| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B S Alexander, M D Woo. [3H]8-OH-DPAT labels the 5-hydroxytryptamine uptake recognition site and the 5-HT1A binding site in the rat striatum. The Journal of pharmacy and pharmacology. vol 40. issue 12. 1989-06-02. PMID:2907586. |
[3h]8-oh-dpat labels the 5-hydroxytryptamine uptake recognition site and the 5-ht1a binding site in the rat striatum. |
1989-06-02 |
2023-08-11 |
rat |
| M Q Paiva, M M Caramona, W Osswal. The actions of 5-hydroxytryptamine receptor agonists and antagonists at pre- and postjunctional level on the canine saphenous vein. Naunyn-Schmiedeberg's archives of pharmacology. vol 338. issue 6. 1989-05-31. PMID:2977424. |
the release of 3h-noradrenaline (3h-na) from incubated saphenous vein strips was inhibited by 5-hydroxytryptamine (5-ht) in a concentration-dependent way (5-ht concentrations: 0.01, 0.1 and 1.0 mumol.l-1), but not by the selective 5-ht1a agonist 8-hydroxy-dipropylaminotetralin (8-oh-dpat; 1 and 10 mumol.l-1). |
1989-05-31 |
2023-08-11 |
dog |
| S de St Hilaire-Kafi, J M Gaillar. Hypnotic action of flunitrazepam in the rat: does 5-HT mechanism play a role? Neuropharmacology. vol 27. issue 12. 1989-05-26. PMID:2977426. |
flunitrazepam, a potent hypnotic, was used alone or combined with parachlorophenylalanine (pcpa), an inhibitor of the synthesis of 5-ht, 8-oh-dpat, a 5-ht1a receptor agonist and fluvoxamine, an inhibitor of the reuptake of 5-ht. |
1989-05-26 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D G Grahame-Smit. 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2466516. |
under these conditions the putative 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) caused a dose-dependent (5-250 micrograms kg-1, s.c.) reduction of 5-ht in hippocampal dialysates. |
1989-05-05 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D G Grahame-Smit. 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2466516. |
similarly, the putative 5-ht1a agonists gepirone (5 mg kg-1, s.c.), ipsapirone (5 mg kg-1, s.c.) and buspirone (5 mg kg-1, s.c.) markedly reduced levels of 5-ht in hippocampal perfusates whereas their common metabolite 1-(2-pyrimidinyl) piperazine (5 mg kg-1, s.c.), which does not bind to central 5-ht1a recognition sites, had no effect. |
1989-05-05 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D G Grahame-Smit. 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2466516. |
these data are direct biochemical evidence that systemically administered putative 5-ht1a and 5-ht1b agonists markedly inhibit 5-ht release in rat ventral hippocampus in vivo. |
1989-05-05 |
2023-08-11 |
rat |
| A A Parsons, E T Whalley, W Feniuk, H E Connor, P P Humphre. 5-HT1-like receptors mediate 5-hydroxytryptamine-induced contraction of human isolated basilar artery. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2538194. |
the contractile action of 5-ht and gr43175 was also not antagonized by (+/-)-cyanopindolol, excluding the activation of receptors similar to 5-ht1a and 5-ht1b recognition sites identified in ligand binding studies. |
1989-05-05 |
2023-08-11 |
human |
| F Gilbert, C T Dourish, C Brazell, S McClue, S M Stah. Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats. Psychoneuroendocrinology. vol 13. issue 6. 1989-05-05. PMID:2907164. |
various putative agonists of the 5-ht1a receptor subtype induce feeding in rats, probably by activating raphé somatodendritic 5-ht autoreceptors. |
1989-05-05 |
2023-08-11 |
rat |
| E Zifa, J Hernandez, C Fayolle, G Fillio. Postnatal development of 5-HT1 receptors: [3H]5-HT binding sites and 5-HT induced adenylate cyclase activations in rat brain cortex. Brain research. Developmental brain research. vol 44. issue 1. 1989-05-03. PMID:3233729. |
5-ht could stimulate the adenylate cyclase activity in adult rat brain cortex with two different affinity constants: km = 1 nm and km = 0.5 microm; these low- and high-affinity constants presumably correspond to 5-ht1a and 5-ht1non-a.non-b.non-c (5-ht1d) respectively. |
1989-05-03 |
2023-08-11 |
rat |
| J Yamada, Y Sugimoto, K Horisak. The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice. European journal of pharmacology. vol 154. issue 3. 1989-04-28. PMID:2976671. |
in addition, the 5-ht1a receptor antagonist, spiperone, inhibited the 5-ht syndrome elicited by 8-oh-dpat, while the dopamine receptor antagonist, haloperidol, affected only the head weaving. |
1989-04-28 |
2023-08-11 |
mouse |
| W Marszalec, E G Anderso. Three putative 5-HT1A agonists act as 5-HT antagonists in frog sensory neurons. European journal of pharmacology. vol 154. issue 3. 1989-04-28. PMID:2976672. |
three putative 5-ht1a agonists act as 5-ht antagonists in frog sensory neurons. |
1989-04-28 |
2023-08-11 |
Not clear |
| B C Hiner, M D Mauk, S J Peroutka, J D Kocsi. Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability. Brain research. vol 461. issue 1. 1989-04-04. PMID:2906267. |
although these agents bind to 5-ht1a receptors, 5-ht application, even at very high (1 mm) concentrations, did not alter axonal responses. |
1989-04-04 |
2023-08-11 |
rat |
| R S Mansbach, M A Geye. Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands. European journal of pharmacology. vol 156. issue 3. 1989-03-09. PMID:2975225. |
the non-benzodiazepine anxiolytics buspirone (1.25-5.0 mg/kg), gepirone (3.0-10.0 mg/kg) and the related 5-ht1a ligand ipsapirone (1.0-10.0 mg/kg) blocked potentiated startle, though effects of the non-selective serotonin antagonist methysergide (0.3-10.0 mg/kg) fell short of significance. |
1989-03-09 |
2023-08-11 |
rat |
| M Muramatsu, J Tamaki-Ohashi, C Usuki, H Araki, S Chaki, H Aihar. 5-HT2 antagonists and minaprine block the 5-HT-induced inhibition of dopamine release from rat brain striatal slices. European journal of pharmacology. vol 153. issue 1. 1989-03-03. PMID:2975224. |
the inhibitory effect of 5-ht was not mimicked by a 5-ht1a receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), and was not prevented by a 5-ht1a and 5-ht1b mixed receptor antagonist, propranolol. |
1989-03-03 |
2023-08-11 |
rat |
| P C Waldmeier, M Williams, P A Baumann, S Bischoff, M A Sills, R F Neal. Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 6. 1989-03-02. PMID:2905765. |
the effects of the compounds on 5-ht release appeared to be correlated with their 5-ht1b rather than 5-ht1a activity. |
1989-03-02 |
2023-08-11 |
rat |
| P C Waldmeier, M Williams, P A Baumann, S Bischoff, M A Sills, R F Neal. Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 6. 1989-03-02. PMID:2905765. |
the possibility that isamoltane and the other beta-adrenoceptor antagonists are antagonists at 5-ht1b receptors and that their effect on 5-ht synthesis in vivo is the net result of their agonist/antagonist effects at 5-ht1a and 5-ht1b receptors is discussed in relation to the potential mechanism of the anxiolytic activity of isamoltane. |
1989-03-02 |
2023-08-11 |
rat |
| C Waeber, P Schoeffter, J M Palacios, D Hoye. Molecular pharmacology of 5-HT1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 6. 1989-03-02. PMID:2975354. |
1) the binding characteristics of [3h]5-ht (5-hydroxytryptamine, serotonin) were investigated in membrane preparations of several regions from calf, pig and human brain in the presence of 100 nmol/l 8-oh-dpat (8-hydroxy-2[di-n-dipropylamino]tetralin) and 100 nmol/l mesulergine in order to mask 5-ht1a and 5-ht1c sites. |
1989-03-02 |
2023-08-11 |
human |
| P Blier, C de Montign. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse (New York, N.Y.). vol 1. issue 5. 1989-02-23. PMID:2905533. |
modification of 5-ht neuron properties by sustained administration of the 5-ht1a agonist gepirone: electrophysiological studies in the rat brain. |
1989-02-23 |
2023-08-11 |
rat |
| P Blier, C de Montign. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse (New York, N.Y.). vol 1. issue 5. 1989-02-23. PMID:2905533. |
the sustained administration of the 5-ht1a agonist gepirone (15 mg/kg/day, s.c.) in the rat produced an initial decrease of the firing activity of dorsal raphe 5-ht neurons which was followed by a progressive recovery to normal after 14 days of treatment. |
1989-02-23 |
2023-08-11 |
rat |
| P Blier, C de Montign. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse (New York, N.Y.). vol 1. issue 5. 1989-02-23. PMID:2905533. |
it is concluded that the progressive restoration of the firing activity of 5-ht neurons, due to a desensitization of the somatodendritic 5-ht autoreceptor, combined with the direct activation of normosensitive postsynaptic 5-ht1a receptor by gepirone, should result in an augmented tonic activation of postsynaptic 5-ht1a receptors. |
1989-02-23 |
2023-08-11 |
rat |