| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evzen Boura, Jan Silhan, Petr Herman, Jaroslav Vecer, Miroslav Sulc, Jan Teisinger, Veronika Obsilova, Tomas Obsi. Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding. The Journal of biological chemistry. vol 282. issue 11. 2007-04-24. PMID:17244620. |
the wing w2 of foxo factors contains a 14-3-3 protein-binding motif that is phosphorylated by protein kinase b in response to insulin or growth factors. |
2007-04-24 |
2023-08-12 |
Not clear |
| Ghislaine Schweizer-Groyer, Guillaume Fallot, Françoise Cadepond, Christelle Girard, André Groye. The cAMP-responsive unit of the human insulin-like growth factor-binding protein-1 coinstitutes a functional insulin-response element. Annals of the New York Academy of Sciences. vol 1091. 2007-03-28. PMID:17341623. |
in this work, using human hepg2 hepatoma cells as a model system, we showed: (1) that insulin inhibited both basal and camp-induced higfbp-1 promoter (nt-1 to -341) activity; (2) that in the absence of insulin, forkhead box class o (foxo) transcription factors enhance constitutive higfbp-1 promoter activity without interfering with the stimulatory effect of camp; (3) that pi-3' kinase signaling is involved in the inhibition of constitutive and camp-induced promoter activities by insulin; (4) that wild-type foxo-1 mediates the inhibitory effect of insulin on the promoter, although foxo-1(ala3), a nonphosphorylatable mutant of foxo-1, does not; (5) that the camp-responsive unit (cru), that includes a putative ire (nt-265 to -282) and a camp responsive element (cre; nt-258 to -263), is sufficient per se to mediate both camp stimulation of a heterologous promoter, and inhibition of both basal and camp-induced promoter activities by insulin; and (6) that the inhibitory effects of insulin on the isolated cru are mediated by the foxos. |
2007-03-28 |
2023-08-12 |
human |
| Catherine Mounier, Barry I Posne. Transcriptional regulation by insulin: from the receptor to the gene. Canadian journal of physiology and pharmacology. vol 84. issue 7. 2007-03-16. PMID:16998535. |
foxo, sterol-response-element-binding protein family (srebp), and sp1) involved in the regulation of gene transcription by insulin. |
2007-03-16 |
2023-08-12 |
Not clear |
| Siobhan Anton, Laura Melville, Graham Ren. Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin. Cellular signalling. vol 19. issue 2. 2007-02-27. PMID:16950602. |
these results indicate that egcg exerts its insulin mimetic effects at least in part by phosphorylation of the foxos through a mechanism that is similar but not identical to insulin and igf-1 induced foxo phosphorylation. |
2007-02-27 |
2023-08-12 |
Not clear |
| Hiroshi Onuma, Beth T Vander Kooi, Jared N Boustead, James K Oeser, Richard M O'Brie. Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin. Molecular endocrinology (Baltimore, Md.). vol 20. issue 11. 2007-02-12. PMID:16840535. |
surprisingly, an analysis of insulin action mediated through the g6pase and igf binding protein-1 irss in the context of a heterologous thymidine kinase promoter reveals that signaling through the latter does not support the accepted model for insulin-stimulated foxo nuclear exclusion. |
2007-02-12 |
2023-08-12 |
Not clear |
| Shaodong Guo, Sarah L Dunn, Morris F Whit. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Molecular endocrinology (Baltimore, Md.). vol 20. issue 12. 2007-02-07. PMID:16916938. |
we used wild-type mouse embryo fibroblasts (mefs)-and irs1(-/-) or irs2(-/-) mefs-to establish the relation between irs1, irs2, and foxo during insulin signaling. |
2007-02-07 |
2023-08-12 |
mouse |
| Shaodong Guo, Sarah L Dunn, Morris F Whit. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Molecular endocrinology (Baltimore, Md.). vol 20. issue 12. 2007-02-07. PMID:16916938. |
pi 3-kinase associated with irs1 and irs2 during insulin stimulation of wt mefs, which strongly promoted akt and foxo phosphorylation, led to foxo nuclear exclusion and degradation. |
2007-02-07 |
2023-08-12 |
mouse |
| Shaodong Guo, Sarah L Dunn, Morris F Whit. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Molecular endocrinology (Baltimore, Md.). vol 20. issue 12. 2007-02-07. PMID:16916938. |
however, insulin failed to activate the akt--> foxo cascade in irs2(-/-) mefs because irs1 expression was reduced in these cells, and p110alpha-pi 3-kinase was inefficiently activated during recruitment by irs1. |
2007-02-07 |
2023-08-12 |
mouse |
| Shaodong Guo, Sarah L Dunn, Morris F Whit. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Molecular endocrinology (Baltimore, Md.). vol 20. issue 12. 2007-02-07. PMID:16916938. |
by contrast, insulin stimulation of irs1(-/-) mefs caused foxo degradation, not only because irs2 expression increased but also because irs2 efficiently activated p110alpha--> akt cascade. |
2007-02-07 |
2023-08-12 |
mouse |
| Shaodong Guo, Sarah L Dunn, Morris F Whit. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Molecular endocrinology (Baltimore, Md.). vol 20. issue 12. 2007-02-07. PMID:16916938. |
importantly, prolonged insulin stimulation restored foxo1 expression in wild-type or irs1(-/-) mefs because irs2 was degraded and irs1 alone failed to activate sufficient p110alpha to promote the akt--> foxo cascade. |
2007-02-07 |
2023-08-12 |
mouse |
| Shaodong Guo, Sarah L Dunn, Morris F Whit. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Molecular endocrinology (Baltimore, Md.). vol 20. issue 12. 2007-02-07. PMID:16916938. |
inhibition of irs2 degradation with rapamycin caused persistent foxo degradation even during prolonged insulin stimulation. |
2007-02-07 |
2023-08-12 |
mouse |
| Hisanori Aoyama, Hiroaki Daitoku, Akiyoshi Fukamiz. Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice. International journal of molecular medicine. vol 18. issue 3. 2006-10-25. PMID:16865227. |
the foxo family of forkhead transcription factor foxo1 (mouse foxo1) is a key regulator that stimulates the expression of gluconeogenic genes in the nucleus but is phosphorylated by akt (also known as protein kinase b; pkb) and translocated to the cytoplasm in response to insulin. |
2006-10-25 |
2023-08-12 |
mouse |
| Young I Kim, Felix N Lee, Woo S Choi, Sarah Lee, Jang H You. Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes. vol 55. issue 8. 2006-10-06. PMID:16873695. |
in the present study, we examined whether insulin's effect on pdk4 expression is impaired in acute insulin-resistant states and, if so, whether this change is accompanied by decreased insulin's effects to stimulate akt and forkhead box class o (foxo) 1 phosphorylation. |
2006-10-06 |
2023-08-12 |
rat |
| Wenwei Zhang, Sandip Patil, Balwant Chauhan, Shaodong Guo, David R Powell, Jamie Le, Angelos Klotsas, Ryan Matika, Xiangshan Xiao, Roberta Franks, Kim A Heidenreich, Mini P Sajan, Robert V Farese, Donna Beer Stolz, Patrick Tso, Seung-Hoi Koo, Marc Montminy, Terry G Unterma. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. The Journal of biological chemistry. vol 281. issue 15. 2006-06-05. PMID:16492665. |
foxo transcription factors are important targets of insulin action. |
2006-06-05 |
2023-08-12 |
mouse |
| Eric L Greer, Anne Brune. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene. vol 24. issue 50. 2005-12-07. PMID:16288288. |
in the presence of insulin and growth factors, foxo proteins are relocalized from the nucleus to the cytoplasm and degraded via the ubiquitin-proteasome pathway. |
2005-12-07 |
2023-08-12 |
human |
| Andreas Barthel, Dieter Schmoll, Terry G Unterma. FoxO proteins in insulin action and metabolism. Trends in endocrinology and metabolism: TEM. vol 16. issue 4. 2005-07-27. PMID:15860415. |
foxo proteins in insulin action and metabolism. |
2005-07-27 |
2023-08-12 |
caenorhabditis_elegans |
| Andreas Barthel, Dieter Schmoll, Terry G Unterma. FoxO proteins in insulin action and metabolism. Trends in endocrinology and metabolism: TEM. vol 16. issue 4. 2005-07-27. PMID:15860415. |
there is increasing evidence that forkhead box 'other' (foxo) proteins, a subgroup of the forkhead transcription factor family, have an important role in mediating the effects of insulin and growth factors on diverse physiological functions, including cell proliferation, apoptosis and metabolism. |
2005-07-27 |
2023-08-12 |
caenorhabditis_elegans |
| Andreas Barthel, Dieter Schmoll, Terry G Unterma. FoxO proteins in insulin action and metabolism. Trends in endocrinology and metabolism: TEM. vol 16. issue 4. 2005-07-27. PMID:15860415. |
studies in mammalian cells reveal that foxo proteins regulate cell cycle progression and promote resistance to oxidative stress; both in vivo and cell culture studies support the concept that foxo proteins have an important role in mediating the effects of insulin on metabolism, including its effects on hepatic glucose production. |
2005-07-27 |
2023-08-12 |
caenorhabditis_elegans |
| Andreas Barthel, Dieter Schmoll, Terry G Unterma. FoxO proteins in insulin action and metabolism. Trends in endocrinology and metabolism: TEM. vol 16. issue 4. 2005-07-27. PMID:15860415. |
this paper provides an overview of studies leading to the identification of foxo proteins as targets of insulin action and the mechanisms mediating the effects of insulin-like signaling on foxo function, emphasizing the role of foxo proteins in mediating the effects of insulin on metabolism. |
2005-07-27 |
2023-08-12 |
caenorhabditis_elegans |
| Lixia Gan, Wenhua Zheng, Jean-Guy Chabot, Terry G Unterman, Remi Quirio. Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. Journal of neurochemistry. vol 93. issue 5. 2005-06-24. PMID:15934941. |
foxo1, a member of the foxo subfamily of forkhead transcription factors, is an important target for insulin and growth factor signaling in the regulation of metabolism, cell cycle and proliferation, and survival in peripheral tissues. |
2005-06-24 |
2023-08-12 |
Not clear |