| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandeep Kumar, Kulbhushan Tiko. Independent role of PP2A and mTORc1 in palmitate induced podocyte death. Biochimie. vol 112. 2016-01-08. PMID:25724269. |
interestingly, selective inhibition of pp2a, by okadaic acid at 5 nm, restored insulin induced phosphorylation of akt, foxo1, sirt1 activity and p53 degradation. |
2016-01-08 |
2023-08-13 |
human |
| Hong-Xing Cai, Zheng-Qiu Zhu, Xiao-Ming Sun, Zhou-Ru Li, Yan-Bo Chen, Guo-Kai Don. Gene expression profile of human esophageal squamous carcinoma cell line TE-1. International journal of clinical and experimental medicine. vol 8. issue 8. 2015-11-09. PMID:26550410. |
after bioinformatic analysis of significantly regulated signaling pathways, we found these transcripts may target 35 gene pathways, including p53 signaling, glioma, ubiquitin-mediated proteolysis, insulin signaling, cell cycle, inositol phosphate metabolism, mtor signaling, and mapk signaling. |
2015-11-09 |
2023-08-13 |
human |
| Pooja Ganguly, Niladri Gangul. Transcriptomic analyses of genes differentially expressed by high-risk and low-risk human papilloma virus E6 oncoproteins. Virusdisease. vol 26. issue 3. 2015-09-23. PMID:26396976. |
gene ontology mapping of 44 genes according cellular pathways revealed 13 pathways namely angiogenesis, alzhemier's, wnt, p53, interleukin, tgf-β, cadherin, integrin, pi3-kinase, catennin, insulin, chemokine and g protein signalling pathways. |
2015-09-23 |
2023-08-13 |
human |
| Reza Homayounfar, Mahmood Jeddi-Tehrani, Makan Cheraghpour, Asghar Ghorbani, Hamid Zan. Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin. General and comparative endocrinology. vol 214. 2015-09-04. PMID:25016051. |
relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin. |
2015-09-04 |
2023-08-13 |
human |
| Reza Homayounfar, Mahmood Jeddi-Tehrani, Makan Cheraghpour, Asghar Ghorbani, Hamid Zan. Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin. General and comparative endocrinology. vol 214. 2015-09-04. PMID:25016051. |
this paper aimed to explore the role of p53 in adipose and some other peripheral tissues of a diet-induced obese model and targeted it using pharmacological approach to ameliorate diet-induced insulin resistance. |
2015-09-04 |
2023-08-13 |
human |
| Reza Homayounfar, Mahmood Jeddi-Tehrani, Makan Cheraghpour, Asghar Ghorbani, Hamid Zan. Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin. General and comparative endocrinology. vol 214. 2015-09-04. PMID:25016051. |
interestingly, the systemic inhibition of p53 was in correlation with improving insulin glucose at serum level. |
2015-09-04 |
2023-08-13 |
human |
| Reza Homayounfar, Mahmood Jeddi-Tehrani, Makan Cheraghpour, Asghar Ghorbani, Hamid Zan. Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin. General and comparative endocrinology. vol 214. 2015-09-04. PMID:25016051. |
the present results clearly showed that p53 activation in peripheral tissues was in correlation with decreased insulin action. |
2015-09-04 |
2023-08-13 |
human |
| Reza Homayounfar, Mahmood Jeddi-Tehrani, Makan Cheraghpour, Asghar Ghorbani, Hamid Zan. Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin. General and comparative endocrinology. vol 214. 2015-09-04. PMID:25016051. |
these results indicated p53 activation in the peripheral tissues of obese subjects as a protective mechanism against chronic insulin elevation, suggested that p53 could be a new target for the treatment of type 2 diabetes. |
2015-09-04 |
2023-08-13 |
human |
| Masataka Yokoyama, Sho Okada, Atsushi Nakagomi, Junji Moriya, Ippei Shimizu, Aika Nojima, Yohko Yoshida, Harumi Ichimiya, Naomi Kamimura, Yoshio Kobayashi, Shigeo Ohta, Marcus Fruttiger, Guillermina Lozano, Tohru Minamin. Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity. Cell reports. vol 7. issue 5. 2015-08-21. PMID:24857662. |
mice with endothelial cell-specific p53 deficiency fed a high-calorie diet showed improvement of insulin sensitivity and less fat accumulation, compared with control littermates. |
2015-08-21 |
2023-08-13 |
mouse |
| Natalia Vydra, Agnieszka Toma, Wieslawa Widla. Pleiotropic role of HSF1 in neoplastic transformation. Current cancer drug targets. vol 14. issue 2. 2015-06-22. PMID:24467529. |
hsf1 affects the key cell-survival and regulatory pathways, including p53, ras/mapk, camp/pka, mtor and insulin signaling. |
2015-06-22 |
2023-08-12 |
Not clear |
| Olga V Leontieva, Liliya R Novototskaya, Geraldine M Paszkiewicz, Elena A Komarova, Andrei V Gudkov, Mikhail V Blagosklonn. Dysregulation of the mTOR pathway in p53-deficient mice. Cancer biology & therapy. vol 14. issue 12. 2015-04-20. PMID:24184801. |
our data indicate that the activity of mtor is increased in some but not all tissues of p53(-/-) mice, associated with the tendency to increased insulin and igf-1 levels. |
2015-04-20 |
2023-08-12 |
mouse |
| Yi Liu, Hua Song, Jing Pan, Jing Zha. Comprehensive gene expression analysis reveals multiple signal pathways associated with prostate cancer. Journal of applied genetics. vol 55. issue 1. 2015-04-17. PMID:24154878. |
after pathway and ppi network analysis, we found these hormone-related degs participated in several important signaling pathways including tgf-β (tgfb2, tgfb3 and tgfbr2), mapk (tgfb2, tgfb3 and tgfbr2), insulin (pik3r3, shc1 and eif4ebp1), and p53 signaling pathways (ccnd2 and cdkn1a). |
2015-04-17 |
2023-08-12 |
human |
| Jin-Ying Zhang, Fan Zhang, Chao-Qun Hong, Armando E Giuliano, Xiao-Jiang Cui, Guang-Ji Zhou, Guo-Jun Zhang, Yu-Kun Cu. Critical protein GAPDH and its regulatory mechanisms in cancer cells. Cancer biology & medicine. vol 12. issue 1. 2015-04-10. PMID:25859407. |
several cancer-related factors, such as insulin, hypoxia inducible factor-1 (hif-1), p53, nitric oxide (no), and acetylated histone, not only modulate gapdh gene expression but also affect protein functions via common pathways. |
2015-04-10 |
2023-08-13 |
Not clear |
| F J Ortega, J M Moreno-Navarrete, D Mayas, M Serino, J I Rodriguez-Hermosa, W Ricart, E Luche, R Burcelin, F J Tinahones, G Frühbeck, G Mingrone, J M Fernández-Rea. Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression. International journal of obesity (2005). vol 38. issue 5. 2015-02-02. PMID:23999197. |
the purpose of this study was to investigate the expression of human adipose tissue protein 53 (p53) in subjects who varied widely in terms of obesity and insulin resistance. |
2015-02-02 |
2023-08-12 |
human |
| Jyothi Kumari Posa, Sudhagar Selvaraj, K N Sangeetha, Sarath Kumar Baskaran, B S Lakshm. p53 mediates impaired insulin signaling in 3T3-L1 adipocytes during hyperinsulinemia. Cell biology international. vol 38. issue 7. 2015-01-16. PMID:24604666. |
p53 mediates impaired insulin signaling in 3t3-l1 adipocytes during hyperinsulinemia. |
2015-01-16 |
2023-08-12 |
Not clear |
| Jyothi Kumari Posa, Sudhagar Selvaraj, K N Sangeetha, Sarath Kumar Baskaran, B S Lakshm. p53 mediates impaired insulin signaling in 3T3-L1 adipocytes during hyperinsulinemia. Cell biology international. vol 38. issue 7. 2015-01-16. PMID:24604666. |
the tumor suppressor p53 has emerged as a crucial factor in the metabolic adaptation of cancer cells under nutritional starvation and is being studied in the development of insulin resistance in adipocytes at physiological level. |
2015-01-16 |
2023-08-12 |
Not clear |
| Jyothi Kumari Posa, Sudhagar Selvaraj, K N Sangeetha, Sarath Kumar Baskaran, B S Lakshm. p53 mediates impaired insulin signaling in 3T3-L1 adipocytes during hyperinsulinemia. Cell biology international. vol 38. issue 7. 2015-01-16. PMID:24604666. |
transient knockdown of p53 partially improved insulin sensitivity revealing a novel link between p53 and insulin signaling in adipocytes. |
2015-01-16 |
2023-08-12 |
Not clear |
| Jyothi Kumari Posa, Sudhagar Selvaraj, K N Sangeetha, Sarath Kumar Baskaran, B S Lakshm. p53 mediates impaired insulin signaling in 3T3-L1 adipocytes during hyperinsulinemia. Cell biology international. vol 38. issue 7. 2015-01-16. PMID:24604666. |
the findings suggest that hyperinsulinemia-induced p53 impairs insulin sensitivity in 3t3-l1 adipocytes. |
2015-01-16 |
2023-08-12 |
Not clear |
| Harry F Heijnen, Richard van Wijk, Tamara C Pereboom, Yvonne J Goos, Cor W Seinen, Brigitte A van Oirschot, Rowie van Dooren, Marc Gastou, Rachel H Giles, Wouter van Solinge, Taco W Kuijpers, Hanna T Gazda, Marc B Bierings, Lydie Da Costa, Alyson W MacInne. Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway. PLoS genetics. vol 10. issue 5. 2014-12-15. PMID:24875531. |
while stimulating rp-deficient cells with insulin reduces autophagy, antioxidant treatment reduces s6 kinase phosphorylation, autophagy, and stabilization of the p53 tumor suppressor. |
2014-12-15 |
2023-08-13 |
zebrafish |
| b' P G Trav\\xc3\\xa9s, V Pardo, M Pimentel-Santillana, \\xc3\\x81 Gonz\\xc3\\xa1lez-Rodr\\xc3\\xadguez, M Mojena, D Rico, Y Montenegro, C Cal\\xc3\\xa9s, P Mart\\xc3\\xadn-Sanz, A M Valverde, L Bosc\\xc3\\xa. Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge. Cell death & disease. vol 5. 2014-10-21. PMID:24625984.' |
microarray analysis in samples from wild-type and ptp1b-deficient macrophages obtained after 24 h of pro-inflammatory stimulation showed an activation of the p53 pathway, including the excision base repair pathway and the insulin signaling pathway in the absence of ptp1b. |
2014-10-21 |
2023-08-12 |
mouse |