| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunyan Yao, Zhiyuan Wang, Huiyong Jiang, Ren Yan, Qianfei Huang, Yin Wang, Hui Xie, Ying Zou, Ying Yu, Longxian L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34211003. |
glaa administration increased the levels of the sleep-promoting neurotransmitter 5-hydroxytryptamine and the tph2, iptr3 and gng13 transcripts in the sleep-regulating serotonergic synapse pathway in the hypothalamus during this process. |
2021-11-08 |
2023-08-13 |
mouse |
| Jingsheng Gu, Zhijie Hou, Xiaotao Zhou, Qinglei Wang, Yanmei Chen, Jichuan Zhan. Activation of 5-HT Neuroscience letters. 2021-10-26. PMID:34699942. |
activation of 5-ht serotonin (5-hydroxytraptamine, 5-ht) is a neurotransmitter plays important roles in emotion and motivation. |
2021-10-26 |
2023-08-13 |
Not clear |
| Andrew M Smith, Linda P Dwoskin, James R Paul. Early exposure to nicotine during critical periods of brain development: Mechanisms and consequences. Journal of pediatric biochemistry. vol 1. issue 2. 2021-10-21. PMID:24904708. |
the purpose of the current review is to provide an overview of the role that nicotinic achrs play in the developing cns and to describe the effects of nicotine exposure during early development on neuronal cell biology, nicotinic achr expression and neurotransmitter system (e.g., dopamine, norepinephrine, serotonin) function. |
2021-10-21 |
2023-08-13 |
Not clear |
| b' Kl\\xc3\\xa1ra Gotvaldov\\xc3\\xa1, Kate\\xc5\\x99ina H\\xc3\\xa1jkov\\xc3\\xa1, Jan Borovi\\xc4\\x8dka, Radek Jurok, Petra Cihl\\xc3\\xa1\\xc5\\x99ov\\xc3\\xa1, Martin Kucha\\xc5\\x9. Stability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis. Drug testing and analysis. vol 13. issue 2. 2021-10-21. PMID:33119971.' |
psilocybin, psilocin, baeocystin, norbaeocystin, and aeruginascin are tryptamines structurally similar to the neurotransmitter serotonin. |
2021-10-21 |
2023-08-13 |
Not clear |
| Yuan Guo, Li Zhang, Jin Zhang, Shu-Xuan Lv, Cheng-Xue Du, Tao Wang, Hui-Sheng Wang, Wen Xie, Jian Li. Activation and Blockade of Serotonin-4 Receptors in the Lateral Habenula Produce Antidepressant Effects in the Hemiparkinsonian Rat. Neuropsychobiology. vol 80. issue 1. 2021-10-18. PMID:32663830. |
the 5-hydroxytryptamine (5-ht) neurotransmitter system and lateral habenula (lhb) are involved in the regulation of depression, while the mechanisms remain to be clarified. |
2021-10-18 |
2023-08-13 |
rat |
| Jenny Slatman, Inge van de Ve. Gut feelings: depression as an embodied and affective phenomenon in Houellebecq's Medical humanities. vol 47. issue 3. 2021-10-15. PMID:32788195. |
gut feelings: depression as an embodied and affective phenomenon in houellebecq's current debates about the possible causes of depression reinforce the age-old body-mind dualism: while some claim that depression is caused by psychological or societal stress, others underline that it results from a shortage of the neurotransmitter serotonin in the central nervous system. |
2021-10-15 |
2023-08-13 |
Not clear |
| B Spurny, T Vanicek, R Seiger, M B Reed, M Klöbl, V Ritter, J Unterholzner, G M Godbersen, L R Silberbauer, D Pacher, S Klug, M E Konadu, G Gryglewski, S Trattnig, W Bogner, R Lanzenberge. Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm. NeuroImage. vol 232. 2021-10-14. PMID:33657450. |
while memory formation is mostly associated with glutamate, also gamma-aminobutyric acid (gaba) and serotonin show attributions in a complex interplay between neurotransmitter systems. |
2021-10-14 |
2023-08-13 |
human |
| Lu Liu, Sergio Oroz Artigas, Anja Ulrich, Jeremy Tardu, Peter N C Mohr, Britta Wilms, Berthold Koletzko, Sebastian M Schmid, Soyoung Q Par. Eating to dare - Nutrition impacts human risky decision and related brain function. NeuroImage. vol 233. 2021-10-14. PMID:33722669. |
neurotransmitter serotonin has been shown to regulate not only food intake, but also economic decisions. |
2021-10-14 |
2023-08-13 |
human |
| Paul Bengart, Theo Gruendler, Bodo Vog. Acute tryptophan depletion in healthy subjects increases preferences for negative reciprocity. PloS one. vol 16. issue 3. 2021-10-13. PMID:33784350. |
the neurotransmitter serotonin (5-ht) modulates human behavior in numerous social situations, such as retaliation in response to perceived unfairness. |
2021-10-13 |
2023-08-13 |
human |
| Carolina Costa, Miguel Semedo, Sandrine P Machado, Virginia Cunha, Marta Ferreira, Ralph Urbatzk. Transcriptional analyses reveal different mechanism of toxicity for a chronic exposure to fluoxetine and venlafaxine on the brain of the marine fish Dicentrarchrus labrax. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 250. 2021-10-08. PMID:34454087. |
both psychopharmaceuticals affected differentially the neurotransmitter mrna expression analyzed by rt-qpcr (serotonin receptors: 5-ht3a, 5-ht3b; dopamine receptors: d2, d3; neurotransmitter transporter: sert, vmat; degrading enzyme: mao). |
2021-10-08 |
2023-08-13 |
Not clear |
| Janet Best, William Duncan, Farrah Sadre-Marandi, Parastoo Hashemi, H Frederik Nijhout, Michael Ree. Autoreceptor control of serotonin dynamics. BMC neuroscience. vol 21. issue 1. 2021-09-02. PMID:32967609. |
serotonin is a neurotransmitter that has been linked to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, alcoholism, anxiety, and affective disorders. |
2021-09-02 |
2023-08-13 |
human |
| Lei Li, Jing-Jing Lu, Wei-Tao Wang, Na Wang, Li-Xiang Wang, Yan-Min Ma, Shu Li. [Potential targets of Euodiae Fructus in treatment of insomnia based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 12. 2021-09-02. PMID:34467691. |
the results revealed that the main compounds of euodiae fructus, such as berberine and rutaecarpine, participated in the biological processes(such as neurotransmitter receptor activity) by regulating c-reactive protein(crp), estrogen receptor 1(esr1), 5-hydroxytryptamine(5-ht) receptor, and interleukin-6(il-6) to exert sedative, anxiolytic, and antidepressant effects. |
2021-09-02 |
2023-08-13 |
mouse |
| Sharon A Smith, Paula D Trotter, Francis P McGlone, Susannah C Walke. Effects of Acute Tryptophan Depletion on Human Taste Perception. Chemical senses. vol 46. 2021-08-26. PMID:33277648. |
serotonin is a key neurotransmitter implicated in the etiology of anxiety and depression; systemic and peripheral manipulations of serotonin signaling have previously been shown to modulate taste detection. |
2021-08-26 |
2023-08-13 |
human |
| Ning Liu, Shiqiang Sun, Pengjie Wang, Yanan Sun, Qingjuan Hu, Xiaoyu Wan. The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine. International journal of molecular sciences. vol 22. issue 15. 2021-08-25. PMID:34360695. |
apart from being an important neurotransmitter and a paracrine signaling molecule in the gut, gut-derived 5-ht was also shown to exert other biological functions (in autism and depression) far beyond the gut. |
2021-08-25 |
2023-08-13 |
Not clear |
| Yushu Qiu, Kan Yu, Xiaogang Yu, Xiaoping Yi, Kang Cai, Huajun Li, Shanshan Xu, Weiye Wang, Lisu Huan. Long-term low-dose oxytetracycline potentially leads to neurobehavioural changes. Ecotoxicology and environmental safety. vol 223. 2021-08-23. PMID:34330038. |
additionally, monoamine neurotransmitter (5-hydroxytryptamine, dopamine, norepinephrine) levels were decreased and gene expression of monoamine oxidase (mao) involved in neurotransmitter metabolism was upregulated at the transcription level after otc exposure. |
2021-08-23 |
2023-08-13 |
zebrafish |
| Hui-Hua Li, Xiao-Yan Yao, Sheng Tao, Xue Sun, Pan-Pan Li, Xi-Xin Li, Zhu-Li Liu, Chao Re. Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease. Behavioural neurology. vol 2021. 2021-08-18. PMID:33859767. |
as a neurotransmitter and neuromodulator, serotonin is involved in the regulation of psychoemotional, sleep, and feeding functions. |
2021-08-18 |
2023-08-13 |
Not clear |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| Yanni Wang, Tingwei Wang, Yukai Du, Dan Hu, Yu Zhang, Honghui Li, Wenyan Pe. Polygenic risk of genes involved in the catecholamine and serotonin pathways for ADHD in children. Neuroscience letters. vol 760. 2021-08-17. PMID:34174344. |
a pathway-based study was conducted in this study to test the association of gene-gene interaction and the cumulative effect of genetic polymorphisms within the dopamine, norepinephrine, and serotonin neurotransmitter pathways with adhd susceptibility. |
2021-08-17 |
2023-08-13 |
Not clear |
| Alice Powell, Catriona Ireland, Simon J G Lewi. Visual Hallucinations and the Role of Medications in Parkinson's Disease: Triggers, Pathophysiology, and Management. The Journal of neuropsychiatry and clinical neurosciences. vol 32. issue 4. 2021-08-16. PMID:32374649. |
while dopaminergic medications have long been associated with pd psychosis, a clear causal link has not been established, and other neurotransmitter systems, particularly noradrenaline, serotonin, and acetylcholine, are implicated and important. |
2021-08-16 |
2023-08-13 |
Not clear |
| Jun-Qi Yao, Chang Liu, Zeng-Liang Jin, Yan-Qin Liu, Yong-Yu Yin, Xin-Xin Fang, Yu-Hua Ran, Li-Ming Zhang, Yun-Feng L. Serotonergic transmission is required for the anxiolytic-like behavioral effects of YL-IPA08, a selective ligand targeting TSPO. Neuropharmacology. vol 178. 2021-08-12. PMID:32693005. |
since 5-ht is one of the most comprehensively studied neurotransmitter systems in the anxiety field, in the present study, we want to investigate whether 5-ht system is involved in the anxiolytic-like effects of yl-ipa08, a novel tspo ligand designed and synthesized at our institute. |
2021-08-12 |
2023-08-13 |
mouse |