| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthieu Lacroix, Laetitia K Linares, Natalia Rueda-Rincon, Katarzyna Bloch, Michela Di Michele, Carlo De Blasio, Caroline Fau, Laurie Gayte, Emilie Blanchet, Aline Mairal, Rita Derua, Fernando Cardona, Diane Beuzelin, Jean-Sebastien Annicotte, Nelly Pirot, Adeline Torro, Francisco J Tinahones, Florence Bernex, Justine Bertrand-Michel, Dominique Langin, Lluis Fajas, Johannes V Swinnen, Laurent Le Ca. The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes. Nature communications. vol 12. issue 1. 2021-12-03. PMID:34857760. |
consistent with the role of this e4f1-p53-steaoryl-coa desaturase-1 axis in adipocytes, p53 inactivation or diet complementation with oleate partly restore adiposity and improve insulin sensitivity in e4f1-deficient mice. |
2021-12-03 |
2023-08-13 |
mouse |
| Matthieu Lacroix, Laetitia K Linares, Natalia Rueda-Rincon, Katarzyna Bloch, Michela Di Michele, Carlo De Blasio, Caroline Fau, Laurie Gayte, Emilie Blanchet, Aline Mairal, Rita Derua, Fernando Cardona, Diane Beuzelin, Jean-Sebastien Annicotte, Nelly Pirot, Adeline Torro, Francisco J Tinahones, Florence Bernex, Justine Bertrand-Michel, Dominique Langin, Lluis Fajas, Johannes V Swinnen, Laurent Le Ca. The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes. Nature communications. vol 12. issue 1. 2021-12-03. PMID:34857760. |
altogether, our findings identify a crosstalk between e4f1 and p53 in the control of lipid metabolism in adipocytes that is relevant to obesity and insulin resistance. |
2021-12-03 |
2023-08-13 |
mouse |
| María Clara Ingaramo, Juan Andrés Sánchez, Norbert Perrimon, Andrés Dekant. Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy under Nutrient Stress via Drosophila Upd2 Repression. Cell reports. vol 33. issue 4. 2021-11-19. PMID:33113367. |
fat body p53 regulates systemic insulin signaling and autophagy under nutrient stress via drosophila upd2 repression. |
2021-11-19 |
2023-08-13 |
drosophila_melanogaster |
| Siamak Tabibzade. Signaling pathways and effectors of aging. Frontiers in bioscience (Landmark edition). vol 26. 2021-10-06. PMID:33049665. |
aging also leads to the imbalanced activation of other pathways and factors including p53, insulin and igf signaling, p13k/akt, mtor, pka, ras, rtk, mek, erk, mapk, crtc-1/creb and nfkb. |
2021-10-06 |
2023-08-13 |
mouse |
| Hyojung Kim, Jeong-Yong Shin, Areum Jo, Ji Hun Kim, Sangwook Park, Jeong-Yun Choi, Ho Chul Kang, Valina L Dawson, Ted M Dawson, Joo-Ho Shin, Yunjong Le. Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration. Brain : a journal of neurology. 2021-09-28. PMID:34581802. |
one phosphorylation-dependent parkin interacting substrate target, mdm4 (a p53 inhibitor that associates with mdm2; also known as mdmx), is transcriptionally repressed in an histone deacetylase-dependent manner via parkin interacting substrate binding to insulin response sequence motifs within the mdm4 promoter. |
2021-09-28 |
2023-08-13 |
mouse |
| Julia Sepel Loreto, Sabrina Antunes Ferreira, Daniel Mp Ardisson-Araújo, Nilda Vargas Barbos. Human type 2 diabetes mellitus-associated transcriptional disturbances in a high-sugar diet long-term exposed Drosophila melanogaster. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 39. 2021-09-24. PMID:34192612. |
moreover, hsd-30% up-regulated both the insulin-like peptides 7 and 8 and down-regulated the insulin receptor substrate p53, isoform a and insulin-like peptide 6 genes, whose functional products are insulin signaling markers. |
2021-09-24 |
2023-08-13 |
human |
| Zhibiao Zhong, Weilan Su, Hongmei Che. MicroRNA‑532‑5p regulates oxidative stress and insulin secretion damage in high glucose‑induced pancreatic β cells by downregulating the expression levels of CCND1. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515323. |
overexpression of mir‑532‑5p downregulated hg‑induced cell insulin secretion, oxidative stress and apoptosis by downregulating ccnd1, which is involved in regulating the expression of p53. |
2021-09-21 |
2023-08-13 |
Not clear |
| Zhibiao Zhong, Weilan Su, Hongmei Che. MicroRNA‑532‑5p regulates oxidative stress and insulin secretion damage in high glucose‑induced pancreatic β cells by downregulating the expression levels of CCND1. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515323. |
to conclude, mir‑532‑5p regulated oxidative stress and insulin secretion damage in hg‑induced pancreatic β cells by downregulating the expression of ccnd1, which is involved in the upregulation of the expression of p53. |
2021-09-21 |
2023-08-13 |
Not clear |
| Syed Aun Muhammad, Syeda Tahira Qousain Naqvi, Thanh Nguyen, Xiaogang Wu, Fahad Munir, Muhammad Babar Jamshed, QiYu Zhan. Cisplatin's potential for type 2 diabetes repositioning by inhibiting CDKN1A, FAS, and SESN1. Computers in biology and medicine. vol 135. 2021-09-13. PMID:34261004. |
from a list of differential expressed genes, cisplatin downregulated the cyclin-dependent kinase inhibitor 1 (cdkn1a), tumor necrosis factor (fas), and sestrin-1 (sesn1) genes responsible for modifying signaling pathways, including the p53, jak-stat, foxo, mapk, mtor, p13-akt, toll-like receptor (tlr), adipocytokine, and insulin signaling pathways. |
2021-09-13 |
2023-08-13 |
Not clear |
| Maria J Gonzalez-Rellan, Marcos F Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernández-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cuñarro, Maria Dp Chantada-Vazquez, Maria Garcia-Vence, Susana B Bravo, Natalia Da Silva Lima, Begoña Porteiro, Carmen Carneiro, Anxo Vidal, Sulay Tovar, Timo D Müller, Johan Ferno, Diana Guallar, Miguel Fidalgo, Guadalupe Sabio, Stephan Herzig, Won Ho Yang, Jin Won Cho, Maria Luz Martinez-Chantar, Roman Perez-Fernandez, Miguel López, Carlos Dieguez, Jose M Mato, Oscar Millet, Roberto Coppari, Ashwin Woodhoo, Gema Fruhbeck, Ruben Nogueira. O-GlcNAcylated p53 in the liver modulates hepatic glucose production. Nature communications. vol 12. issue 1. 2021-08-31. PMID:34417460. |
moreover, insulin decreases p53 levels, and over-expression of p53 impairs insulin sensitivity. |
2021-08-31 |
2023-08-13 |
mouse |
| Bo Wen, Xueping Wang, Lulu Yang, Ting Wang, Xiaolan Hou, Xuefeng Qi, Jingyu Wan. Transcriptome Analysis Reveals the Potential Role of Long Noncoding RNAs in Regulating Fowl Adenovirus Serotype 4-Induced Apoptosis in Leghorn Male Hepatocellular Cells. Viruses. vol 13. issue 8. 2021-08-31. PMID:34452487. |
target prediction and analyses revealed that 775 de lncrnas whose 671 target mrnas were among the de mrnas were involved in several signaling pathways, including the ampk signaling pathway, p53 signaling pathway and insulin signaling pathway. |
2021-08-31 |
2023-08-13 |
Not clear |
| Tarek Khamis, Abdelalim F Abdelalim, Ahmed A Saeed, Nagah M Edress, Alaa Nafea, Huda F Ebian, Reem Algendy, Doaa M Hendawy, Ahmed Hamed Arisha, Somia Hassan Abdalla. Breast milk MSCs upregulated β-cells PDX1, Ngn3, and PCNA expression via remodeling ER stress /inflammatory /apoptotic signaling pathways in type 1 diabetic rats. European journal of pharmacology. vol 905. 2021-08-11. PMID:34004210. |
and, for the first time, our results revealed that intraperitoneally transplanted br-mscs homed to the diabetic islet and improved fasting blood glucose, serum insulin level, pancreatic oxidative stress, upregulated pancreatic mrna expression for: regenerative markers (pdx1, ngn3, pcna), ins, beta-cell receptors (irs1, irβ, pparγ), pancreatic growth factors (igf-1, vegfβ1, fgfβ), anti-inflammatory cytokine (il10) and anti-apoptotic marker (bcl2) too, br-mscs downregulated pancreatic mrna expression for: inflammatory markers (nfkβ, tnfα, il1β, il6, il8, mcp1), apoptotic markers for both intrinsic and extrinsic pathways (fas, fas-l, p53, p38, bax, caspase3), er stress markers (atf6, atf3, atf4, bip, chop, jnk, xbp1) and autophagy inhibitor (mtor). |
2021-08-11 |
2023-08-13 |
rat |
| Ti-Wei Miao, Wei Xiao, Long-Yi Du, Bing Mao, Wei Huang, Xue-Mei Chen, Cong Li, Yan Wang, Juan-Juan F. High expression of SPP1 in patients with chronic obstructive pulmonary disease (COPD) is correlated with increased risk of lung cancer. FEBS open bio. vol 11. issue 4. 2021-08-09. PMID:33626243. |
there were 1544 degs in patients with lc and coexisting copd compared with copd, and these degs are mainly involved in the cell cycle, dna replication, p53 signalling and insulin signalling. |
2021-08-09 |
2023-08-13 |
Not clear |
| Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Matthew Moran, Martonio Ponte Viana, Sarah L Schlichte, Matthew C Zimmerman, Oleh Khalimonchuk, Mark W Feinberg, Xinghui Su. Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity. Redox biology. vol 40. 2021-06-21. PMID:33508742. |
we found that the attenuation of cellular senescence of hepatic endothelium by ablating p53 expression in vascular endothelium can restore impaired glucose homeostasis and insulin signaling in obesity. |
2021-06-21 |
2023-08-13 |
mouse |
| Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating P53 and RAP2A in vitro and in vivo [Retraction]. Drug design, development and therapy. vol 15. 2021-06-17. PMID:34135572. |
metformin decreases insulin resistance in type 1 diabetes through regulating p53 and rap2a in vitro and in vivo [retraction]. |
2021-06-17 |
2023-08-13 |
Not clear |
| Jiahua Zhang, Yubang Shen, Xiaoyan Xu, Yafan Dai, Jiale L. Transcriptome Analysis of the Liver and Muscle Tissues of Black Carp (Mylopharyngodon piceus) of Different Growth Rates. Marine biotechnology (New York, N.Y.). vol 22. issue 5. 2021-05-26. PMID:32914204. |
the kegg pathway analysis showed significant differences in the expression of some genes involved in growth- and development-related metabolic pathways such as the foxo signaling pathway, p53 signaling pathway, pi3k-akt signaling pathway, apoptosis, tgf-β signaling pathway, and insulin signaling pathway. |
2021-05-26 |
2023-08-13 |
Not clear |
| Hyun Kyu Ahn, Young Hwa Lee, Kyo Chul Ko. Current Status and Application of Metformin for Prostate Cancer: A Comprehensive Review. International journal of molecular sciences. vol 21. issue 22. 2021-04-05. PMID:33198356. |
liver kinase b1 (lkb1) and adenosine monophosphate-activated protein kinase (ampk) activation, inhibition of the mammalian target of rapamycin (mtor) activity and protein synthesis, induction of apoptosis and autophagy by p53 and p21, and decreased blood insulin level have been suggested as direct anti-cancer mechanisms of metformin. |
2021-04-05 |
2023-08-13 |
Not clear |
| Gao-Fei Ren, Li-Li Xiao, Xiao-Jun Ma, Yu-Shan Yan, Peng-Fei Jia. Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo. Drug design, development and therapy. vol 14. 2021-03-30. PMID:32606605. |
metformin decreases insulin resistance in type 1 diabetes through regulating p53 and rap2a in vitro and in vivo. |
2021-03-30 |
2023-08-13 |
Not clear |
| Seung-Hyun Ro, Julianne Fay, Cesar I Cyuzuzo, Yura Jang, Naeun Lee, Hyun-Seob Song, Edward N Harri. SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health. Frontiers in cell and developmental biology. vol 8. 2021-01-12. PMID:33425907. |
while sestrins are originally reported as one of several p53 target genes, recent studies have further delineated the roles of this group of stress-sensing proteins in the regulation of insulin sensitivity, glucose and fat metabolism, and redox-function in metabolic disease and aging. |
2021-01-12 |
2023-08-13 |
Not clear |
| Yanxin Shen, Huiling Xu, Xiaoyuan Pan, Weijiang Wu, Hui Wang, Linlin Yan, Miaomiao Zhang, Xia Liu, Sheng Xia, Qixiang Sha. miR-34a and miR-125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285097. |
however, no correlation among mir-34a, mir-125b and the value of homeostasis model assessment of insulin resistance, homeostasis model assessment of β-cell function and the genes of b lymphocyte-induced maturation protein-1, interferon regulatory factor-4, p53 and retinoid-related orphan receptor γt were observed. |
2020-10-01 |
2023-08-13 |
Not clear |