| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S el Mestikawy, D Taussig, H Gozlan, M B Emerit, M Ponchant, M Hamo. Chromatographic analyses of the serotonin 5-HT1A receptor solubilized from the rat hippocampus. Journal of neurochemistry. vol 53. issue 5. 1989-11-15. PMID:2529352. |
similarly, 8-meo-n-pbat-affigel 202 allowed the adsorption and subsequent elution (by 1 mm 5-ht) of active 5-ht1a binding sites solubilized from rat hippocampal membranes. |
1989-11-15 |
2023-08-11 |
rat |
| P M Whitaker-Azmitia, E C Azmiti. Stimulation of astroglial serotonin receptors produces culture media which regulates growth of serotonergic neurons. Brain research. vol 497. issue 1. 1989-11-14. PMID:2790458. |
primary cultures of astroglial cells were exposed to serotonin (5-ht) or the selective receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-d-pat, for 5-ht1a receptors) or trifluoro-methyl-phenyl-piperazine (tfmpp) and m-chlorophenylpiperazine (mcpp) (for 5-ht1b receptors). |
1989-11-14 |
2023-08-11 |
Not clear |
| P Schoeffter, D Hoye. How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 1. 1989-11-08. PMID:2552330. |
gr 43175 displayed the following order of affinity for 5-ht recognition sites (pkd values, -log mol/l, in parentheses): 5-ht1d (7.54) greater than 5-ht1b (6.35) greater than 5-ht1a (6.13) much greater than 5-ht1c (4.13) greater than 5-ht2 (3.67). |
1989-11-08 |
2023-08-11 |
human |
| Y Liu, C Mellin, L Björk, B Svensson, I Csöregh, A Helander, L Kenne, N E Andén, U Hacksel. (R)- and (S)-5,6,7,8-tetrahydro-1-hydroxy-N,N-dipropyl-9H-benzocyclohepten- 8-ylamine. Stereoselective interactions with 5-HT1A receptors in the brain. Journal of medicinal chemistry. vol 32. issue 10. 1989-11-01. PMID:2795604. |
the stereoselectivity of the interaction of 3 with 5-ht1a receptors was more pronounced than that of 8-hydroxy-2-(dipropylamino)tetralin (1; 8-oh-dpat); only (r)-3 displayed 5-ht activity. |
1989-11-01 |
2023-08-11 |
rat |
| L M Brown, D L Smith, G M Williams, D J Smit. Alterations in serotonin binding sites after 5,7-dihydroxytryptamine treatment in the rat spinal cord. Neuroscience letters. vol 102. issue 1. 1989-10-13. PMID:2779841. |
at 3, 7 and 14 days post 5,7-dht, competitive radioligand binding assays were performed using 2 nm [3h]5-ht and varying concentrations of trifluoromethylphenylpiperazine (tfmpp), a drug which interacts with 5-ht1b and 5-ht1a binding sites (affinity of 5-ht1b site greater than 5-ht1a site for tfmpp). |
1989-10-13 |
2023-08-11 |
rat |
| A B Tobin, N N Osborn. Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body. Journal of neurochemistry. vol 53. issue 3. 1989-09-18. PMID:2547897. |
the 5-ht1a [5-hydroxytryptamine (serotonin) type 1a] receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone mimic the serotonin response in reducing the forskolin-stimulated cyclic amp levels, as do the indole derivatives 5-methoxytryptamine, 5-hydroxtryptophan, and tryptamine. |
1989-09-18 |
2023-08-11 |
rabbit |
| A B Tobin, N N Osborn. Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body. Journal of neurochemistry. vol 53. issue 3. 1989-09-18. PMID:2547897. |
however, the ineffectiveness of the 5-ht1a agonist ipsapirone and the inability of spiroxatrine to block the serotonin response show that classical 5-ht1a receptors are not involved. |
1989-09-18 |
2023-08-11 |
rabbit |
| P H Hutson, G S Sarna, M T O'Connell, G Curzo. Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474776. |
infusion of the serotonin-1a (5-ht1a) agonist, 8-hydroxy-2-di(n-propylamino)tetralin (8-ohdpat) (0.5, 1.0 and 2.0 micrograms) into the dorsal raphe, decreased extracellular 5-ht as measured by dialysis in the ventral hippocampus and also decreased 5-ht synthesis in both the hippocampus and the rest of the brain as measured by 5-hydroxytryptophan (5-htp) accumulation following decarboxylase inhibition by nsd 1015. |
1989-09-15 |
2023-08-11 |
Not clear |
| V Hillegaart, S Hjort. Median raphe, but not dorsal raphe, application of the 5-HT1A agonist 8-OH-DPAT stimulates rat motor activity. European journal of pharmacology. vol 160. issue 2. 1989-09-15. PMID:2527161. |
by activating somatodendritic 5-ht1a autoreceptors in the median raphe, 8-oh-dpat may disinhibit locomotor-enforcing neural pathways that receive 5-ht afferents from this nucleus. |
1989-09-15 |
2023-08-11 |
rat |
| R A Glennon, N A Naiman, M E Pierson, J D Smith, A M Ismaiel, M Titeler, R A Lyo. N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites? Journal of medicinal chemistry. vol 32. issue 8. 1989-09-07. PMID:2754715. |
n-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-ht1a serotonin binding sites? |
1989-09-07 |
2023-08-11 |
Not clear |
| R A Glennon, N A Naiman, M E Pierson, J D Smith, A M Ismaiel, M Titeler, R A Lyo. N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites? Journal of medicinal chemistry. vol 32. issue 8. 1989-09-07. PMID:2754715. |
several classes of agents are known to bind at central 5-ht1a serotonin sites in order to challenge the hypothesis that these agents bind in a relatively similar manner (i.e., share common aryl and terminal amine sites), we prepared n-(phthalimidobutyl) derivatives of examples of several such agents. |
1989-09-07 |
2023-08-11 |
Not clear |
| N Kolassa, K D Beller, K H Sander. Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil. The American journal of cardiology. vol 64. issue 7. 1989-09-05. PMID:2569265. |
stimulation of serotonin-1a (5-hydroxytryptamine) (5-ht1a) receptors in the brain stem has been suggested to contribute to the antihypertensive action of the alpha 1-adrenoceptor antagonist urapidil. |
1989-09-05 |
2023-08-11 |
Not clear |
| L A Connell, D I Walli. 5-Hydroxytryptamine depolarizes neonatal rat motorneurones through a receptor unrelated to an identified binding site. Neuropharmacology. vol 28. issue 6. 1989-08-29. PMID:2755565. |
amongst agents with activity at 5-ht1a sites, the selective 5-ht1a receptor agonist, 8-hydyroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), neither mimicked the action of 5-ht nor antagonised it, while spiperone (10(-8)-10(-7 m) antagonised responses to 5-ht in a concentration-related manner. |
1989-08-29 |
2023-08-11 |
rat |
| H Koda, T Hashimoto, M Katsura, K Kuriyam. Effect of (+/-)-methyl 3-ethyl-2,3,3a,4-tetrahydro-1H-indolo-[3,2,1-de] [1,5] naphthyridine-6-carboxylate hydrochloride (OM-853), a new vincamine analogue, on the metabolism and function of cerebral serotonergic neurons. Japanese journal of pharmacology. vol 49. issue 3. 1989-08-25. PMID:2526270. |
om-853 had more potent inhibitory effect on the binding of [3h]8-hydroxy-2-(di-n-propylamino)tetralin (8-hydroxy dpat) to 5-ht1a receptors and/or 5-ht autoreceptors than that of [3h]-ketanserin to 5-ht2 receptors. |
1989-08-25 |
2023-08-11 |
rat |
| S Leonhardt, K Herrick-Davis, M Titele. Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein. Journal of neurochemistry. vol 53. issue 2. 1989-08-25. PMID:2664084. |
to investigate the non-5-ht1d component of the binding, 100 nm 5-ct (to block 5-ht1a, 5-ht1b, and 5-ht1d receptors) was coincubated with [3h]5-ht, membranes, and mesulergine. |
1989-08-25 |
2023-08-11 |
human |
| S G Bec. 5-Carboxyamidotryptamine mimics only the 5-HT elicited hyperpolarization of hippocampal pyramidal cells via 5-HT1A receptor. Neuroscience letters. vol 99. issue 1-2. 1989-08-18. PMID:2748003. |
5-carboxyamidotryptamine mimics only the 5-ht elicited hyperpolarization of hippocampal pyramidal cells via 5-ht1a receptor. |
1989-08-18 |
2023-08-11 |
rat |
| S G Bec. 5-Carboxyamidotryptamine mimics only the 5-HT elicited hyperpolarization of hippocampal pyramidal cells via 5-HT1A receptor. Neuroscience letters. vol 99. issue 1-2. 1989-08-18. PMID:2748003. |
5-carboxyaminotryptamine (5-ct) mimics the membrane hyperpolarization elicited by 5-ht through its action on the 5-ht1a receptor; however, 5-ct does not mimic 5-ht in reducing the amplitude of the ahp or the depolarization of membrane potential. |
1989-08-18 |
2023-08-11 |
rat |
| S G Bec. 5-Carboxyamidotryptamine mimics only the 5-HT elicited hyperpolarization of hippocampal pyramidal cells via 5-HT1A receptor. Neuroscience letters. vol 99. issue 1-2. 1989-08-18. PMID:2748003. |
these data provide evidence that the inhibitory effect of 5-ht is mediated primarily by the 5-ht1a receptor. |
1989-08-18 |
2023-08-11 |
rat |
| A E Calogero, R Bernardini, A N Margioris, G Bagdy, W T Gallucci, P J Munson, L Tamarkin, T P Tomai, L Brady, P W Gol. Effects of serotonergic agonists and antagonists on corticotropin-releasing hormone secretion by explanted rat hypothalami. Peptides. vol 10. issue 1. 1989-08-14. PMID:2787501. |
the response was bell-shaped with peak of effect reached at the concentration of 10(-9) m. we also tested the ability of the 5ht agonist meta-chlorophenylpiperazine (m-cpp) and of the selective 5ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) to cause crh secretion. |
1989-08-14 |
2023-08-11 |
rat |
| D H Bobker, J T William. Serotonin agonists inhibit synaptic potentials in the rat locus ceruleus in vitro via 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors. The Journal of pharmacology and experimental therapeutics. vol 250. issue 1. 1989-08-11. PMID:2526217. |
8-hydroxy-2-(di-n-propylamino)tetralin, a selective 5-ht1a receptor ligand, also inhibited the dsp, but only produced about 65% of the maximal 5-ct or 5-ht response (ec50 = 50 nm). |
1989-08-11 |
2023-08-11 |
rat |