| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacob J Crouse, Joseph R Phillips, Marjan Jahanshahi, Ahmed A Moustaf. Postural instability and falls in Parkinson's disease. Reviews in the neurosciences. vol 27. issue 5. 2018-01-02. PMID:26966928. |
the delayed effect of dopaminergic medication combined with the success of extrastriatal deep brain stimulation suggests that pi involves neurotransmitter systems other than dopamine and brain regions extending beyond the basal ganglia, further challenging the traditional view of pd as a predominantly single-system neurodegenerative disease. |
2018-01-02 |
2023-08-13 |
Not clear |
| Susan Westfall, Nikita Lomis, Imen Kahouli, Si Yuan Dia, Surya Pratap Singh, Satya Prakas. Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis. Cellular and molecular life sciences : CMLS. vol 74. issue 20. 2017-12-13. PMID:28643167. |
age is a common factor in the development of neurodegenerative disease and probiotics prevent many harmful effects of aging such as decreased neurotransmitter levels, chronic inflammation, oxidative stress and apoptosis-all factors that are proven aggravators of neurodegenerative disease. |
2017-12-13 |
2023-08-13 |
Not clear |
| Richard L Dot. Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate? The Lancet. Neurology. vol 16. issue 6. 2017-06-30. PMID:28504111. |
for example, the amount of damage to forebrain neurotransmitter and neuromodulator circuits, most notably those involving cholinergic transmission, appears to be correlated with quantitative smell test scores across a wide range of neurodegenerative diseases. |
2017-06-30 |
2023-08-13 |
Not clear |
| Zdeněk Fiša. Drugs related to monoamine oxidase activity. Progress in neuro-psychopharmacology & biological psychiatry. vol 69. 2017-04-10. PMID:26944656. |
the increase in monoamine neurotransmitter availability, decrease in hydrogen peroxide production, and neuroprotective effects evoked by mao inhibitors represent an important approach in the development of new drugs for the treatment of mental disorders and neurodegenerative diseases. |
2017-04-10 |
2023-08-13 |
Not clear |
| Jing Guo, Waichiu Ng, Jie Yuan, Suwen Li, Mansun Cha. A 200-Channel Area-Power-Efficient Chemical and Electrical Dual-Mode Acquisition IC for the Study of Neurodegenerative Diseases. IEEE transactions on biomedical circuits and systems. vol 10. issue 3. 2016-12-13. PMID:26529782. |
microelectrode array (mea) can be used in the study of neurodegenerative diseases by monitoring the chemical neurotransmitter release and the electrical potential simultaneously at the cellular level. |
2016-12-13 |
2023-08-13 |
Not clear |
| Marwa Y Sallam, Sahar M El-Gowilly, Abdel-Galil A Abdel-Galil, Mahmoud M El-Ma. Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 3. 2016-11-14. PMID:26685896. |
γ-aminobutyric acid (gaba), the principal brain inhibitory neurotransmitter, modulates inflammatory and neurodegenerative disease. |
2016-11-14 |
2023-08-13 |
rat |
| Yasuhiro Yoshioka, Hisatsugu Kadoi, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maed. Noradrenaline increases intracellular glutathione in human astrocytoma U-251 MG cells by inducing glutamate-cysteine ligase protein via β3-adrenoceptor stimulation. European journal of pharmacology. vol 772. 2016-11-01. PMID:26724392. |
the neurotransmitter noradrenaline is known to modulate the functions of astrocytes and has been suggested to have neuroprotective properties in neurodegenerative diseases. |
2016-11-01 |
2023-08-13 |
human |
| C Subathra Devi, V Mohanasrinivasan, C George Priyadoss, Nikhil Arora, Bharti Singh, Neetu Mittal, Shubham Agarwal, Shwetank Saxen. NGA- A Novel Hypothetical Drug Model: Combinatorial Approach to Multifactorial Alzheimer's Disease. Current drug discovery technologies. vol 12. issue 4. 2016-10-19. PMID:26572486. |
a combinatory use of nsaid with a natural neurotransmitter will allow for an efficient control of amyloid beta toxicity and will open doors for the treatment of a myriad of other neurodegenerative diseases. |
2016-10-19 |
2023-08-13 |
Not clear |
| Eleni Stamoula, Theofanis Vavilis, Eleni Aggelidou, Aikaterini Kaidoglou, Angeliki Cheva, Kyriakos Mellidis, Antigone Lazou, Costas Haitoglou, Maria Albani, Aristeidis Kriti. Low Dose Administration of Glutamate Triggers a Non-Apoptotic, Autophagic Response in PC12 Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 37. issue 5. 2016-08-31. PMID:26584276. |
increasing amounts of the neurotransmitter glutamate are associated with excitotoxicity, a phenomenon related both to homeostatic processes and neurodegenerative diseases such as multiple sclerosis. |
2016-08-31 |
2023-08-13 |
Not clear |
| Justine Renaud, Seyed Fazel Nabavi, Maria Daglia, Seyed Mohammad Nabavi, Maria-Grazia Martinol. Epigallocatechin-3-Gallate, a Promising Molecule for Parkinson's Disease? Rejuvenation research. vol 18. issue 3. 2016-03-15. PMID:25625827. |
parkinson's disease (pd) is the second most common neurodegenerative disease, and it is characterized by the loss of the neurotransmitter dopamine and neuronal degeneration in the substantia nigra pars compacta. |
2016-03-15 |
2023-08-13 |
human |
| Andrzej Szutowicz, Hanna Bielarczyk, Agnieszka Jankowska-Kulawy, Anna Ronowska, Tadeusz Pawełczy. Retinoic acid as a therapeutic option in Alzheimer's disease: a focus on cholinergic restoration. Expert review of neurotherapeutics. vol 15. issue 3. 2015-11-25. PMID:25683350. |
its capacities, facilitating maturation of neurotransmitter phenotype in different groups of neurons, pave the way for its application as a potential therapeutic agent in neurodegenerative diseases including alzheimer's disease. |
2015-11-25 |
2023-08-13 |
Not clear |
| Rukmini Mridula Kandadai, Shaik Afshan Jabeen, Meena A Kanikannan, Rupam Borgohai. Safinamide for the treatment of Parkinson's disease. Expert review of clinical pharmacology. vol 7. issue 6. 2015-06-15. PMID:25300164. |
parkinson's disease (pd) is a neurodegenerative disease caused by a complex interaction of loss of dopaminergic and non-dopaminergic neurotransmitter systems. |
2015-06-15 |
2023-08-13 |
Not clear |
| Li-Nan Zhang, Liang Hao, Hai-Yan Wang, Hong-Ning Su, Yong-Jun Sun, Xiao-Yue Yang, Bin Che, Jiao Xue, Zi Bin Ga. Neuroprotective effect of resveratrol against glutamate-induced excitotoxicity. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 24. issue 1. 2015-06-02. PMID:25923101. |
as the major neurotransmitter in the mammalian central nervous system (cns), excessive extracellular glutamate (glu) can activate the glu receptors and neuronal calcium (ca2+) overload, then produce neurotoxicity, which is a common pathway for neuronal injury or death, and is associated with acute and chronic neurodegenerative diseases. |
2015-06-02 |
2023-08-13 |
Not clear |
| Bin Lai, Ping Zhen. The influence of mitochondrial complex inhibition on neuronal ion channel and neurotransmitter release. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 6. 2015-05-16. PMID:23258337. |
therefore, understanding the influence of mitochondrial complex inhibition on neuronal ion channels and neurotransmitter release is helpful to illuminate the pathophysiology of neurodegenerative diseases. |
2015-05-16 |
2023-08-12 |
Not clear |
| Kenneth S Hettie, Jessica L Klockow, Timothy E Glas. Three-input logic gates with potential applications for neuronal imaging. Journal of the American Chemical Society. vol 136. issue 13. 2015-05-15. PMID:24611584. |
convenient methods for the direct visualization of neurotransmitter trafficking would bolster investigations into the development of neurodegenerative diseases. |
2015-05-15 |
2023-08-12 |
Not clear |
| Jingping Zhang, Taixiang Saur, Angela N Duke, Seth G N Grant, Donna M Platt, James K Rowlett, Ole Isacson, Wei-Dong Ya. Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95. Journal of neurogenetics. vol 28. issue 1-2. 2015-01-07. PMID:24702501. |
excessive activation of the n-methyl-d-aspartate (nmda) receptor and the neurotransmitter dopamine (da) mediate neurotoxicity and neurodegeneration under many neurological conditions, including huntington's disease (hd), an autosomal dominant neurodegenerative disease characterized by the preferential loss of medium spiny projection neurons (msns) in the striatum. |
2015-01-07 |
2023-08-13 |
mouse |
| Na Ye, Zilan Song, Ao Zhan. Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents. Current medicinal chemistry. vol 21. issue 4. 2014-09-17. PMID:24164194. |
psychiatric disorders like schizophrenia and neurodegenerative diseases like parkinson's disease are associated with poly-factorial pathogenic mechanisms, with several neurotransmitter systems closely involved. |
2014-09-17 |
2023-08-12 |
Not clear |
| Richard L Doty, Vidyulata Kamat. The influences of age on olfaction: a review. Frontiers in psychology. vol 5. 2014-06-24. PMID:24570664. |
as described in this review, multiple factors contribute to such age-related loss, including altered nasal engorgement, increased propensity for nasal disease, cumulative damage to the olfactory epithelium from viral and other environmental insults, decrements in mucosal metabolizing enzymes, ossification of cribriform plate foramina, loss of selectivity of receptor cells to odorants, changes in neurotransmitter and neuromodulator systems, and neuronal expression of aberrant proteins associated with neurodegenerative disease. |
2014-06-24 |
2023-08-12 |
Not clear |
| David A Zhang, Emily Rand, Michael Marsh, Russell J Andrews, Kendall H Lee, M Meyyappan, Jessica E Koehn. Carbon nanofiber electrode for neurochemical monitoring. Molecular neurobiology. vol 48. issue 2. 2014-04-21. PMID:23975638. |
the ability to rapidly detect neurotransmitter release has broad implications in the study of a variety of neurodegenerative diseases. |
2014-04-21 |
2023-08-12 |
Not clear |
| Alexa E Horner, Christopher J Heath, Martha Hvoslef-Eide, Brianne A Kent, Chi Hun Kim, Simon R O Nilsson, Johan Alsiö, Charlotte A Oomen, Andrew Holmes, Lisa M Saksida, Timothy J Busse. The touchscreen operant platform for testing learning and memory in rats and mice. Nature protocols. vol 8. issue 10. 2014-04-01. PMID:24051959. |
applications include the study of cognition in rodent models of psychiatric and neurodegenerative diseases (e.g., alzheimer's disease, schizophrenia, huntington's disease, frontotemporal dementia), as well as the characterization of the role of select brain regions, neurotransmitter systems and genes in rodents. |
2014-04-01 |
2023-08-12 |
mouse |