| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G J Marek, A A Li, L S Seide. Evidence for involvement of 5-hydroxytryptamine1 receptors in antidepressant-like drug effects on differential-reinforcement-of-low-rate 72-second behavior. The Journal of pharmacology and experimental therapeutics. vol 250. issue 1. 1989-08-11. PMID:2746511. |
direct 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin and 5-methoxy-n,n-dimethyltryptamine and the 5-ht precursor 5-hydroxytryptophan all increased the reinforcement rate. |
1989-08-11 |
2023-08-11 |
rat |
| T Nabeshima, K Itoh, K Kawashima, T Kameyam. Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice. Pharmacology, biochemistry, and behavior. vol 32. issue 3. 1989-08-01. PMID:2500672. |
the antiamnesic effect of ritanserin on cxm-induced amnesia was antagonized by 5-ht (icv), but not by nonselective 5-ht agonist 5-methoxy-n,n-dimethyltryptamine and 5-ht1a selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. |
1989-08-01 |
2023-08-11 |
mouse |
| C S Aulakh, J L Hill, D L Murph. A comparison of feeding and locomotion responses to serotonin agonists in three rat strains. Pharmacology, biochemistry, and behavior. vol 31. issue 3. 1989-07-18. PMID:2977992. |
the hyperphagic effects of two selective 5-ht1a agonists (8-ohdpat and buspirone) in a free feeding paradigm and the locomotor suppressant effect of the serotonin agonist, m-chlorophenylpiperazine (m-cpp) were compared in three different rat strains: wistar, sprague-dawley (sd), and fawn-hooded (fh) rats. |
1989-07-18 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D Clark, D G Grahame-Smit. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2470860. |
injection of the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)tetralin (0.5 and 2.5 micrograms) into the dorsal raphe nucleus caused a dose-related fall in hippocampal output of 5-ht compared to saline-injected controls. |
1989-07-13 |
2023-08-11 |
rat |
| J Arnt, J Hytte. Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI. European journal of pharmacology. vol 161. issue 1. 1989-07-12. PMID:2524390. |
the potency of the serotonin 1a (5-ht1a) agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-ohdpat), to induce forepaw treading was increased 20-fold after co-treatment with the 5-ht2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi). |
1989-07-12 |
2023-08-11 |
rat |
| J Arnt, J Hytte. Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI. European journal of pharmacology. vol 161. issue 1. 1989-07-12. PMID:2524390. |
these results indicate a complex and different interaction between 5-ht1a and 5-ht2 receptors in the expression of two behavioural responses mediated by 5-ht. |
1989-07-12 |
2023-08-11 |
rat |
| B Olivier, J Mos, J van der Heyden, J Harto. Serotonergic modulation of social interactions in isolated male mice. Psychopharmacology. vol 97. issue 2. 1989-07-03. PMID:2498921. |
several 5-ht1a agonists (8-oh-dpat, ipsapirone, buspirone, 5-me-odmt) and a 5-ht uptake blocker (fluvoxamine) also reduced aggression. |
1989-07-03 |
2023-08-11 |
mouse |
| D S Robinson, D R Alms, R C Shrotriya, M Messina, P Wickramaratn. Serotonergic anxiolytics and treatment of depression. Psychopathology. vol 22 Suppl 1. 1989-07-03. PMID:2657837. |
the serotonin 5-hydroxytryptamine-1a (5-ht1a) receptor agonists buspirone and gepirone have effects on serotonergic systems, including presynaptic and postsynaptic receptors, that predict both anxiolytic and antidepressant activity. |
1989-07-03 |
2023-08-11 |
Not clear |
| E Adler-Graschinsky, A B Elgoyhen, N V Butt. Different receptor subtypes mediate the dual presynaptic effects of 5-hydroxytryptamine on peripheral sympathetic neurones. Journal of autonomic pharmacology. vol 9. issue 1. 1989-06-29. PMID:2524497. |
in the guinea-pig isolated atria, the inhibitory effect of 5-ht on the chronotropic responses to cardioaccelerans nerve stimulation was mimicked by the mixed 5-ht1a + 5-ht1b + 5-ht1d receptor agonist 5-carboxamidotryptamine (5-ct 0.1 and 1 microm). |
1989-06-29 |
2023-08-11 |
cat |
| K P Nanry, H A Tilso. The role of 5HT1A receptors in the modulation of the acoustic startle reflex in rats. Psychopharmacology. vol 97. issue 4. 1989-06-27. PMID:2524858. |
these data suggest that 5-ht1a and 5-ht1b receptors play opposite roles in the modulation of the acoustic startle response and that 5-ht plays little, if any, role in the prepulse inhibition of the acoustic startle response. |
1989-06-27 |
2023-08-11 |
rat |
| C A Seyfried, H E Greiner, A F Haas. Biochemical and functional studies on EMD 49,980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems. European journal of pharmacology. vol 160. issue 1. 1989-06-20. PMID:2565817. |
control experiments indicate that inhibition of 5-htp accumulation by emd 49,980 is induced mainly via direct activation of 5-ht1a receptors, although some contribution due to 5-ht uptake inhibition is likely. |
1989-06-20 |
2023-08-11 |
rat |
| C A Seyfried, H E Greiner, A F Haas. Biochemical and functional studies on EMD 49,980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems. European journal of pharmacology. vol 160. issue 1. 1989-06-20. PMID:2565817. |
furthermore, results with various reference compounds make it unlikely that there are indirect effects, also via alpha 2-receptors in the models used and support the view that d-2 agonistic, 5-ht uptake inhibiting and 5-ht1a agonistic actions are independent properties of emd 49,980. |
1989-06-20 |
2023-08-11 |
rat |
| P R Harti. Molecular biology of 5-HT receptors. Trends in pharmacological sciences. vol 10. issue 2. 1989-06-19. PMID:2655240. |
within the past six months, isolation of cdna or genomic clones has been reported for three 5-ht receptors, the 5-ht1c, 5-ht1a and 5-ht2 subtypes. |
1989-06-19 |
2023-08-11 |
Not clear |
| b' Y Hong, K Krnjevi\\xc4\\x8. Serotonin blocks the facilitatory action of muscarinic and nicotinic agents in the hippocampus in vivo. Canadian journal of physiology and pharmacology. vol 67. issue 1. 1989-06-16. PMID:2653594.' |
spiperone, used as a 5-hydroxytryptamine1a (5-ht1a) antagonist, suppressed the inhibitory action of serotonin in 14 of 21 tests. |
1989-06-16 |
2023-08-11 |
rat |
| b' Y Hong, K Krnjevi\\xc4\\x8. Serotonin blocks the facilitatory action of muscarinic and nicotinic agents in the hippocampus in vivo. Canadian journal of physiology and pharmacology. vol 67. issue 1. 1989-06-16. PMID:2653594.' |
thus serotonin, probably acting on 5-ht1a receptors, blocks effectively but indiscriminately all cholinergic facilitations, whether mediated by nicotinic or muscarinic receptors. |
1989-06-16 |
2023-08-11 |
rat |
| M E Clement, R B McCal. Characterization of midline medulla role in the trigeminal depressor response. The American journal of physiology. vol 256. issue 5 Pt 2. 1989-06-16. PMID:2719153. |
these included 1) a slow regular discharge rate, 2) sensitivity to the inhibitory action of the 5-ht1a agonist 8-oh 8-hydroxy-2-(di-n-propylamino)tetralin, 3) failure to respond to baroreceptor reflex activation, and 4) the discharges of the 5-ht neurons were not related to sympathetic activity. |
1989-06-16 |
2023-08-11 |
Not clear |
| J E Barrett, S M Hoffmann, S N Olmstead, M J Foust, C Harrod, B A Weissma. Behavioral and neurochemical effects of the serotonin (5-HT)1A receptor ligand spiroxatrine. Psychopharmacology. vol 97. issue 3. 1989-06-15. PMID:2524083. |
the effects of spiroxatrine, a putative antagonist with selectivity for the serotonin (5-ht)1a receptor, were compared with compounds believed to function as agonists at the 5-ht1a receptor. |
1989-06-15 |
2023-08-11 |
pigeon |
| M Abou-Gharbia, J A Moyer, U Patel, M Webb, G Schiehser, T Andree, J T Haskin. Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents. Journal of medicinal chemistry. vol 32. issue 5. 1989-06-06. PMID:2565399. |
they also demonstrated high affinity and selectivity for the 5-ht1a receptor site (ki = 10 nm) and exhibited partial agonist/antagonist activity in the serotonin syndrome test. |
1989-06-06 |
2023-08-11 |
Not clear |
| S Hjorth, T Magnusso. The 5-HT 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 338. issue 5. 1989-06-02. PMID:2469021. |
the present study was undertaken in an attempt to assess whether the effects of the potent and selective 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin, 8-oh-dpat, on cerebral 5-hydroxytryptamine (5-ht) neurochemistry in vivo are mediated via 5-ht autoreceptors on the cell bodies or on the terminals, and or via postsynaptic 5-ht receptors. |
1989-06-02 |
2023-08-11 |
rat |
| S Hjorth, T Magnusso. The 5-HT 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 338. issue 5. 1989-06-02. PMID:2469021. |
these findings provide direct neurochemical evidence that by preferentially stimulating somatodendritic 5-ht1a receptors, 8-oh-dpat inhibits the 5-ht neuronal impulse flow, thereby effectuating decreased terminal 5-ht synthesis and release. |
1989-06-02 |
2023-08-11 |
rat |