| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Di Cara, N Dusticier, C Forni, J C Lievens, A Daszut. Serotonin depletion produces long lasting increase in striatal glutamatergic transmission. Journal of neurochemistry. vol 78. issue 2. 2001-08-23. PMID:11461959. |
the ability of serotonin (5-ht) to influence striatal glutamatergic transmission was examined by determining changes over time in glutamate extracellular levels, transporter expression and synaptosomal uptake in rats with lesion of serotonergic neurones. |
2001-08-23 |
2023-08-12 |
rat |
| B Di Cara, N Dusticier, C Forni, J C Lievens, A Daszut. Serotonin depletion produces long lasting increase in striatal glutamatergic transmission. Journal of neurochemistry. vol 78. issue 2. 2001-08-23. PMID:11461959. |
by 8 days after intraraphe injections of 5,7-dihydroxytryptamine, producing 80% decreases in striatal tissue 5-ht levels, no changes were observed in the glutamatergic transmission. |
2001-08-23 |
2023-08-12 |
rat |
| B Di Cara, N Dusticier, C Forni, J C Lievens, A Daszut. Serotonin depletion produces long lasting increase in striatal glutamatergic transmission. Journal of neurochemistry. vol 78. issue 2. 2001-08-23. PMID:11461959. |
these results suggest that 5-ht has a long lasting and tonic inhibitory influence on the striatal glutamatergic input, without affecting the basal dopaminergic transmission. |
2001-08-23 |
2023-08-12 |
rat |
| S Rossignol, N Giroux, C Chau, J Marcoux, E Brustein, T A Reade. Pharmacological aids to locomotor training after spinal injury in the cat. The Journal of physiology. vol 533. issue Pt 1. 2001-08-02. PMID:11351014. |
in turn, this suggests that although the locomotor rhythm might normally be triggered and modulated by the activation of a variety of receptors (noradrenaline, serotonin, glutamate), after spinalization there appears to be a predominance of glutamatergic mechanisms. |
2001-08-02 |
2023-08-12 |
cat |
| B N Smith, P J Sollars, F E Dudek, G E Pickar. Serotonergic modulation of retinal input to the mouse suprachiasmatic nucleus mediated by 5-HT1B and 5-HT7 receptors. Journal of biological rhythms. vol 16. issue 1. 2001-07-26. PMID:11220775. |
as previously described in the hamster, a mixed 5-ht(1a/1b) receptor agonist, 1-[3-(trifluoromethyl)phenyl]-piperazine hydrochloride (tfmpp), reduced the amplitude of glutamatergic excitatory postsynaptic currents (epscs) evoked by selectively stimulating the optic nerve of wild-type mice. |
2001-07-26 |
2023-08-12 |
mouse |
| B N Smith, P J Sollars, F E Dudek, G E Pickar. Serotonergic modulation of retinal input to the mouse suprachiasmatic nucleus mediated by 5-HT1B and 5-HT7 receptors. Journal of biological rhythms. vol 16. issue 1. 2001-07-26. PMID:11220775. |
the findings indicate that 5-ht may modulate rht glutamatergic input to the scn through 2 or more 5-ht receptors. |
2001-07-26 |
2023-08-12 |
mouse |
| A Meneses, J A Terró. Role of 5-HT(1A) and 5-HT(7) receptors in the facilitatory response induced by 8-OH-DPAT on learning consolidation. Behavioural brain research. vol 121. issue 1-2. 2001-06-28. PMID:11275281. |
blockade of 5-ht(2) receptors, and perhaps of 5-ht(7) receptors as well, may provide some benefit in reversing learning deficits associated with decreased cholinergic and/or glutamatergic neurotransmission. |
2001-06-28 |
2023-08-12 |
Not clear |
| M A Belenky, G E Pickar. Subcellular distribution of 5-HT(1B) and 5-HT(7) receptors in the mouse suprachiasmatic nucleus. The Journal of comparative neurology. vol 432. issue 3. 2001-05-31. PMID:11246214. |
the suprachiasmatic nucleus (scn), a circadian oscillator, receives glutamatergic afferents from the retina and serotonergic (5-ht) afferents from the median raphe. |
2001-05-31 |
2023-08-12 |
mouse |
| F Shutoh, S Hamada, M Shibata, M Narita, T Shiga, E C Azmitia, N Okad. Long term depletion of serotonin leads to selective changes in glutamate receptor subunits. Neuroscience research. vol 38. issue 4. 2001-04-26. PMID:11164563. |
the present study was carried out to clarify possible modulation mechanism of serotonin (5-ht) on glutamatergic neurotransmission in the rat cerebral cortex. |
2001-04-26 |
2023-08-12 |
rat |
| J L Scruggs, S Patel, M Bubser, A Y Deutc. DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102493. |
this band of fos immunoreactive neurons was in register with anterogradely labeled axons from the ventrobasal thalamus, which have previously been shown to be glutamatergic and express the 5-ht(2a) transcript. |
2001-02-08 |
2023-08-12 |
rat |
| M T Abellán, R Martín-Ruiz, F Artiga. Local modulation of the 5-HT release in the dorsal striatum of the rat: an in vivo microdialysis study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 6. 2001-02-08. PMID:11115735. |
these data suggest that the striatal 5-ht release is influenced by local serotonergic and glutamatergic (but not gabaergic) inputs. |
2001-02-08 |
2023-08-12 |
rat |
| M Yoshimur. Analgesic mechanism of calcitonin. Journal of bone and mineral metabolism. vol 18. issue 4. 2000-11-15. PMID:10874604. |
glutamatergic short- and long-latency epscs, mediated by a delta and c afferent fibers, respectively, were observed after stimulation of the dorsal root, and both were depressed in amplitude by serotonin in sham rats, whereas only a delta-mediated epscs but not c-mediated were inhibited in ovx rats. |
2000-11-15 |
2023-08-12 |
rat |
| A Ito, E Kumamoto, M Takeda, K Shibata, H Sagai, M Yoshimur. Mechanisms for ovariectomy-induced hyperalgesia and its relief by calcitonin: participation of 5-HT1A-like receptor on C-afferent terminals in substantia gelatinosa of the rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934282. |
hyperalgesia could be attributed to the elimination of presynaptic inhibition by 5-ht of glutamatergic primary c-afferent terminals and an associated decrease in the density of [(3)h]8-oh-dpat binding sites whose receptors are neither 5-ht(1a)- nor 5-ht(7)-subtype. |
2000-08-31 |
2023-08-12 |
rat |
| G E Stutzmann, J E LeDou. GABAergic antagonists block the inhibitory effects of serotonin in the lateral amygdala: a mechanism for modulation of sensory inputs related to fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 11. 2000-05-22. PMID:10341269. |
neurons in the lateral amygdala (la) receive glutamatergic sensory input from the auditory thalamus and auditory cortex, and these inputs can be modulated by serotonin (5-ht). |
2000-05-22 |
2023-08-12 |
Not clear |
| G K Aghajanian, G J Mare. Serotonin model of schizophrenia: emerging role of glutamate mechanisms. Brain research. Brain research reviews. vol 31. issue 2-3. 2000-05-17. PMID:10719157. |
this review focuses on two brain regions, the locus coeruleus and the cerebral cortex, where the actions of indoleamine and the phenethylamine hallucinogens have been shown to be mediated by 5-ht(2a) receptors; in each case, the hallucinogens (via 5-ht(2a) receptors) have been found to enhance glutamatergic transmission. |
2000-05-17 |
2023-08-12 |
Not clear |
| J Flett, C S Colwel. Serotonin modulation of calcium transients in cells in the suprachiasmatic nucleus. Journal of biological rhythms. vol 14. issue 5. 1999-11-02. PMID:10511003. |
the authors became interested in the possibility that 5ht can inhibit the glutamatergic regulation of ca2+ in scn neurons and, by this mechanism, modulate light-induced phase shifts of the circadian system. |
1999-11-02 |
2023-08-12 |
Not clear |
| N R Newberry, D R Footitt, V Papanastassiou, D J Reynold. Actions of 5-HT on human neocortical neurones in vitro. Brain research. vol 833. issue 1. 1999-07-27. PMID:10375681. |
the action of 5-ht (30-50 microm) was studied on 21 cells (from 12 individuals) which had electrophysiological characteristics of glutamatergic pyramidal neurones. |
1999-07-27 |
2023-08-12 |
human |
| H S Kim, I S Park, H K Lim, H S Cho. NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in PCPA-treated mice. Archives of pharmacal research. vol 22. issue 2. 1999-06-28. PMID:10230499. |
previous work in our laboratory has shown that the n-methyl-d-aspartate (nmda) receptor antagonists, ap-5, cpp, mk-801, ketamine, dextrorphan and dextromethorphan cause a pronounced enhancement of 5-hydroxytryptamine (5-ht)-induced head-twitch response (htr) in intact mice, suggesting the involvement of nmda receptors in the glutamatergic modulation of serotonergic function at the postsynaptic 5-ht2 receptors. |
1999-06-28 |
2023-08-12 |
mouse |
| G E Pickard, B N Smith, M Belenky, M A Rea, F E Dudek, P J Sollar. 5-HT1B receptor-mediated presynaptic inhibition of retinal input to the suprachiasmatic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 10. 1999-06-01. PMID:10234032. |
the suprachiasmatic nucleus (scn) receives glutamatergic afferents from the retina and serotonergic afferents from the midbrain, and serotonin (5-ht) can modify the response of the scn circadian oscillator to light. |
1999-06-01 |
2023-08-12 |
mouse |
| G K Aghajanian, G J Mare. Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain research. vol 825. issue 1-2. 1999-05-26. PMID:10216183. |
previously, serotonin (5-ht) was found to induce a marked increase in glutamatergic spontaneous excitatory postsynaptic currents (epscs) in apical dendrites of layer v pyramidal cells of prefrontal cortex; this effect was mediated by 5-ht2a receptors, a proposed site of action of hallucinogenic and atypical antipsychotic drugs. |
1999-05-26 |
2023-08-12 |
rat |