| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R W Ransom, K B Asarch, J C Shi. Photoaffinity labeling of the 5-hydroxytryptamine 1A receptor in rat hippocampus. Journal of neurochemistry. vol 47. issue 4. 1986-10-15. PMID:3746296. |
this incorporation could be blocked when membranes were incubated with 1 microm of several agents that have high affinity for 5-ht1a sites [5-ht, 8-hydroxy-2-(di-n-propylamino)tetraline, tvx q 7821, spiperone, buspirone, d-lysergic acid diethylamide, metergoline]. |
1986-10-15 |
2023-08-11 |
rat |
| L M Smith, S J Peroutk. Differential effects of 5-hydroxytryptamine1a selective drugs on the 5-HT behavioral syndrome. Pharmacology, biochemistry, and behavior. vol 24. issue 6. 1986-09-17. PMID:2942947. |
the effects of 8-hydroxy-2-(di-n-propyl-amino) tetralin (8-oh-dpat), 5-methoxy-n,n-dimethyltryptamine (5-meodmt), buspirone and isapirone were examined at 5-hydroxytryptamine1a (5-ht1a) binding sites and on the 5-ht behavioral syndrome in the rat. |
1986-09-17 |
2023-08-11 |
rat |
| L M Smith, S J Peroutk. Differential effects of 5-hydroxytryptamine1a selective drugs on the 5-HT behavioral syndrome. Pharmacology, biochemistry, and behavior. vol 24. issue 6. 1986-09-17. PMID:2942947. |
therefore, these data suggest that specific components of the 5-ht behavioral syndrome are mediated by 5-ht1a receptors. |
1986-09-17 |
2023-08-11 |
rat |
| S D Mendelson, B B Gorzalk. 5-HT1A receptors: differential involvement in female and male sexual behavior in the rat. Physiology & behavior. vol 37. issue 2. 1986-09-17. PMID:2942955. |
the peripheral administration of the serotonin type 1a (5-ht1a) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh dpat) inhibited lordosis behavior in ovariectomized rats primed with estradiol benzoate. |
1986-09-17 |
2023-08-11 |
rat |
| S D Mendelson, B B Gorzalk. 5-HT1A receptors: differential involvement in female and male sexual behavior in the rat. Physiology & behavior. vol 37. issue 2. 1986-09-17. PMID:2942955. |
furthermore, it is proposed that 5-ht1a receptors mediate inhibitory effects, whereas 5-ht1b receptors mediate presynaptic, facilitatory effects of serotonin. |
1986-09-17 |
2023-08-11 |
rat |
| M D Hall, H Gozlan, M B Emerit, S el Mestikawy, L Pichat, M Hamo. Differentiation of pre- and post-synaptic high affinity serotonin receptor binding sites using physico-chemical parameters and modifying agents. Neurochemical research. vol 11. issue 6. 1986-09-17. PMID:3016581. |
[3h]8-oh-dpat hl binding sites were particularly abundant in the hippocampus, septum and cerebral cortex, and exhibited pharmacological properties typical of the postsynaptic 5-ht1a subsites previously characterized with [3h]5-ht as the ligand. |
1986-09-17 |
2023-08-11 |
rat |
| M Göthert, P Kollecker, N Rohm, H R Zerkowsk. Inhibitory presynaptic 5-hydroxytryptamine (5-HT) receptors on the sympathetic nerves of the human saphenous vein. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 4. 1986-09-16. PMID:2942782. |
5-ht and the preferential 5-ht1a receptor agonist 8-oh-dpat [8-hydroxy-2-(di-n-propylamino)tetralin] concentration-dependently inhibited the evoked 3h overflow. |
1986-09-16 |
2023-08-11 |
human |
| G M Goodwin, R J De Souza, A R Gree. The effects of a 5-HT1 receptor ligand isapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and rats. Psychopharmacology. vol 89. issue 3. 1986-08-21. PMID:2941817. |
the data suggest that tvx q 7821 is a good presynaptic 5-ht1a antagonist in mice, as indicated by the 8-oh-dpat-induced hypothermia and 5-ht synthesis rate studies. |
1986-08-21 |
2023-08-11 |
mouse |
| D Hoyer, A Pazos, A Probst, J M Palacio. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain research. vol 376. issue 1. 1986-08-19. PMID:3719375. |
[3h]5-ht was used to label both 5-ht1a and 5-ht1b receptor subtypes. |
1986-08-19 |
2023-08-11 |
human |
| D Hoyer, A Pazos, A Probst, J M Palacio. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain research. vol 376. issue 1. 1986-08-19. PMID:3719375. |
in contrast to 5-ht1a receptors, it was not possible to identify 5-ht receptors having the pharmacological properties of 5-ht1b sites in the human brain, using either [3h]5-ht or [125i]cyp as ligands. |
1986-08-19 |
2023-08-11 |
human |
| S J Peroutka, S Huang, G S Alle. Canine basilar artery contractions mediated by 5-hydroxytryptamine1A receptors. The Journal of pharmacology and experimental therapeutics. vol 237. issue 3. 1986-07-16. PMID:2940360. |
in the third group, 5-ht, d-lysergic acid diethylamide, 1-(m-trifluoromethylphenyl)piperazine, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyrimidinyl) 1h indole, quipazine and pirenperone are essentially equipotent at both 5-ht1a and 5-ht1 sites. |
1986-07-16 |
2023-08-11 |
rat |
| M L Cohen, W E Colber. Relationship between receptors mediating serotonin (5-HT) contractions in the canine basilar artery to 5-HT1, 5-HT2 and rat stomach fundus 5-HT receptors. The Journal of pharmacology and experimental therapeutics. vol 237. issue 3. 1986-07-16. PMID:3712277. |
similarity of the contractile effects of 5-ht in the rat stomach fundus and in the basilar artery coupled to the previous observations that receptors mediating 5-ht-induced contractions in the fundus were not 5-ht1, 5-ht1a, 5-ht1b or 5-ht2 led us to consider the possibility that 5-ht receptors in the canine basilar artery may resemble those in the rat stomach fundus. |
1986-07-16 |
2023-08-11 |
rat |
| M Raiteri, G Maura, G Bonanno, A Pittalug. Differential pharmacology and function of two 5-HT1 receptors modulating transmitter release in rat cerebellum. The Journal of pharmacology and experimental therapeutics. vol 237. issue 2. 1986-06-23. PMID:2871177. |
on the contrary, the 5-ht1a agonist 8-hydroxy-2-di-n-propylamino)tetralin activated the presynaptic heteroreceptors (pec30 = 7.98), but was ineffective as a 5-ht autoreceptor agonist. |
1986-06-23 |
2023-08-11 |
rat |
| P A Blurton, M D Woo. Identification of multiple binding sites for [3H]5-hydroxytryptamine in the rat CNS. Journal of neurochemistry. vol 46. issue 5. 1986-05-19. PMID:3958711. |
these results suggest the presence of three binding sites for [3h]5-ht, one blocked by low concentrations of spiperone (5-ht1a), one blocked by low concentrations of mianserin (5-ht1c), and one blocked only by high concentrations of both mianserin and spiperone (5-ht1b). |
1986-05-19 |
2023-08-11 |
rat |
| C Bendotti, R Samani. 8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons. European journal of pharmacology. vol 121. issue 1. 1986-04-30. PMID:2937644. |
a subcutaneous injection of 0.5 mg/kg 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), a drug with high affinity for 5-hydroxytryptamine (5-ht1a) binding sites, substantially increased eating in non-deprived rats. |
1986-04-30 |
2023-08-11 |
rat |
| K G Charlton, R A Bond, D E Clark. An inhibitory prejunctional 5-HT1-like receptor in the isolated perfused rat kidney. Apparent distinction from the 5-HT1A, 5-HT1B and 5-HT1C subtypes. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 1. 1986-04-22. PMID:3951568. |
it is concluded that the receptor to 5-ht conforms to general criteria defining 5-ht1-like receptors but at the present time the receptor site cannot be fitted to the designated 5-ht1a, 5-ht1b or 5-ht1c subtypes. |
1986-04-22 |
2023-08-11 |
rat |
| M Devivo, S Maayan. Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists. European journal of pharmacology. vol 119. issue 3. 1986-04-03. PMID:2936612. |
the ec50 values of cat, pat and 5-ht and the kb of spiperone suggest that this receptor may correspond to the 5-ht1a binding site. |
1986-04-03 |
2023-08-11 |
cat |
| D Hoyer, G Engel, H O Kalkma. Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935410. |
[3h]8-oh-dpat bound in rat and pig cortex to the 5-ht1a recognition site characterized by high affinity for 5-ct (5-carboxamido-tryptamine), 8-oh-dpat, 5-ht (5-hydroxytryptamine, serotonin) and low affinity for pirenperone, ketanserin and mesulergine. |
1986-03-05 |
2023-08-11 |
rat |
| D Hoyer, G Engel, H O Kalkma. Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935410. |
finally, the beta-adrenoceptor antagonist (-)21-009 which has different affinities for 5-ht1a, 5-ht1b and 5-ht1c recognition sites, yielded triphasic competition curves for [3h]5-ht binding in rat cortex membranes providing evidence that [3h]5-ht labels three distinct 5-ht1 sites in these membranes. |
1986-03-05 |
2023-08-11 |
rat |
| E W Taylor, S P Duckles, D L Nelso. Dissociation constants of serotonin agonists in the canine basilar artery correlate to Ki values at the 5-HT1A binding site. The Journal of pharmacology and experimental therapeutics. vol 236. issue 1. 1986-02-20. PMID:2934545. |
dissociation constants of serotonin agonists in the canine basilar artery correlate to ki values at the 5-ht1a binding site. |
1986-02-20 |
2023-08-11 |
Not clear |