| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siyuan Feng, Jideng Ma, Keren Long, Jinwei Zhang, Wanling Qiu, Yan Li, Long Jin, Xun Wang, Anan Jiang, Lingyan Liu, Weihang Xiao, Xuewei Li, Qianzi Tang, Mingzhou L. Comparative microRNA Transcriptomes in Domestic Goats Reveal Acclimatization to High Altitude. Frontiers in genetics. vol 11. 2020-09-28. PMID:32849809. |
notably, the interplay between de mirna and de target genes strongly indicated post-transcriptional regulation in the hypoxia inducible factor 1, insulin, and p53 signaling pathways, which might play significant roles in high-altitude acclimatization in domestic goats. |
2020-09-28 |
2023-08-13 |
Not clear |
| Rive Sarfstein, Haim Werne. Tumor suppressor p53 regulates insulin receptor ( Oncotarget. vol 11. issue 25. 2020-07-09. PMID:32637033. |
tumor suppressor p53 regulates insulin receptor ( a significant volume of clinical and epidemiological data provides support to the concept that insulin and the insulin receptor (insr) have an important role in breast cancer. |
2020-07-09 |
2023-08-13 |
human |
| Liang Zheng, Jingting Jiang, Yingting Liu, Xiao Zheng, Changping W. Correlations of recurrence after radical surgery for esophageal cancer with glucose-lipid metabolism, insulin resistance, inflammation, stress and serum p53 expression. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 24. issue 4. 2020-03-04. PMID:31646823. |
correlations of recurrence after radical surgery for esophageal cancer with glucose-lipid metabolism, insulin resistance, inflammation, stress and serum p53 expression. |
2020-03-04 |
2023-08-13 |
Not clear |
| Liang Zheng, Jingting Jiang, Yingting Liu, Xiao Zheng, Changping W. Correlations of recurrence after radical surgery for esophageal cancer with glucose-lipid metabolism, insulin resistance, inflammation, stress and serum p53 expression. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 24. issue 4. 2020-03-04. PMID:31646823. |
to investigate the correlations of recurrence after radical surgery for esophageal cancer with glucose-lipid metabolism, insulin resistance, inflammation, stress and serum p53 expression. |
2020-03-04 |
2023-08-13 |
Not clear |
| Xiaohui Wu, Jun Xu, Jinhu Wang, Weizhong Gu, Chaochun Zo. Childhood adrenocortical tumor: A clinical and immunohistochemical study of 13 cases. Medicine. vol 98. issue 46. 2019-12-06. PMID:31725643. |
immunohistochemistry of vimentin, chromogranin a, s100, synaptophysin, cytokeratin (ck), type 2 3β-hydroxysteroid dehydrogenase (3βhsd), cytochrome p45017α, p53, p21, p27, cyclin d1, ki-67, insulin growth facter-2 (igf-2), and β-catenin were undertaken for 13 tumors and 3 adjacent normal tissues. |
2019-12-06 |
2023-08-13 |
Not clear |
| Srivastav Ranganathan, Samir K Maji, Ranjith Padinhateer. Defining a Physical Basis for Diversity in Protein Self-Assemblies Using a Minimal Model. Journal of the American Chemical Society. vol 138. issue 42. 2019-11-20. PMID:27690405. |
it has been observed that diverse set of proteins (e.g., alpha-synuclein, insulin, tata-box binding protein, sup35, p53), independent of their sequence, native structure, or function could self-assemble into highly ordered structures known as amyloids. |
2019-11-20 |
2023-08-13 |
Not clear |
| Justyna Strycharz, Jozef Drzewoski, Janusz Szemraj, Agnieszka Sliwinsk. Erratum to "Is p53 Involved in Tissue-Specific Insulin Resistance Formation?" Oxidative medicine and cellular longevity. vol 2017. 2019-11-20. PMID:29098064. |
erratum to "is p53 involved in tissue-specific insulin resistance formation?" |
2019-11-20 |
2023-08-13 |
Not clear |
| Hye-Na Cha, Soyoung Park, Yongwook Dan, Jae-Ryong Kim, So-Young Par. Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 74. issue 2. 2019-11-01. PMID:29733327. |
p53 expression was negatively correlated with skeletal muscle insulin sensitivity in old mice. |
2019-11-01 |
2023-08-13 |
mouse |
| Wenyan Fu, Yang Liu, Christina Sun, Hang Yi. Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 1. 2019-08-19. PMID:30052487. |
in aged mice, inducible p53 ablation in differentiated adipocytes restored cold-induced wat beiging and augmented whole-body energy expenditure and insulin sensitivity. |
2019-08-19 |
2023-08-13 |
mouse |
| Wenyan Fu, Yang Liu, Christina Sun, Hang Yi. Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 1. 2019-08-19. PMID:30052487. |
these findings suggest that p53-induced mitophagy in aged white adipocytes impedes wat beiging and may be therapeutically targeted to improve insulin sensitivity in aged wat.-fu, w., liu, y., sun, c., yin, h. transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy. |
2019-08-19 |
2023-08-13 |
mouse |
| Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Le. High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone. Journal of diabetes research. vol 2019. 2019-06-04. PMID:30729133. |
levels of tumor suppressor proteins p53 and cav-1 were downregulated while those of the oncogenic protein as c-myc were upregulated under high glucose and insulin supplementation in hblepc cotreated with pioglitazone and metformin. |
2019-06-04 |
2023-08-13 |
human |
| Justyna Strycharz, Ewa Świderska, Adam Wróblewski, Marta Podolska, Piotr Czarny, Janusz Szemraj, Aneta Balcerczyk, Józef Drzewoski, Jacek Kasznicki, Agnieszka Śliwińsk. Hyperglycemia Affects miRNAs Expression Pattern during Adipogenesis of Human Visceral Adipocytes-Is Memorization Involved? Nutrients. vol 10. issue 11. 2019-01-23. PMID:30445791. |
bioinformatics analysis revealed the involvement of these micrornas in cell cycles, lipid metabolism, ecm⁻receptor interaction, oxidative stress, signaling of insulin, mapk, tgf-β, p53, and more. |
2019-01-23 |
2023-08-13 |
human |
| Wenhu Zhang, Shaozhuang Liu, Hanxiang Zhan, Zhibo Yan, Guangyong Zhan. Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30106143. |
genes in cluster 1 were significantly involved in metabolism of xenobiotics by cytochrome p450, genes in cluster 2 were majorly involved in apoptosis, tight junction formation, and platelet activation, genes in cluster 3 were primarily enriched in the p53 signaling pathway and genes in cluster 4 were significantly enriched in the insulin resistance pathway. |
2019-01-09 |
2023-08-13 |
Not clear |
| Zhibin Yan, Xiaokang Miao, Bangzhi Zhang, Junqiu Xi. p53 as a double-edged sword in the progression of non-alcoholic fatty liver disease. Life sciences. vol 215. 2018-12-11. PMID:30473026. |
in this review, the crosstalk among p53, lipid metabolism, insulin resistance, inflammation and oxidative stress in nafld is discussed, and we suggest that a better understanding of p53 would present a promising potential new strategy for nafld prevention and treatment. |
2018-12-11 |
2023-08-13 |
Not clear |
| Qi Wang, Yafeng Zheng, Weijing Zhuang, Xu Lu, Xianliang Luo, Baodong Zhen. Genome-wide transcriptional changes in type 2 diabetic mice supplemented with lotus seed resistant starch. Food chemistry. vol 264. 2018-10-02. PMID:29853397. |
the analysis results of gene ontology (go) functions and kyoto encyclopedia of genes and genomes (kegg) pathways indicated that the protective effect of lsrs supplementation was most likely driven by modulating expression levels of various key factors involved in insulin secretion, insulin signal transmission, cell apoptosis, antioxidant activity and p53 signaling pathways. |
2018-10-02 |
2023-08-13 |
mouse |
| Jordi Blanco, Sarah Tomás-Hernández, Tania García, Miquel Mulero, Mercedes Gómez, Jose L Domingo, Domènec J Sánche. Oral exposure to silver nanoparticles increases oxidative stress markers in the liver of male rats and deregulates the insulin signalling pathway and p53 and cleaved caspase 3 protein expression. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 115. 2018-08-16. PMID:29604305. |
oral exposure to silver nanoparticles increases oxidative stress markers in the liver of male rats and deregulates the insulin signalling pathway and p53 and cleaved caspase 3 protein expression. |
2018-08-16 |
2023-08-13 |
rat |
| Ping Peng, Chunling Ma, Shumei Wan, Wensheng Jin, Yan Gao, Tianqing Huang, Qi Cheng, Changlan Y. Inhibition of p53 Relieves Insulin Resistance in Fetal Growth Restriction Mice with Catch-Up Growth via Activating IGFBP3/IGF-1/IRS-1/Akt Signaling Pathway. Journal of nanoscience and nanotechnology. vol 18. issue 6. 2018-08-06. PMID:29442728. |
inhibition of p53 relieves insulin resistance in fetal growth restriction mice with catch-up growth via activating igfbp3/igf-1/irs-1/akt signaling pathway. |
2018-08-06 |
2023-08-13 |
mouse |
| Ping Peng, Chunling Ma, Shumei Wan, Wensheng Jin, Yan Gao, Tianqing Huang, Qi Cheng, Changlan Y. Inhibition of p53 Relieves Insulin Resistance in Fetal Growth Restriction Mice with Catch-Up Growth via Activating IGFBP3/IGF-1/IRS-1/Akt Signaling Pathway. Journal of nanoscience and nanotechnology. vol 18. issue 6. 2018-08-06. PMID:29442728. |
in conclusion, insulin resistance in cug-fgr mice is correlated with the igfbp3/igf-1/irs-1/akt signaling pathway and inhibited p53 could activate this signaling pathway and relieve insulin resistance. |
2018-08-06 |
2023-08-13 |
mouse |
| Ting Zhao, Jun Bai, Qingyun Zou, Feng Chen, Yan Xi. Insulin in combination with cisplatin induces the apoptosis of ovarian cancer cells via p53 and JNK activation. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039558. |
insulin in combination with cisplatin induces the apoptosis of ovarian cancer cells via p53 and jnk activation. |
2018-06-22 |
2023-08-13 |
Not clear |
| Elena Valentino, Arianna Bellazzo, Giulio Di Minin, Daria Sicari, Mattia Apollonio, Giosuè Scognamiglio, Maurizio Di Bonito, Gerardo Botti, Giannino Del Sal, Licio Collavi. Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 29. 2018-06-08. PMID:28667123. |
mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor dab2ip. |
2018-06-08 |
2023-08-13 |
Not clear |