| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Simpson, D I Lubman, P Slater, J F Deaki. Autoradiography with [3H]8-OH-DPAT reveals increases in 5-HT(1A) receptors in ventral prefrontal cortex in schizophrenia. Biological psychiatry. vol 39. issue 11. 1997-05-29. PMID:9162203. |
in view of the evidence that one serotonin (5-ht) receptor, the 5-ht(1a) subtype, is associated with cortical glutamatergic neurons, we have used quantitative receptor autoradiography to measure the specific binding of the 5-ht(1a) receptor ligand [3h]8-oh-dpat (2 nm) in sections of orbital frontal cortex taken from 18 control and 12 schizophrenic postmortem brains. |
1997-05-29 |
2023-08-12 |
Not clear |
| P Boulenguez, J N Rawlins, J Chauveau, M H Joseph, S N Mitchell, J A Gra. Modulation of dopamine release in the nucleus accumbens by 5-HT1B agonists: involvement of the hippocampo-accumbens pathway. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025099. |
it is concluded that: (1) serotonin interacts with the mesolimbic dopaminergic system through 5-ht1b, but not 5-ht1a, receptors: and (2) serotonin interaction with the mesolimbic dopaminergic system involves postjunctional 5-ht1b heteroreceptors located in the ventral subicular area, which modulate the activity of glutamatergic hippocampo-accumbens pathways and only secondarily alter da levels in the n. acc. |
1997-05-28 |
2023-08-12 |
rat |
| C Lebrand, O Cases, C Adelbrecht, A Doye, C Alvarez, S El Mestikawy, I Seif, P Gaspa. Transient uptake and storage of serotonin in developing thalamic neurons. Neuron. vol 17. issue 5. 1997-01-07. PMID:8938116. |
in these glutamatergic neurons, internalized 5-ht might thus be stored and used as a "borrowed transmitter" for extraneuronal signaling or could exert an intraneuronal control on thalamic maturation. |
1997-01-07 |
2023-08-12 |
mouse |
| S R Robinson, D F Noone, B S O'Dow. Ependymocytes and supra-ependymal axons in rat brain contain glutamate. Glia. vol 17. issue 4. 1997-01-03. PMID:8856331. |
the neurones of origin contain both serotonin and phosphate-activated glutaminase, which raises the possibility that the supra-ependymal axons are also glutamatergic. |
1997-01-03 |
2023-08-12 |
rat |
| M A Pacheco, C Stockmeier, H Y Meltzer, J C Overholser, G E Dilley, R S Jop. Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain. Brain research. vol 723. issue 1-2. 1996-12-03. PMID:8813380. |
receptor-coupled, g-protein-mediated [3h]pi hydrolysis induced with carbachol, histamine, trans-1-aminocyclopentyl-1, 3-dicarboxylic acid (acpd, a glutamatergic metabotropic receptor agonist), serotonin, or 2-methylthio-adenosine triphosphate (2matp, a purinergic receptor agonist) in the presence of gtp-gamma-s stimulated equivalent responses in the two groups of subjects in each brain region. |
1996-12-03 |
2023-08-12 |
human |
| J Strosznajder, M Chalimoniuk, M Samochock. Activation of serotonergic 5-HT1A receptor reduces Ca(2+)- and glutamatergic receptor-evoked arachidonic acid and No/cGMP release in adult hippocampus. Neurochemistry international. vol 28. issue 4. 1996-10-29. PMID:8740452. |
in conclusion, the interaction of serotonin with the glutamatergic system in the hippocampus may play an important role in the modulation of a signal transduction pathway, and by this molecular mechanism serotonin may exert a neuroprotective effect on hippocampal neurons. |
1996-10-29 |
2023-08-12 |
rat |
| D Schmitz, R M Empson, U Heineman. Serotonin and 8-OH-DPAT reduce excitatory transmission in rat hippocampal area CA1 via reduction in presumed presynaptic Ca2+ entry. Brain research. vol 701. issue 1-2. 1996-10-25. PMID:8925288. |
these results suggest that 5-ht acts at presynaptic 5-ht1a receptors to reduce ca2+ entry and thereby glutamatergic synaptic transmission. |
1996-10-25 |
2023-08-12 |
rat |
| E Bracci, L Ballerini, A Nistr. Spontaneous rhythmic bursts induced by pharmacological block of inhibition in lumbar motoneurons of the neonatal rat spinal cord. Journal of neurophysiology. vol 75. issue 2. 1996-10-10. PMID:8714641. |
rhythmic bursts thus appear to result from large, synchronous synaptic events generated by a network modulated by 5-ht and highly sensitive to variations in efficacy of glutamatergic synaptic transmission. |
1996-10-10 |
2023-08-12 |
rat |
| G B Varty, G A Higgin. Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology. vol 122. issue 1. 1996-09-11. PMID:8711060. |
there is also evidence to suggest a role of serotonergic (5-ht) and glutamatergic systems in schizophrenia, and accordingly ppi can be disrupted by the 5-ht2 agonist doi, and the non-competitive nmda antagonist, dizocilpine. |
1996-09-11 |
2023-08-12 |
rat |
| J R Mohammed, T A Saska, J Chi, R L Stephen. Stimulation of the nucleus raphe obscurus produces marked serotonin release into the dorsal medulla of fed but not fasted rats--glutamatergic dependence. Brain research. vol 695. issue 1. 1996-03-12. PMID:8574642. |
stimulation of the nucleus raphe obscurus produces marked serotonin release into the dorsal medulla of fed but not fasted rats--glutamatergic dependence. |
1996-03-12 |
2023-08-12 |
rat |
| O Shupliakov, V A Pieribone, H Gad, L Brodi. Synaptic vesicle depletion in reticulospinal axons is reduced by 5-hydroxytryptamine: direct evidence for presynaptic modulation of glutamatergic transmission. The European journal of neuroscience. vol 7. issue 5. 1995-08-23. PMID:7613617. |
synaptic vesicle depletion in reticulospinal axons is reduced by 5-hydroxytryptamine: direct evidence for presynaptic modulation of glutamatergic transmission. |
1995-08-23 |
2023-08-12 |
Not clear |
| O Shupliakov, V A Pieribone, H Gad, L Brodi. Synaptic vesicle depletion in reticulospinal axons is reduced by 5-hydroxytryptamine: direct evidence for presynaptic modulation of glutamatergic transmission. The European journal of neuroscience. vol 7. issue 5. 1995-08-23. PMID:7613617. |
5-hydroxytryptamine (5-ht; serotonin) is known to depress glutamatergic synaptic transmission in the spinal cord of vertebrates. |
1995-08-23 |
2023-08-12 |
Not clear |
| K Ohta, N Araki, M Shibata, S Komatsumoto, K Shimazu, Y Fukuuch. Presynaptic ionotropic glutamate receptors modulate in vivo release and metabolism of striatal dopamine, noradrenaline, and 5-hydroxytryptamine: involvement of both NMDA and AMPA/kainate subtypes. Neuroscience research. vol 21. issue 1. 1995-05-11. PMID:7535906. |
in order to explore further the presynaptic modulation of monoamine release by glutamatergic nerve fibers, we investigated the effects of selective agonists for ionotropic glutamate (glu) receptors on striatal release of dopamine (da), noradrenaline (na) and 5-hydroxytryptamine (5-ht). |
1995-05-11 |
2023-08-12 |
rat |
| P Piguet, M Galva. Transient and long-lasting actions of 5-HT on rat dentate gyrus neurones in vitro. The Journal of physiology. vol 481 ( Pt 3). 1995-05-08. PMID:7707231. |
5-ht (30 microm) shortened the decay time constants of the glutamatergic and gabaergic evoked epsps and ipsps without changing their amplitudes. |
1995-05-08 |
2023-08-12 |
human |
| J Strosznajder, M Samochocki, M Dura. Serotonin, a potent modulator of arachidonic acid turnover, interaction with glutamatergic receptor in brain cortex. Neurochemistry international. vol 25. issue 2. 1995-01-19. PMID:7994200. |
serotonin, a potent modulator of arachidonic acid turnover, interaction with glutamatergic receptor in brain cortex. |
1995-01-19 |
2023-08-12 |
Not clear |
| J Strosznajder, M Samochocki, M Dura. Serotonin, a potent modulator of arachidonic acid turnover, interaction with glutamatergic receptor in brain cortex. Neurochemistry international. vol 25. issue 2. 1995-01-19. PMID:7994200. |
our results indicated that serotonin directly, through the specific receptors, or indirectly, through the interaction with glutamatergic receptors, modulates turnover and the level of arachidonic acid in the brain. |
1995-01-19 |
2023-08-12 |
Not clear |
| R S Jope, L Song, R Power. [3H]PtdIns hydrolysis in postmortem human brain membranes is mediated by the G-proteins Gq/11 and phospholipase C-beta. The Biochemical journal. vol 304 ( Pt 2). 1995-01-13. PMID:7999004. |
agonists inducing [3h]ptdins hydrolysis include carbachol, trans-1-aminocyclopentyl-1,3-dicarboxylate (acpd; a glutamatergic metabotropic receptor agonist), serotonin and atp, with the latter two agonists producing the largest responses. |
1995-01-13 |
2023-08-12 |
human |
| D A McCormick, Z Wang, J Huguenar. Neurotransmitter control of neocortical neuronal activity and excitability. Cerebral cortex (New York, N.Y. : 1991). vol 3. issue 5. 1994-01-25. PMID:7903176. |
the pattern of activity and excitability of cortical neurons and neuronal circuits is dependent upon the interaction between glutamatergic and gabaergic fast-activating transmitter systems as well as the state of the more slowly acting transmitters such as ach, norepinephrine, 5-ht, and histamine. |
1994-01-25 |
2023-08-12 |
Not clear |
| N Merahi, H S Orer, R Laguzz. 5-HT2 receptors in the nucleus tractus solitarius: characterisation and role in cardiovascular regulation in the rat. Brain research. vol 575. issue 1. 1992-09-24. PMID:1504784. |
the potentiation of nmda depressor effects by 5-ht or dob could be totally prevented by ketanserin or piremperone, suggesting that 5-ht acting upon 5-ht2 receptors in the nts may intervene in the reflex control of blood pressure by modulating the glutamatergic transmission. |
1992-09-24 |
2023-08-11 |
rat |
| D Becquet, M Faudon, F Her. In vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of GABA neurons. Brain research. vol 519. issue 1-2. 1990-10-16. PMID:1975768. |
in vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of gaba neurons. |
1990-10-16 |
2023-08-11 |
cat |