cause resistance of tissues to insulin. |
2004-08-13 |
2023-08-12 |
human |
| Tomoshige Kino, George P Chrouso. Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? Annals of the New York Academy of Sciences. vol 1024. 2004-08-13. PMID:15265780. |
through these two newly identified functions of vpr, namely, coactivation of glucocorticoid receptor activity and inhibition of insulin effects on foxo proteins, vpr may participate in the development of aids-related insulin resistance/lipodystrophy syndrome. |
2004-08-13 |
2023-08-12 |
human |
| Dae Sung Hwangbo, Boris Gershman, Boris Gersham, Meng-Ping Tu, Michael Palmer, Marc Tata. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature. vol 429. issue 6991. 2004-06-24. PMID:15175753. |
caenorhabditis elegans lifespan is also extended when insulin signalling is inhibited in certain tissues, or when repressed in adult worms, and this requires the forkhead transcription factor (foxo) encoded by daf-16 (ref. |
2004-06-24 |
2023-08-12 |
caenorhabditis_elegans |
| Hye-Sook Kwon, Boli Huang, Terry G Unterman, Robert A Harri. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. Diabetes. vol 53. issue 4. 2004-05-20. PMID:15047604. |
insulin suppresses the hpdk4 induction by glucocorticoids through inactivation of the foxo factors. |
2004-05-20 |
2023-08-12 |
human |
| Anne Brunet, Lora B Sweeney, J Fitzhugh Sturgill, Katrin F Chua, Paul L Greer, Yingxi Lin, Hien Tran, Sarah E Ross, Raul Mostoslavsky, Haim Y Cohen, Linda S Hu, Hwei-Ling Cheng, Mark P Jedrychowski, Steven P Gygi, David A Sinclair, Frederick W Alt, Michael E Greenber. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (New York, N.Y.). vol 303. issue 5666. 2004-04-22. PMID:14976264. |
we show that in mammalian cells, the sir2 homolog sirt1 appears to control the cellular response to stress by regulating the foxo family of forkhead transcription factors, a family of proteins that function as sensors of the insulin signaling pathway and as regulators of organismal longevity. |
2004-04-22 |
2023-08-12 |
Not clear |
| Wen-Chi Tsai, Nisan Bhattacharyya, Li-Ying Han, John A Hanover, Matthew M Rechle. Insulin inhibition of transcription stimulated by the forkhead protein Foxo1 is not solely due to nuclear exclusion. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:14500580. |
the foxo family of forkhead transcription factors stimulates the transcription of target genes involved in many fundamental cell processes, including cell survival, cell cycle progression, dna repair, and insulin sensitivity. |
2004-01-05 |
2023-08-12 |
mouse |
| Wen-Chi Tsai, Nisan Bhattacharyya, Li-Ying Han, John A Hanover, Matthew M Rechle. Insulin inhibition of transcription stimulated by the forkhead protein Foxo1 is not solely due to nuclear exclusion. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:14500580. |
the activity of foxo proteins is principally regulated by activation of protein kinase b (pkb)/akt by insulin and other cytokines. |
2004-01-05 |
2023-08-12 |
mouse |
| Wen-Chi Tsai, Nisan Bhattacharyya, Li-Ying Han, John A Hanover, Matthew M Rechle. Insulin inhibition of transcription stimulated by the forkhead protein Foxo1 is not solely due to nuclear exclusion. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:14500580. |
similar results were obtained using reporter plasmids containing the rat igf-binding protein-1 promoter or a minimal promoter with three copies of the insulin response element to which foxo proteins bind. |
2004-01-05 |
2023-08-12 |
mouse |
| Jamie M Kramer, Jason T Davidge, Joseph M Lockyer, Brian E Stavele. Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC developmental biology. vol 3. 2003-12-01. PMID:12844367. |
the foxo (forkhead box, sub-group "o") transcription factors regulate cellular processes under conditions of low levels of insulin signaling. |
2003-12-01 |
2023-08-12 |
caenorhabditis_elegans |
| J Julie Kim, Hugh S Taylor, G Eda Akbas, Isabelle Foucher, Alain Trembleau, Randal C Jaffe, Asgerally T Fazleabas, Terry G Unterma. Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells. Biology of reproduction. vol 68. issue 1. 2003-08-08. PMID:12493691. |
fkhr, a foxo forkhead transcription factor, stimulates igfbp-1 promoter activity in liver cells through the insulin response sequences (irss). |
2003-08-08 |
2023-08-12 |
human |
| Xiaohui Zhang, Lixia Gan, Haiyun Pan, Shaodong Guo, Xiaowei He, Steven T Olson, Andrew Mesecar, Stephen Adam, Terry G Unterma. Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. The Journal of biological chemistry. vol 277. issue 47. 2003-01-07. PMID:12228231. |
fkhr is a member of the foxo subfamily of forkhead transcription factors, which are important targets for insulin and growth factor signaling. |
2003-01-07 |
2023-08-12 |
Not clear |