| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Babak Razani, Chu Feng, Clay F Semenkovic. p53 is required for chloroquine-induced atheroprotection but not insulin sensitization. Journal of lipid research. vol 51. issue 7. 2010-10-18. PMID:20208057. |
however, chloroquine improved glucose tolerance, enhanced insulin sensitivity, and increased hepatic akt signaling regardless of the p53 genotype. |
2010-10-18 |
2023-08-12 |
mouse |
| Adnan Ero. Unraveling the molecular mechanisms behind the metabolic basis of sporadic Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19221404. |
peripheral insulin resistance related intense interactions between jnk, gsk3, foxo factors, and p53, which may lead to apoptotic neuronal death, are outlined in a postulate. |
2009-12-16 |
2023-08-12 |
Not clear |
| Yifat Merbl, Royi Itzchak, Tal Vider-Shalit, Yoram Louzoun, Francisco J Quintana, Ezra Vadai, Lea Eisenbach, Irun R Cohe. A systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice. PloS one. vol 4. issue 6. 2009-11-17. PMID:19557135. |
the informative patterns included autoantibodies binding to self-molecules not known to be tumor-associated antigens (including insulin, dna, myosin, fibrinogen) as well as to known tumor-associated antigens (including p53, cytokeratin, carbonic anhydrases, tyrosinase). |
2009-11-17 |
2023-08-12 |
mouse |
| Ida Autiero, Susan Costantini, Giovanni Colonn. Human sirt-1: molecular modeling and structure-function relationships of an unordered protein. PloS one. vol 4. issue 10. 2009-11-03. PMID:19806227. |
sirt-1 down-regulates p53 activity, rising lifespan, and cell survival; it also deacetylases peroxisome proliferator-activated receptor-gamma (ppar-gamma) and its coactivator 1 alpha (pgc-1alpha), promoting lipid mobilization, positively regulating insulin secretion, and increasing mitochondrial dimension and number. |
2009-11-03 |
2023-08-12 |
human |
| Tohru Minamino, Masayuki Orimo, Ippei Shimizu, Takeshige Kunieda, Masataka Yokoyama, Takashi Ito, Aika Nojima, Akira Nabetani, Yuichi Oike, Hisahiro Matsubara, Fuyuki Ishikawa, Issei Komur. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nature medicine. vol 15. issue 9. 2009-10-02. PMID:19718037. |
a crucial role for adipose tissue p53 in the regulation of insulin resistance. |
2009-10-02 |
2023-08-12 |
mouse |
| Tohru Minamino, Masayuki Orimo, Ippei Shimizu, Takeshige Kunieda, Masataka Yokoyama, Takashi Ito, Aika Nojima, Akira Nabetani, Yuichi Oike, Hisahiro Matsubara, Fuyuki Ishikawa, Issei Komur. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nature medicine. vol 15. issue 9. 2009-10-02. PMID:19718037. |
here we show that p53 expression in adipose tissue is crucially involved in the development of insulin resistance, which underlies age-related cardiovascular and metabolic disorders. |
2009-10-02 |
2023-08-12 |
mouse |
| Tohru Minamino, Masayuki Orimo, Ippei Shimizu, Takeshige Kunieda, Masataka Yokoyama, Takashi Ito, Aika Nojima, Akira Nabetani, Yuichi Oike, Hisahiro Matsubara, Fuyuki Ishikawa, Issei Komur. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nature medicine. vol 15. issue 9. 2009-10-02. PMID:19718037. |
inhibition of p53 activity in adipose tissue markedly ameliorated these senescence-like changes, decreased the expression of proinflammatory cytokines and improved insulin resistance in mice with type 2 diabetes-like disease. |
2009-10-02 |
2023-08-12 |
mouse |
| Tohru Minamino, Masayuki Orimo, Ippei Shimizu, Takeshige Kunieda, Masataka Yokoyama, Takashi Ito, Aika Nojima, Akira Nabetani, Yuichi Oike, Hisahiro Matsubara, Fuyuki Ishikawa, Issei Komur. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nature medicine. vol 15. issue 9. 2009-10-02. PMID:19718037. |
conversely, upregulation of p53 in adipose tissue caused an inflammatory response that led to insulin resistance. |
2009-10-02 |
2023-08-12 |
mouse |
| Tohru Minamino, Masayuki Orimo, Ippei Shimizu, Takeshige Kunieda, Masataka Yokoyama, Takashi Ito, Aika Nojima, Akira Nabetani, Yuichi Oike, Hisahiro Matsubara, Fuyuki Ishikawa, Issei Komur. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nature medicine. vol 15. issue 9. 2009-10-02. PMID:19718037. |
our results show a previously unappreciated role of adipose tissue p53 expression in the regulation of insulin resistance and suggest that cellular aging signals in adipose tissue could be a new target for the treatment of diabetes (pages 996-967). |
2009-10-02 |
2023-08-12 |
mouse |
| Francisco J Alcaín, José M Villalb. Sirtuin activators. Expert opinion on therapeutic patents. vol 19. issue 4. 2009-07-27. PMID:19441923. |
sirt1 down-regulates p53 activity, increasing lifespan, cell survival, and neuroprotection; it also deacetylates peroxisome proliferator-activated receptor-gamma and its coactivator 1alpha, promoting fat mobilization, increasing mitochondrial size and number, and positively regulating insulin secretion. |
2009-07-27 |
2023-08-12 |
Not clear |
| Martha L Slattery, Roger K Wolff, Karen Curtin, Frank Fitzpatrick, Jennifer Herrick, John D Potter, Bette J Caan, Wade S Samowit. Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. Mutation research. vol 660. issue 1-2. 2009-03-24. PMID:18992263. |
using data from a large study of colon cancer, we examine genetic variants in insulin, inflammation, estrogen, metabolizing enzymes, and energy homeostasis genes to explore associations with microsatellite instability (msi), cpg island methylator phenotype (cimp), mutations of p53 in exons 5 through 8, and mutations in codons 12 and 13 of ki-ras. |
2009-03-24 |
2023-08-12 |
Not clear |
| Rasoul Nourizadeh-Lillabadi, Jan L Lyche, Camilla Almaas, Benedicte Stavik, S Jannicke Moe, Mona Aleksandersen, Vidar Berg, Kjetill S Jakobsen, Nils Chr Stenseth, Janneche Utne Skåre, Peter Alestrøm, Erik Ropsta. Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP). Journal of toxicology and environmental health. Part A. vol 72. issue 3-4. 2009-02-25. PMID:19184727. |
the transcriptomics changes included (1) key regulator genes for steroid and thyroid hormone functions (cga, ncoa3), (2) insulin signaling and metabolic homeostasis (pik3r1, pfkfb3, ptb1), and (3) p53 activation (mdm4). |
2009-02-25 |
2023-08-12 |
human |
| Rijin Xiao, Ying Su, Rosalia C M Simmen, Frank A Simme. Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 4. 2008-05-22. PMID:18239060. |
spi consumption resulted in decreased serum insulin levels and decreased azoxymethane-induced tumor suppressor p53 phosphorylation in colon crypt epithelium. |
2008-05-22 |
2023-08-12 |
rat |
| Shin Yuen Nam, Ming Kei Lee, Kanaga Sabapath. The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation. The Journal of physiology. vol 586. issue 2. 2008-04-23. PMID:18006584. |
we have therefore utilized an established mouse model for diabetes in which the mhc class i antigen is overexpressed in pancreatic beta cells under the rat insulin promoter, to investigate the role of p53. |
2008-04-23 |
2023-08-12 |
mouse |
| S M Mense, A Sengupta, M Zhou, C Lan, G Bentsman, D J Volsky, L Zhan. Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiological genomics. vol 25. issue 3. 2007-11-08. PMID:16507782. |
furthermore, gene ontology and computational algorithms revealed that many target genes of the egf and insulin signaling pathways and the transcriptional regulators myc, jun, and p53 were selectively altered by hypoxia in astrocytes. |
2007-11-08 |
2023-08-12 |
human |
| Lars Adamson, Erik Walu. Insulin and IGF-1 mediated inhibition of apoptosis in CHO cells grown in suspension in a protein-free medium. Alternatives to laboratory animals : ATLA. vol 35. issue 3. 2007-09-19. PMID:17650954. |
at the highest concentrations of igf-1 and insulin, the expression of ice, bcl-2 and bax was fully suppressed, whereas the p53 product level increased, despite still being detectable in a minority of cells. |
2007-09-19 |
2023-08-12 |
Not clear |
| Alain Beliveau, Paul Yaswe. Soothing the watchman: telomerase reduces the p53-dependent cellular stress response. Cell cycle (Georgetown, Tex.). vol 6. issue 11. 2007-08-09. PMID:17534147. |
this heightened activity of the p53 pathway enhanced the efficiency with which cells arrested growth in response to tgfbeta or to egf or insulin withdrawal, and was abolished by ectopic expression of htert, the catalytic subunit of telomerase. |
2007-08-09 |
2023-08-12 |
human |
| J Rabczynski, H Milnerowicz, M Sliwinska-Mosson, M Jablonowska, S Milneriwicz, W Knast, M Zabe. Hormone-producing serous cystadenoma of the pancreas. Neoplasma. vol 53. issue 6. 2007-03-13. PMID:17167718. |
the test applied to immunohistochemically localize paraffin-embedded sections of neoplastic tissues of the pancreas was the lsab2-hrp test using monoclonal antibodies against epithelial membrane antigen (ema), carcinoembryonic antigen (cea), synaptophysin, p53 and polyclonal antibodies against insulin, glucagon, somatostatin and pancreatic polypeptide. |
2007-03-13 |
2023-08-12 |
Not clear |
| Nataniel Lester-Coll, Enrique J Rivera, Stephanie J Soscia, Kathryn Doiron, Jack R Wands, Suzanne M de la Mont. Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 9. issue 1. 2006-07-28. PMID:16627931. |
the ic-stz-injected rats did not have elevated blood glucose levels, and pancreatic architecture and insulin immunoreactivity were similar to control, yet their brains were reduced in size and exhibited neurodegeneration associated with cell loss, gliosis, and increased immunoreactivity for p53, active glycogen synthase kinase 3beta, phospho-tau, ubiquitin, and amyloid-beta. |
2006-07-28 |
2023-08-12 |
human |
| Suzanne M de la Monte, Jack R Wand. Alzheimer-associated neuronal thread protein mediated cell death is linked to impaired insulin signaling. Journal of Alzheimer's disease : JAD. vol 6. issue 3. 2004-10-07. PMID:15201478. |
in cells that expressed ad7c-ntp, insulin or igf-1 stimulation was associated with reduced viability with increased levels of p53, p21/waf-1, phospho-jnk, and phospho-tau, and reduced levels of bcl-2 and phospho-erk mapk. |
2004-10-07 |
2023-08-12 |
human |