| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Valentino, Arianna Bellazzo, Giulio Di Minin, Daria Sicari, Mattia Apollonio, Giosuè Scognamiglio, Maurizio Di Bonito, Gerardo Botti, Giannino Del Sal, Licio Collavi. Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 29. 2018-06-08. PMID:28667123. |
we report that breast and prostate cancer cells with mutant p53 respond to insulin stimulation by increasing cell proliferation and invasivity, and that such a response depends on the presence of mutp53. |
2018-06-08 |
2023-08-13 |
Not clear |
| Elena Valentino, Arianna Bellazzo, Giulio Di Minin, Daria Sicari, Mattia Apollonio, Giosuè Scognamiglio, Maurizio Di Bonito, Gerardo Botti, Giannino Del Sal, Licio Collavi. Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 29. 2018-06-08. PMID:28667123. |
this molecular axis reveals a specific gain of function for mutant p53 in the response to insulin stimulation, offering an additional perspective to understand the relationship between hyperinsulinemia and cancer evolution. |
2018-06-08 |
2023-08-13 |
Not clear |
| Shanshan Geng, Weiwei Zhu, Shijia Wang, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Yuan Li, Yue Chen, Xiaoqian Wang, Yu Meng, Qi Zhang, Jiaqi Chen, Caiyun Zhon. P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways. Biochemical and biophysical research communications. vol 495. issue 3. 2018-02-13. PMID:29258820. |
p53 modulates hepatic insulin sensitivity through nf-κb and p38/erk mapk pathways. |
2018-02-13 |
2023-08-13 |
mouse |
| Shanshan Geng, Weiwei Zhu, Shijia Wang, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Yuan Li, Yue Chen, Xiaoqian Wang, Yu Meng, Qi Zhang, Jiaqi Chen, Caiyun Zhon. P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways. Biochemical and biophysical research communications. vol 495. issue 3. 2018-02-13. PMID:29258820. |
nevertheless, the function of p53 with respect to insulin resistance appears highly controversial. |
2018-02-13 |
2023-08-13 |
mouse |
| Shanshan Geng, Weiwei Zhu, Shijia Wang, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Yuan Li, Yue Chen, Xiaoqian Wang, Yu Meng, Qi Zhang, Jiaqi Chen, Caiyun Zhon. P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways. Biochemical and biophysical research communications. vol 495. issue 3. 2018-02-13. PMID:29258820. |
to address this issue, we investigated the expression of p53 in experimental model of insulin resistance. |
2018-02-13 |
2023-08-13 |
mouse |
| Shanshan Geng, Weiwei Zhu, Shijia Wang, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Yuan Li, Yue Chen, Xiaoqian Wang, Yu Meng, Qi Zhang, Jiaqi Chen, Caiyun Zhon. P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways. Biochemical and biophysical research communications. vol 495. issue 3. 2018-02-13. PMID:29258820. |
here we showed that p53 protein level was decreased in the hepatic tissue of high-fat diet-induced insulin resistance mice, genetically diabetic ob/ob mice and palmitate (pa) treated hepg2 cells. |
2018-02-13 |
2023-08-13 |
mouse |
| Shanshan Geng, Weiwei Zhu, Shijia Wang, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Yuan Li, Yue Chen, Xiaoqian Wang, Yu Meng, Qi Zhang, Jiaqi Chen, Caiyun Zhon. P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways. Biochemical and biophysical research communications. vol 495. issue 3. 2018-02-13. PMID:29258820. |
but activation of p53 with nutlin-3α prevented pa-induced reduction of glucose consumption and suppression of insulin signaling pathways. |
2018-02-13 |
2023-08-13 |
mouse |
| Shanshan Geng, Weiwei Zhu, Shijia Wang, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Yuan Li, Yue Chen, Xiaoqian Wang, Yu Meng, Qi Zhang, Jiaqi Chen, Caiyun Zhon. P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways. Biochemical and biophysical research communications. vol 495. issue 3. 2018-02-13. PMID:29258820. |
in contrast, inhibition of p53 with pft-α decreased glucose consumption and suppressed insulin signaling pathway. |
2018-02-13 |
2023-08-13 |
mouse |
| Shanshan Geng, Weiwei Zhu, Shijia Wang, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Yuan Li, Yue Chen, Xiaoqian Wang, Yu Meng, Qi Zhang, Jiaqi Chen, Caiyun Zhon. P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways. Biochemical and biophysical research communications. vol 495. issue 3. 2018-02-13. PMID:29258820. |
overall, these results suggest that p53 is involved in improving insulin sensitivity of hepatic cells via inhibition of mitogen-activated protein kinases (mapks) and nf-κb pathways. |
2018-02-13 |
2023-08-13 |
mouse |
| Bas Ter Braak, Christine L Siezen, Joo S Lee, Pooja Rao, Charlotte Voorhoeve, Eytan Ruppin, Jan Willem van der Laan, Bob van de Wate. Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production. Breast cancer research : BCR. vol 19. issue 1. 2017-12-22. PMID:28173837. |
we found that chronic treatment with insulin analogues with high affinity towards the igf1r (igf1 and x10) decreased the mammary gland tumor latency time in a p53 |
2017-12-22 |
2023-08-13 |
mouse |
| Kazimierz Gasiorowski, Barbara Brokos, Jerzy Leszek, Vadim V Tarasov, Ghulam Md Ashraf, Gjumrakch Alie. Insulin Resistance in Alzheimer Disease: p53 and MicroRNAs as Important Players. Current topics in medicinal chemistry. vol 17. issue 12. 2017-07-05. PMID:28049397. |
insulin resistance in alzheimer disease: p53 and micrornas as important players. |
2017-07-05 |
2023-08-13 |
Not clear |
| Philip J Atherton, Paul L Greenhaff, Stuart M Phillips, Sue C Bodine, Christopher M Adams, Charles H Lan. Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence. American journal of physiology. Endocrinology and metabolism. vol 311. issue 3. 2017-06-16. PMID:27382036. |
these proceedings focus on 1) the role of insulin resistance in mediating disuse-induced changes in muscle protein synthesis (mps) and breakdown (mpb), as well as cross-talk between carbohydrate and protein metabolism; 2) the relative importance of mps/mpb in mediating involuntary muscle loss in humans and animals; 3) interpretative limitations associated with mps/mpb "markers," e.g., murf1/mafbx mrna; and finally, 4) how omic technologies can be leveraged to identify molecular pathways (e.g., atf4, p53, p21) mediating disuse atrophy. |
2017-06-16 |
2023-08-13 |
human |
| Che-Pei Kung, Maureen E Murph. The role of the p53 tumor suppressor in metabolism and diabetes. The Journal of endocrinology. vol 231. issue 2. 2017-05-22. PMID:27613337. |
here, we present a review of the literature on the role of p53 in metabolism, diabetes, pancreatic function, glucose homeostasis and insulin resistance. |
2017-05-22 |
2023-08-13 |
human |
| Bastien Vergoni, Pierre-Jean Cornejo, Jérôme Gilleron, Mansour Djedaini, Franck Ceppo, Arnaud Jacquel, Gwennaelle Bouget, Clémence Ginet, Teresa Gonzalez, Julie Maillet, Véronique Dhennin, Marie Verbanck, Patrick Auberger, Philippe Froguel, Jean-François Tanti, Mireille Cormon. DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes. Diabetes. vol 65. issue 10. 2017-05-19. PMID:27388216. |
activation of the p53 pathway in adipose tissue contributes to insulin resistance associated with obesity. |
2017-05-19 |
2023-08-13 |
mouse |
| Xuemei Zhang, Wei Duan, Wai-Nang Paul Lee, Yuewei Zhang, Fenfen Xiang, Qian Liu, Vay Liang W Go, Gary Guishan Xia. Overexpression of p53 Improves Blood Glucose Control in an Insulin Resistant Diabetic Mouse Model. Pancreas. vol 45. issue 7. 2017-03-28. PMID:27101570. |
overexpression of p53 improves blood glucose control in an insulin resistant diabetic mouse model. |
2017-03-28 |
2023-08-13 |
mouse |
| Justyna Strycharz, Jozef Drzewoski, Janusz Szemraj, Agnieszka Sliwinsk. Is p53 Involved in Tissue-Specific Insulin Resistance Formation? Oxidative medicine and cellular longevity. vol 2017. 2017-03-14. PMID:28194257. |
is p53 involved in tissue-specific insulin resistance formation? |
2017-03-14 |
2023-08-13 |
Not clear |
| Hua Ning, Zongxiang Sun, Yunyun Liu, Lei Liu, Liuyi Hao, Yaxin Ye, Rennan Feng, Jie Li, Ying Li, Xia Chu, Songtao Li, Changhao Su. Insulin Protects Hepatic Lipotoxicity by Regulating ER Stress through the PI3K/Akt/p53 Involved Pathway Independently of Autophagy Inhibition. Nutrients. vol 8. issue 4. 2016-12-20. PMID:27104558. |
pre-treating hepatocytes with insulin significantly stimulated phosphorylated-akt and reversed sfa-induced up-regulation of p53. |
2016-12-20 |
2023-08-13 |
mouse |
| Hua Ning, Zongxiang Sun, Yunyun Liu, Lei Liu, Liuyi Hao, Yaxin Ye, Rennan Feng, Jie Li, Ying Li, Xia Chu, Songtao Li, Changhao Su. Insulin Protects Hepatic Lipotoxicity by Regulating ER Stress through the PI3K/Akt/p53 Involved Pathway Independently of Autophagy Inhibition. Nutrients. vol 8. issue 4. 2016-12-20. PMID:27104558. |
the pi3k/akt pathway blockade by its special antagonist abolished the protective role of insulin against sfa-induced lipotoxicity and p53 up-regulation. |
2016-12-20 |
2023-08-13 |
mouse |
| Jinyang Chen, Xiaochun Du, Qian Chen, Charlie Xian. Effects of donors' age and passage number on the biological characteristics of menstrual blood-derived stem cells. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-26. PMID:26823782. |
however, some important signal pathways including mapk, the insulin signaling pathway, pathways involved in carcinogenesis such as ppar and p53, and cytokines and their receptors, as well as other pathways associated with immune response and aging, changed to various extents under the conditions of aging after a long time in vitro. |
2016-10-26 |
2023-08-13 |
human |
| Sandeep Kumar, Kulbhushan Tiko. Independent role of PP2A and mTORc1 in palmitate induced podocyte death. Biochimie. vol 112. 2016-01-08. PMID:25724269. |
this impairment in insulin signalling prevents insulin induced sirt 1 expression and deacetylation of p53. |
2016-01-08 |
2023-08-13 |
human |