| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rona R Ramsay, Livia Basile, Antonin Maniquet, Stefanie Hagenow, Matteo Pappalardo, Maria Chiara Saija, Sharon D Bryant, Alen Albreht, Salvatore Guccion. Parameters for Irreversible Inactivation of Monoamine Oxidase. Molecules (Basel, Switzerland). vol 25. issue 24. 2021-04-14. PMID:33322203. |
the irreversible inhibitors of monoamine oxidases (mao) slow neurotransmitter metabolism in depression and neurodegenerative diseases. |
2021-04-14 |
2023-08-13 |
human |
| Zeynep Özdemir, Mehmet Abdullah Alagöz, Harun Uslu, Arzu Karakurt, Acelya Erikci, Gulberk Ucar, Mehtap Uysa. Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors. Pharmacological reports : PR. vol 72. issue 3. 2021-04-12. PMID:32144745. |
since brain neurotransmitter levels are associated with the pathology of various neurodegenerative diseases like parkinson and alzheimer, monoamineoxidase (mao) plays a critical role in balancing these neurotransmitters in the brain. |
2021-04-12 |
2023-08-13 |
human |
| Ewa Baranowska-Wójcik, Dominik Szwajgier, Anna Winiarska-Miecza. Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors. Nutrients. vol 12. issue 3. 2020-12-21. PMID:32155927. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized, among others, by abnormally low levels of the neurotransmitter acetylcholine in the brain. |
2020-12-21 |
2023-08-13 |
Not clear |
| Antonio M G de Diego, Diana Ortega-Cruz, Antonio G Garcí. Disruption of Exocytosis in Sympathoadrenal Chromaffin Cells from Mouse Models of Neurodegenerative Diseases. International journal of molecular sciences. vol 21. issue 6. 2020-12-01. PMID:32178443. |
synaptic disruption and altered neurotransmitter release occurs in the brains of patients and in murine models of neurodegenerative diseases (ndds). |
2020-12-01 |
2023-08-13 |
mouse |
| Pradeep Paudel, Srijan Shrestha, Se Eun Park, Su Hui Seong, Fazlin Mohd Fauzi, Hyun Ah Jung, Jae Sue Cho. Emodin Derivatives as Multi-Target-Directed Ligands Inhibiting Monoamine Oxidase and Antagonizing Vasopressin V ACS omega. vol 5. issue 41. 2020-10-29. PMID:33110998. |
emodin derivatives as multi-target-directed ligands inhibiting monoamine oxidase and antagonizing vasopressin v the brain neurotransmitter level is associated with the pathology of various neurodegenerative diseases, and age-dependent increase in the blood level of vasopressin, human brain monoamine oxidase (hmao) level, oxidative stress, and imbalance in aminergic signaling are common disease-modifying factors leading to various neurodegenerative disorders. |
2020-10-29 |
2023-08-13 |
human |
| Zahra Abedi, Huzwah Khaza'ai, Sharmili Vidyadaran, Mohd Sokhini Abd Mutali. The Modulation of NMDA and AMPA/Kainate Receptors by Tocotrienol-Rich Fraction and Α-Tocopherol in Glutamate-Induced Injury of Primary Astrocytes. Biomedicines. vol 5. issue 4. 2020-10-01. PMID:29194360. |
glutamate, as a main excitatory amino acid neurotransmitter in the mammalian central nervous system, can be excitotoxic, playing a key role in many chronic neurodegenerative diseases. |
2020-10-01 |
2023-08-13 |
mouse |
| Geoffrey Hollett, David S Roberts, Mollie Sewell, Emma Wensley, Julia Wagner, William Murray, Alex Krotz, Bryan Toth, Vibha Vijayakumar, Michael J Sailo. Quantum Ensembles of Silicon Nanoparticles: Discrimination of Static and Dynamic Photoluminescence Quenching Processes. The journal of physical chemistry. C, Nanomaterials and interfaces. vol 123. issue 29. 2020-09-28. PMID:32489514. |
the application of this concept to imaging of amc, the oxidized form of the neurotransmitter dopamine that is of interest for its role in neurodegenerative diseases, is demonstrated. |
2020-09-28 |
2023-08-13 |
Not clear |
| Marta Maiolino, Nathanael O'Neill, Vincenzo Lariccia, Salvatore Amoroso, Sergiy Sylantyev, Plamena R Angelova, Andrey Y Abramo. Inorganic Polyphosphate Regulates AMPA and NMDA Receptors and Protects Against Glutamate Excitotoxicity via Activation of P2Y Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 31. 2020-06-19. PMID:31147524. |
excessive amounts of this neurotransmitter lead to glutamate excitotoxicity, which is accountable for neuronal death in acute neurological disorders, including stroke and trauma, and in neurodegenerative diseases. |
2020-06-19 |
2023-08-13 |
rat |
| Meng Huang, Shailendra S Rathore, Manfred Linda. Drug testing complementary metal-oxide-semiconductor chip reveals drug modulation of transmitter release for potential therapeutic applications. Journal of neurochemistry. vol 151. issue 1. 2020-06-16. PMID:31274190. |
a variety of drugs that modulate neurotransmitter levels have been used for the treatment of the neurodegenerative diseases but with limited efficacy. |
2020-06-16 |
2023-08-13 |
cattle |
| Riri Shi, Qiong Wu, Chenqi Xin, Houzhi Yu, Kah-Leong Lim, Xin Li, Zhenxiong Shi, Cheng-Wu Zhang, Linghui Qian, Lin Li, Wei Huan. Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases. Chembiochem : a European journal of chemical biology. vol 20. issue 12. 2020-04-06. PMID:30664830. |
maos play important roles in maintaining the homeostasis of monoamines, and the aberrant expression or activation of maos underlies the pathogenesis of monoamine neurotransmitter disorders, including neuropsychiatric and neurodegenerative diseases. |
2020-04-06 |
2023-08-13 |
Not clear |
| Todd W Costantini, Theresa W Chan, Olga Cohen, Simone Langness, Sabrina Treadwell, Elliot Williams, Brian P Eliceiri, Andrew Bair. Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 16. 2020-03-23. PMID:30944217. |
one example is chrfam7a, a dominant-negative inhibitor of the antiinflammatory α7 nicotinic acetylcholine receptor (α7nachr/chrna7) that is also a neurotransmitter receptor linked to cognitive function, mental health, and neurodegenerative disease. |
2020-03-23 |
2023-08-13 |
mouse |
| Jessie Fanglu Fu, Ivan Klyuzhin, Jessamyn McKenzie, Nicole Neilson, Elham Shahinfard, Katie Dinelle, Martin J McKeown, A Jon Stoessl, Vesna Soss. Joint pattern analysis applied to PET DAT and VMAT2 imaging reveals new insights into Parkinson's disease induced presynaptic alterations. NeuroImage. Clinical. vol 23. 2020-03-20. PMID:31091502. |
most neurodegenerative diseases are known to affect several aspects of brain function, including neurotransmitter systems, metabolic and functional connectivity. |
2020-03-20 |
2023-08-13 |
human |
| Rona R Ramsay, Alen Albreh. Kinetics, mechanism, and inhibition of monoamine oxidase. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 11. 2019-11-11. PMID:29516165. |
in neurodegenerative diseases, mao inhibitors can help to maintain neurotransmitter levels, making it a common feature in novel multi-target combinations designed to combat alzheimer's disease, albeit not yet proven clinically. |
2019-11-11 |
2023-08-13 |
Not clear |
| Brandi Wasek, Erland Arning, Teodoro Bottiglier. The use of microwave irradiation for quantitative analysis of neurotransmitters in the mouse brain. Journal of neuroscience methods. vol 307. 2019-10-15. PMID:29802857. |
assessing neurotransmitter metabolism in the brain is essential in studying the effects of drugs, dietary modification and characterizing transgenic mouse models of human neurodegenerative diseases. |
2019-10-15 |
2023-08-13 |
mouse |
| Hudifah Rabie, Yixiao Zhang, Nicholas Pasquale, Maureen J Lagos, Philip E Batson, Ki-Bum Le. NIR Biosensing of Neurotransmitters in Stem Cell-Derived Neural Interface Using Advanced Core-Shell Upconversion Nanoparticles. Advanced materials (Deerfield Beach, Fla.). vol 31. issue 14. 2019-07-18. PMID:30761616. |
nondestructive neurotransmitter detection and real-time monitoring of stem cell differentiation are both of great significance in the field of neurodegenerative disease and regenerative medicine. |
2019-07-18 |
2023-08-13 |
Not clear |
| Xiao-Ling Zhong, Jie-Qiong Li, Li Sun, Ya-Qing Li, Hui-Fu Wang, Xi-Peng Cao, Chen-Chen Tan, Ling Wang, Lan Tan, Jin-Tai Y. A Genome-Wide Association Study of α-Synuclein Levels in Cerebrospinal Fluid. Neurotoxicity research. vol 35. issue 1. 2019-02-20. PMID:29959729. |
α-synuclein is a 140-amino acid protein produced predominantly by neurons in the brain which plays a role in the regulation of neurotransmitter release, synaptic function, and plasticity, thus making it the focus in understanding the etiology of a group of neurodegenerative diseases. |
2019-02-20 |
2023-08-13 |
human |
| Sita Sharan Patel, Ramsaneh Raghuwanshi, Misha Masood, Ashish Acharya, Surendra Kumar Jai. Medicinal plants with acetylcholinesterase inhibitory activity. Reviews in the neurosciences. vol 29. issue 5. 2018-10-23. PMID:29303784. |
alzheimer's disease, a progressive neurodegenerative disease, is characterised by hypofunction of acetylcholine (ach) neurotransmitter in the distinct region of brain. |
2018-10-23 |
2023-08-13 |
human |
| Doral Fredericks, James C Norton, Carolyn Atchison, Robert Schoenhaus, Michael W Pil. Parkinson's disease and Parkinson's disease psychosis: a perspective on the challenges, treatments, and economic burden. The American journal of managed care. vol 23. issue 5 Suppl. 2018-04-18. PMID:28715903. |
parkinson's disease (pd) is a progressive neurodegenerative disease associated with a decrease in the neurotransmitter dopamine and characterized by the cardinal motor hallmarks of resting tremor, rigidity, bradykinesia/akinesia, and postural instability. |
2018-04-18 |
2023-08-13 |
Not clear |
| Adnane Kara, Camille Rouillard, Jessy Mathault, Martin Boisvert, Frédéric Tessier, Hamza Landari, Imene Melki, Myriam Laprise-Pelletier, Elodie Boisselier, Marc-André Fortin, Eric Boilard, Jesse Greener, Amine Mile. Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept. Sensors (Basel, Switzerland). vol 16. issue 6. 2018-02-05. PMID:27240377. |
this architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. |
2018-02-05 |
2023-08-13 |
Not clear |
| Steven M Wellman, Takashi D Y Koza. Understanding the Inflammatory Tissue Reaction to Brain Implants To Improve Neurochemical Sensing Performance. ACS chemical neuroscience. vol 8. issue 12. 2018-01-30. PMID:29120167. |
neurochemical sensing probes are a valuable diagnostic and therapeutic tool that can be used to study neurodegenerative diseases involving deficiencies in neurotransmitter signaling. |
2018-01-30 |
2023-08-13 |
Not clear |