| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Glennon, M Titeler, R A Lyo. A preliminary investigation of the psychoactive agent 4-bromo-2,5-dimethoxyphenethylamine: a potential drug of abuse. Pharmacology, biochemistry, and behavior. vol 30. issue 3. 1989-02-23. PMID:3211969. |
however, unlike dob, the alpha-desmethyl derivative also binds with significant affinity to 5-ht1a, 5-ht1b, and 5-ht1c serotonin receptors and, as such, is less selective than dob. |
1989-02-23 |
2023-08-11 |
rat |
| P Blier, C de Montigny, D Tardi. Short-term lithium treatment enhances responsiveness of postsynaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brain. Synapse (New York, N.Y.). vol 1. issue 3. 1989-02-21. PMID:2850622. |
short-term lithium treatment enhances responsiveness of postsynaptic 5-ht1a receptors without altering 5-ht autoreceptor sensitivity: an electrophysiological study in the rat brain. |
1989-02-21 |
2023-08-11 |
rat |
| P Blier, C de Montigny, D Tardi. Short-term lithium treatment enhances responsiveness of postsynaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brain. Synapse (New York, N.Y.). vol 1. issue 3. 1989-02-21. PMID:2850622. |
the effect of intravenous lsd, an agonist of the somatodendritic 5-ht autoreceptor, on the firing activity of 5-ht neurons was not modified by the lithium treatment, whereas that of intravenous 8-oh-dpat, a 5-ht1a receptor agonist, was increased two-fold. |
1989-02-21 |
2023-08-11 |
rat |
| P Blier, C de Montigny, D Tardi. Short-term lithium treatment enhances responsiveness of postsynaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brain. Synapse (New York, N.Y.). vol 1. issue 3. 1989-02-21. PMID:2850622. |
it is concluded that short-term lithium treatment does not alter the function of terminal and somatodendritic 5-ht autoreceptors and that it enhances the sensitivity of a subset of postsynaptic 5-ht1a receptors involved in controlling 5-ht neuron firing activity, presumably through a feedback loop. |
1989-02-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
a direct comparison was made of the effects of serotonin 5-ht1a and 5-ht1b selective compounds on the spontaneous firing rate of dorsal raphe serotoninergic neurons in chloral-hydrate-anesthetized rats. |
1989-02-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
low microiontophoretic currents of ipsapirone and ly 165163 were also effective in suppressing spontaneous firing; dose-response relationships for the 5-ht1a compounds were indistinguishable from that of 5-ht itself. |
1989-02-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
in intracellular studies, ipsapirone and ly 165163, when added to the media bathing brain slices, mimicked the actions of 5-ht in hyperpolarizing dorsal raphe cell membranes and decreasing input resistance; however, the maximal effects of the 5-ht1a compounds on these membrane properties exceeded those of 5-ht. |
1989-02-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
in summary, dorsal raphe 5-ht neurons appear highly responsive to 5-ht1a, but not to 5-ht1b compounds; these findings are discussed with regard to the 5-ht receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphe neurons. |
1989-02-21 |
2023-08-11 |
rat |
| N Naiman, R A Lyon, A E Bullock, L T Rydelek, M Titeler, R A Glenno. 2-(Alkylamino)tetralin derivatives: interaction with 5-HT1A serotonin binding sites. Journal of medicinal chemistry. vol 32. issue 1. 1989-02-06. PMID:2521252. |
2-(alkylamino)tetralin derivatives: interaction with 5-ht1a serotonin binding sites. |
1989-02-06 |
2023-08-11 |
rat |
| N Naiman, R A Lyon, A E Bullock, L T Rydelek, M Titeler, R A Glenno. 2-(Alkylamino)tetralin derivatives: interaction with 5-HT1A serotonin binding sites. Journal of medicinal chemistry. vol 32. issue 1. 1989-02-06. PMID:2521252. |
8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) is a selective 5-ht1a serotonin agonist. |
1989-02-06 |
2023-08-11 |
rat |
| K J Simansky, L E Schechte. Properties of some 1-arylpiperazines as antagonists of stereotyped behaviors mediated by central serotonergic receptors in rodents. The Journal of pharmacology and experimental therapeutics. vol 247. issue 3. 1989-01-31. PMID:3144595. |
this investigation evaluated the effects of the 1-arylpiperazines (1-(1-naphthyl)piperazine (1-np), 1-(2-[4-aminophenylethyl]-4-[3-trifluoromethylphenyl]piperazine (papp), 1-(3-trifluoromethylphenyl)piperazine (tfmpp) and 1-(3-chlorophenyl)piperazine (mcpp) on head-twitching elicited by central 5-hydroxytryptamine2, (5-ht2) agonists and on the 5-ht motor syndrome associated with stimulating 5-ht1a receptors in rodents. |
1989-01-31 |
2023-08-11 |
mouse |
| T Mizuta, T Segaw. Chronic effects of imipramine and lithium on postsynaptic 5-HT1A and 5-HT1B sites and on presynaptic 5-HT3 sites in rat brain. Japanese journal of pharmacology. vol 47. issue 2. 1989-01-26. PMID:3199589. |
it is concluded that enhanced 5-ht neurotransmission which develops during chronic treatment with imipramine or lithium seems tob e related to the down-regulation of postsynaptic 5-ht1a receptors in addition to postsynaptic 5-ht2 receptors, which may also have an important role in the antidepressant effects of these drugs. |
1989-01-26 |
2023-08-11 |
rat |
| A Dumuis, R Bouhelal, M Sebben, R Cory, J Bockaer. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Molecular pharmacology. vol 34. issue 6. 1989-01-23. PMID:2849052. |
the action of antagonists acting on 5-ht1 or 5-ht2 receptors, such as methiothepin (5-ht1 and 5-ht2), metergoline (5-ht1 and 5-ht2), spiperone (5-ht1a and 5-ht2), (-)-pindolol (5-ht1b), mesulergine (5-ht1c), and ketanserin (5-ht2), were almost inactive in reversing the 5-ht stimulating effect. |
1989-01-23 |
2023-08-11 |
mouse |
| W Marszalec, R S Scroggs, E G Anderso. Serotonin-induced reduction of the calcium-dependent plateau in frog dorsal root ganglion cells is blocked by serotonergic agents acting at 5-hydroxytryptamine1A sites. The Journal of pharmacology and experimental therapeutics. vol 247. issue 2. 1988-12-21. PMID:2972829. |
the antagonists' action on 5-ht narrowing [blockade by methiothepin, spiperone and spiroxitrine, but not by ketanserin or 3-tropyl-indole-3-carboxylate (ics 205-930)] suggests that this response is mediated by 5-ht1a receptors. |
1988-12-21 |
2023-08-11 |
Not clear |
| W Marszalec, R S Scroggs, E G Anderso. Serotonin-induced reduction of the calcium-dependent plateau in frog dorsal root ganglion cells is blocked by serotonergic agents acting at 5-hydroxytryptamine1A sites. The Journal of pharmacology and experimental therapeutics. vol 247. issue 2. 1988-12-21. PMID:2972829. |
these results suggest the 5-ht receptors mediating 5-ht action potential narrowing in these cells are of the 5-ht1a subtype, but that they differ from the 5-ht1a receptors described in other tissues in which 8-oh-dpat is an agonist or a partial agonist. |
1988-12-21 |
2023-08-11 |
Not clear |
| C L Broekkamp, S K Oosterloo, H H Berendsen, A M van Delf. Effect of metergoline, fenfluramine, and 8-OHDPAT on catalepsy induced by haloperidol or morphine. Naunyn-Schmiedeberg's archives of pharmacology. vol 338. issue 2. 1988-12-21. PMID:2972934. |
the influences of the indirect serotonin agonist fenfluramine (5; 10 mg/kg s.c.), the serotonin antagonist metergoline (5; 10 mg/kg s.c.) and the 5-ht1a agonist 8-ohdpat (0.1; 0.2; 0.46 mg/kg s.c.) on haloperidol-induced catalepsy in rats or mice and on morphine-induced catalepsy in rats were studied. |
1988-12-21 |
2023-08-11 |
mouse |
| K Herrick-Davis, M Titeler, S Leonhardt, R Struble, D Pric. Serotonin 5-HT1D receptors in human prefrontal cortex and caudate: interaction with a GTP binding protein. Journal of neurochemistry. vol 51. issue 6. 1988-12-20. PMID:3141589. |
[3h]5-ht binding, in the presence of pindolol (to block 5-ht1a and 5-ht1b receptors) and mesulergine (to block 5-ht1c receptors), was specific, saturable, reversible, and of high affinity. |
1988-12-20 |
2023-08-11 |
human |
| M A Harrington, D Oksenberg, S J Peroutk. 5-Hydroxytryptamine1A receptors are linked to a Gi-adenylate cyclase complex in rat hippocampus. European journal of pharmacology. vol 154. issue 1. 1988-12-01. PMID:2972552. |
the ability of 5-hydroxytryptamine (5-ht) and the 5-ht1a selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) to modulate adenylate cyclase activity was measured in rat hippocampus. |
1988-12-01 |
2023-08-11 |
rat |
| F Chaouloff, B Serrurrier, D Mérino, D Laude, J L Elghoz. Feeding responses to a high dose of 8-OH-DPAT in young and adult rats: influence of food texture. European journal of pharmacology. vol 151. issue 2. 1988-11-23. PMID:2458945. |
the influence of the 5-ht1a agonist on midbrain serotonin (5-hydroxytryptamine, 5-ht) turnover was examined. |
1988-11-23 |
2023-08-11 |
rat |
| R Bouhelal, L Smounya, J Bockaer. 5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra. European journal of pharmacology. vol 151. issue 2. 1988-11-23. PMID:2971554. |
spiroperidol, mesulergine and ketanserin, which are potent 5-ht1a, 5-ht1c and 5-ht2 antagonists respectively, were unable to reverse the 5-ht-mediated inhibition of forskolin-stimulated adenylate cyclase whereas the beta-adrenoceptor antagonists, (+/-)-cyanopindolol and (+/-)-propranolol or metergoline, fully reversed the 5-ht effect with calculated ki of 34 +/- 18, 82 +/- 19 and 248 +/- 47 nm, respectively. |
1988-11-23 |
2023-08-11 |
rat |