| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Fayolle, M P Fillion, P Barone, P Oudar, J C Rousselle, G Fillio. 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Fundamental & clinical pharmacology. vol 2. issue 3. 1988-09-15. PMID:3402898. |
on the other hand, the high-affinity activation of the enzyme induced by 5-ht, 5-methoxytryptamine, bufotenin, lsd, and the activation induced by tfmpp were not inhibited by spiperone (1 microm), by propranolol (3 microm), or by mesulergine (0.1 microm), which selectively block 5-ht1a, 5-ht1b, and 5-ht1c sites. |
1988-09-15 |
2023-08-11 |
rat |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
the neuroleptic spiperone, which binds to 5-ht1a, 5-ht2 and dopamine (da) receptors, was studied for its effects on serotonin (5-ht) and da neurons in dorsal raphe nucleus and substantia nigra pars compacta, respectively. |
1988-08-31 |
2023-08-11 |
Not clear |
| C Waeber, M M Dietl, D Hoyer, A Probst, J M Palacio. Visualization of a novel serotonin recognition site (5-HT1D) in the human brain by autoradiography. Neuroscience letters. vol 88. issue 1. 1988-08-26. PMID:3399126. |
8-oh-dpat (8-hydroxy-2-[n,n-di-n-propyl-amino]tetralin) was used to block [3h]5-ht binding to 5-ht1a, the beta-blocker (-)-21 009 (4-[3-ter-butyl-amino-2-hydroxy-propoxy]indol-2-carbonic acid isopropyl ester) to 5-ht1b and the ergoline mesulergine to 5-ht1c recognition sites. |
1988-08-26 |
2023-08-11 |
human |
| Y Chaput, C de Montign. Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system. The Journal of pharmacology and experimental therapeutics. vol 246. issue 1. 1988-08-17. PMID:2839669. |
it is concluded that bmy 7378 is an effective antagonist of 5-ht1a receptors in vivo and that the mechanism of its enhancing effect on 5-ht transmission at low doses, although still undetermined, is not due to a competitive interaction at the terminal 5-ht autoreceptor. |
1988-08-17 |
2023-08-11 |
rat |
| M Abou-Gharbia, U R Patel, M B Webb, J A Moyer, T H Andree, E A Mut. Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies. Journal of medicinal chemistry. vol 31. issue 7. 1988-08-05. PMID:2898533. |
several compounds demonstrated moderate to high affinity for the 5-ht1a receptor binding site; compounds 27 and 36 containing the serotonin mimetic (o-methoxyphenyl)piperazinyl moiety and compounds 42 and 50 containing the 2-pyrimidinylpiperazinyl moiety displayed the highest affinity, being equal to that of the 5-ht1a agonist 8-oh-dpat (ki = 1-1.3 nm). |
1988-08-05 |
2023-08-11 |
rat |
| R E Solomon, G F Gebhar. Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:2455040. |
the 5-ht1a agonist 8-hydroxy-n,n-dipropyl-2-aminotetralin and the 5ht1b agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole (ru-24969) also produced depressor effects but, in contrast to 5-ht, facilitated the tail-flick reflex, whereas the 5-ht2 agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, 6-chloro-2-(1-piperazinyl)-pyrazine (mk-212) and quipazine produced dose-dependent antinociception and had little or no effect on blood pressure. |
1988-07-29 |
2023-08-11 |
rat |
| P Wang, C S Aulakh, J L Hill, D L Murph. Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists. Psychopharmacology. vol 94. issue 4. 1988-07-14. PMID:2967518. |
the food intake suppressant effects of three serotonin agonists, m-cpp (a selective 5-ht1b agonist), 8-ohdpat (a selective 5-ht1a agonist) and fenfluramine (a 5-ht releasing agent) were compared in three different rat strains: wistar, sprague-dawley (sd) and fawn-hooded (fh) rats. |
1988-07-14 |
2023-08-11 |
rat |
| T Nishimura, T Tokimasa, T Akas. 5-hydroxytryptamine inhibits cholinergic transmission through 5-HT1A receptor subtypes in rabbit vesical parasympathetic ganglia. Brain research. vol 442. issue 2. 1988-06-30. PMID:3370457. |
5-hydroxytryptamine inhibits cholinergic transmission through 5-ht1a receptor subtypes in rabbit vesical parasympathetic ganglia. |
1988-06-30 |
2023-08-11 |
rabbit |
| M F Hibert, M W Gittos, D N Middlemiss, A K Mir, J R Fozar. Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor. Journal of medicinal chemistry. vol 31. issue 6. 1988-06-30. PMID:3373482. |
a conformational study of four 5-ht1a (serotonin) receptor ligands ((r-(-)-methiothepin, spiperone, (s)-(-)-propranolol, and buspirone) led to the definition of a pharmacophore and a three-dimensional map of the 5-ht1a antagonist recognition site. |
1988-06-30 |
2023-08-11 |
rat |
| M H Makman, B Dvorkin, S M Crai. Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by opioids, serotonin and pertussis toxin. Brain research. vol 445. issue 2. 1988-06-29. PMID:3370465. |
the serotonin effect appears to be mediated by 5-ht1a receptors, based on relative agonist and antagonist selectivity. |
1988-06-29 |
2023-08-11 |
mouse |
| H N Doods, H W Boddeke, H O Kalkman, D Hoyer, M J Mathy, P A van Zwiete. Central 5-HT1A receptors and the mechanism of the central hypotensive effect of (+)8-OH-DPAT, DP-5-CT, R28935, and urapidil. Journal of cardiovascular pharmacology. vol 11. issue 4. 1988-06-28. PMID:2453746. |
this study investigated the central hypotensive effects of drugs that possess a high affinity for central 5-hydroxytryptamine (5-ht1a) binding sites; (+)8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), n,n-dipropylcarboxamidotryptamine (dp-5-ct), erythro-1-(1-[2(1,4-benzodioxan-2-yl)-2-hydroxyethyl]- 4-piperidyl)-2-benzimidazolinone (r28935) and urapidil proved to possess high affinity and selectivity for central 5-ht1a binding sites, labeled by [3h]8-oh-dpat. |
1988-06-28 |
2023-08-11 |
Not clear |
| J R Dochert. Investigations of cardiovascular 5-hydroxytryptamine receptor subtypes in the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 1. 1988-06-16. PMID:3368008. |
in pithed spontaneously hypertensive rats, 5-carboxamidotryptamine, 5-ht, and to a lesser extent the 5-ht1 receptor agonist ru 24969, but not the 5-ht1a receptor agonist 8-oh-dpat, produced depressor responses which were antagonised by methysergide and metitepin, but which do not clearly fit with any of the 5-ht1 ligand binding sites. |
1988-06-16 |
2023-08-11 |
rat |
| D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters. vol 85. issue 3. 1988-06-02. PMID:2966310. |
in human caudate and cortex membranes, [3h]serotonin ([3h]5-ht) labels 5-ht1a and 5-ht1c recognition sites which show nanomolar affinity for 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-ht1b binding could be identified. |
1988-06-02 |
2023-08-11 |
human |
| D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters. vol 85. issue 3. 1988-06-02. PMID:2966310. |
however, the majority of the sites labelled by [3h]5-ht (greater than or equal to 60% in cortex, 90% in caudate) are different from 5-ht1a, 5-ht1b and 5-ht1c sites. |
1988-06-02 |
2023-08-11 |
human |
| P H Wu, N Gurevich, P L Carle. Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine. Neuroscience letters. vol 86. issue 1. 1988-06-02. PMID:2966313. |
these observations suggest that the long-lasting hyperpolarization produced by 5-ht may be mediated by the activation of the 5-ht1a receptor subtype. |
1988-06-02 |
2023-08-11 |
Not clear |
| M R Pranzatell. The comparative pharmacology of the behavioral syndromes induced by TRH and by 5-HT in the rat. General pharmacology. vol 19. issue 2. 1988-05-12. PMID:2895033. |
a 5-ht1a agonist (8-oh-dpat) blocked wds, but like putative 5-ht1b (ru 24969) and 5-ht2 (doi) agonists and the 5-ht antagonists methysergide (non-selective), ritanserin (5-ht2 selective), and l-propranolol (5-ht1 selective), it did not block other antagonists behavioural effects of mk-771. |
1988-05-12 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. The Journal of physiology. vol 394. 1988-05-12. PMID:3443977. |
detailed analysis using 5-ht antagonists and agonists indicates that the hyperpolarization is mediated by a 5-ht1a receptor. |
1988-05-12 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. The Journal of physiology. vol 394. 1988-05-12. PMID:3443977. |
in agreement with the distribution of 5-ht1a binding sites, responses to 5-ht were most prominent in the stratum radiatum. |
1988-05-12 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. The Journal of physiology. vol 394. 1988-05-12. PMID:3443977. |
by 5-ht reduces spike frequency adaptation and counteracts the inhibitory action of 5-ht on 5-ht1a receptors. |
1988-05-12 |
2023-08-11 |
rat |
| R A Glennon, M Titeler, R A Lyon, R M Slushe. N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin. Journal of medicinal chemistry. vol 31. issue 4. 1988-05-10. PMID:2965244. |
8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) is a serotonergic agonist with high affinity and selectivity for a particular population of central serotonin (5-ht) binding sites (i.e., 5-ht1a sites). |
1988-05-10 |
2023-08-11 |
rat |