| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Brown, J Amedro, G Williams, D Smit. A pharmacological analysis of the rat spinal cord serotonin (5-HT) autoreceptor. European journal of pharmacology. vol 145. issue 2. 1988-05-06. PMID:2965026. |
the 5-ht receptor agonists serotonin (1-100 nm), lysergic acid diethylamide (10 nm-1 microm) and the 5-ht1b receptor agonists 1-(m-trifluoromethylphenyl)piperazine (100 nm-1 microm) and 1-(m-chlorophenyl) piperazine (100 nm-3 microm) concentration dependently decreased [3h]5-ht release, while 8-hydroxy-2-(di-n-propylamino)tetralin, a selective 5-ht1a receptor agonist, was inactive. |
1988-05-06 |
2023-08-11 |
rat |
| G Gross, G Hanft, N Kolass. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 6. 1988-05-03. PMID:2832770. |
urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-ht) binding sites of the 5-ht1a subtype and for alpha 1-adrenoceptor binding sites. |
1988-05-03 |
2023-08-11 |
Not clear |
| G Gross, G Hanft, N Kolass. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 6. 1988-05-03. PMID:2832770. |
5-hydroxytryptamine (5-ht) receptors of the 5-ht1a subtype have been implicated with the central control of cardiovascular function. |
1988-05-03 |
2023-08-11 |
Not clear |
| G Gross, G Hanft, N Kolass. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 6. 1988-05-03. PMID:2832770. |
in the present study, the affinities of these urapidil derivatives (5-acetyl, 5-formyl- and 5-methyl-urapidil) for 5-ht receptors were investigated using 3h-8-hydroxy-2-(di-n-propyl-amino)tetralin (3h-8-oh-dpat), 125i-iodocyanopindolol (125i-icyp) and 3h-ketanserin for labelling 5-ht1a, 5-ht1b and 5-ht2 binding sites, respectively. |
1988-05-03 |
2023-08-11 |
Not clear |
| R M Murphy, F P Zemla. Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352865. |
the effect of selective 5-ht1a and 5-ht1b agonists on k+-evoked release of [3h]5-ht and the binding of [3h]5-ht were examined. |
1988-04-22 |
2023-08-11 |
rat |
| R M Murphy, F P Zemla. Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352865. |
conversely, the potencies of the 5-ht1a agonists 5-meodmt and 8-ohdpat, at the 5-ht autoreceptor, were negatively correlated (r = -0.77, p less than 0.10) with their potencies at displacing [3h]5-ht from the 5-ht1a subsite (binding of [3h]5-ht in the presence of 1 microm mcpp). |
1988-04-22 |
2023-08-11 |
rat |
| B A McMillen, J K Chamberlain, J P DaVanz. Effects of housing and muricidal behavior on serotonergic receptors and interactions with novel anxiolytic drugs. Journal of neural transmission. vol 71. issue 2. 1988-04-18. PMID:2894404. |
binding of [3h]-5-hydroxytryptamine (5ht) to 5ht1a receptors decreased in septum of both groups of isolated rats and binding to 5ht1b receptors decreased 50% in hippocampus of isolated and aggregated muricidal rats. |
1988-04-18 |
2023-08-11 |
mouse |
| M J Gilbert, N R Newberr. A 5-HT1-like receptor mediates a sympathetic ganglionic hyperpolarization. European journal of pharmacology. vol 144. issue 3. 1988-04-18. PMID:2964375. |
these results suggest that 5-ht hyperpolarizes the rat superior cervical ganglion via a 5-ht1-like receptor which resembles the central 5-ht1a binding site. |
1988-04-18 |
2023-08-11 |
rat |
| H Gozlan, M Ponchant, G Daval, D Verge, F Menard, A Vanhove, J P Beaucourt, M Hamo. 125I-Bolton-Hunter-8-methoxy-2-[N-propyl-N-propylamino]tetralin as a new selective radioligand of 5-HT1A sites in the rat brain. In vitro binding and autoradiographic studies. The Journal of pharmacology and experimental therapeutics. vol 244. issue 2. 1988-04-12. PMID:2964524. |
in vitro binding assays with 125i-[8-methoxy-2-[n-propyl-n-(3'-iodo-4'-hydroxyphenyl)-propionamido -n'- propylamino] tetralin] (125i-bh-8-meo-n-pat), a 125i-labeled derivative of the potent serotonin (5-ht) agonist 8-hydroxy-2-[di-n-propylamino]tetralin [( 3h]-8-oh-dpat), showed that this compound recognized specific sites with nanomolar affinity for 5-ht and 5-ht1a ligands such as spiroxatrine, ipsapirone, buspirone and gepirone in rat hippocampal membranes. |
1988-04-12 |
2023-08-11 |
rat |
| G Daval, D Vergé, A I Basbaum, S Bourgoin, M Hamo. Autoradiographic evidence of serotonin1 binding sites on primary afferent fibres in the dorsal horn of the rat spinal cord. Neuroscience letters. vol 83. issue 1-2. 1988-04-12. PMID:3441302. |
spinal serotonin1 (5-ht1)(labelled by [3h]5-ht), 5-ht1a (labelled by [3h]8-hydroxy-2-(di-n-propylamino)tetralin ([3h]8-oh-dpat)), mu- (labelled by [3h]tyr-d-ala-gly-(me)phe-gly-ol ([3h]dago) and [3h]naloxone) and delta-opiate (labelled by [3h]tyr-d-ser-gly-phe-leu-thr [( 3h]dstle] receptor binding sites were studied in adult rats using quantitative autoradiography after either neonatal treatment with capsaicin or unilateral cervical dorsal rhizotomy. |
1988-04-12 |
2023-08-11 |
rat |
| P Giral, P Martin, P Soubrié, P Simo. Reversal of helpless behavior in rats by putative 5-HT1A agonists. Biological psychiatry. vol 23. issue 3. 1988-03-24. PMID:2892540. |
this study is designed to measure effects of serotonin 1a (5-ht1a) agonists on escape deficits produced by inescapable shock in rats--a model of learned helplessness. |
1988-03-24 |
2023-08-11 |
rat |
| M D Mauk, S J Peroutka, J D Kocsi. Buspirone attenuates synaptic activation of hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 1. 1988-03-08. PMID:3339401. |
the actions of 5-hydroxytryptamine (5-ht) and buspirone, an anxiolytic agent that displays high and selective affinity for 5-ht1a receptor sites, on synaptic activation of hippocampal ca1 pyramidal cells were studied in vitro. |
1988-03-08 |
2023-08-11 |
Not clear |
| D S Houston, P M Vanhoutt. Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery. The Journal of pharmacology and experimental therapeutics. vol 244. issue 1. 1988-02-24. PMID:2961880. |
rings without endothelium contracted to serotonin; this contraction was not blocked by cyanopindolol and was only weakly inhibited by ketanserin, but was antagonized in an apparently competitive fashion by methiothepin and was mimicked by 8-hydroxy-2-di-n-propylamino tetralin (although at higher concentrations than would be expected for its action at a 5-ht1a receptor). |
1988-02-24 |
2023-08-11 |
Not clear |
| K Herrick-Davis, M Titele. [3H]spiroxatrine: a 5-HT1A radioligand with agonist binding properties. Journal of neurochemistry. vol 50. issue 2. 1988-02-23. PMID:2961850. |
of special interest was the observation that 5-ht1a agonists such as serotonin, 8-oh-dpat, and ipsapirone competed with equal high affinities for [3h]spiroxatrine or [3h]8-oh-dpat-labelled 5-ht1a receptors. |
1988-02-23 |
2023-08-11 |
rat |
| J R Ieni, L R Meyerso. The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. Life sciences. vol 42. issue 3. 1988-02-23. PMID:2961966. |
the 5-ht1a receptor probe [3h]8-oh-dpat labels the 5-ht transporter in human platelets. |
1988-02-23 |
2023-08-11 |
human |
| J R Ieni, L R Meyerso. The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. Life sciences. vol 42. issue 3. 1988-02-23. PMID:2961966. |
for example, 8-oh-dpat 5ht1a had an ic50 of 117 nm; tfmpp 5ht1b (2.3 microm0 and papp 1a + 5ht2 (9 microm); ipsapirone 5ht1a (21.1 microm) and buspirone 5ht1a (greater than 100 microm); ketanserin 5ht2 (greater than 100 microm); 5-ht uptake inhibitors: paroxetine (13 nm); chlorimipramine (73 nm) and fluoxetine (653 nm). |
1988-02-23 |
2023-08-11 |
human |
| T J Wander, A Nelson, H Okazaki, E Richelso. Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro. European journal of pharmacology. vol 143. issue 2. 1988-02-02. PMID:2891550. |
antagonism by neuroleptics of serotonin 5-ht1a and 5-ht2 receptors of normal human brain in vitro. |
1988-02-02 |
2023-08-11 |
human |
| T J Wander, A Nelson, H Okazaki, E Richelso. Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro. European journal of pharmacology. vol 143. issue 2. 1988-02-02. PMID:2891550. |
using radioligand binding techniques and human frontal cortex, we determined the equilibrium dissociation constants (kds) of 17 neuroleptics at the serotonin 5-ht1a and serotonin 5-ht2 receptors with [3h]wb4101 and [3h]ketanserin, respectively. |
1988-02-02 |
2023-08-11 |
human |
| T J Wander, A Nelson, H Okazaki, E Richelso. Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro. European journal of pharmacology. vol 143. issue 2. 1988-02-02. PMID:2891550. |
at the serotonin 5-ht1a receptor, the most and least potent neuroleptics were chlorprothixene (kd = 230 nm) and fluphenazine (kd = 40 microm), respectively. |
1988-02-02 |
2023-08-11 |
human |
| P H Hutson, T P Donohoe, G Curzo. Hypothermia induced by the putative 5-HT1A agonists LY165163 and 8-OH-DPAT is not prevented by 5-HT depletion. European journal of pharmacology. vol 143. issue 2. 1988-02-02. PMID:2961583. |
hypothermia induced by the putative 5-ht1a agonists ly165163 and 8-oh-dpat is not prevented by 5-ht depletion. |
1988-02-02 |
2023-08-11 |
rat |