| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyung-Suk Yoo, Ushananthini Shanmugalingam, Patrice D Smit. Potential roles of branched-chain amino acids in neurodegeneration. Nutrition (Burbank, Los Angeles County, Calif.). vol 103-104. 2022-07-17. PMID:35843039. |
despite having disease-specific pathologic features and symptoms, neurodegenerative diseases share common mechanisms, such as excitotoxicity, neuroinflammation, and neurotransmitter dysregulation. |
2022-07-17 |
2023-08-14 |
Not clear |
| Jiaxing Chen, Sofia Zaer, Paz Drori, Joanna Zamel, Khalil Joron, Nir Kalisman, Eitan Lerner, Nikolay V Dokholya. Multifunctions of α-Synuclein Explained by Its Dynamic Heterogeneous Conformations with a Hierarchy of Transition Times. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553518. |
α-synuclein plays essential roles in synaptic vesicle homeostasis and neurotransmitter release through the interaction with membrane, while α-synuclein aggregates have been associated with several neurodegenerative diseases, especially parkinson's disease. |
2022-05-13 |
2023-08-13 |
Not clear |
| Zeping Zuo, Ting Kang, Shilong Hu, Wuyue Su, Yu Gan, Zhuang Miao, Hanqing Zhao, Ping Feng, Bowen Ke, Minyong L. A Bioluminescent Probe for Detecting Norepinephrine Analytical chemistry. 2022-04-22. PMID:35452217. |
a bioluminescent probe for detecting norepinephrine as a neurotransmitter, norepinephrine (ne) is critical for psychiatric conditions, neurodegenerative diseases, and pheochromocytoma. |
2022-04-22 |
2023-08-13 |
Not clear |
| Mazzura Wan Chik, Nurul Aqmar Mohd Nor Hazalin, Gurmeet Kaur Surindar Sing. Regulation of Phase I and Phase II Neurosteroid Enzymes in the Hippocampus of an Alzheimer's Disease Rat Model: A Focus on Sulphotransferases and UDP-Glucuronosyltransferases. Steroids. 2022-04-11. PMID:35405201. |
neurosteroids have been associated with neurodegenerative diseases because they are involved in the modulation of neurotransmitter, neurotropic and neuroprotective actions. |
2022-04-11 |
2023-08-13 |
rat |
| Leonardo Provetti Cunha, Leopoldo Antônio Pires, Marcelo Maroco Cruzeiro, Ana Laura Maciel Almeida, Luiza Cunha Martins, Pedro Nascimento Martins, Nadia Shigaeff, Thiago Cardoso Val. Optical coherence tomography in neurodegenerative disorders. Arquivos de neuro-psiquiatria. vol 80. issue 2. 2022-03-30. PMID:35352756. |
the retina shares embryological, histological, biochemical, microvascular and neurotransmitter similarities with the cerebral cortex, thus making it a uniquely promising biomarker for neurodegenerative diseases. |
2022-03-30 |
2023-08-13 |
Not clear |
| Joyce Keife. Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease. Journal of neuroscience research. 2022-02-07. PMID:35128708. |
research demonstrates that the neural mechanisms underlying synaptic plasticity and learning and memory involve mobilization of ampa-type neurotransmitter receptors at glutamatergic synaptic contacts, and that these mechanisms are targeted during neurodegenerative disease. |
2022-02-07 |
2023-08-13 |
Not clear |
| Yuvaraj Balan, Archana Gaur, Varatharajan Sakthivadivel, Bhushan Kamble, Raja Sundaramurth. Is the Gut Microbiota a Neglected Aspect of Gut and Brain Disorders? Cureus. vol 13. issue 11. 2021-12-23. PMID:34938619. |
in brain disorders, gut dysbiosis is involved in neuropsychiatric manifestations, including autism spectrum disorder, anxiety, and depression by interfering with neurotransmitter homeostasis, and neurodegenerative diseases, such as alzheimer's disease and parkinson's disease by releasing abnormal metabolites from the gut. |
2021-12-23 |
2023-08-13 |
human |
| Małgorzata Kujawska, Sheetal K Bhardwaj, Yogendra Kumar Mishra, Ajeet Kaushi. Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson's Disease Diagnostics. Biosensors. vol 11. issue 11. 2021-11-28. PMID:34821649. |
parkinson's disease (pd) is a neurodegenerative disease in which the neurotransmitter dopamine (da) depletes due to the progressive loss of nigrostriatal neurons. |
2021-11-28 |
2023-08-13 |
Not clear |
| Baiping Liu, Yongping Zhang, Zhiyou Yang, Meijun Liu, Cai Zhang, Yuntao Zhao, Cai Son. ω-3 DPA Protected Neurons from Neuroinflammation by Balancing Microglia M1/M2 Polarizations through Inhibiting NF-κB/MAPK p38 Signaling and Activating Neuron-BDNF-PI3K/AKT Pathways. Marine drugs. vol 19. issue 11. 2021-11-28. PMID:34822458. |
microglia m1 phenotype causes hpa axis hyperactivity, neurotransmitter dysfunction, and production of proinflammatory mediators and oxidants, which may contribute to the etiology of depression and neurodegenerative diseases. |
2021-11-28 |
2023-08-13 |
Not clear |
| Hamdullah Khadim Sheikh, Tanzila Arshad, Zainab Sher Mohammad, Isra Khalil Moussa, Rafia Usman, Muhammad Mohtasheemul Hasa. Derivatives of diisopropyl phenoxyphosphate with controlled reactivity for enhancement of Acetylcholine (ACh) neurotransmitter. Pakistan journal of pharmaceutical sciences. vol 33. issue 5(Supplementary). 2021-11-18. PMID:33832896. |
this increased neurotransmitter concentration can enhance memory and cognition thus improving symptoms of neurodegenerative diseases such as alzheimer disease and down syndrome. |
2021-11-18 |
2023-08-13 |
Not clear |
| Bernardo Patella, Alessia Sortino, Francesca Mazzara, Giuseppe Aiello, Giuseppe Drago, Claudia Torino, Antonio Vilasi, Alan O'Riordan, Rosalinda Inguant. Electrochemical detection of dopamine with negligible interference from ascorbic and uric acid by means of reduced graphene oxide and metals-NPs based electrodes. Analytica chimica acta. vol 1187. 2021-11-11. PMID:34753568. |
dopamine is an important neurotransmitter involved in many human biological processes as well as in different neurodegenerative diseases. |
2021-11-11 |
2023-08-13 |
human |
| Wiebke Frank, Katrin S Lindenberg, Alzbeta Mühlbäck, Jan Lewerenz, G Bernhard Landwehrmeye. [Disease-modifying treatment approaches in Huntington disease : Past and future]. Der Nervenarzt. 2021-11-11. PMID:34762178. |
in the past emphasis was placed on the compensation of a suspected neurotransmitter deficit (gaba) analogous to parkinson's disease and on classical neuroprotective strategies to influence hypothetical common pathways in neurodegenerative diseases (e.g., excitotoxicity, mitochondrial dysfunction, oxidative stress). |
2021-11-11 |
2023-08-13 |
Not clear |
| Francisco José Sanz, Cristina Solana-Manrique, Josema Torres, Esther Masiá, María J Vicent, Nuria Parici. A High-Throughput Chemical Screen in DJ-1β Mutant Flies Identifies Zaprinast as a Potential Parkinson's Disease Treatment. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2021-10-26. PMID:34697772. |
in the search for novel disease-modifying therapies that target other relevant molecular and cellular mechanisms, drosophila has emerged as a valuable tool to study neurodegenerative diseases due to the presence of a complex central nervous system, the blood-brain barrier, and a similar neurotransmitter profile to humans. |
2021-10-26 |
2023-08-13 |
human |
| Saad Latif, Muhammad Jahangeer, Dure Maknoon Razia, Mehvish Ashiq, Abdul Ghaffar, Muhammad Akram, Aicha El Allam, Abdelhakim Bouyahya, Larisa Garipova, Mohammad Ali Shariati, Muthu Thiruvengadam, Mohammad Azam Ansar. Dopamine in Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry. vol 522. 2021-09-28. PMID:34389279. |
parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie, cells critical to the production of dopamine, an important neurotransmitter in the brain. |
2021-09-28 |
2023-08-13 |
Not clear |
| Atul Goel, Ramkumar Sugumaran, Sunil K Naraya. Zonisamide in Parkinson's disease: a current update. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 10. 2021-09-17. PMID:34448999. |
parkinson's disease (pd) is a progressive neurodegenerative disease due to the depletion of the neurotransmitter dopamine in basal ganglia. |
2021-09-17 |
2023-08-13 |
Not clear |
| Emily E Noble, Christine A Olson, Elizabeth Davis, Linda Tsan, Yen-Wei Chen, Ruth Schade, Clarissa Liu, Andrea Suarez, Roshonda B Jones, Claire de La Serre, Xia Yang, Elaine Y Hsiao, Scott E Kanosk. Gut microbial taxa elevated by dietary sugar disrupt memory function. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33790226. |
hippocampus transcriptome analyses revealed that early life sugar consumption altered gene expression in intracellular kinase and synaptic neurotransmitter signaling pathways, whereas parabacteroides microbial enrichment altered gene expression in pathways associated with metabolic function, neurodegenerative disease, and dopaminergic signaling. |
2021-06-28 |
2023-08-13 |
rat |
| Oritoke Modupe Aluko, Joy Dubem Iroegbu, Omamuyovwi Meashack Ijomone, Solomon Umukor. Methyl Jasmonate: Behavioral and Molecular Implications in Neurological Disorders. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 19. issue 2. 2021-06-01. PMID:33888651. |
the molecular mechanisms such as modulation of the antioxidant defense, inflammatory biomarkers, neurotransmitter regulation, and neuronal regeneration, underlying its actions in managing neurodegenerative diseases like alzheimer's and parkinson's diseases are also discussed. |
2021-06-01 |
2023-08-13 |
Not clear |
| Elodie Lamy, Léa Pilyser, Claire Paquet, Elodie Bouaziz-Amar, Stanislas Grassin-Delyl. High-sensitivity quantification of acetylcholine and choline in human cerebrospinal fluid with a validated LC-MS/MS method. Talanta. vol 224. 2021-05-14. PMID:33379090. |
acetylcholine is the neurotransmitter of the parasympathetic nervous system, synthesized from choline and involved in several neurodegenerative diseases. |
2021-05-14 |
2023-08-13 |
human |
| Apoorva M Kulkarni, Shailima Rampogu, Keun Woo Le. Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-28. PMID:33897801. |
alkaloids owing to their neurotransmitter modulatory, anti-amyloid, anti-oxidant, and anti-inflammatory activities have shown potential in neurodegenerative disease. |
2021-04-28 |
2023-08-13 |
Not clear |
| Samaneh Zarei, Mohammad Shafiei, Maryam Firouzi, Loghman Firoozpour, Kouros Divsalar, Ali Asadipour, Tahmineh Akbarzadeh, Alireza Foroumad. Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4 Heliyon. vol 7. issue 4. 2021-04-21. PMID:33869871. |
design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4 alzheimer's disease (ad), is among the most growing neurodegenerative diseases, which is mainly caused by the acetylcholine neurotransmitter loss in the hippocampus and cortex. |
2021-04-21 |
2023-08-13 |
Not clear |