| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Daval, D Vergé, A Becerril, H Gozlan, U Spampinato, M Hamo. Transient expression of 5-HT1A receptor binding sites in some areas of the rat CNS during postnatal development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 5. issue 3. 1988-11-23. PMID:2972174. |
the transient expression of 5-ht1a receptor binding sites in a structure such as the cerebellum which develops exclusively for the postnatal period further supports that 5-ht might play a trophic role during maturation of the cns. |
1988-11-23 |
2023-08-11 |
rat |
| Y Takeuchi, W Yang, J C Shi. Identification of 5-hydroxytryptamine1A receptor proteins in bovine frontal cortex. Journal of neurochemistry. vol 51. issue 5. 1988-11-22. PMID:3171582. |
the intensity of these two protein bands and the incorporation of [3h]p-azido-papp into these two proteins decreased significantly when the solubilized fraction was preincubated with excess 5-ht or papp (saturating all 5-ht1a receptors) prior to affinity column chromatography. |
1988-11-22 |
2023-08-11 |
cattle |
| R A Glennon, N A Naiman, R A Lyon, M Titele. Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands. Journal of medicinal chemistry. vol 31. issue 10. 1988-11-18. PMID:3172131. |
arylpiperazine derivatives as high-affinity 5-ht1a serotonin ligands. |
1988-11-18 |
2023-08-11 |
Not clear |
| R A Glennon, N A Naiman, R A Lyon, M Titele. Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands. Journal of medicinal chemistry. vol 31. issue 10. 1988-11-18. PMID:3172131. |
although simple arylpiperazines are commonly considered to be moderately selective for 5-ht1b serotonin binding sites, n4-substitution of such compounds can enhance their affinity for 5-ht1a sites and/or decrease their affinity for 5-ht1b sites. |
1988-11-18 |
2023-08-11 |
Not clear |
| R A Glennon, N A Naiman, R A Lyon, M Titele. Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands. Journal of medicinal chemistry. vol 31. issue 10. 1988-11-18. PMID:3172131. |
one of these compounds, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine (18), possesses a higher affinity than 5-ht and represents the highest affinity (ki = 0.6 nm) agent yet reported for 5-ht1a sites. |
1988-11-18 |
2023-08-11 |
Not clear |
| F G Szele, D L Murphy, N A Garric. Effects of fenfluramine, m-chlorophenylpiperazine, and other serotonin-related agonists and antagonists on penile erections in nonhuman primates. Life sciences. vol 43. issue 16. 1988-11-16. PMID:3172981. |
in contrast, serotonin (5-ht) agonists with 5-ht1a site specificity (8-oh-dpat, buspirone) as well as trazodone, ritanserin, and metergoline were no different from saline in producing penile erections. |
1988-11-16 |
2023-08-11 |
monkey |
| M Mynlieff, T V Dunwiddi. Noradrenergic depression of synaptic responses in hippocampus of rat: evidence for mediation by alpha 1-receptors. Neuropharmacology. vol 27. issue 4. 1988-10-27. PMID:2843779. |
the depressant effect of ne was not antagonized by the antagonist of serotonin and dopamine, spiperone (100 nm); conversely, the effect of 8-hydroxy-2-(di-n-propylamine) tetralin (50 microm), a 5-ht1a receptor-selective agonist, which also depresses the amplitude of the population spike, was not antagonized by phentolamine (5 microm). |
1988-10-27 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
responses of hippocampal pyramidal cells to putative serotonin 5-ht1a and 5-ht1b agonists: a comparative study with dorsal raphe neurons. |
1988-10-24 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
in low cerveau isolé transected rats, the effects of microiontophoretic application of putative serotonin 5-ht1a and 5-ht1b agonists on the spontaneous firing rate of ca1 pyramidal cells were compared to those of 5-ht. |
1988-10-24 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
in contrast to the large current-dependent suppression of unit activity observed with 5-ht, the 5-ht1a compounds, ipsapirone, 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)-tetralin) and ly 165163 (p-aminophenylethyl-m-trifluoromethylphenylpiperazine) and the 5-ht1b compounds, mcpp (m-chlorophenylpiperazine) and tfmpp (trifluoromethylphenylpiperazine), produced only weak inhibition of spontaneous firing. |
1988-10-24 |
2023-08-11 |
rat |
| I I Abramets, I V Komissarov, I M Samoĭlovic. [Spinal ganglion neurons of rats--a model for the study of the central serotonin receptors]. Biulleten' eksperimental'noi biologii i meditsiny. vol 106. issue 8. 1988-10-21. PMID:3416053. |
5-ht depolarizing responses of rdg neurons were mediated by 5-ht2 receptors activation and decreased membrane potassium conductivity; 5-ht hyperpolarizing responses were mediated by 5-ht1a receptor activation and increased potassium conductivity. |
1988-10-21 |
2023-08-11 |
rat |
| C R Gardne. Potential use of drugs modulating 5HT activity in the treatment of anxiety. General pharmacology. vol 19. issue 3. 1988-10-20. PMID:2901381. |
development of 5ht agonists and antagonists selective for different 5ht receptor sub-types (5ht1a, 5ht1b, 5ht2, 5ht3) has opened a new avenue for investigation of the potential role of 5ht in anxiety. |
1988-10-20 |
2023-08-11 |
Not clear |
| C R Gardne. Potential use of drugs modulating 5HT activity in the treatment of anxiety. General pharmacology. vol 19. issue 3. 1988-10-20. PMID:2901381. |
5ht1a agonists may act to suppress the activity of 5ht neurones as a major part of their action. |
1988-10-20 |
2023-08-11 |
Not clear |
| A Fargin, J R Raymond, M J Lohse, B K Kobilka, M G Caron, R J Lefkowit. The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature. vol 335. issue 6188. 1988-10-17. PMID:3138543. |
we now report that the protein product of the genomic clone, g21, transiently expressed in monkey kidney cells has all the typical ligand-binding characteristics of the 5-hydroxytryptamine (5-ht1a) receptor. |
1988-10-17 |
2023-08-11 |
monkey |
| M Muramatsu, J Tamaki-Ohashi, C Usuki, H Araki, H Aihar. Serotonin-2 receptor-mediated regulation of release of acetylcholine by minaprine in cholinergic nerve terminal of hippocampus of rat. Neuropharmacology. vol 27. issue 6. 1988-10-17. PMID:3419543. |
the attenuating effect of 5-ht was not mimicked by the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and was not prevented by a 5-ht1a and 5-ht1b mixed receptor antagonist, propranolol, or by the 5-ht3 receptor antagonists, cocaine and metoclopramide. |
1988-10-17 |
2023-08-11 |
rat |
| N el-Yassir, S M Fleetwood-Walker, R Mitchel. Heterogeneous effects of serotonin in the dorsal horn of rat: the involvement of 5-HT1 receptor subtypes. Brain research. vol 456. issue 1. 1988-10-13. PMID:2970278. |
the use of agonists, shown to discriminate between subtypes of 5-ht1 receptor revealed that a 5-ht1a receptor agonist mimicked the non-selective effects of 5-ht, whereas a 5-ht1b receptor agonist mimicked the selective antinociceptive effects of 5-ht. |
1988-10-13 |
2023-08-11 |
rat |
| S Manaker, S B Caine, A Winoku. Alterations in receptors for thyrotropin-releasing hormone, serotonin, and acetylcholine in amyotrophic lateral sclerosis. Neurology. vol 38. issue 9. 1988-10-05. PMID:3412596. |
we utilized quantitative autoradiography to examine thyrotropin-releasing hormone (trh) receptors, serotonin type 1a (5-ht1a) receptors, muscarinic cholinergic receptors, choline uptake sites, beta-adrenergic receptors, and norepinephrine uptake sites in discrete laminae of spinal cord from patients with amyotrophic lateral sclerosis (als) and non-neurologic controls. |
1988-10-05 |
2023-08-11 |
Not clear |
| M Hamon, C M Fattaccini, J Adrien, M C Gallissot, P Martin, H Gozla. Alterations of central serotonin and dopamine turnover in rats treated with ipsapirone and other 5-hydroxytryptamine1A agonists with potential anxiolytic properties. The Journal of pharmacology and experimental therapeutics. vol 246. issue 2. 1988-09-19. PMID:2457083. |
the reduced 5-ht turnover probably resulted from the stimulation of 5-ht1a autoreceptors within the anterior raphe nuclei as in vitro tests [( 3h]-8-hydroxy-2-[di-n-propylamino]tetralin binding and adenylate cyclase assays) demonstrated that ipsapirone was a 5-ht1a agonist almost as potent as 8-oh-dpat, and the same decrease in 5-hydroxytryptophan accumulation could be induced by the i.p. |
1988-09-19 |
2023-08-11 |
rat |
| C Fayolle, M P Fillion, P Barone, P Oudar, J C Rousselle, G Fillio. 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Fundamental & clinical pharmacology. vol 2. issue 3. 1988-09-15. PMID:3402898. |
5-hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-ht1 subtype different from 5-ht1a, 5-ht1b, and 5-ht1c. |
1988-09-15 |
2023-08-11 |
rat |
| C Fayolle, M P Fillion, P Barone, P Oudar, J C Rousselle, G Fillio. 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Fundamental & clinical pharmacology. vol 2. issue 3. 1988-09-15. PMID:3402898. |
5-ht binding sites of the 5-ht1 type are heterogeneous and appear to comprise several subtypes (5-ht1a, 5-ht1b and 5-ht1c); their physiological role is as yet unclear. |
1988-09-15 |
2023-08-11 |
rat |