| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
plasma glucose and insulin levels, hba1c, glucose tolerance, apoptosis, and expression of proliferating cell nuclear antigen (pcna), p38, p53, caspase-3, extracellular signal-regulated kinase-1/2 (erk-1/2), forkhead box protein o1 (foxo1) and insulin receptor substrate-1 (irs-1) as well as histone acetylation were evaluated. |
2014-05-27 |
2023-08-12 |
rat |
| Atsushi Hoshino, Makoto Ariyoshi, Yoshifumi Okawa, Satoshi Kaimoto, Motoki Uchihashi, Kuniyoshi Fukai, Eri Iwai-Kanai, Koji Ikeda, Tomomi Ueyama, Takehiro Ogata, Satoaki Matob. Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 8. 2014-04-22. PMID:24516131. |
the occurrence of mitophagy is maintained in stz-treated p53(-/-) mice that exhibit preserved glucose oxidation capacity and subsequent insulin secretion signaling, leading to better glucose tolerance. |
2014-04-22 |
2023-08-12 |
mouse |
| Fausto Bogazzi, Francesco Raggi, Dania Russo, Mohammad Bohlooly-Y, Chiara Sardella, Claudio Urbani, Martina Lombardi, Luca Manetti, Isabella Lupi, Jan Tornell, Enio Martin. Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice. Endocrinology. vol 154. issue 11. 2014-01-08. PMID:23913444. |
obe mice had insulin resistance, which was sustained by a selective increased expression of p53 in adipose tissue. |
2014-01-08 |
2023-08-12 |
mouse |
| Fausto Bogazzi, Francesco Raggi, Dania Russo, Mohammad Bohlooly-Y, Chiara Sardella, Claudio Urbani, Martina Lombardi, Luca Manetti, Isabella Lupi, Jan Tornell, Enio Martin. Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice. Endocrinology. vol 154. issue 11. 2014-01-08. PMID:23913444. |
normal insulin sensitivity was restored, and adipose p53 expression normalized when the gh pathway was blocked. |
2014-01-08 |
2023-08-12 |
mouse |
| Fausto Bogazzi, Francesco Raggi, Dania Russo, Mohammad Bohlooly-Y, Chiara Sardella, Claudio Urbani, Martina Lombardi, Luca Manetti, Isabella Lupi, Jan Tornell, Enio Martin. Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice. Endocrinology. vol 154. issue 11. 2014-01-08. PMID:23913444. |
gh seems to be necessary for the increased adipose p53 expression and for insulin resistance of obese mice. |
2014-01-08 |
2023-08-12 |
mouse |
| T R Dias, L Rato, A D Martins, V L Simões, T T Jesus, M G Alves, P F Oliveir. Insulin deprivation decreases caspase-dependent apoptotic signaling in cultured rat sertoli cells. ISRN urology. vol 2013. 2013-11-14. PMID:24228182. |
scs cultured in insulin deprivation demonstrated a significant decrease on mrna levels of p53, bax, caspase-9, and caspase-3 followed by a significant increase of bax and decrease of caspase-9 protein levels relatively to the control. |
2013-11-14 |
2023-08-12 |
rat |
| Anna Rita Bonfigli, Cristina Sirolla, Roberto Testa, Michela Cucchi, Liana Spazzafumo, Stefano Salvioli, Antonio Ceriello, Fabiola Olivieri, Roberto Festa, Antonio Domenico Procopio, Gabriele Brandoni, Massimo Boemi, Maurizio Marra, Claudio Francesch. The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study. Acta diabetologica. vol 50. issue 3. 2013-10-29. PMID:23269546. |
the p53 codon 72 (arg72pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study. |
2013-10-29 |
2023-08-12 |
human |
| Anna Rita Bonfigli, Cristina Sirolla, Roberto Testa, Michela Cucchi, Liana Spazzafumo, Stefano Salvioli, Antonio Ceriello, Fabiola Olivieri, Roberto Festa, Antonio Domenico Procopio, Gabriele Brandoni, Massimo Boemi, Maurizio Marra, Claudio Francesch. The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study. Acta diabetologica. vol 50. issue 3. 2013-10-29. PMID:23269546. |
linear regression analyses, based on the assumption of an additive genetic model adjusted for age, sex and bmi, highlight p53 gene-diabetes interaction effects on fasting insulin (β = -1.27; p = 0.001) and homa-ir (β = -0.22; p = 0.006). |
2013-10-29 |
2023-08-12 |
human |
| Anna Rita Bonfigli, Cristina Sirolla, Roberto Testa, Michela Cucchi, Liana Spazzafumo, Stefano Salvioli, Antonio Ceriello, Fabiola Olivieri, Roberto Festa, Antonio Domenico Procopio, Gabriele Brandoni, Massimo Boemi, Maurizio Marra, Claudio Francesch. The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study. Acta diabetologica. vol 50. issue 3. 2013-10-29. PMID:23269546. |
our findings suggest that p53 codon 72 (arg72pro) polymorphism influences insulin resistance in type 2 diabetic patients independently of body mass. |
2013-10-29 |
2023-08-12 |
human |
| Manqing Liu, Wei Zhang, Wei Luo, Qinghua Ni. Overexpression of TDRP1 gene in swine testis cell and its global transcriptome analysis. DNA and cell biology. vol 32. issue 9. 2013-10-24. PMID:23837542. |
among the 17 upregulated genes, the pmaip1 gene was significantly enriched in the p53 signaling pathway, and the others were the ddit3 gene in the mitogen-activated protein kinases (mapk) signaling pathway, the ppp1r3c gene in the insulin signaling pathway, as well as the gadd45a gene in the p53 signaling pathway, mapk signaling pathway, and the cell cycle. |
2013-10-24 |
2023-08-12 |
Not clear |
| Manqing Liu, Wei Zhang, Wei Luo, Qinghua Ni. Overexpression of TDRP1 gene in swine testis cell and its global transcriptome analysis. DNA and cell biology. vol 32. issue 9. 2013-10-24. PMID:23837542. |
this study indicated that the tdrp1 gene regulated pmaip1, gadd45a, ddit3, and ppp1r3c expression, and these genes involving p53, mapk, insulin, and wnt signaling pathways are related to spermatogenesis or reproduction in pig. |
2013-10-24 |
2023-08-12 |
Not clear |
| Omid Tavana, Nahum Puebla-Osorio, Jiseong Kim, Mei Sang, Stella Jang, Chengming Zh. Ku70 functions in addition to nonhomologous end joining in pancreatic β-cells: a connection to β-catenin regulation. Diabetes. vol 62. issue 7. 2013-09-09. PMID:23474484. |
we previously showed that the lack of nonhomologous end joining (nhej) dna repair factor ligase iv leads to an accumulation of dna damage that permanently halts β-cell proliferation and dramatically decreases insulin production, causing overt diabetes in a hypomorphic p53(r172p) background. |
2013-09-09 |
2023-08-12 |
mouse |
| Eman Maher Othman, Michael C Kreissl, Franz R Kaiser, Paula-Anahi Arias-Loza, Helga Stoppe. Insulin-mediated oxidative stress and DNA damage in LLC-PK1 pig kidney cell line, female rat primary kidney cells, and male ZDF rat kidneys in vivo. Endocrinology. vol 154. issue 4. 2013-05-06. PMID:23456362. |
in kidneys from healthy, lean zdf rats, which were infused with insulin to yield normal or high blood insulin levels, while keeping blood glucose levels constant, the amounts of ros and the tumor protein (p53) were elevated in the high-insulin group compared with the control level group. |
2013-05-06 |
2023-08-12 |
rat |
| Toshiya Ueno, Naoya Teraoka, Shinji Takasu, Katsuya Nakano, Mami Takahashi, Masafumi Yamamoto, Gen Fujii, Masami Komiya, Akinori Yanaka, Keiji Wakabayashi, Michihiro Muto. Suppressive effect of pioglitazone, a PPAR gamma ligand, on azoxymethane-induced colon aberrant crypt foci in KK-Ay mice. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 8. 2013-04-18. PMID:23098518. |
these results suggest that pioglitazone prevented obesity-associated colon carcinogenesis through improvement of dysregulated adipocytokine levels and high serum levels of triglyceride and insulin, and increase of p27 and p53 mrna levels in the colorectal mucosa. |
2013-04-18 |
2023-08-12 |
mouse |
| William A Freije, Sudip Mandal, Utpal Banerje. Expression profiling of attenuated mitochondrial function identifies retrograde signals in Drosophila. G3 (Bethesda, Md.). vol 2. issue 8. 2013-04-01. PMID:22908033. |
the transcriptional changes alter many signaling systems, including p53, insulin, hypoxia-induced factor α, and conserved mitochondrial retrograde responses. |
2013-04-01 |
2023-08-12 |
drosophila_melanogaster |
| Jared M Campbell, Mark B Nottle, Ivan Vassiliev, Megan Mitchell, Michelle Lan. Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway. Stem cells and development. vol 21. issue 13. 2013-01-23. PMID:22339667. |
the inhibition of glycogen synthase kinase 3 (gsk3) or p53, 2 s messengers inactivated by insulin signaling (via ct99021 or pifithrin-α, respectively), increased epiblast cell numbers. |
2013-01-23 |
2023-08-12 |
mouse |
| Jared M Campbell, Mark B Nottle, Ivan Vassiliev, Megan Mitchell, Michelle Lan. Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway. Stem cells and development. vol 21. issue 13. 2013-01-23. PMID:22339667. |
the induced activation of gsk3 and p53, via the inhibition of proteins responsible for their inactivation (pka via h-89 and sirt-1 via nicotinamide, respectively), blocked the insulin's effect on the epiblast.from our findings, we conclude that insulin increases epiblast cell number via the activation of pi3k, which ultimately inactivates gsk3 and p53. |
2013-01-23 |
2023-08-12 |
mouse |
| Xi Yan, Matthew P Pepper, Marko Z Vatamaniuk, Carol A Roneker, Li Li, Xin Gen Le. Dietary selenium deficiency partially rescues type 2 diabetes-like phenotypes of glutathione peroxidase-1-overexpressing male mice. The Journal of nutrition. vol 142. issue 11. 2013-01-02. PMID:23014491. |
dietary se deficiency decreased (p < 0.05) oe islet mrna levels of 2 key transcriptional activators (beta2 and foxa2) and removed genotype differences in islet mrna levels of 7 genes (beta2, cfos, foxa2, pregluc, ins1, p53, and sur1) related to insulin synthesis and secretion. |
2013-01-02 |
2023-08-12 |
mouse |
| Lin Wang, Juxiang Huang, Minghu Jiang, Hong Li. Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation. Immunologic research. vol 52. issue 3. 2012-09-04. PMID:22528125. |
tsta3-activated network enhanced the regulation of apoptosis, cyclin-dependent protein kinase activity, cell migration, insulin secretion, transcription, cell division, cell proliferation, dna replication, postreplication repair, cell differentiation, t-cell homeostasis, neutrophil-mediated immunity, neutrophil chemotaxis, interleukin-8 production, inflammatory response, immune response, b-cell activation, humoral immune response, actin filament organization, xenobiotic metabolism, lipid metabolism, phospholipid metabolism, leukotriene biosynthesis, organismal lipid catabolism, phosphatidylcholine metabolism, arachidonic acid secretion, activation of phospholipase a2, deoxyribonucleotide biosynthesis, heterophilic cell adhesion, activation of mapk activity, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, g-protein-coupled receptor protein signaling pathway, response to toxin, acute-phase response, dna damage response, intercellular junction assembly, cell communication, and cell recognition, as a result of inducing immune response-mediated metabolism coupling cell cycle to postreplication repair in no-tumor hepatitis/cirrhotic tissues. |
2012-09-04 |
2023-08-12 |
human |
| Tenzin W Lhakhang, M Ahmad Chaudhr. Interactome of Radiation-Induced microRNA-Predicted Target Genes. Comparative and functional genomics. vol 2012. 2012-08-27. PMID:22924026. |
the mirna-targeted genes were found to play key roles in previously identified ir stress pathways such as cell cycle, p53 pathway, tgf-beta pathway, ubiquitin-mediated proteolysis, focal adhesion pathway, mapk signaling, thyroid cancer pathway, adherens junction, insulin signaling pathway, oocyte meiosis, regulation of actin cytoskeleton, and renal cell carcinoma pathway. |
2012-08-27 |
2023-08-12 |
Not clear |