| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dina Fomina-Yadlin, Stefan Kubicek, Amedeo Vetere, Kai Hui Hu He, Kaihui Hu He, Stuart L Schreiber, Bridget K Wagne. GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. PloS one. vol 7. issue 1. 2012-05-08. PMID:22242153. |
gw8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. |
2012-05-08 |
2023-08-12 |
Not clear |
| Ippei Shimizu, Yohko Yoshida, Taro Katsuno, Kaoru Tateno, Sho Okada, Junji Moriya, Masataka Yokoyama, Aika Nojima, Takashi Ito, Rudolf Zechner, Issei Komuro, Yoshio Kobayashi, Tohru Minamin. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell metabolism. vol 15. issue 1. 2012-05-03. PMID:22225876. |
here, we report a mechanism of insulin resistance associated with heart failure that involves upregulation of p53 in adipose tissue. |
2012-05-03 |
2023-08-12 |
Not clear |
| Ippei Shimizu, Yohko Yoshida, Taro Katsuno, Kaoru Tateno, Sho Okada, Junji Moriya, Masataka Yokoyama, Aika Nojima, Takashi Ito, Rudolf Zechner, Issei Komuro, Yoshio Kobayashi, Tohru Minamin. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell metabolism. vol 15. issue 1. 2012-05-03. PMID:22225876. |
in the presence of pressure overload, inhibition of lipolysis by sympathetic denervation significantly downregulated adipose p53 expression and inflammation, thereby improving insulin resistance. |
2012-05-03 |
2023-08-12 |
Not clear |
| Ippei Shimizu, Yohko Yoshida, Taro Katsuno, Kaoru Tateno, Sho Okada, Junji Moriya, Masataka Yokoyama, Aika Nojima, Takashi Ito, Rudolf Zechner, Issei Komuro, Yoshio Kobayashi, Tohru Minamin. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell metabolism. vol 15. issue 1. 2012-05-03. PMID:22225876. |
likewise, disruption of p53 activation in adipose tissue attenuated inflammation and improved insulin resistance but also ameliorated cardiac dysfunction induced by chronic pressure overload. |
2012-05-03 |
2023-08-12 |
Not clear |
| Ippei Shimizu, Yohko Yoshida, Taro Katsuno, Kaoru Tateno, Sho Okada, Junji Moriya, Masataka Yokoyama, Aika Nojima, Takashi Ito, Rudolf Zechner, Issei Komuro, Yoshio Kobayashi, Tohru Minamin. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell metabolism. vol 15. issue 1. 2012-05-03. PMID:22225876. |
these results indicate that chronic pressure overload upregulates adipose tissue p53 by promoting lipolysis via the sympathetic nervous system, leading to an inflammatory response of adipose tissue and insulin resistance. |
2012-05-03 |
2023-08-12 |
Not clear |
| Yujiro Tanaka, Aya Nakamura, Masaki Suimye Morioka, Shoko Inoue, Mimi Tamamori-Adachi, Kazuhiko Yamada, Kenji Taketani, Junya Kawauchi, Miki Tanaka-Okamoto, Jun Miyoshi, Hiroshi Tanaka, Shigetaka Kitajim. Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046379. |
further analysis of effects of atf3 knockdown on these targets revealed that stress-induced atf3 regulates genes in metabolic pathways, cell cycle, apoptosis, cell adhesion, and signalling including insulin, p53, wnt, and vegf pathways. |
2012-03-26 |
2023-08-12 |
human |
| M-C Lacroix, A Rodriguez-Enfedaque, D Grébert, I Laziz, N Meunier, R Monnerie, M-A Persuy, S Riviere, M Caillol, F Renau. Insulin but not leptin protects olfactory mucosa from apoptosis. Journal of neuroendocrinology. vol 23. issue 7. 2011-11-07. PMID:21554433. |
insulin addition to the culture medium reduced p53 phosphorylation, caspase-3 and caspase-9 cleavage, and caspase-3 enzymatic activity induced by etoposide. |
2011-11-07 |
2023-08-12 |
Not clear |
| Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Minoru Shigekawa, Hinako Tsunematsu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Satoshi Kubota, Masaharu Takigawa, Yoshito Tomimaru, Akira Tomokuni, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Norio Hayash. Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. The Journal of clinical investigation. vol 121. issue 8. 2011-10-03. PMID:21747166. |
the tumor suppressor p53 has been implicated in the pathogenesis of non-cancer-related conditions such as insulin resistance, cardiac failure, and early aging. |
2011-10-03 |
2023-08-12 |
mouse |
| G Donati, S Bertoni, E Brighenti, M Vici, D Treré, S Volarevic, L Montanaro, M Derenzin. The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells. Oncogene. vol 30. issue 29. 2011-09-21. PMID:21399665. |
furthermore, we demonstrated that in three different experimental models characterised by an upregulation of rrna synthesis, cancer cells treated with insulin or exposed to the insulin-like growth factor 1, rat liver stimulated by cortisol and regenerating rat liver after partial hepatectomy, the p53 protein level was reduced due to a lowered ribosomal protein availability for mdm2 binding. |
2011-09-21 |
2023-08-12 |
human |
| Zhengtang Qi, Jie He, Yuan Zhang, Yue Shao, Shuzhe Din. Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats. Free radical biology & medicine. vol 50. issue 7. 2011-08-01. PMID:21185935. |
these data indicate that exercise training can attenuate oxidative stress and increase mitochondrial dna content in skeletal muscle in rats with t2dm and that exercise-induced suppression of p53 and tigar expression may play a role in preventing oxidative stress in insulin resistance. |
2011-08-01 |
2023-08-12 |
rat |
| Hisako Matsui-Hirai, Toshio Hayashi, Seiji Yamamoto, Koichiro Ina, Morihiko Maeda, Hitoshi Kotani, Akihisa Iguchi, Louis J Ignarro, Yuichi Hattor. Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide. The Journal of pharmacology and experimental therapeutics. vol 337. issue 3. 2011-07-19. PMID:21357660. |
physiological concentrations of insulin also reversed high glucose-induced increases in p53 and vascular cell adhesion molecule-1 and decreases in senescence marker protein-30. |
2011-07-19 |
2023-08-12 |
human |
| Ana Richelia Jara-Lazaro, Puay Hoon Ta. Molecular pathogenesis of progression and recurrence in breast phyllodes tumors. American journal of translational research. vol 1. issue 1. 2011-07-14. PMID:19966935. |
inverse correlations between epithelial and stromal overexpression for various biological markers like estrogen receptor, p53, c-kit, ki-67, endothelin-1, epidermal growth factor receptor, heparan sulfate, in addition to findings of epithelial wnt signalling with stromal insulin growth factors and beta-catenin expression, suggest an initial epithelial-stromal interdependence at the benign phase. |
2011-07-14 |
2023-08-12 |
Not clear |
| Oliver D K Maddocks, Karen H Vousde. Metabolic regulation by p53. Journal of molecular medicine (Berlin, Germany). vol 89. issue 3. 2011-06-01. PMID:21340684. |
by transcriptional activation and other means, p53 is able to contribute to the regulation of glycolysis, oxidative phosphorylation, glutaminolysis, insulin sensitivity, nucleotide biosynthesis, mitochondrial integrity, fatty acid oxidation, antioxidant response, autophagy and mtor signalling. |
2011-06-01 |
2023-08-12 |
human |
| Anutosh Chakraborty, J Kent Werner, Michael A Koldobskiy, Asif K Mustafa, Krishna R Juluri, Joseph Pietropaoli, Adele M Snowman, Solomon H Snyde. Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 6. 2011-03-30. PMID:21262846. |
the inositol pyrophosphate, diphosphoinositol pentakisphosphate, regulates p53 and protein kinase akt signaling, and its aberrant increase in cells has been implicated in apoptosis and insulin resistance. |
2011-03-30 |
2023-08-12 |
Not clear |
| Zoltan Derdak, Charles H Lang, Kristine A Villegas, Ming Tong, Nicholas M Mark, Suzanne M de la Monte, Jack R Wand. Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. Journal of hepatology. vol 54. issue 1. 2011-03-24. PMID:20961644. |
activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. |
2011-03-24 |
2023-08-12 |
rat |
| Zoltan Derdak, Charles H Lang, Kristine A Villegas, Ming Tong, Nicholas M Mark, Suzanne M de la Monte, Jack R Wand. Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. Journal of hepatology. vol 54. issue 1. 2011-03-24. PMID:20961644. |
we hypothesize that p53 activation and altered insulin signaling may influence the susceptibility of rats to ethanol-induced liver damage. |
2011-03-24 |
2023-08-12 |
rat |
| Zoltan Derdak, Charles H Lang, Kristine A Villegas, Ming Tong, Nicholas M Mark, Suzanne M de la Monte, Jack R Wand. Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. Journal of hepatology. vol 54. issue 1. 2011-03-24. PMID:20961644. |
furthermore, p53 not only activates programmed cell death pathways and suppresses hepatocellular survival signals, but also promotes gluconeogenesis to increase systemic insulin resistance due to a novel metabolic function. |
2011-03-24 |
2023-08-12 |
rat |
| Heather L Armata, Diane Golebiowski, Dae Young Jung, Hwi Jin Ko, Jason K Kim, Hayla K Slus. Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Molecular and cellular biology. vol 30. issue 24. 2011-01-13. PMID:20956556. |
to test whether the atm pathway that regulates insulin resistance is mediated by p53 phosphorylation, we examined insulin sensitivity in mice with a germ line mutation that replaces the p53 phosphorylation site with alanine. |
2011-01-13 |
2023-08-12 |
mouse |
| Huiping Yuan, Yonggang Lu, Xiuqing Huang, Qinghua He, Yong Man, Yingsheng Zhou, Shu Wang, Jian L. Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells. The FEBS journal. vol 277. issue 24. 2011-01-13. PMID:21073655. |
furthermore, high glucose concentrations led to apoptosis of β-cells by activation of p38mapk and p53, and dysfunction of β-cells through phosphatase and tensih homolog (pten)-dependent jun n-terminal kinase (jnk) activation and protein kinase b (akt/pkb) inhibition, which induced the translocation of forkhead box o1 and pancreatic duodenal homeobox-1, followed by reduced insulin expression and secretion. |
2011-01-13 |
2023-08-12 |
rat |
| Babak Razani, Chu Feng, Clay F Semenkovic. p53 is required for chloroquine-induced atheroprotection but not insulin sensitization. Journal of lipid research. vol 51. issue 7. 2010-10-18. PMID:20208057. |
p53 is required for chloroquine-induced atheroprotection but not insulin sensitization. |
2010-10-18 |
2023-08-12 |
mouse |