| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexa E Horner, Christopher J Heath, Martha Hvoslef-Eide, Brianne A Kent, Chi Hun Kim, Simon R O Nilsson, Johan Alsiö, Charlotte A Oomen, Andrew Holmes, Lisa M Saksida, Timothy J Busse. The touchscreen operant platform for testing learning and memory in rats and mice. Nature protocols. vol 8. issue 10. 2014-04-01. PMID:24051959. |
applications include the study of cognition in rodent models of psychiatric and neurodegenerative diseases (e.g., alzheimer's disease, schizophrenia, huntington's disease, frontotemporal dementia), as well as the characterization of the role of select brain regions, neurotransmitter systems and genes in rodents. |
2014-04-01 |
2023-08-12 |
mouse |
| M G Sánchez, M Morissette, T Di Paol. Oestradiol modulation of serotonin reuptake transporter and serotonin metabolism in the brain of monkeys. Journal of neuroendocrinology. vol 25. issue 6. 2013-12-26. PMID:23414342. |
serotonin (5-hydroxytryptamine; 5-ht) is an important brain neurotransmitter that is implicated in mental and neurodegenerative diseases and is modulated by ovarian hormones. |
2013-12-26 |
2023-08-12 |
monkey |
| Robin J Kleiman, Douglas S Chapin, Curt Christoffersen, Jody Freeman, Kari R Fonseca, Kieran F Geoghegan, Sarah Grimwood, Victor Guanowsky, Mihály Hajós, John F Harms, Christopher J Helal, William E Hoffmann, Geralyn P Kocan, Mark J Majchrzak, Dina McGinnis, Stafford McLean, Frank S Menniti, Fredrick Nelson, Robin Roof, Anne W Schmidt, Patricia A Seymour, Diane T Stephenson, Francis David Tingley, Michelle Vanase-Frawley, Patrick R Verhoest, Christopher J Schmid. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. The Journal of pharmacology and experimental therapeutics. vol 341. issue 2. 2012-08-20. PMID:22328573. |
thus, pde9a activity regulates neuronal cgmp signaling downstream of multiple neurotransmitter systems, and inhibition of pde9a may provide therapeutic benefits in psychiatric and neurodegenerative diseases promoted by the dysfunction of these diverse neurotransmitter systems. |
2012-08-20 |
2023-08-12 |
human |
| Maria Trinidad Herrero, Javier Pagonabarraga, Gurutz Linazasor. Neuroprotective role of dopamine agonists: evidence from animal models and clinical studies. The neurologist. vol 17. issue 6 Suppl 1. 2012-02-21. PMID:22045327. |
parkinson disease is a progressive neurodegenerative disease that affects, among other neurotransmitter systems, the nigrostriatal dopaminergic projection. |
2012-02-21 |
2023-08-12 |
Not clear |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
acetylcholinesterase (ache; ec 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. |
2011-11-10 |
2023-08-12 |
mouse |
| William Rostèn. [New prospects for chemokines]. Biologie aujourd'hui. vol 204. issue 4. 2011-04-06. PMID:21215243. |
thus chemokines have been shown to regulate immune functions involving infection and inflammation, stem cell migration during development, to be implicated in oncogenic, neovascularization and atherosclerosis processes, to modulate neuronal excitability regulating neurotransmitter release, and to play a key role in the pathogenesis of various neurodegenerative diseases such as parkinson's disease or age-related-macular degeneration and in pain. |
2011-04-06 |
2023-08-12 |
Not clear |
| Marimuthu Parthiban, Piramanayagam Shanmughavel, Ramanathan Sowdhamin. In silico point mutation and evolutionary trace analysis applied to nicotinic acetylcholine receptors in deciphering ligand-binding surfaces. Journal of molecular modeling. vol 16. issue 10. 2010-12-13. PMID:20204665. |
malfunction of this neurotransmitter receptor is believed to cause various neurodegenerative diseases, such as alzheimer's disease, parkinson's disease and schizophrenia, and nachrs are thus important drug targets. |
2010-12-13 |
2023-08-12 |
Not clear |
| Gurutz J Linazasor. Neuroprotection in Parkinson's disease: love story or mission impossible? Expert review of neurotherapeutics. vol 2. issue 3. 2010-06-25. PMID:19810872. |
parkinson's disease was the first neurodegenerative disease in which a deficient neurotransmitter (dopamine) was successfully replaced by a systemically administered drug (levodopa). |
2010-06-25 |
2023-08-12 |
Not clear |
| Alessandra Cifra, Francesca Nani, Elina Sharifullina, Andrea Nistr. A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 364. issue 1529. 2009-10-30. PMID:19651651. |
hypoglossal motoneurons are destroyed early in amyotrophic lateral sclerosis (als), a fatal neurodegenerative disease often associated with a deficit in the transport system of the neurotransmitter glutamate. |
2009-10-30 |
2023-08-12 |
Not clear |
| Rafael Franc. Neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 8. 2009-09-24. PMID:19002553. |
neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity. |
2009-09-24 |
2023-08-12 |
Not clear |
| Pertti Panula, Ville Sallinen, Maria Sundvik, Juha Kolehmainen, Veera Torkko, Anu Tiittula, Maxim Moshnyakov, Piotr Podlas. Modulatory neurotransmitter systems and behavior: towards zebrafish models of neurodegenerative diseases. Zebrafish. vol 3. issue 2. 2008-04-14. PMID:18248264. |
modulatory neurotransmitter systems and behavior: towards zebrafish models of neurodegenerative diseases. |
2008-04-14 |
2023-08-12 |
human |
| Vincenzo Micale, Carmen Mazzola, Filippo Drag. Endocannabinoids and neurodegenerative diseases. Pharmacological research. vol 56. issue 5. 2008-04-08. PMID:17950616. |
thus, both the possible neuroprotective role of ecs and their modulating action on neurotransmitter systems affected in several neurodegenerative diseases such as alzheimer's disease (ad), huntington's disease (hd) and multiple sclerosis (ms) are currently under investigation. |
2008-04-08 |
2023-08-12 |
Not clear |
| M V Ugriumo. [Expression of the enzymes of dopamine synthesis in non-dopaminergic neurons: functional significance and regulation]. Uspekhi fiziologicheskikh nauk. vol 38. issue 4. 2008-01-16. PMID:18064905. |
thus, non-dopaminergic monoenzymatic neurons expressing enzymes of da synthesis produce this neurotransmitter in cooperation that is a compensatory reaction under functional insufficiency of da-ergic neurons, in neurodegenerative diseases, hyperprolactinemia and parkinson's disease, in particular. |
2008-01-16 |
2023-08-12 |
Not clear |
| Jae-Sung Bae, Hyung Soo Han, Dong-Ho Youn, Janet E Carter, Michel Modo, Edward H Schuchman, Hee Kyung Ji. Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration. Stem cells (Dayton, Ohio). vol 25. issue 5. 2007-05-16. PMID:17470534. |
this study provides the first in vivo evidence that upregulation of neurotransmitter receptors may contribute to synapse formation via cell fusion-like processes after bm-msc transplantation into mice with neurodegenerative disease. |
2007-05-16 |
2023-08-12 |
mouse |
| Tamuna Lekishvili, Shirley Hesketh, Marcus W Brazier, David R Brow. Mouse galectin-1 inhibits the toxicity of glutamate by modifying NR1 NMDA receptor expression. The European journal of neuroscience. vol 24. issue 11. 2007-02-23. PMID:17156363. |
one of the major causes of neuronal death in neurodegenerative disease is excitotoxicity from the neurotransmitter glutamate. |
2007-02-23 |
2023-08-12 |
mouse |
| Cindy V Ly, Patrik Verstreke. Mitochondria at the synapse. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 12. issue 4. 2006-09-19. PMID:16840705. |
additionally, they will summarize recent data that implicate synaptic mitochondria in the regulation of neurotransmitter release during intense neuronal activity and link these findings to the pathogenesis of neurodegenerative diseases that feature disrupted synaptic mitochondria, including amyotrophic lateral sclerosis and hereditary spastic paraplegia. |
2006-09-19 |
2023-08-12 |
Not clear |
| Jillian Madine, Andrew J Doig, David A Middleto. A study of the regional effects of alpha-synuclein on the organization and stability of phospholipid bilayers. Biochemistry. vol 45. issue 18. 2006-06-23. PMID:16669622. |
associations between the protein alpha-synuclein (alpha-syn) and presynaptic vesicles have been implicated in synaptic plasticity and neurotransmitter release and may also affect how the protein aggregates into fibrils found in lewy bodies, the cellular inclusions associated with neurodegenerative diseases. |
2006-06-23 |
2023-08-12 |
Not clear |
| Samina S Riaz, Spyridon Theofilopoulos, Eric Jauniaux, Gerald M Stern, Henry F Bradfor. The differentiation potential of human foetal neuronal progenitor cells in vitro. Brain research. Developmental brain research. vol 153. issue 1. 2004-12-21. PMID:15464216. |
the controlled trans-differentiation potential of these cell could pave the way for development and harvesting of large numbers of neurons of the appropriate neurotransmitter phenotype for future transplantation therapies for the treatment of neurodegenerative diseases such as parkinson's disease (pd) and alzheimer's disease. |
2004-12-21 |
2023-08-12 |
human |
| Yasuhiko Iida, Mikako Ogawa, Masashi Ueda, Akiko Tominaga, Hidekazu Kawashima, Yasuhiro Magata, Shingo Nishiyama, Hideo Tsukada, Takahiro Mukai, Hideo Saj. Evaluation of 5-(11)C-methyl-A-85380 as an imaging agent for PET investigations of brain nicotinic acetylcholine receptors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 45. issue 5. 2004-06-10. PMID:15136639. |
central nicotinic acetylcholine receptors (nachrs) represent major neurotransmitter receptors responsible for various brain functions, and changes in the density of nachrs have recently been reported in several neurodegenerative diseases. |
2004-06-10 |
2023-08-12 |
human |
| Tiffany C Wheeler, Lih-Shen Chin, Yankun Li, Francine L Roudabush, Lian L. Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. The Journal of biological chemistry. vol 277. issue 12. 2002-04-29. PMID:11786535. |
although synaptophysin has been implicated in neurotransmitter release, and decreased synaptophysin levels have been associated with several neurodegenerative diseases, the molecular mechanism that regulates the degradation of synaptophysin remains unsolved. |
2002-04-29 |
2023-08-12 |
rat |