| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonella Miglietta, Maria Luisa Panno, Francesca Bozzo, Ludovica Gabriel, Claudia Bocc. Insulin can modulate MCF-7 cell response to paclitaxel. Cancer letters. vol 209. issue 2. 2004-07-27. PMID:15159015. |
furthermore, combined administrations of insulin and paclitaxel affected mapk pathway, raf-1 activation and p53 expression levels. |
2004-07-27 |
2023-08-12 |
human |
| Hakan Akca, Selma Yenisoy, Atila Yanikoglu, Osman Nidai Oze. Tumor necrosis factor-alpha-induced accumulation of tumor suppressor protein p53 and cyclin-dependent protein kinase inhibitory protein p21 is inhibited by insulin in ME-180S cells. Clinical chemistry and laboratory medicine. vol 40. issue 8. 2003-07-10. PMID:12392301. |
tumor necrosis factor-alpha-induced accumulation of tumor suppressor protein p53 and cyclin-dependent protein kinase inhibitory protein p21 is inhibited by insulin in me-180s cells. |
2003-07-10 |
2023-08-12 |
human |
| Hakan Akca, Selma Yenisoy, Atila Yanikoglu, Osman Nidai Oze. Tumor necrosis factor-alpha-induced accumulation of tumor suppressor protein p53 and cyclin-dependent protein kinase inhibitory protein p21 is inhibited by insulin in ME-180S cells. Clinical chemistry and laboratory medicine. vol 40. issue 8. 2003-07-10. PMID:12392301. |
however, pretreatment of these cells with insulin inhibits tnf-alpha-dependent cell killing, induction of p53, p21 and apoptosis. |
2003-07-10 |
2023-08-12 |
human |
| A J Barber, M Nakamura, E B Wolpert, C E Reiter, G M Seigel, D A Antonetti, T W Gardne. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11443130. |
the rescue effect of insulin does not appear to be mediated by nf-kappab or p53. |
2001-10-18 |
2023-08-12 |
rat |
| A J Barber, M Nakamura, E B Wolpert, C E Reiter, G M Seigel, D A Antonetti, T W Gardne. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11443130. |
p53 and akt were examined by immunoblotting after serum deprivation and insulin treatment, and caspase-3 activation was examined by immunocytochemistry. |
2001-10-18 |
2023-08-12 |
rat |
| M C Dugan, F H Sarka. Current concepts in pancreatic cancer: symposium summary. Pancreas. vol 17. issue 4. 1999-01-19. PMID:9821173. |
among the findings: peptic ulcer disease is a significant predisposing risk factor (odds ratio = 3.9) for pancreatic cancer; as many as 50% of all intraductal papillary mucinous neoplasms are associated with invasive adenocarcinomas; alteration of gene expression via methylation of a gene promotor region constitutes a potentially reversible method of tumor suppressor gene inactivation; > 400 transcriptional alterations of gene expression have been identified for pancreatic cancer; some common molecular markers such as p53 and her-2/neu may be related to morphologic alterations of in situ neoplasia and to transcriptional alterations of gene expression rather than mutational events; epidermal growth factor (egf), transforming growth factor beta (tgf-beta), and related molecules may modulate gene transcription via "autocrine" or "paracrine" mechanisms; several cytokines, amylin (islet amyloid polypeptide), and other cachexia factors are responsible for paraneoplastic peripheral insulin resistance, ineffective utilization of glucose, and profound cachexia. |
1999-01-19 |
2023-08-12 |
Not clear |
| Z P Chen, D C Yeun. Regulation of p53 expression in HeLa cells. Biochemistry and molecular biology international. vol 38. issue 3. 1996-10-17. PMID:8829621. |
incubation of hela cells in the presence of insulin results in suppression of p53 expression. |
1996-10-17 |
2023-08-12 |
Not clear |
| Z P Chen, D C Yeun. Regulation of p53 expression in HeLa cells. Biochemistry and molecular biology international. vol 38. issue 3. 1996-10-17. PMID:8829621. |
furthermore, simultaneous presence of both insulin and phosphotyrosine did not result in a greater suppression of the p53 message than when either of the agents was acting singly. |
1996-10-17 |
2023-08-12 |
Not clear |
| K Pavelic, R Hrascan, S Kapitanovic, Z Vranes, T Cabrijan, S Spaventi, M Korsic, S Krizanac, Y Q Li, P Stambrook, J L Gluckman, Z P Paveli. Molecular genetics of malignant insulinoma. Anticancer research. vol 16. issue 4A. 1996-09-10. PMID:8712689. |
also analyzed was the expression of the growth factors tgf-alpha, egf, and insulin as well as the egf receptor (egf-r), p53 and the putative anti-metastasis gene nm23-h1. |
1996-09-10 |
2023-08-12 |
Not clear |
| A M Rampalli, P S Zelenk. Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 6. issue 8. 1996-02-20. PMID:8547223. |
to explore the mechanism of the action of insulin as a survival factor for 6-day embryonic lens explants, we compared the pattern of cell cycle markers (c-fos, c-jun, c-myc, p53, histone h3, thymidine kinase, and cyclin b) in both apoptotic and differentiating lens explants. |
1996-02-20 |
2023-08-12 |
chicken |
| K Tsuji, K Ogaw. Recovery from ultraviolet-induced growth arrest of primary rat hepatocytes by p53 antisense oligonucleotide treatment. Molecular carcinogenesis. vol 9. issue 3. 1994-05-04. PMID:8142018. |
when primary neonatal rat hepatocytes were exposed to a nonlethal dose of ultraviolet light, actinomycin d, or mitomycin c, most cells expressed abundant p53 with an abnormally extended half life in their nuclei, and their growth was arrested despite treatment with growth factors (epidermal growth factor and insulin). |
1994-05-04 |
2023-08-12 |
rat |