| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P H Hutson, T P Donohoe, G Curzo. Hypothermia induced by the putative 5-HT1A agonists LY165163 and 8-OH-DPAT is not prevented by 5-HT depletion. European journal of pharmacology. vol 143. issue 2. 1988-02-02. PMID:2961583. |
results indicate that the hypothermia induced by the putative 5-ht1a agonists ly165163 and 8-oh-dpat in the rat is not dependent on presynaptic 5-ht stores and is therefore probably mediated by postsynaptic 5-ht receptors. |
1988-02-02 |
2023-08-11 |
rat |
| W J Brunken, N W Da. The actions of serotonergic agonists and antagonists on the activity of brisk ganglion cells in the rabbit retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 12. 1988-01-28. PMID:2961853. |
selective antagonists or agonists of serotonin at the 5-ht2 or 5-ht1a receptors were applied, and the changes in light-evoked and spontaneous activity were studied. |
1988-01-28 |
2023-08-11 |
rabbit |
| G J Molderings, K Fink, E Schlicker, M Göther. Inhibition of noradrenaline release via presynaptic 5-HT1B receptors of the rat vena cava. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 3. 1988-01-11. PMID:3683595. |
ketanserin, a 5-ht2 receptor antagonist, and spiperone, which blocks 5-ht2 and 5-ht1a but not 5-ht1b or 5-ht1c receptors, failed to antagonize the effect of 5-ht. |
1988-01-11 |
2023-08-11 |
rat |
| K F Martin, R Maso. Isapirone is a partial agonist at 5-hydroxytryptamine 1A (5-HT1A) receptors in the rat hippocampus: electrophysiological evidence. European journal of pharmacology. vol 141. issue 3. 1987-12-16. PMID:2889611. |
isapirone is a partial agonist at 5-hydroxytryptamine 1a (5-ht1a) receptors in the rat hippocampus: electrophysiological evidence. |
1987-12-16 |
2023-08-11 |
rat |
| K F Martin, R Maso. Isapirone is a partial agonist at 5-hydroxytryptamine 1A (5-HT1A) receptors in the rat hippocampus: electrophysiological evidence. European journal of pharmacology. vol 141. issue 3. 1987-12-16. PMID:2889611. |
using iontophoretic techniques we observed that in vivo isapirone (tvx q 7821), a selective ligand for the 5-ht1a binding site, at low ejection currents (5-30 na) antagonised 5-ht and 8-hydroxy-2-(di-n-propylamino) tetralin (dpat)-induced suppression of hippocampal unit activity, with little effect on baseline firing rate itself. |
1987-12-16 |
2023-08-11 |
rat |
| K F Martin, R Maso. Isapirone is a partial agonist at 5-hydroxytryptamine 1A (5-HT1A) receptors in the rat hippocampus: electrophysiological evidence. European journal of pharmacology. vol 141. issue 3. 1987-12-16. PMID:2889611. |
these data demonstrate that isapirone is a 5-ht1a receptor antagonist with partial agonist properties on 5-ht sensitive neurones in the rat hippocampus. |
1987-12-16 |
2023-08-11 |
rat |
| J M Cossery, H Gozlan, U Spampinato, C Perdicakis, G Guillaumet, L Pichat, M Hamo. The selective labelling of central 5-HT1A receptor binding sites by [3H]5-methoxy-3-(di-n-propylamino)chroman. European journal of pharmacology. vol 140. issue 2. 1987-12-16. PMID:2959487. |
investigations on the pharmacological properties of a series of chroman derivatives indicated that 5-methoxy-3-(di-n-propylamino)chroman (5-meo-dpac) acts in the nm range on 5-ht1a sites but recognizes very poorly other 5-ht sites and d2 sites in rat brain membranes. |
1987-12-16 |
2023-08-11 |
rat |
| J M Cossery, H Gozlan, U Spampinato, C Perdicakis, G Guillaumet, L Pichat, M Hamo. The selective labelling of central 5-HT1A receptor binding sites by [3H]5-methoxy-3-(di-n-propylamino)chroman. European journal of pharmacology. vol 140. issue 2. 1987-12-16. PMID:2959487. |
in contrast to [3h]8-oh-dpat, [3h]5-meo-dpac did not bind to presynaptic striatal sites (possibly associated with 5-ht reuptake in serotoninergic terminals), which indicated that this new chroman derivative was even more selective than the [3h]tetralin ligand for the in vitro labelling of 5-ht1a sites. |
1987-12-16 |
2023-08-11 |
rat |
| R B McCall, B N Patel, L T Harri. Effects of serotonin1 and serotonin2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity. The Journal of pharmacology and experimental therapeutics. vol 242. issue 3. 1987-11-05. PMID:2958619. |
it is suggested that 5-ht1a agonists inhibit snd through a process of disfacilitation by inhibiting the firing rate of 5-ht neurons. |
1987-11-05 |
2023-08-11 |
Not clear |
| J L Ram, M A Kreiman, D Gol. LY165163 and 8-OH-DPAT have agonist effects on a serotonin responsive muscle of Aplysia. European journal of pharmacology. vol 139. issue 2. 1987-10-29. PMID:2958301. |
two 5-ht1a ligands, ly165163 and 8-oh-dpat, mimicked the effect of serotonin, although with slower kinetics. |
1987-10-29 |
2023-08-11 |
aplysia |
| B S Alexander, M D Woo. Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. The Journal of pharmacy and pharmacology. vol 39. issue 8. 1987-10-26. PMID:2888864. |
stereoselective blockade of central [3h]5-hydroxytryptamine binding to multiple sites (5-ht1a, 5-ht1b and 5-ht1c) by mianserin and propranolol. |
1987-10-26 |
2023-08-11 |
rat |
| B S Alexander, M D Woo. Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. The Journal of pharmacy and pharmacology. vol 39. issue 8. 1987-10-26. PMID:2888864. |
the interaction of the enantiomers of mianserin and propranolol with the binding of [3h]5-hydroxytryptamine ([3h]5-ht) to the 5-ht1a, 5-ht1b and 5-ht1c sites, and with the binding of [3h]ketanserin to the 5-ht2 site, has been evaluated in rat brain membranes. |
1987-10-26 |
2023-08-11 |
rat |
| H Gozlan, M B Emerit, S el Mestikawy, J M Cossery, A Marquet, R Besselievre, M Hamo. Photoaffinity labelling and solubilization on the central 5-HT1A receptor binding site. Journal of receptor research. vol 7. issue 1-4. 1987-10-22. PMID:2957498. |
thus, 3h-incorporation into the 63 kd band could be prevented by microm concentrations of 5-ht, 8-oh-dpat and other selective 5-ht1a ligands such as isapirone. |
1987-10-22 |
2023-08-11 |
rat |
| T P Donohoe, P H Hutson, G Curzo. Blockade of dopamine receptors explains the lack of 5-HT stereotypy on treatment with the putative 5-HT1A agonist LY165163. Psychopharmacology. vol 93. issue 1. 1987-10-21. PMID:2957721. |
blockade of dopamine receptors explains the lack of 5-ht stereotypy on treatment with the putative 5-ht1a agonist ly165163. |
1987-10-21 |
2023-08-11 |
rat |
| K A Cunningham, P M Callahan, J B Appe. Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT): implications for understanding the actions of novel anxiolytics. European journal of pharmacology. vol 138. issue 1. 1987-10-16. PMID:2887435. |
although not primarily selective for 5-ht, lisuride may also mimic 8-ohdpat by direct or indirect stimulation of 5-ht1a receptors. |
1987-10-16 |
2023-08-11 |
rat |
| M Joëls, P Shinnick-Gallagher, J P Gallaghe. Effect of serotonin and serotonin analogues on passive membrane properties of lateral septal neurons in vitro. Brain research. vol 417. issue 1. 1987-10-13. PMID:2957026. |
two other 5-ht1a analogues, tvx q 7821 and buspirone, could also mimick the effect of 5-ht. |
1987-10-13 |
2023-08-11 |
rat |
| J I Koenig, G A Gudelsky, H Y Meltze. Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5-HT receptor subtype activation. European journal of pharmacology. vol 137. issue 1. 1987-08-28. PMID:2956114. |
changes in plasma concentrations of corticosterone and beta-endorphin (beta-end) were determined in male rats after treatment with the selective 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) or the non-selective 5-ht agonist 6-chloro-2-(1-piperazinyl)pyrazine (mk-212). |
1987-08-28 |
2023-08-11 |
rat |
| G M Goodwin, R J De Souza, A R Gree. Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat. Psychopharmacology. vol 91. issue 4. 1987-06-30. PMID:2954178. |
attenuation by electroconvulsive shock and antidepressant drugs of the 5-ht1a receptor-mediated hypothermia and serotonin syndrome produced by 8-oh-dpat in the rat. |
1987-06-30 |
2023-08-11 |
rat |
| S A Lorens, L D Van de Ka. Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology. vol 45. issue 4. 1987-06-01. PMID:2952898. |
differential effects of serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. |
1987-06-01 |
2023-08-11 |
Not clear |
| S A Lorens, L D Van de Ka. Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology. vol 45. issue 4. 1987-06-01. PMID:2952898. |
the present study was designed to investigate the effect of distinct serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. |
1987-06-01 |
2023-08-11 |
Not clear |